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ALYREF Aly/REF export factor [ Homo sapiens (human) ]

Gene ID: 10189, updated on 6-Jul-2014
Official Symbol
ALYREFprovided by HGNC
Official Full Name
Aly/REF export factorprovided by HGNC
Primary source
HGNC:19071
See related
Ensembl:ENSG00000183684; HPRD:09168; MIM:604171; Vega:OTTHUMG00000160470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALY; BEF; REF; THOC4; ALY/REF
Summary
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]
See ALYREF in Epigenomics, MapViewer
Location:
17q25.3
Exon count :
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (81887835..81891586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79845711..79849464, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase, beta polypeptide Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene sirtuin 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Aly/REF export factor (ALYREF; THO complex subunit 4, THOC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag, Pr55 gag Tandem affinity purification and mass spectrometry analysis identify Aly/REF export factor (ALYREF; THO complex subunit 4, THOC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef, p27 nef Tandem affinity purification and mass spectrometry analysis identify Aly/REF export factor (ALYREF; THO complex subunit 4, THOC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Aly/REF export factor (ALYREF; THO complex subunit 4, THOC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
 
regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
THO complex subunit 4
Names
THO complex subunit 4
tho4
THO complex 4
bZIP enhancing factor
ally of AML-1 and LEF-1
bZIP-enhancing factor BEF
transcriptional coactivator Aly/REF

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005782.3NP_005773.3  THO complex subunit 4

    Status: REVIEWED

    Source sequence(s)
    BC052302, BU624466
    Consensus CDS
    CCDS32768.2
    UniProtKB/TrEMBL
    E9PB61
    UniProtKB/Swiss-Prot
    Q86V81
    Related
    ENSP00000421592, OTTHUMP00000218275, ENST00000505490, OTTHUMT00000360729
    Conserved Domains (2) summary
    COG0724
    Location:114210
    Blast Score: 167
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12680
    Location:114187
    Blast Score: 414
    RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    81887835..81891586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256333.2XP_005256390.1  

    Conserved Domains (2) summary
    COG0724
    Location:114183
    Blast Score: 148
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12680
    Location:114179
    Blast Score: 371
    RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    75247636..75251146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    79931915..79935666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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