COPB2 coatomer protein complex, subunit beta 2 (beta prime) [Homo sapiens] - Gene

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Summary

Official Symbol: COPB2provided by HGNC
Official Full Name: coatomer protein complex, subunit beta 2 (beta prime)provided by HGNC
Primary source: HGNC:2232
See related: Ensembl:ENSG00000184432; HPRD:06103; MIM:606990; Vega:OTTHUMG00000159959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: beta'-COP
Summary: The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]

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Genomic context

Location :: 3q23

Sequence :: Chromosome: 3; NC_000003.11 (139076433..139108522, complement)

See COPB2 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data suggest that beta-COP plays a critical role in the forward transport of TREK1 channel to the plasma membrane.
Title: Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.
Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat
Title: Coat-tether interaction in Golgi organization.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004757.1	NP_054735.2	SACM1L	BIND	PubMed	hSac1 interacts with beta-COP.
P35606	P48444	ARCN1	HPRD	PubMed
P35606	P53621	COPA	HPRD	PubMed
P35606	Q92597	NDRG1	HPRD	PubMed
P35606	Q02156	PRKCE	HPRD	PubMed
P35606	P41220	RGS2	HPRD	PubMed
P35606	P49798	RGS4	HPRD	PubMed
P35606	Suppressor of actin mutations 1 like	SACM1L	HPRD	PubMed
BioGRID:114693	BioGRID:107709	COPA	BioGRID	PubMed	Two-hybrid
BioGRID:114693	BioGRID:107710	COPB1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114693	BioGRID:116447	COPE	BioGRID	PubMed	Two-hybrid
BioGRID:114693	BioGRID:116496	COPG1	BioGRID	PubMed	Two-hybrid
BioGRID:114693	BioGRID:198835	Copa	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:122485	DDA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:36866	GLO3	BioGRID	PubMed	Two-hybrid
BioGRID:114693	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:109824	ILK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:115669	NDRG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:111567	PRKCE	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114693	BioGRID:111929	RGS2	BioGRID	PubMed	Co-fractionation
BioGRID:114693	BioGRID:111931	RGS4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114693	BioGRID:119572	TH1L	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:114374	TSC22D1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:122964	UBA5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114693	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
COPI coating of Golgi vesicle	TAS Traceable Author Statement more info
cellular membrane organization	TAS Traceable Author Statement more info
intra-Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
intracellular protein transport	IEA Inferred from Electronic Annotation more info
retrograde vesicle-mediated transport, Golgi to ER	TAS Traceable Author Statement more info
vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
COPI vesicle coat	IDA Inferred from Direct Assay more info	PubMed
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Golgi membrane	IEA Inferred from Electronic Annotation more info
actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info
membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: coatomer subunit beta'

Names: coatomer subunit beta'; p102; betaprime-COP; beta'-coat protein; coatomer binding complex, beta prime subunit

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004766.2 → NP_004757.1 coatomer subunit beta'

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate splice donor site in the first coding exon and is predicted to encode a protein.

Source sequence(s)

BC000326, DC347783, X70476

Consensus CDS

CCDS3108.1

UniProtKB/Swiss-Prot

P35606

Related

ENSP00000329419, OTTHUMP00000217144, ENST00000333188, OTTHUMT00000358495

Conserved Domains (3) summary

cd00200
Location:8 – 297
Blast Score: 552

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

COG2319
Location:24 – 433
Blast Score: 307

COG2319; FOG: WD40 repeat [General function prediction only]

pfam04053
Location:320 – 763
Blast Score: 1577

Coatomer_WDAD; Coatomer WD associated region

RNA

NR_023350.1 RNA Sequence

Description

Transcript Variant: This variant (2) uses an alternate splice donor site which introduces a stop codon shortly after the initiating AUG site and renders the transcript a candidate for nonsense-mediated decay.

Source sequence(s)

BC000326, DC347783, DC385126

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

139076433..139108522, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

136451880..136483977, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC024933.34 (102055..134083)	None
genomic	CH471052.2	EAW79039.1
		EAW79040.1
genomic	CS185545.1	CAJ42726.1
mRNA	AK302943.1	BAG64100.1
mRNA	AK304219.1	BAG65091.1
mRNA	BC000326.2	AAH00326.1
mRNA	DC347783.1	None
mRNA	DC385126.1	None
mRNA	X70476.1	CAA49900.1
other-genetic	JF432305.1	ADZ15522.1