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TNFRSF8 tumor necrosis factor receptor superfamily member 8 [ Homo sapiens (human) ]

Gene ID: 943, updated on 15-May-2016
Official Symbol
TNFRSF8provided by HGNC
Official Full Name
tumor necrosis factor receptor superfamily member 8provided by HGNC
Primary source
HGNC:HGNC:11923
See related
Ensembl:ENSG00000120949 HPRD:01074; MIM:153243; Vega:OTTHUMG00000001827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD30; Ki-1; D1S166E
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p36
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (12063330..12144207)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12123434..12204264)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitofusin 2 Neighboring gene migration and invasion inhibitory protein Neighboring gene microRNA 6729 Neighboring gene tumor necrosis factor receptor superfamily member 1B Neighboring gene microRNA 7846 Neighboring gene microRNA 4632

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed
Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) in Vif-expression T cells PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of TRAIL biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
tumor necrosis factor receptor superfamily member 8
Names
CD30L receptor
Ki-1 antigen
cytokine receptor CD30
lymphocyte activation antigen CD30
tumor necrosis factor receptor superfamily, member 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029573.2 RefSeqGene

    Range
    5001..85831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243.4NP_001234.3  tumor necrosis factor receptor superfamily member 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001234.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL357835, BC136400, BC141804, M83554
    Consensus CDS
    CCDS144.1
    UniProtKB/Swiss-Prot
    P28908
    UniProtKB/TrEMBL
    A5D8T4
    Related
    ENSP00000263932, OTTHUMP00000001783, ENST00000263932, OTTHUMT00000005130
    Conserved Domains (1) summary
    cd13409
    Location:17131
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  2. NM_001281430.2NP_001268359.2  tumor necrosis factor receptor superfamily member 8 isoform 3

    See identical proteins and their annotated locations for NP_001268359.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AL357835, BC136400, BC141804, M83554
    Consensus CDS
    CCDS59989.1
    UniProtKB/Swiss-Prot
    P28908
    UniProtKB/TrEMBL
    A5D8T4
    Related
    ENSP00000390650, ENST00000417814
    Conserved Domains (2) summary
    cd13409
    Location:62195
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    cl22855
    Location:120
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    12063330..12144207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542441.1XP_011540743.1  

    Conserved Domains (1) summary
    cd13409
    Location:17131
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  2. XM_011542444.1XP_011540746.1  

    See identical proteins and their annotated locations for XP_011540746.1

    Conserved Domains (1) summary
    cd13409
    Location:124257
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  3. XM_011542442.1XP_011540744.1  

    See identical proteins and their annotated locations for XP_011540744.1

    Conserved Domains (1) summary
    cd13409
    Location:124257
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  4. XM_011542443.1XP_011540745.1  

    Conserved Domains (2) summary
    cd13409
    Location:62195
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    cl22855
    Location:120
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    12111329..12192169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152942.2: Suppressed sequence

    Description
    NM_152942.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.