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    MAP1LC3B microtubule-associated protein 1 light chain 3 beta [ Homo sapiens ]

    Gene ID: 81631, updated on 11-May-2012
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    Summary

    Official Symbol
    MAP1LC3Bprovided by HGNC
    Official Full Name
    microtubule-associated protein 1 light chain 3 betaprovided by HGNC
    Primary source
    HGNC:13352
    See related
    Ensembl:ENSG00000140941; HPRD:14358; MIM:609604; Vega:OTTHUMG00000137654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3
    Summary
    The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    16q24.2
    Sequence :
    Chromosome: 16; NC_000016.9 (87425801..87438380)
    See MAP1LC3B in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 95 Neighboring gene F-box protein 31 Neighboring gene zinc finger, CCHC domain containing 14 Neighboring gene junctophilin 3 Neighboring gene uncharacterized LOC100129215

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8. Hong SB, et al. Nat Struct Mol Biol, 2011 Nov 6. PMID 22056771.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Lee SJ, et al. Am J Respir Crit Care Med, 2011 Mar 1. PMID 20889906.
    4. Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors. Huang X, et al. J Clin Neurosci, 2010 Dec. PMID 20863706.
    5. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.

    See all (33) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of pulmonary hypertension
      Title: Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
    2. The progression of astrocytic tumors was related to a decrease in autophagic capacity represented by the loss of LC3B-II and Beclin 1 expression
      Title: Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors.
    3. The positive rates of Beclin1 and MAPLC3 were significantly lower in non-small cell lung cancer tissues than in adjacent non-cancerous tissues and normal tissues.
      Title: [Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer].
    4. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
      Title: The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
    5. A large number of MAP1LC3A and MAP1LC3B positive breast cancer tissues cores have high proportion of stained cells (81-100%) as compared with normal breast tissues.
      Title: Immunohistochemical expression of MAP1LC3A and MAP1LC3B protein in breast carcinoma tissues.
    6. the essential site for the distinct post-translation modification of microtubule-associated protein 1 light chain 3B is Lys-122 rather than the conserved Gly-120
      Title: Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
    7. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p
      Title: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
    8. Results indicate that the carboxyl terminus of MAP1LC3B is cleaved to expose Gly(120) for further ubiquitylation-like reactions.
      Title: Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9GZQ8 Q9NT62 ATG3    HPRD  PubMed  
    Q9GZQ8 Q9Y4P1 ATG4B    HPRD  PubMed  
    Q9GZQ8 O95352 ATG7    HPRD  PubMed  
    Q9GZQ8 Q8WVZ9 KBTBD7    HPRD  PubMed  
    Q9GZQ8 Chromosome 19 open reading frame 50 KXD1    HPRD  PubMed  
    Q9GZQ8 Q9Y383 LUC7L2    HPRD  PubMed  
    Q9GZQ8 O60671 RAD1    HPRD  PubMed  
    Q9GZQ8 Q13501 SQSTM1    HPRD  PubMed  
    Q9GZQ8 Q9HAU5 UPF2    HPRD  PubMed  
    BioGRID:123565 BioGRID:106532 AAMP    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:106631 ADD1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:116967 ADNP    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:120856 ARFGAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:120375 ATG16L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:35832 ATG3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123565 BioGRID:122171 ATG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:116801 ATG4B    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:123565 BioGRID:114859 ATG5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:115787 ATG7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:113715 BRD3    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:107291 CASP8    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:115038 CLINT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:107621 CLTA    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:107990 DBI    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:107995 DBN1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:108126 DNMT3B    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:108128 DOCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:114265 EED    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:108373 EPS8    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:122558 FAM134A    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:119968 FAM190B    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:122715 FAM65A    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:122669 FYCO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:116465 GABARAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:109280 HADHA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:109282 HADHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:123873 KBTBD7    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:119278 KLHL5    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:122501 KXD1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:119646 LUC7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:110303 MAP1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:110304 MAP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:124137 MAP1LC3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:117141 MKRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:125039 MRFAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:110690 MYBL2    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:114080 NIPSNAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:111570 PRKCI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:111844 RAP1GAP    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:123689 RASSF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:112095 RPLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:112201 SAFB    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:113692 SHFM1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:112482 SMARCB1    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:114505 SPAG9    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:123565 BioGRID:112664 STK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:112665 STK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:112742 TAF7    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:123298 THAP7    BioGRID  PubMed Two-hybrid 
    BioGRID:123565 BioGRID:120296 TMEM160    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123565 BioGRID:118899 TMOD3    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    autophagic vacuole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    autophagic vacuole membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3B
    Names
    microtubule-associated proteins 1A/1B light chain 3B
    MAP1A/MAP1B LC3 B
    MAP1A/MAP1B light chain 3 B
    MAP1 light chain 3-like protein 2
    autophagy-related ubiquitin-like modifier LC3 B
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029030.1 RefSeqGene

      Range
      5001..17580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022818.4 → NP_073729.1  microtubule-associated proteins 1A/1B light chain 3B

      Status: REVIEWED

      Source sequence(s)
      AK025556, AL834298, DA577457, DB055844
      Consensus CDS
      CCDS10960.1
      UniProtKB/TrEMBL
      Q658J6
      UniProtKB/Swiss-Prot
      Q9GZQ8
      Related
      ENSP00000268607, OTTHUMP00000175009, ENST00000268607, OTTHUMT00000269106
      Conserved Domains (1) summary
      cd01611
      Location:7 – 120
      Blast Score: 447
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      87425801..87438380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      73168889..73180793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010531.8 (151817..164378) None
    genomic CH471114.2 EAW95392.1
      EAW95393.1
      EAW95394.1
      EAW95395.1
      EAW95396.1
      EAW95397.1
      EAW95398.1
      EAW95399.1
    mRNA AF087871.1 AAM10499.1
    mRNA AF183417.1 AAG09686.1
    mRNA AF303888.1 AAG23182.1
    mRNA AK024571.1 None
    mRNA AK025556.1 BAB15169.1
    mRNA AK290956.1 BAF83645.1
    mRNA AK310224.1 None
    mRNA AK310335.1 None
    mRNA AL834298.1 CAD38970.1
    mRNA BC018634.2 AAH18634.1
    mRNA BC041874.1 AAH41874.1
    mRNA BC045759.1 AAH45759.1
    mRNA BC048009.1 None
    mRNA BC067797.1 AAH67797.1
    mRNA BG771621.1 None
    mRNA DA577457.1 None
    mRNA DB055844.1 None
    mRNA JN663879.1 AEZ06292.1
    other-genetic AM393561.1 CAL38438.1
    other-genetic DQ893152.2 ABM84078.1
    other-genetic DQ896448.2 ABM87447.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49A36 GenPept UniProtKB/TrEMBL:Q49A36
    Q658J6 GenPept UniProtKB/TrEMBL:Q658J6
    Q9GZQ8.3 GenPept UniProtKB/Swiss-Prot:Q9GZQ8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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