My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 [ Homo sapiens ]

    Gene ID: 3113, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    HLA-DPA1provided by HGNC
    Official Full Name
    major histocompatibility complex, class II, DP alpha 1provided by HGNC
    Primary source
    HGNC:4938
    Locus tag
    DAAP-277G18.1
    See related
    Ensembl:ENSG00000231389; HPRD:00835; MIM:142880; Vega:OTTHUMG00000031058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
    Summary
    HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (33032346..33048555, complement)
    See HLA-DPA1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene bromodomain containing 2 Neighboring gene major histocompatibility complex, class II, DO alpha Neighboring gene major histocompatibility complex, class II, DP beta 1 Neighboring gene ribosomal protein L32 pseudogene 1 Neighboring gene major histocompatibility complex, class II, DP alpha 2 (pseudogene) Neighboring gene collagen, type XI, alpha 2 pseudogene

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. Noguchi E, et al. PLoS Genet, 2011 Jul. PMID 21814517.
    2. A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. An P, et al. J Infect Dis, 2011 Apr 1. PMID 21402545.
    3. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Gharavi AG, et al. Nat Genet, 2011 Mar 13. PMID 21399633.
    4. Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. O'Brien TR, et al. Genes Immun, 2011 Sep. PMID 21346778.
    5. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Guo X, et al. Hepatology, 2011 Feb. PMID 21274863.

    See all (94) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
      Title: Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver.
    2. genetic variants in the HLA-DPA1 and HLA-DPB1 locus are associated with the risk of pediatric asthma in Asian populations.
      Title: Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.
    3. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic hepatitis B virus infection (odds ratio, .62; P = .001), consistent with the previous report.
      Title: A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
    4. Genetic variants in the HLA-DP locus are strongly associated with persistent chronic hepatitis B virus infection in the Han Chinese population.
      Title: Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population.
    5. DPA1*020107 was identified from a woman of Ugandan origin by a taxonomy-based sequence analysis of human leukocyte antigen DPA1. It is identical to DPA1*020101 with the exception of a single nucleotide synonymous substitution at codon 58 (GGC-->GGT).
      Title: Identification of HLA-DPA1*020107 in an individual of Ugandan descent.
    6. HLA-DPA1 allelic and haplotypic diversity contributes significantly to the risk for type 1 diabetes
      Title: HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families.
    7. Observational study of genetic testing. (HuGE Navigator)
      Title: HLA genotyping in the international Type 1 Diabetes Genetics Consortium.
    8. Our findings show that genetic variants in the HLA-DPA1 locus are strongly associated with risk of persistent infection with hepatitis B virus.
      Title: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Submit: New GeneRIF Correction See all (15)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies susceptibility loci for IgA nephropathy.

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag PubMed
    env Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules PubMed
    Envelope surface glycoprotein gp160, precursor env Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC PubMed
    Envelope transmembrane glycoprotein gp41 env A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions PubMed
    env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    Tat tat HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P20036 P01730 CD4    HPRD  PubMed  
    P20036 P04233 CD74    HPRD  PubMed  
    P20036 P04440 HLA-DPB1    HPRD  PubMed  
    BioGRID:109358 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Asthma, organism-specific biosystem (from KEGG)
      Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Asthma, conserved biosystem (from KEGG)
      Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class II receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    HLA class II histocompatibility antigen, DP alpha 1 chain
    Names
    HLA class II histocompatibility antigen, DP alpha 1 chain
    MHC class II DPA1
    HLA-SB alpha chain
    MHC class II antigen
    MHC class II DP3-alpha
    Primed lymphocyte test-1
    MHC class II HLA-DPA1 antigen
    HLA class II histocompatibility antigen, DP alpha chain
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242524.1 → NP_001229453.1  HLA class II histocompatibility antigen, DP alpha 1 chain precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL645931, BI553587, BU687966, CD516536, X00457
      Consensus CDS
      CCDS4764.1
      UniProtKB/Swiss-Prot
      P20036
      UniProtKB/TrEMBL
      Q5STP1
      Related
      ENSP00000393566, OTTHUMP00000029066, ENST00000419277, OTTHUMT00000076071
      Conserved Domains (2) summary
      cd05767
      Location:117 – 210
      Blast Score: 421
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl03058
      Location:35 – 115
      Blast Score: 180
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    2. NM_001242525.1 → NP_001229454.1  HLA class II histocompatibility antigen, DP alpha 1 chain precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL645931, BI553587, BU687966, X00457
      Consensus CDS
      CCDS4764.1
      UniProtKB/Swiss-Prot
      P20036
      UniProtKB/TrEMBL
      Q5STP1
      Conserved Domains (2) summary
      cd05767
      Location:117 – 210
      Blast Score: 421
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl03058
      Location:35 – 115
      Blast Score: 180
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    3. NM_033554.3 → NP_291032.2  HLA class II histocompatibility antigen, DP alpha 1 chain precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL645931, BP338039, BU687966, X00457
      Consensus CDS
      CCDS4764.1
      UniProtKB/Swiss-Prot
      P20036
      UniProtKB/TrEMBL
      Q5STP1
      Related
      ENSP00000402872, ENST00000428995
      Conserved Domains (2) summary
      cd05767
      Location:117 – 210
      Blast Score: 421
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl03058
      Location:35 – 115
      Blast Score: 180
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      33032346..33048555, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      4319165..4335362, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      4476526..4492734, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      4313685..4329894, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      4489886..4506101, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      4369219..4385416, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      4264797..4281012, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      4512850..4529059, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      32774786..32790995, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF013767.1 AAC64233.1
    genomic AF015295.1 AAC61669.1
    genomic AF074847.1 AAD39684.1
    genomic AF074848.1 AAD39685.1
    genomic AF076284.1 AAD42927.1
    genomic AF076285.1 AAD42928.1
    genomic AF092049.1 AAF00051.1
    genomic AF098794.1 AAC72845.1
    genomic AF165160.1 AAD47826.1
    genomic AF346471.1 AAK27152.1
    genomic AL645931.7 (72951..81535) None
    genomic AL662824.9 (46980..55564) None
    genomic AL805913.4 CAI18549.1
    genomic AY335522.1 AAR01827.1
    genomic AY335523.1 AAR01829.1
    genomic AY335524.1 AAR01831.1
    genomic AY335525.1 AAR01833.1
    genomic AY335526.1 AAR01835.1
    genomic AY335527.1 AAR01837.1
    genomic AY335528.1 AAR01839.1
    genomic AY335529.1 AAR01841.1
    genomic AY335530.1 AAR01843.1
    genomic AY335531.1 AAR01845.1
    genomic AY335532.1 AAR01847.1
    genomic AY335533.1 AAR01849.1
    genomic AY335534.1 AAR01851.1
    genomic AY335535.1 AAR01853.1
    genomic AY335536.1 AAR01855.1
    genomic AY335537.1 AAR01857.1
    genomic AY335538.1 AAR01859.1
    genomic AY335539.1 AAR01861.1
    genomic AY335540.1 AAR01863.1
    genomic AY335541.1 AAR01865.1
    genomic AY335542.1 AAR01867.1
    genomic AY335543.1 AAR01869.1
    genomic AY335544.1 AAR01871.1
    genomic AY375760.1 AAQ84179.1
    genomic AY375761.1 AAQ84180.1
    genomic AY375762.1 AAQ84181.1
    genomic AY375763.1 AAQ84182.1
    genomic AY375764.1 AAQ84183.1
    genomic AY375765.1 AAQ84184.1
    genomic AY375766.1 AAQ84185.1
    genomic AY375767.1 AAQ84186.1
    genomic AY375768.1 AAQ84187.1
    genomic AY375769.1 AAQ84188.1
    genomic AY375770.1 AAQ84190.1
    genomic AY375771.1 AAQ84189.1
    genomic AY375775.1 AAQ84191.1
    genomic AY375780.1 AAQ84192.1
    genomic AY375781.1 AAQ84193.1
    genomic AY375787.1 AAQ84194.1
    genomic AY375791.1 AAQ84195.1
    genomic AY375827.1 AAQ84196.1
    genomic AY375828.1 AAQ84197.1
    genomic AY375829.1 AAQ84198.1
    genomic AY375830.1 AAQ84199.1
    genomic AY375831.1 AAQ84200.1
    genomic AY375832.1 AAQ84201.1
    genomic AY375833.1 AAQ84202.1
    genomic AY375834.1 AAQ84203.1
    genomic AY375835.1 AAQ84204.1
    genomic AY375836.1 AAQ84205.1
    genomic AY375837.1 AAQ84206.1
    genomic AY375838.1 AAQ84207.1
    genomic AY375839.1 AAQ84208.1
    genomic AY375840.1 AAQ84209.1
    genomic AY603382.1 AAT39912.1
    genomic AY603383.1 AAT39913.1
    genomic AY603384.1 AAT39914.1
    genomic AY603385.1 AAT39915.1
    genomic AY603386.1 AAT39916.1
    genomic AY618552.1 AAT92096.1
    genomic AY618553.1 AAT92097.1
    genomic AY650051.1 AAT67468.1
    genomic BX005422.5 CAM26119.1
    genomic BX120009.10 CAM25980.1
      CAM25981.1
      CAM25982.1
      CAM25983.1
    genomic CH471081.1 EAX03669.1
      EAX03670.1
      EAX03671.1
    genomic CR759795.4 CAQ07433.1
    genomic CR759829.6 CAQ07261.1
    genomic CR759904.5 CAQ09865.1
    genomic CR762479.5 CAQ10344.1
      CAQ10345.1
      CAQ10346.1
      CAQ10347.1
    genomic CR847849.5 CAQ07485.1
    genomic DQ274060.1 ABB88406.1
    genomic DQ274061.1 ABB88407.1
    genomic K00514.1 AAA59786.1
    genomic M23903.1 None
    genomic M23904.1 None
    genomic U87556.1 AAB97110.1
    genomic X02228.1 CAA26148.1
    genomic X03100.1 CAA26887.1
    genomic X78199.1 None
    genomic X82393.1 None
    genomic X82394.1 None
    mRNA AB209058.1 BAD92295.1
    mRNA AK292709.1 BAF85398.1
    mRNA BC009956.2 AAH09956.1
    mRNA BI553587.1 None
    mRNA BP338039.1 None
    mRNA BU687966.1 None
    mRNA CD516536.1 None
    mRNA M27487.1 AAA63220.1
    mRNA X00457.1 CAA25143.1
    other-genetic DQ893463.2 ABM84389.1
    other-genetic DQ896324.2 ABM87323.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O19680 GenPept UniProtKB/TrEMBL:O19680
    O78000 GenPept UniProtKB/TrEMBL:O78000
    O98050 GenPept UniProtKB/TrEMBL:O98050
    P20036.1 GenPept UniProtKB/Swiss-Prot:P20036
    Q29ZN0 GenPept UniProtKB/TrEMBL:Q29ZN0
    Q29ZN1 GenPept UniProtKB/TrEMBL:Q29ZN1
    Q29ZN2 GenPept UniProtKB/TrEMBL:Q29ZN2
    Q29ZN3 GenPept UniProtKB/TrEMBL:Q29ZN3
    Q29ZN4 GenPept UniProtKB/TrEMBL:Q29ZN4
    Q49U27 GenPept UniProtKB/TrEMBL:Q49U27
    Q49U29 GenPept UniProtKB/TrEMBL:Q49U29
    Q49U31 GenPept UniProtKB/TrEMBL:Q49U31
    Q49U33 GenPept UniProtKB/TrEMBL:Q49U33
    Q49U35 GenPept UniProtKB/TrEMBL:Q49U35
    Q49U37 GenPept UniProtKB/TrEMBL:Q49U37
    Q49U39 GenPept UniProtKB/TrEMBL:Q49U39
    Q49U41 GenPept UniProtKB/TrEMBL:Q49U41
    Q49U43 GenPept UniProtKB/TrEMBL:Q49U43
    Q49U45 GenPept UniProtKB/TrEMBL:Q49U45
    Q49U47 GenPept UniProtKB/TrEMBL:Q49U47
    Q49U49 GenPept UniProtKB/TrEMBL:Q49U49
    Q49U51 GenPept UniProtKB/TrEMBL:Q49U51
    Q49U53 GenPept UniProtKB/TrEMBL:Q49U53
    Q49U55 GenPept UniProtKB/TrEMBL:Q49U55
    Q49U57 GenPept UniProtKB/TrEMBL:Q49U57
    Q49U59 GenPept UniProtKB/TrEMBL:Q49U59
    Q49U61 GenPept UniProtKB/TrEMBL:Q49U61
    Q49U63 GenPept UniProtKB/TrEMBL:Q49U63
    Q49U65 GenPept UniProtKB/TrEMBL:Q49U65
    Q49U67 GenPept UniProtKB/TrEMBL:Q49U67
    Q49U69 GenPept UniProtKB/TrEMBL:Q49U69
    Q49U71 GenPept UniProtKB/TrEMBL:Q49U71
    Q59GQ1 GenPept UniProtKB/TrEMBL:Q59GQ1
    Q5EY04 GenPept UniProtKB/TrEMBL:Q5EY04
    Q5STP1 GenPept UniProtKB/TrEMBL:Q5STP1
    Q67AL9 GenPept UniProtKB/TrEMBL:Q67AL9
    Q67AM0 GenPept UniProtKB/TrEMBL:Q67AM0
    Q67AM1 GenPept UniProtKB/TrEMBL:Q67AM1
    Q67AM2 GenPept UniProtKB/TrEMBL:Q67AM2
    Q67AM3 GenPept UniProtKB/TrEMBL:Q67AM3
    Q67AM4 GenPept UniProtKB/TrEMBL:Q67AM4
    Q67AM5 GenPept UniProtKB/TrEMBL:Q67AM5
    Q67AM6 GenPept UniProtKB/TrEMBL:Q67AM6
    Q67AM7 GenPept UniProtKB/TrEMBL:Q67AM7
    Q67AM8 GenPept UniProtKB/TrEMBL:Q67AM8
    Q67AM9 GenPept UniProtKB/TrEMBL:Q67AM9
    Q67AN0 GenPept UniProtKB/TrEMBL:Q67AN0
    Q67AN1 GenPept UniProtKB/TrEMBL:Q67AN1
    Q67AN2 GenPept UniProtKB/TrEMBL:Q67AN2
    Q67AR8 GenPept UniProtKB/TrEMBL:Q67AR8
    Q67AS2 GenPept UniProtKB/TrEMBL:Q67AS2
    Q67AS8 GenPept UniProtKB/TrEMBL:Q67AS8
    Q67AS9 GenPept UniProtKB/TrEMBL:Q67AS9
    Q67AT4 GenPept UniProtKB/TrEMBL:Q67AT4
    Q67AT8 GenPept UniProtKB/TrEMBL:Q67AT8
    Q67AT9 GenPept UniProtKB/TrEMBL:Q67AT9
    Q67AU0 GenPept UniProtKB/TrEMBL:Q67AU0
    Q67AU1 GenPept UniProtKB/TrEMBL:Q67AU1
    Q67AU2 GenPept UniProtKB/TrEMBL:Q67AU2
    Q67AU3 GenPept UniProtKB/TrEMBL:Q67AU3
    Q67AU4 GenPept UniProtKB/TrEMBL:Q67AU4
    Q67AU5 GenPept UniProtKB/TrEMBL:Q67AU5
    Q67AU6 GenPept UniProtKB/TrEMBL:Q67AU6
    Q67AU7 GenPept UniProtKB/TrEMBL:Q67AU7
    Q67AU8 GenPept UniProtKB/TrEMBL:Q67AU8
    Q67AU9 GenPept UniProtKB/TrEMBL:Q67AU9
    Q95HB9 GenPept UniProtKB/TrEMBL:Q95HB9
    Q9TPP2 GenPept UniProtKB/TrEMBL:Q9TPP2
    Q9TQA9 GenPept UniProtKB/TrEMBL:Q9TQA9
    Q9TQB0 GenPept UniProtKB/TrEMBL:Q9TQB0
    Q9XS09 GenPept UniProtKB/TrEMBL:Q9XS09
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...