TNFRSF8 tumor necrosis factor receptor superfamily, member 8 [Homo sapiens] - Gene

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Summary

Official Symbol: TNFRSF8provided by HGNC
Official Full Name: tumor necrosis factor receptor superfamily, member 8provided by HGNC
Primary source: HGNC:11923
See related: Ensembl:ENSG00000120949; HPRD:01074; MIM:153243; Vega:OTTHUMG00000001827
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD30; Ki-1; D1S166E
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1p36

Sequence :: Chromosome: 1; NC_000001.10 (12123434..12204264)

See TNFRSF8 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD30-targeted therapy in combination with galectin-1 treatment may induce effective killing of ALCL cells but not of HL cells
Title: Galectin-1-mediated cell death is increased by CD30-induced signaling in anaplastic large cell lymphoma cells but not in Hodgkin lymphoma cells.
[REVIEW] observations suggest that advanced systemic mastocytosis has to be considered as a differential diagnosis of CD30-positive lymphoid neoplasms
Title: Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms.
Soluble CD30 and Hepatocyte growth factor as predictive markers of antibody-mediated rejection of the kidney allograft.
Title: Soluble CD30 and Hepatocyte growth factor as predictive markers of antibody-mediated rejection of the kidney allograft.
The association of CD23 and CD30 antigen blood levels with the development of non-Hodgkin lymphoma in HIV patients is reported.
Title: Can serum soluble CD23 or CD30 predict the occurrence of lymphoma in HIV-infected patients?
posttransplant measurement of sCD30 on day 30 may have a role in subsequent graft loss in kidney transplant recipients
Title: Posttransplant sCD30 as a predictor of kidney graft outcome.
CD30 is preferentially expressed in neoplastic mast cells in advanced mast cell neoplasms.
Title: Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis.
The data provide evidence that sCD30 can be used as a marker for diagnosing Epstein-Barr virus-associated lymphoproliferative diseases.
Title: Soluble CD30: a serum marker for Epstein-Barr virus-associated lymphoproliferative diseases.
High serum levels post-transplantation is associated with poorer graft function at one year
Title: Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation.
reduction in serum post-transplant levels correlates with full graft function
Title: Relative reductions in soluble CD30 levels post-transplant predict acute graft function in islet allograft recipients receiving three different immunosuppression protocols.
increase in serum levels predicts graft-versus-host-disease following allogeneic hematopoietic stem cell transplantation
Title: A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation.

Submit: New GeneRIF Correction See all (100)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001234.1	NP_005649.1	TRAF1	BIND	PubMed	TRAF1 interacts with CD30.
NP_001234.1	NP_066961.2	TRAF2	BIND	PubMed	TRAF2 interacts with CD30.
NP_001234.1	NP_663777.1	TRAF3	BIND	PubMed	CRAF1 interacts with CD30.
P28908	Q9UM73	ALK	HPRD	PubMed
P28908	O95551	TDP2	HPRD	PubMed
P28908	P28908	TNFRSF8	HPRD	PubMed
P28908	P32971	TNFSF8	HPRD	PubMed
P28908	Q13077	TRAF1	HPRD	PubMed
P28908	Q12933	TRAF2	HPRD	PubMed
P28908	Q13114	TRAF3	HPRD	PubMed
P28908	O00463	TRAF5	HPRD	PubMed
BioGRID:107381	BioGRID:107076	BCL6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107381	BioGRID:119615	TDP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107381	BioGRID:107382	TNFSF8	BioGRID	PubMed	Reconstituted Complex
BioGRID:107381	BioGRID:113038	TRAF2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107381	BioGRID:113040	TRAF5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107381	BioGRID:115581	TRAIP	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
tumor necrosis factor-activated receptor activity	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of TRAIL biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tumor necrosis factor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info
tumor necrosis factor-mediated signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tumor necrosis factor receptor superfamily member 8

Names: tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029573.1 RefSeqGene

Range

5001..85831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243.3 → NP_001234.2 tumor necrosis factor receptor superfamily member 8 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL357835, M83554

Consensus CDS

CCDS144.1

UniProtKB/Swiss-Prot

P28908

Related

ENSP00000263932, OTTHUMP00000001783, ENST00000263932, OTTHUMT00000005130

Conserved Domains (2) summary

cd00185
Location:43 – 129
Blast Score: 159

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

cl12111
Location:225 – 304
Blast Score: 119

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
NM_152942.2 → NP_694421.1 tumor necrosis factor receptor superfamily member 8 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AL357835, BC063482

Consensus CDS

CCDS44057.1

UniProtKB/Swiss-Prot

P28908

Related

ENSP00000398337, OTTHUMP00000221481, ENST00000413146, OTTHUMT00000005131

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

12123434..12204264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

11277612..11357523

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AJ272029.1	CAC03488.1
genomic	AJ289159.1	CAC16652.1
genomic	AL357835.11	CAH73719.1
genomic	AY498860.1	AAR32099.1
genomic	CH471130.1	EAW71730.1
genomic	HI179076.1	CBX53846.1
genomic	HI179078.1	CBX53847.1
genomic	HI574144.1	CBX47561.1
genomic	HI574146.1	CBX47562.1
mRNA	BC063482.1	AAH63482.2
mRNA	BC073839.1	AAH73839.1
mRNA	BC136400.1	AAI36401.1
mRNA	BC141804.1	AAI41805.1
mRNA	BC171762.1	None
mRNA	D86042.1	BAA12973.1
mRNA	M83554.1	AAA51947.1
mRNA	S75768.1	AAD14188.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P28908.1	GenPept	UniProtKB/Swiss-Prot:P28908
Q6GMU3	GenPept	UniProtKB/TrEMBL:Q6GMU3
Q9HCX5	GenPept	UniProtKB/TrEMBL:Q9HCX5