My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CD151 CD151 molecule (Raph blood group) [ Homo sapiens ]

    Gene ID: 977, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CD151provided by HGNC
    Official Full Name
    CD151 molecule (Raph blood group)provided by HGNC
    Primary source
    HGNC:1630
    See related
    Ensembl:ENSG00000177697; HPRD:03763; MIM:602243; Vega:OTTHUMG00000133311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    11p15.5
    Sequence :
    Chromosome: 11; NC_000011.9 (832952..838835)
    See CD151 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene uncharacterized LOC100506720 Neighboring gene EF-hand calcium binding domain 4A Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa Neighboring gene tetraspanin 4

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. Kwon MJ, et al. Br J Cancer, 2012 Feb 28. PMID 22294188.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma. Devbhandari RP, et al. PLoS One, 2011. PMID 21961047.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Zhang F, et al. Blood, 2011 Oct 13. PMID 21832275.

    See all (80) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
      Title: Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
    2. Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
      Title: Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
    3. CD151 maintains vascular stability by promoting endothelial cell adhesions, especially cell-cell adhesion, and confining cytoskeletal tension.
      Title: Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension.
    4. High expression levels of CD151 and alpha6 promote invasiveness of HCC cells.
      Title: CD151 amplifies signaling by integrin α6β1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells.
    5. mAbs targeting CD151 may be of significant interest for cancer biotherapy.
      Title: Tetraspanin CD151 as a target for antibody-based cancer immunotherapy.
    6. CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in pancreatic ductal adenocarcinoma. CD151 and c-Met might be new molecular markers to predict the prognosis of pancreatic ductal adenocarcinoma patients.
      Title: Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma.
    7. High CD151 expression is associated with tumor proliferation and invasiveness in esophageal squamous cell carcinoma.
      Title: Prognostic significance of CD151 expression in esophageal squamous cell carcinoma with aggressive cell proliferation and invasiveness.
    8. formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways
      Title: Role of tetraspanin CD151-α3/α6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.
    9. High CD151 expression is associated with advanced stage and high nuclear grade in clear cell renal cell carcinoma
      Title: CD151 expression can predict cancer progression in clear cell renal cell carcinoma.
    10. Tetraspanin protein CD151 interacts directly with both alpha3beta1 and alpha6beta4 integrins and with other tetraspanins, thereby promoting alpha3beta1 and alpha6beta4 association with tetraspanin-enriched microdomains on the cell surface
      Title: Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by α3β1 versus α6β4 integrin.
    Submit: New GeneRIF Correction See all (48)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Blood group, Raph

    Nephropathy with pretibial epidermolysis bullosa and deafness

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_620599.1     BIND  PubMed CD151 interacts with Integrin alpha-6 beta-4 
    NP_620599.1     BIND  PubMed CD151 interacts with Integrin alpha-6 beta-1 
    NP_620599.1     BIND  PubMed CD151 interacts with Integrin alpha-3 beta-1 
    NP_620599.1     BIND  PubMed CD151 interacts with Integrin alpha-6 beta-1 
    NP_620599.1     BIND  PubMed CD151 interacts with Integrin alpha-3 beta-1 
    P48509 P26006 ITGA3    HPRD  PubMed  
    P48509 P23229 ITGA6    HPRD  PubMed  
    P48509 P05556 ITGB1    HPRD  PubMed  
    P48509 P09237 MMP7    HPRD  PubMed  
    P48509 Q9P2B2 PTGFRN    HPRD  PubMed  
    BioGRID:107415 BioGRID:110346 CD46    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107415 BioGRID:109935 CD82    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107415 BioGRID:109882 ITGA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107415 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107415 BioGRID:111710 PTGFRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107415 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Type I hemidesmosome assembly, organism-specific biosystem (from REACTOME)
      Type I hemidesmosome assembly, organism-specific biosystemHemidesmosomes (HDs) are specialized multiprotein junctional complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix and play a critical role in the maintenan...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell junction assembly TAS
    Traceable Author Statement
    more info
    		  
    hemidesmosome assembly TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    CD151 antigen
    Names
    CD151 antigen
    tspan-24
    tetraspanin-24
    membrane glycoprotein SFA-1
    CD151 antigen (Raph blood group)
    hemidesmosomal tetraspanin CD151
    platelet surface glycoprotein gp27
    platelet-endothelial tetraspan antigen 3
    platelet-endothelial cell tetraspan antigen 3
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007478.1 RefSeqGene

      Range
      5001..10884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039490.1 → NP_001034579.1  CD151 antigen

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate segment of sequence in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK130369, AU099249, BC001374, BQ957432
      Consensus CDS
      CCDS7719.1
      UniProtKB/Swiss-Prot
      P48509
      UniProtKB/TrEMBL
      Q6ZNZ0
      Related
      ENSP00000432990, OTTHUMP00000229174, ENST00000528011, OTTHUMT00000383118
      Conserved Domains (2) summary
      cd03155
      Location:112 – 220
      Blast Score: 407
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 – 248
      Blast Score: 337
      Tetraspannin; Tetraspanin family

    2. NM_004357.4 → NP_004348.2  CD151 antigen

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK130369, AU099249, BC001374
      Consensus CDS
      CCDS7719.1
      UniProtKB/Swiss-Prot
      P48509
      UniProtKB/TrEMBL
      Q6ZNZ0
      Related
      ENSP00000324101, ENST00000322008
      Conserved Domains (2) summary
      cd03155
      Location:112 – 220
      Blast Score: 407
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 – 248
      Blast Score: 337
      Tetraspannin; Tetraspanin family

    3. NM_139029.1 → NP_620598.1  CD151 antigen

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK130369, AU099249, BC001374, BC013302
      Consensus CDS
      CCDS7719.1
      UniProtKB/Swiss-Prot
      P48509
      UniProtKB/TrEMBL
      Q6ZNZ0
      Related
      ENSP00000380565, OTTHUMP00000164434, ENST00000397420, OTTHUMT00000257108
      Conserved Domains (2) summary
      cd03155
      Location:112 – 220
      Blast Score: 407
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 – 248
      Blast Score: 337
      Tetraspannin; Tetraspanin family

    4. NM_139030.3 → NP_620599.1  CD151 antigen

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK130369, AU099249, BC001374
      Consensus CDS
      CCDS7719.1
      UniProtKB/Swiss-Prot
      P48509
      UniProtKB/TrEMBL
      Q6ZNZ0
      Related
      ENSP00000380566, ENST00000397421
      Conserved Domains (2) summary
      cd03155
      Location:112 – 220
      Blast Score: 407
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 – 248
      Blast Score: 337
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      832952..838835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      648214..654180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF315942.1 AAK14179.1
    genomic AP006621.1 (127866..129988) None
    genomic AP006623.1 (16311..20050) None
    genomic CH471158.1 EAX02400.1
      EAX02401.1
      EAX02402.1
      EAX02403.1
      EAX02404.1
      EAX02405.1
      EAX02406.1
      EAX02407.1
    genomic DQ074789.1 AAY68211.1
    mRNA AK130369.1 BAC85335.1
    mRNA AK223186.1 BAD96906.1
    mRNA AK293073.1 BAF85762.1
    mRNA AL161965.1 None
    mRNA AU099249.1 None
    mRNA BC001374.2 AAH01374.1
    mRNA BC013302.2 AAH13302.1
    mRNA BQ957432.1 None
    mRNA BT007397.1 AAP36061.1
    mRNA BT020132.1 AAV38934.1
    mRNA CR456826.1 CAG33107.1
    mRNA CR542098.1 CAG46895.1
    mRNA D29963.1 BAA06229.1
    mRNA U14650.1 AAA87064.1
    other-genetic DQ893670.2 ABM84596.1
    other-genetic DQ895817.2 ABM86743.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48509.3 GenPept UniProtKB/Swiss-Prot:P48509
    Q53FU5 GenPept UniProtKB/TrEMBL:Q53FU5
    Q6ZNZ0 GenPept UniProtKB/TrEMBL:Q6ZNZ0
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...