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HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens (human) ]

Gene ID: 9146, updated on 14-May-2013

Summary

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Official Symbol: HGSprovided by HGNC
Official Full Name: hepatocyte growth factor-regulated tyrosine kinase substrateprovided by HGNC
Primary source: HGNC:4897
See related: Ensembl:ENSG00000185359; HPRD:05085; MIM:604375; Vega:OTTHUMG00000178109
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HRS
Summary: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Genomic context

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Location :: 17q25

Sequence :: Chromosome: 17; NC_000017.10 (79650962..79669151)

See HGS in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hrs tyrosine phosphorylation detected upon EGF-stimulation.
Title: Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.
These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved.
Title: Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.
Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
Title: Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.
Title: The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.
Plasma hepatocyte growth factor is associated with periampullary cancer.
Title: Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy.
hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.
Title: Spatial regulation of EGFR signaling by Sprouty2.
Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor degradation.
Title: Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Data show that Trak1 interacts with hepatocyte-growth-factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting and trafficking machinery.
Title: Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.
HGS and GUK1 were significantly over expressed in GH-secreting adenomas, compared with ACTH-secreting adenomas and nonfunctioning tumors, and with PRL-secreting adenomas, respectively.
Title: Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.
these results indicate that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner that is independent of UIM-ubiquitin binding
Title: Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain.

Submit: New GeneRIF Correction See all (30)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Digital quantification of human eye color highlights genetic association of three new loci.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Gag, Pr55	gag	Overexpression of the C-terminal fragment of HRS (residues 391-777) or HRS mutants lacking either the N-terminal FYVE domain (residues 215-290) or the PSAP (residues 348-351) motif efficiently inhibit HIV-1 Gag particle production	PubMed
Vpu, p16	vpu	HRS interacts with both HIV-1 Vpu and tetherin by co-precipitation analysis	PubMed
	vpu	HRS, an ESCRT-0 complex component, is required for the Vpu-induced downregulation of BST-2, indicating that Vpu-induced BST-2 degradation involves the ESCRT/MVB pathway	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004703.1	NP_000259.1	NF2	BIND	PubMed	merlin interacts with HRS.
NP_004703.1	NP_006283.1	TSG101	BIND	PubMed	TSG101 interacts with HGS (Hrs).
NP_004703.1	NP_006283.1	TSG101	BIND	PubMed	HRS interacts with TSG101.
O14964	Brain enriched guanylate kinase associated protein	BEGAIN	HPRD	PubMed
O14964	Coiled-coil domain containing 33	CCDC33	HPRD	PubMed
O14964	Q00610	CLTC	HPRD	PubMed
O14964	Q15038	DAZAP2	HPRD	PubMed
O14964	P78352	DLG4	HPRD	PubMed
O14964	P00533	EGFR	HPRD	PubMed
O14964	Q96KQ7	EHMT2	HPRD	PubMed
O14964	P42566	EPS15	HPRD	PubMed
O14964	Q9UPT5	EXOC7	HPRD	PubMed
O14964	Q8IYI6	EXOC8	HPRD	PubMed
O14964	Growth factor independent 1B	GFI1B	HPRD	PubMed
O14964	G kinase anchoring protein 1	GKAP1	HPRD	PubMed
O14964	P54257	HAP1	HPRD	PubMed
O14964	P05783	KRT18	HPRD	PubMed
O14964	P08727	KRT19	HPRD	PubMed
O14964	O95751	LDOC1	HPRD	PubMed
O14964	Q96LR2	LURAP1	HPRD	PubMed
O14964	Q99698	LYST	HPRD	PubMed
O14964	O43318	MAP3K7	HPRD	PubMed
O14964	O43513	MED7	HPRD	PubMed
O14964	P08581	MET	HPRD	PubMed
O14964	AD023 protein	MIF4GD	HPRD	PubMed
O14964	P46934	NEDD4	HPRD	PubMed
O14964	P35240	NF2	HPRD	PubMed
O14964	Q13287	NMI	HPRD	PubMed
O14964	Q13153	PAK1	HPRD	PubMed
O14964	Q8IZL8	PELP1	HPRD	PubMed
O14964	P27986	PIK3R1	HPRD	PubMed
O14964	Q15796	SMAD2	HPRD	PubMed
O14964	P84022	SMAD3	HPRD	PubMed
O14964	P60880	SNAP25	HPRD	PubMed
O14964	Q13596	SNX1	HPRD	PubMed
O14964	Q92783	STAM	HPRD	PubMed
O14964	O75886	STAM2	HPRD	PubMed
O14964	O75478	TADA2A	HPRD	PubMed
O14964	O75674	TOM1L1	HPRD	PubMed
O14964	Q99816	TSG101	HPRD	PubMed
O14964	P62987	UBA52	HPRD	PubMed
O14964	P62988	UBB	HPRD	PubMed
O14964	Ubiquitin B	UBB	HPRD	PubMed
O14964	P63279	UBE2I	HPRD	PubMed
O14964	Q9UMX0	UBQLN1	HPRD	PubMed
O14964	Q9NRR5	UBQLN4	HPRD	PubMed
O14964	Q8N6Y0	USHBP1	HPRD	PubMed
O14964	Hepatocellular carcinoma related protein 1	VPS37A	HPRD	PubMed
O14964	Vacuolar protein sorting 37C	VPS37C	HPRD	PubMed
O14964	Vacuolar protein sorting 37 homolog D	VPS37D	HPRD	PubMed
BioGRID:114593	BioGRID:106537	ABCA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:106563	ACLY	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:106596	ACTN4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:114593	BioGRID:106675	AES	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:115987	AHCYL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:106821	APC	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:106831	APLP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:116812	ARL6IP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:117376	ARMC8	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114593	BioGRID:106900	ARR3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:121616	ARRDC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:124894	ARRDC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:106966	ATP1A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:106978	ATP2A2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:131172	ATXN1L	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:121647	BEGAIN	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:107147	BSG	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:107149	BST2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:114141	CASK	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:107321	CBS	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:123126	CCDC33	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:120465	CEP55	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:116290	CIT	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:107623	CLTC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:107790	CRMP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:115143	DAZAP2	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:115794	DCTN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:108030	DECR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:108086	DLG4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114593	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114593	BioGRID:116123	EHMT2	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:108374	EPS15	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:108407	ESRRG	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:116867	EXOC7	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:127206	EXOC8	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:119398	FAM203A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:130891	FAM5C	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:108554	FGFR2	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:114593	BioGRID:108938	GFAP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:113924	GFI1B	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:116697	GGA2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:108964	GJA1	BioGRID	PubMed	Co-localization
BioGRID:114593	BioGRID:123231	GKAP1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:114480	HAP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:115308	HNRPDL	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:109544	HSPA8	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:109775	IL2RB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114593	BioGRID:109780	IL4R	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114593	BioGRID:123343	ILKAP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:109854	INSR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:123747	ITCH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:106689	JAG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110073	KRT18	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:110078	KRT19	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:117169	LDOC1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:131547	LINC00265	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:139071	LURAP1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:107552	LYST	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:110440	MAP3K10	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:112748	MAP3K7	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:121760	MARK4	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:110314	MAT2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:114833	MED7	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:110390	MEST	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:121511	MIF4GD	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:114138	MKNK1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:117409	MTHFD1L	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:110728	MYO5A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110811	NEDD4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114593	BioGRID:116915	NEDD4L	BioGRID	PubMed	Biochemical Activity
BioGRID:114593	BioGRID:110815	NEDD8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110844	NF2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:114561	NMI	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:111004	OCLN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:125380	OSBPL5	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:111095	PAK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:117973	PELP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:111234	PFKM	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:117173	PLD3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:124414	PPP1R16A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:111502	PPP1R7	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:120366	PTCD3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:118866	RANGRF	BioGRID	PubMed	Co-fractionation
BioGRID:114593	BioGRID:118927	REPIN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:116510	RHOBTB3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:117941	RNF11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:112103	RPS3A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:112164	RSU1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:115378	SCAMP3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:112241	SCNN1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:115145	SCRN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:116146	SF3A3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:117016	SF3B3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:115096	SLK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:110261	SMAD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110262	SMAD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110264	SMAD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:110265	SMAD5	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114593	BioGRID:112500	SNAP25	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:112525	SNX1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114593	BioGRID:115547	SPRY2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:113722	STAM	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:115548	STAM2	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Co-localization; Two-hybrid
BioGRID:114593	BioGRID:117191	STX12	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:112681	STXBP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:117312	SUN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:112734	TADA2A	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:112895	TFRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:119451	TIMMDC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:114809	TJP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:112954	TLR4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:115240	TMCC2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:132320	TMEM189	BioGRID	PubMed	Affinity Capture-Western; FRET
BioGRID:114593	BioGRID:115352	TOM1L1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:116570	TRAK1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:114593	BioGRID:115435	TRAP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:115858	TRIM3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:113102	TSG101	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:113119	TTC4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:128444	TUBB	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:113131	TUBB2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:113165	UBA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:158705	UBB	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:114593	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114593	BioGRID:160681	UBC	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:119007	UBQLN1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114593	BioGRID:121223	UBQLN4	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:123791	USHBP1	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:112711	VAMP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:113265	VEGFA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:123567	VMP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:120855	VPS35	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:120371	VPS37C	BioGRID	PubMed	Two-hybrid
BioGRID:114593	BioGRID:118059	VPS4A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:122532	WDR77	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114593	BioGRID:114773	ZFYVE9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:120987	ZNF302	BioGRID	PubMed	Reconstituted Complex
BioGRID:114593	BioGRID:101221	sh3rf1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114593	BioGRID:1205543	vpu	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
EGFR downregulation, organism-specific biosystem (from REACTOME)
EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
ESCRT-0 complex, organism-specific biosystem (from KEGG)
ESCRT-0 complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystemMany plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to th...
Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
Internalization of ErbB1, organism-specific biosystem
Internalization of ErbB1
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

G35510 (e-PCR)
- UniSTS:44150

Homology

Homologs of the HGS gene: The HGS gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cellular membrane organization	TAS Traceable Author Statement more info
endosomal transport	NAS Non-traceable Author Statement more info	PubMed
endosomal transport	TAS Traceable Author Statement more info
endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
intracellular protein transport	IEA Inferred from Electronic Annotation more info
negative regulation of JAK-STAT cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
regulation of protein catabolic process	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
early endosome	IDA Inferred from Direct Assay more info	PubMed
early endosome membrane	IEA Inferred from Electronic Annotation more info
endosome	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
multivesicular body membrane	IEA Inferred from Electronic Annotation more info
secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hepatocyte growth factor-regulated tyrosine kinase substrate

Names: hepatocyte growth factor-regulated tyrosine kinase substrate; protein pp110; human growth factor-regulated tyrosine kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004712.4 → NP_004703.1 hepatocyte growth factor-regulated tyrosine kinase substrate

Status: REVIEWED

Source sequence(s)

AI365104, BC003565, DR001213

Consensus CDS

CCDS11784.1

UniProtKB/Swiss-Prot

O14964

Related

ENSP00000331201, OTTHUMP00000258518, ENST00000329138, OTTHUMT00000440541

Conserved Domains (5) summary

cd00065
Location:162 – 218
Blast Score: 251

FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;

cd03569
Location:4 – 145
Blast Score: 605

VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...

pfam12210
Location:406 – 485
Blast Score: 342

Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate

smart00064
Location:157 – 221
Blast Score: 291

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

cl00928
Location:514 – 557
Blast Score: 85

dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

79650962..79669151

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

75097132..75115050

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

80763936..80782123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01032159.1 (25228..41090)	None
genomic	ABBA01032160.1	None
genomic	AC139530.3 (27571..45699)	None
genomic	AMYH01008718.1 (89332..107519)	None
genomic	CH471099.1	EAW89675.1
		EAW89676.1
		EAW89677.1
		EAW89678.1
		EAW89679.1
mRNA	AF260566.1	AAF82361.1
mRNA	AI365104.1	None
mRNA	AK021483.1	None
mRNA	AK097197.1	None
mRNA	AK294190.1	BAG57506.1
mRNA	AK303800.1	BAG64754.1
mRNA	BC003565.1	AAH03565.1
mRNA	BT009754.1	AAP88756.1
mRNA	D84064.1	BAA23366.1
mRNA	DR001213.1	None
mRNA	U43895.1	AAC51929.1
other-genetic	DQ892551.2	ABM83477.1
other-genetic	DQ895762.2	ABM86688.1