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    EPHB2 EPH receptor B2 [ Homo sapiens ]

    Gene ID: 2048, updated on 11-May-2012
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    Summary

    Official Symbol
    EPHB2provided by HGNC
    Official Full Name
    EPH receptor B2provided by HGNC
    Primary source
    HGNC:3393
    See related
    Ensembl:ENSG00000133216; HPRD:02997; MIM:600997; Vega:OTTHUMG00000002881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492
    Summary
    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p36.1-p35
    Sequence :
    Chromosome: 1; NC_000001.10 (23037331..23241823)
    See EPHB2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent, C chain Neighboring gene complement component 1, q subcomponent, B chain Neighboring gene microRNA 4684 Neighboring gene microRNA 4253 Neighboring gene lactamase, beta-like 1 Neighboring gene uncharacterized LOC729059

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia. Azab F, et al. Clin Cancer Res, 2012 Jan 1. PMID 22010211.
    2. Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes. Walsh R, et al. J Cell Physiol, 2012 Jun. PMID 21809346.
    3. A paradigm shift in EPH receptor interaction: biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell lines. Fox BP, et al. Cancer Genomics Proteomics, 2011 Jul-Aug. PMID 21737611.
    4. EphB2 SNPs and sporadic prostate cancer risk in African American men. Robbins CM, et al. PLoS One, 2011. PMID 21603658.
    5. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. Tanabe H, et al. Int J Oncol, 2011 Jul. PMID 21503576.

    See all (107) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Define the transcriptional targets of the reverse signaling by EphB2 acting exclusively as a ligand in epidermal keratinocyte differentiation.
      Title: Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes.
    2. High Eph-B2 is associated with Waldenstrom's macroglobulinemia.
      Title: Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia.
    3. EphB2 is an ephrin receptor and is up-regulated in invasive tumors but its role needs to be confirmed in further cases of Wilms tumors.
      Title: Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors.
    4. EPHB2 interacts with EPHB6 in breast tumor cell lines
      Title: A paradigm shift in EPH receptor interaction: biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell lines.
    5. data suggest that genetic variation at the EphB2 locus may increase risk of sporadic prostate cancer risk in African American men.
      Title: EphB2 SNPs and sporadic prostate cancer risk in African American men.
    6. The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer.
      Title: Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
    7. Mutation in EphB2 gene is associated with colorectal adenocarcinoma
      Title: Influence of A9 region mutation in EphB2 gene in the prognosis of patients with colorectal adenocarcinoma.
    8. at least in the context of pancreatic carcinoma CFPAC-1 cells, EphB2 plays a tumor suppressor role in cell proliferation and apoptosis
      Title: Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Even a moderate level of EphB2 expression has effects on tumour cells which results in reduced migration and invasiveness and slows the growth of colonic tumour implants in an in vivo model.
      Title: Loss of cell-surface receptor EphB2 is important for the growth, migration, and invasiveness of a colon cancer cell line.
    Submit: New GeneRIF Correction See all (40)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Prostate cancer, progression and metastasis of

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004433.2 NP_004420.1 EFNB1    BIND  PubMed The membrane bound ligand ELK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between ELK-L from human and NUK from mouse. 
    NP_004433.2 NP_004084.1 EFNB2    BIND  PubMed The membrane bound ligand HTK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between HTK-L from human and NUK from mouse. 
    NP_004433.2 NP_005927.1 MLLT4    BIND  PubMed EphB2 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB2 from human and mouse AF6. 
    P29323 P00519 ABL1    HPRD  PubMed  
    P29323 P42684 ABL2    HPRD  PubMed  
    P29323 P24666 ACP1    HPRD  PubMed  
    P29323 P29972 AQP1    HPRD  PubMed  
    P29323 Q15052 ARHGEF6    HPRD  PubMed  
    P29323 P52803 EFNA5    HPRD  PubMed  
    P29323 P98172 EFNB1    HPRD  PubMed  
    P29323 P52799 EFNB2    HPRD  PubMed  
    P29323 P29323 EPHB2    HPRD  PubMed  
    P29323 P29323 EPHB2    HPRD  PubMed  
    P29323 P50548 ERF    HPRD  PubMed  
    P29323 P01100 FOS    HPRD  PubMed  
    P29323 P62993 GRB2    HPRD  PubMed  
    P29323 Q05586 GRIN1    HPRD  PubMed  
    P29323 Q13224 GRIN2B    HPRD  PubMed  
    P29323 Q15811 ITSN1    HPRD  PubMed  
    P29323 O60229 KALRN    HPRD  PubMed  
    P29323 Q8IVT5 KSR1    HPRD  PubMed  
    P29323 P55196 MLLT4    HPRD  PubMed  
    P29323 P08253 MMP2    HPRD  PubMed  
    P29323 P14780 MMP9    HPRD  PubMed  
    P29323 P16333 NCK1    HPRD  PubMed  
    P29323 Q9NRD5 PICK1    HPRD  PubMed  
    P29323 Q05397 PTK2    HPRD  PubMed  
    P29323 P20936 RASA1    HPRD  PubMed  
    P29323 P10301 RRAS    HPRD  PubMed  
    P29323 P34925 RYK    HPRD  PubMed  
    P29323 P34741 SDC2    HPRD  PubMed  
    P29323 O00560 SDCBP    HPRD  PubMed  
    P29323 Q8N5H7 SH2D3C    HPRD  PubMed  
    P29323 P12931 SRC    HPRD  PubMed  
    P29323 O43426 SYNJ1    HPRD  PubMed  
    P29323 P52735 VAV2    HPRD  PubMed  
    P29323 P15692 VEGFA    HPRD  PubMed  
    BioGRID:108362 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108362 BioGRID:106545 ABL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108362 BioGRID:106568 ACP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108362 BioGRID:106739 ALK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108362 BioGRID:107068 BCL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108362 BioGRID:107788 CRK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108362 BioGRID:108268 EFNB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108362 BioGRID:108362 EPHB2    BioGRID  PubMed Co-crystal Structure 
    BioGRID:108362 BioGRID:112351 ITSN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108362 BioGRID:110447 MLLT4    BioGRID  PubMed Two-hybrid 
    BioGRID:108362 BioGRID:119722 MST4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108362 BioGRID:111351 PLCG1    BioGRID  PubMed Two-hybrid 
    BioGRID:108362 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108362 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108362 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108362 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108362 BioGRID:113357 YES1    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • EphrinB-EPHB pathway, organism-specific biosystem (from Pathway Interaction Database)
      EphrinB-EPHB pathway, organism-specific biosystem
      EphrinB-EPHB pathway
    • Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
      Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • MAP kinase cascade, organism-specific biosystem (from BIOCYC)
      MAP kinase cascade, organism-specific biosystemThe MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a com...
    • NLR proteins, organism-specific biosystem (from WikiPathways)
      NLR proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMP...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane-ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    palate development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		  
    regulation of body fluid levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    urogenital system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ephrin type-B receptor 2
    Names
    ephrin type-B receptor 2
    EPH-like kinase 5
    eph tyrosine kinase 3
    elk-related tyrosine kinase
    protein-tyrosine kinase HEK5
    tyrosine-protein kinase TYRO5
    renal carcinoma antigen NY-REN-47
    tyrosine-protein kinase receptor EPH-3
    developmentally-regulated Eph-related tyrosine kinase
    NP_004433.2
    NP_059145.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011804.1 RefSeqGene

      Range
      5001..209493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004442.6 → NP_004433.2  ephrin type-B receptor 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform 2).
      Source sequence(s)
      AL035704, AL158086, AL512444, L41939
      Consensus CDS
      CCDS230.1
      UniProtKB/Swiss-Prot
      P29323
      Related
      ENSP00000363763, OTTHUMP00000002916, ENST00000374632, OTTHUMT00000008061
      Conserved Domains (7) summary
      cd00063
      Location:436 – 527
      Blast Score: 163
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05065
      Location:617 – 885
      Blast Score: 1559
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911 – 981
      Blast Score: 392
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:911 – 978
      Blast Score: 225
      SAM; Sterile alpha motif.
      cd10477
      Location:19 – 196
      Blast Score: 988
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam07714
      Location:622 – 881
      Blast Score: 1072
      Pkinase_Tyr; Protein tyrosine kinase
      cl12111
      Location:241 – 322
      Blast Score: 107
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

    2. NM_017449.3 → NP_059145.2  ephrin type-B receptor 2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AF025304, AL035704, AL158086, AL512444
      Consensus CDS
      CCDS229.2
      UniProtKB/Swiss-Prot
      P29323
      Related
      ENSP00000363761, OTTHUMP00000002914, ENST00000374630, OTTHUMT00000008059
      Conserved Domains (7) summary
      cd00063
      Location:436 – 527
      Blast Score: 163
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05065
      Location:616 – 884
      Blast Score: 1560
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910 – 980
      Blast Score: 392
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910 – 977
      Blast Score: 225
      SAM; Sterile alpha motif.
      cd10477
      Location:19 – 196
      Blast Score: 988
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam07714
      Location:621 – 880
      Blast Score: 1072
      Pkinase_Tyr; Protein tyrosine kinase
      cl12111
      Location:241 – 322
      Blast Score: 107
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      23037331..23241823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      21351920..21485793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035704.9 CAI22644.1
      CAI22645.1
      CAI22646.1
      CAI22647.2
    genomic AL158086.32 CAI22897.1
      CAI22898.1
      CAI22899.2
    genomic AL512444.20 CAI16427.1
      CAI16428.1
      CAI16429.1
      CAI16430.2
    genomic AL611946.14 (2000..44920) None
    genomic CH471134.1 EAW95022.1
      EAW95023.1
      EAW95024.1
      EAW95025.1
      EAW95026.1
    genomic GM868975.1 CAT16948.1
    genomic X59292.1 CAA41981.1
    mRNA AB210018.1 BAE06100.1
    mRNA AF025304.1 AAB94602.1
    mRNA AK298898.1 BAG61009.1
    mRNA AK299701.1 BAG61602.1
    mRNA AL530874.3 None
    mRNA BC007903.2 None
    mRNA BC018763.1 None
    mRNA BC041017.1 None
    mRNA BC067861.1 AAH67861.1
    mRNA BQ641281.1 None
    mRNA D14717.1 BAA03537.1
    mRNA D31661.1 BAA06506.1
    mRNA D37827.1 BAA07073.1
    mRNA HM437237.1 ADN43068.1
    mRNA L36643.1 AAA74244.1
    mRNA L41939.1 AAA99310.1
    other-genetic BC146296.1 AAI46297.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29323.5 GenPept UniProtKB/Swiss-Prot:P29323
    Q4LE53 GenPept UniProtKB/TrEMBL:Q4LE53
    Q6NVW1 GenPept UniProtKB/TrEMBL:Q6NVW1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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