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ADAR adenosine deaminase, RNA-specific [ Homo sapiens (human) ]

Gene ID: 103, updated on 15-May-2016
Official Symbol
ADARprovided by HGNC
Official Full Name
adenosine deaminase, RNA-specificprovided by HGNC
Primary source
HGNC:HGNC:225
See related
Ensembl:ENSG00000160710 HPRD:07528; MIM:146920; Vega:OTTHUMG00000037261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP
Summary
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Orthologs
Location:
1q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (154582057..154628013, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154554533..154600456, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC105371449

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Aicardi-goutieres syndrome 6
MedGen: C3539013 OMIM: 615010 GeneReviews: Not available
Compare labs
Symmetrical dyschromatosis of extremities
MedGen: C0406775 OMIM: 127400 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
env Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, adenosine deaminase, RNA-specific (ADAR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ADAR is increased by RRE PubMed
rev ADAR1-mediated A-to-G mutations in RRE region of the env gene affect the binding of HIV-1 Rev PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of RNA-specific adenosine deaminase (ADAR) in the nucleoli of Jurkat T-cells PubMed
capsid gag ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
gag Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
reverse transcriptase gag-pol ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed

Go to the HIV-1, Human Interaction Database

  • C6 deamination of adenosine, organism-specific biosystem (from REACTOME)
    C6 deamination of adenosine, organism-specific biosystemHydrolytic deamination of adenosine leads to inosine. Ammonia is presumed to be released during this reaction.
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Formation of editosomes by ADAR proteins, organism-specific biosystem (from REACTOME)
    Formation of editosomes by ADAR proteins, organism-specific biosystemIt is still unclear how ADAR 1 and ADAR 2 proteins form the editosomes with the target RNA. Other components of these editosomes for A to I editing are unknown.
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • mRNA Editing, organism-specific biosystem (from REACTOME)
    mRNA Editing, organism-specific biosystemAfter transcription, some RNA molecules are altered to contain bases not encoded in the genome. Most often this involves the editing or modification of one base to another, but in some organisms can ...
  • mRNA Editing: A to I Conversion, organism-specific biosystem (from REACTOME)
    mRNA Editing: A to I Conversion, organism-specific biosystemIn humans the deamination of adenosines to inosines is the most common editing event. It is particularly prevalent in the brain, where it leads to amino acid changes that affect the conductance of se...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA adenosine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA adenosine deaminase activity NAS
Non-traceable Author Statement
more info
PubMed 
double-stranded RNA adenosine deaminase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adenosine to inosine editing IDA
Inferred from Direct Assay
more info
PubMed 
adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenosine to inosine editing TAS
Traceable Author Statement
more info
 
base conversion or substitution editing IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
miRNA loading onto RISC involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RNA interference IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic diversification of immune receptors via somatic mutation IEA
Inferred from Electronic Annotation
more info
 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
supraspliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
double-stranded RNA-specific adenosine deaminase
Names
136 kDa double-stranded RNA-binding protein
adenosine deaminase acting on RNA 1-A
dsRNA adenosine deaminase
interferon-induced protein 4
interferon-inducible protein 4
NP_001020278.1
NP_001102.2
NP_001180424.1
NP_056655.2
NP_056656.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011844.1 RefSeqGene

    Range
    24714..50905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025107.2NP_001020278.1  double-stranded RNA-specific adenosine deaminase isoform d

    See identical proteins and their annotated locations for NP_001020278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AA449679, AL592078, BX538232, BX640741, CD108625, DA507408
    Consensus CDS
    CCDS30879.1
    UniProtKB/Swiss-Prot
    P55265
    Related
    ENSP00000357456, OTTHUMP00000035373, ENST00000368471, OTTHUMT00000090692
    Conserved Domains (3) summary
    smart00552
    Location:544927
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:208274
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:564
    z-alpha; Adenosine deaminase z-alpha domain
  2. NM_001111.4NP_001102.2  double-stranded RNA-specific adenosine deaminase isoform a

    See identical proteins and their annotated locations for NP_001102.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as ADAR-a).
    Source sequence(s)
    AA449679, AL592078, AL606500, CD108625, U10439
    Consensus CDS
    CCDS1071.1
    UniProtKB/Swiss-Prot
    P55265
    Related
    ENSP00000357459, OTTHUMP00000035372, ENST00000368474, OTTHUMT00000090691
    Conserved Domains (4) summary
    smart00550
    Location:294359
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8391222
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:503569
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:140201
    z-alpha; Adenosine deaminase z-alpha domain
  3. NM_001193495.1NP_001180424.1  double-stranded RNA-specific adenosine deaminase isoform d

    See identical proteins and their annotated locations for NP_001180424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AA449679, AL592078, AL606500, CD108625, X79448
    Consensus CDS
    CCDS30879.1
    UniProtKB/Swiss-Prot
    P55265
    Conserved Domains (3) summary
    smart00552
    Location:544927
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:208274
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:564
    z-alpha; Adenosine deaminase z-alpha domain
  4. NM_015840.3NP_056655.2  double-stranded RNA-specific adenosine deaminase isoform b

    See identical proteins and their annotated locations for NP_056655.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b, also referred to as ADAR-b) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
    Source sequence(s)
    AA449679, AL592078, AL606500, CD108625, U10439
    UniProtKB/Swiss-Prot
    P55265
    Related
    ENSP00000431794, OTTHUMP00000231779, ENST00000529168, OTTHUMT00000387579
    Conserved Domains (4) summary
    smart00550
    Location:294359
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8131196
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:503569
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:140201
    z-alpha; Adenosine deaminase z-alpha domain
  5. NM_015841.3NP_056656.2  double-stranded RNA-specific adenosine deaminase isoform c

    See identical proteins and their annotated locations for NP_056656.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (c, also referred to as ADAR-c) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
    Source sequence(s)
    AA449679, AL592078, AL606500, CD108625, U10439
    UniProtKB/Swiss-Prot
    P55265
    Conserved Domains (4) summary
    smart00550
    Location:294359
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:7941177
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:503569
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:140201
    z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    154582057..154628013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509061.1XP_011507363.1  

    Conserved Domains (4) summary
    smart00550
    Location:337402
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8561239
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:546612
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:183244
    z-alpha; Adenosine deaminase z-alpha domain
  2. XM_011509060.1XP_011507362.1  

    Conserved Domains (4) summary
    smart00550
    Location:337402
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8821265
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:546612
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:183244
    z-alpha; Adenosine deaminase z-alpha domain
  3. XM_006711109.1XP_006711172.1  

    Conserved Domains (4) summary
    smart00550
    Location:304369
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8491232
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:513579
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:150211
    z-alpha; Adenosine deaminase z-alpha domain
  4. XM_006711112.1XP_006711175.1  

    See identical proteins and their annotated locations for XP_006711175.1

    UniProtKB/Swiss-Prot
    P55265
    Conserved Domains (3) summary
    smart00552
    Location:544927
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:208274
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:564
    z-alpha; Adenosine deaminase z-alpha domain
  5. XM_006711113.1XP_006711176.1  

    See identical proteins and their annotated locations for XP_006711176.1

    UniProtKB/Swiss-Prot
    P55265
    Conserved Domains (3) summary
    smart00552
    Location:544927
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:208274
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:564
    z-alpha; Adenosine deaminase z-alpha domain
  6. XM_011509062.1XP_011507364.1  

    Conserved Domains (4) summary
    smart00550
    Location:300365
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    smart00552
    Location:8451228
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:509575
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:146207
    z-alpha; Adenosine deaminase z-alpha domain
  7. XM_006711111.2XP_006711174.1  

    See identical proteins and their annotated locations for XP_006711174.1

    UniProtKB/Swiss-Prot
    P55265
    Conserved Domains (3) summary
    smart00552
    Location:544927
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:208274
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02295
    Location:564
    z-alpha; Adenosine deaminase z-alpha domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    155950933..155996946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)