CD209 CD209 molecule [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CD209provided by HGNC
Official Full Name: CD209 moleculeprovided by HGNC
Primary source: HGNC:1641
See related: Ensembl:ENSG00000090659; HPRD:05241; MIM:604672; Vega:OTTHUMG00000182530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
Summary: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Genomic context

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Location :: 19p13

Sequence :: Chromosome: 19; NC_000019.9 (7804879..7812464, complement)

See CD209 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

DC-SIGN plays an important role in Dengue virus pathogenesis.
Title: Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.
The C-type lectin DC-SIGN was found to serve as a receptor for severe fever with thrombocytopenia virus Gn/Gc glycoprotein-driven entry into cell lines and dendritic cells.
Title: Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines.
Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.
Title: Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.
These data demonstrated that the envelope of CRF07_BC from China has the capability of resulting in infection to CD34+ HPCs, which may serve as a mechanism for long-term latency of HIV-1 infection in vivo.
Title: In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus.
The present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to tuberculosis susceptibility.
Title: Association between CD209 -336A/G and -871A/G polymorphisms and susceptibility of tuberculosis: a meta-analysis.
The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells
Title: The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells.
In the DC-SIGN promoter region, -336C may be a genetic risk factor for developing chronic hepatitis B, but -139T may be associated with protection against HBV.
Title: Mutation analysis of DC-SIGN promoter in chronic hepatitis B patients.
This study provides compelling evidence to support an important role of DC-SIGN in intrauterine HIV-1 infection.
Title: Naturally-occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission.
The CD209-336A/G polymorphism may not contribute to susceptibility to tuberculosis.
Title: Association between the CD209 promoter -336A/G polymorphism and susceptibility to tuberculosis: a meta-analysis.
No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DC-SIGN (CD/HC: P=0.25 and UC/HC: P=0.36).
Title: Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.

Submit: New GeneRIF Correction See all (200)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	DC-SIGN binding to the HIV envelope protein effectively increases exposure of the CD4 binding site, which leads to enhance the relative rate of infection of the CD4-dependent strain	PubMed
	env	DC-SIGN increases the binding affinity of trimeric gp140 envelope glycoproteins to CD4 on permissive cell surface	PubMed
	env	CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs	PubMed
	env	Enrichment of oligomannose N-glycans on HIV-1 gp140 enhances DC-SIGN binding but reduces the subsequent transmission to target cells	PubMed
Envelope surface glycoprotein gp120	env	DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface	PubMed
	env	HIV-1 gp120 N275Q or N351Q mutants isolated from recombinant CRF07_BC decrease significantly to the DC-SIGN-binding capacity, indicating that the N275 and N351 glycan sites mediate the interaction between CRF07_BC gp120 and DC-SIGN	PubMed
	env	CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs	PubMed
	env	Enrichment of oligomannose N-glycans on HIV-1 gp120 enhances DC-SIGN binding but reduces the subsequent transmission to target cells	PubMed
	env	One HIV-1 gp120 triple glycosylation mutant form 134mut (carrying N293Q, N382Q, and N388Q mutations in gp120) exhibits a significant increase in sensitivity to both mannan competition and endoglycosidase H digestion in a DC-SIGN binding assay	PubMed
	env	Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN)	PubMed
	env	Binding of HIV-1 gp120 to DC-SIGN does not result in increased adhesion levels of LFA-1 to its ligand ICAM-1 in both immature dendritic cells (DC) and Raji-DC-SIGN cells	PubMed
	env	AM3 (Inmunoferon) inhibits the interaction of DC-SIGN with both ICAM3 and HIV-1 gp120 protein and blocks the DC-SIGN-dependent capture of HIV virions and the HIV trans-infection capability of DC-SIGN transfectants	PubMed
	env	Mermaid shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120	PubMed
	env	Oligomannose glycans play as ligands for DC-SIGN, and can inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN	PubMed
	env	End-stage CCR5-tropic HIV-1 have a reduced ability to use DC-SIGN resulting from the loss of potential N-linked glycosylation sites (PNGS) in the gp120 V2 and V4 regions, which are present in the majority of chronic stage CCR5-tropic variants	PubMed
	env	DC-SIGN-mediated blockage of HIV budding is due to internalization of gp120 by DC-SIGN. The 364 amino-acid residues of extracellular and transmembrane domains in DC-SIGN are essential for the blockage	PubMed
	env	Interaction of gp120 with DC-SIGN activates Raf-1 and phosphorylates Raf-1 at positions Ser338, Tyr340, and Tyr341	PubMed
	env	DC-SIGN triacidic cluster (353EEE355) mutant is impaired in receptor-mediated endocytosis of HIV-1 gp120 in transfected human myeloid K-562 cells	PubMed
	env	Monoclonal antibodies produced from hybridoma clones recognize DC-SIGN on monocyte-derived dendritic cells and on dermal-type macrophages to interfere with DC-SIGN binding to HIV-1 gp120	PubMed
	env	Glycopolymers effectively prevent the interactions between a human dendritic cell associated lectin (DC-SIGN) and the HIV-1 gp120	PubMed
	env	Raji-DC-SIGN cells preferentially enhance CXCR4 usage of dual-tropic HIV-1 with higher V3 charges in gp120	PubMed
	env	Expression of CD4 on Raji B cells strongly inhibits DC-SIGN-mediated HIV-1 (gp120) transmission to T cells; co-expression of CD4 and DC-SIGN in Raji cells promotes internalization and intracellular retention of HIV-1	PubMed
	env	The cis expression of DC-SIGN on multiple lymphoid cell lines enables more efficient entry and replication of CXCR4-tropic and CCR5/CXCR4 dual-tropic HIV-1 through its binding to the HIV-1 gp120-CD4-CXCR4 complex	PubMed
	env	Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR in combination with binding studies reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides of HIV-1 gp120	PubMed
	env	A dendritic cells (DC)-specific C-type lectin, DC-SIGN, is highly expressed on DC present in mucosal tissues, binds to the HIV-1 envelope glycoprotein gp120, and facilitates infection of HIV-1 permissive cells in trans	PubMed
	env	HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin	PubMed
	env	Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor	PubMed
	env	Using an siRNA approach indicates DC-SIGN is not required for efficient trans-enhancement of HIV-1 (gp120) infectivity by dendritic cells (DCs)	PubMed
	env	The HIV-1 gp120 binding site in DC-SIGN is different from that of ICAM-2 and ICAM-3; alanine-scanning mutagenesis of DC-SIGN at N311, R345, V351, G352, E353, S360, G361, and N362 abrogate ICAM-2/3 binding, whereas the HIV-1 gp120 interaction is unaffected	PubMed
	env	DC-SIGN tetramers are essential for high affinity interactions with the HIV-1 high mannose glycoprotein gp120	PubMed
	env	Mutagenesis of conserved residues (Gly-346, Glu-347, Asn-349, Glu-354, and Asp-355) of DC-SIGN significantly compromises binding to HIV-1 gp120	PubMed
	env	DC-SIGN and MBL bind primarily to glycans on HIV-1 gp120/gp41; preincubation of CXCR4-, CCR5- or dual-tropic HIV-1 strains with MBL prevents DC-SIGN-mediated trans infection of T cells	PubMed
	env	Bovine lactoferrin (bLF) binds strongly to DC-SIGN, thus blocking the interaction between DC-SIGN and HIV-1 gp120 and preventing virus capture and subsequent transmission; bLF is a much more efficient inhibitor of transmission than human lactoferrin	PubMed
Nef, p27	nef	HIV-1 Nef upregulates DC-SIGN in HIV-1 infected dendritic cells by inhibiting DC-SIGN endocytosis, which dramatically increases clustering of dendritic cells with T lymphocytes, thereby enhancing HIV-1 transmission	PubMed
	nef	Substitution of HIV-1 Nef acidic residue E160 with uncharged residues impairs the ability of Nef to upregulate the expression of DC-SIGN and the invariant chain of MHC class II at the cell surface	PubMed
	nef	Mutation of the dileucine motif at amino acids 165-166 of HIV-1 Nef abolishes the Nef-mediated upregulation of DC-SIGN on the surface of HIV-1 infected dendritic cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000019.8	NP_612482.2	SP1	BIND	PubMed	Sp1 interacts with the CD209 promoter.
NP_066978.1	NP_671491.1	HCVgp1	BIND	PubMed	HCV strain H77 glycoprotein E2 interacts with DC-SIGN.
NP_066978.1	BAA01583.1		BIND	PubMed	HCV strain HC-J4 glycoprotein E2 interacts with DC-SIGN.
NP_066978.1	BAA01583.1		BIND	PubMed	HCV strain HC-J4 glycoprotein E1 interacts with DC-SIGN.
NP_066978.1	CAB46677.1		BIND	PubMed	E1 interacts with DC-SIGN.
NP_066978.1	CAB46677.1		BIND	PubMed	E2 interacts with DC-SIGN.
NP_066978.1			BIND	PubMed	E1/E2 heterodimer interacts with DC-SIGN. This interaction was modeled on a demonstrated interaction between E1/E2 heterodimer from hepatitis C virus type 1b and human DC-SIGN.
Q9NNX6	Q9NNX6	CD209	HPRD	PubMed
Q9NNX6	P13688	CEACAM1	HPRD	PubMed
Q9NNX6	Q9H2X3	CLEC4M	HPRD	PubMed
Q9NNX6	P13598	ICAM2	HPRD	PubMed
Q9NNX6	P32942	ICAM3	HPRD	PubMed
Q9NNX6	P11215	ITGAM	HPRD	PubMed
BioGRID:119051	BioGRID:119051	CD209	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:119051	BioGRID:107478	CEACAM5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119051	BioGRID:115615	CLEC4M	BioGRID	PubMed	Reconstituted Complex
BioGRID:119051	BioGRID:107603	CLU	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:119051	BioGRID:110150	LGALS3BP	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Pathways from BioSystems

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Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

General gene information

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Markers

SHGC-149275 (e-PCR)
- UniSTS:176900

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

CD209_523 (e-PCR)
- UniSTS:277070

RH98479 (e-PCR)
- UniSTS:92273

D1S1423 (e-PCR)
- UniSTS:149619

STS-AA028127 (e-PCR)
- UniSTS:82341

PMC114396P1 (e-PCR)
- UniSTS:270265

NoName (e-PCR)
- UniSTS:481741

NoName (e-PCR)
- UniSTS:482545

Genotypes

See CD209 SNP Geneview Report
See CD209 SNP Genotype Report
See CD209 SNP Variation Viewer Report

Homology

Homologs of the CD209 gene: The CD209 gene is conserved in chimpanzee, Rhesus monkey, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
carbohydrate binding	NAS Non-traceable Author Statement more info	PubMed
mannose binding	TAS Traceable Author Statement more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
peptide antigen binding	NAS Non-traceable Author Statement more info	PubMed
virion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
antigen processing and presentation	NAS Non-traceable Author Statement more info	PubMed
cell-cell recognition	TAS Traceable Author Statement more info	PubMed
endocytosis	IEA Inferred from Electronic Annotation more info
heterophilic cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
innate immune response	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
intracellular virion transport	TAS Traceable Author Statement more info	PubMed
leukocyte cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
peptide antigen transport	NAS Non-traceable Author Statement more info	PubMed
regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
viral attachment to host cell	TAS Traceable Author Statement more info	PubMed
viral genome replication	NAS Non-traceable Author Statement more info	PubMed
virus-host interaction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	NAS Non-traceable Author Statement more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD209 antigen

Names: CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012167.1 RefSeqGene

Range

5001..12586

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144893.1 → NP_001138365.1 CD209 antigen isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1. The encoded isoform (5) lacks the transmembrane domain and has 4.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK313585, AY042227

Consensus CDS

CCDS59344.1

UniProtKB/TrEMBL

B2R907

UniProtKB/TrEMBL

M0R0P0

UniProtKB/Swiss-Prot

Q9NNX6

Related

ENSP00000301357, ENST00000301357

Conserved Domains (1) summary

cd03590
Location:120 – 243
Blast Score: 460

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144894.1 → NP_001138366.1 CD209 antigen isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks multiple exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and lacks the transmembrane domain compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042226

Consensus CDS

CCDS45949.1

UniProtKB/TrEMBL

B2R907

UniProtKB/Swiss-Prot

Q9NNX6

Conserved Domains (1) summary

cd03590
Location:212 – 335
Blast Score: 480

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144895.1 → NP_001138367.1 CD209 antigen isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 7) compared to isoform 1. The encoded isoform (7) has 4.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK313585, AY042223

Consensus CDS

CCDS45952.1

UniProtKB/TrEMBL

B2R907

UniProtKB/TrEMBL

G5E9C4

UniProtKB/Swiss-Prot

Q9NNX6

Conserved Domains (1) summary

cd03590
Location:164 – 287
Blast Score: 470

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144896.1 → NP_001138368.1 CD209 antigen isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter and lacks the transmembrane domain compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042225

Consensus CDS

CCDS45950.1

UniProtKB/TrEMBL

B2R907

UniProtKB/Swiss-Prot

Q9NNX6

Conserved Domains (1) summary

cd03590
Location:232 – 355
Blast Score: 480

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144897.1 → NP_001138369.1 CD209 antigen isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042222

Consensus CDS

CCDS45951.1

UniProtKB/TrEMBL

B2R907

UniProtKB/Swiss-Prot

Q9NNX6

Conserved Domains (2) summary

cd03590
Location:256 – 373
Blast Score: 466

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl01234
Location:38 – 184
Blast Score: 87

PilO; Pilus assembly protein, PilO
NM_001144899.1 → NP_001138371.1 CD209 antigen isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 8) compared to isoform 1. The encoded isoform (8) has 1.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK304190, AK313585

Consensus CDS

CCDS59345.1

UniProtKB/TrEMBL

B2R907

UniProtKB/TrEMBL

B4E2A8

Conserved Domains (1) summary

cd03590
Location:95 – 218
Blast Score: 455

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_021155.3 → NP_066978.1 CD209 antigen isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC008763, AK313585, AY042221

Consensus CDS

CCDS12186.1

UniProtKB/TrEMBL

B2R907

UniProtKB/Swiss-Prot

Q9NNX6

Related

ENSP00000315477, OTTHUMP00000269508, ENST00000315599, OTTHUMT00000462241

Conserved Domains (2) summary

cd03590
Location:256 – 379
Blast Score: 487

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl01234
Location:38 – 184
Blast Score: 87

PilO; Pilus assembly protein, PilO

RNA

NR_026692.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC008763, AK313585, AY042229

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p10 Primary Assembly

Range

7804879..7812464, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

7474941..7482525, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018930.1 Alternate CHM1_1.0

Range

7744198..7751782, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01010887.1 (38806..46390)	None
genomic	AC008763.9 (170805..176898)	None
genomic	AC008812.7 (50262..50630)	None
genomic	AF209479.1	AAG13814.1
genomic	AMYH01009412.1 (69715..77299)	None
genomic	CH471139.2	EAW68991.1
		EAW68992.1
		EAW68993.1
		EAW68994.1
		EAW68995.1
		EAW68996.1
		EAW68997.1
		EAW68998.1
		EAW68999.1
		EAW69000.1
		EAW69001.1
genomic	CQ796864.1	CAG26528.1
genomic	CS126908.1	CAJ18838.1
mRNA	AF290886.1	AAK20997.1
mRNA	AK293089.1	BAF85778.1
mRNA	AK304190.1	BAG65070.1
mRNA	AK308595.1	None
mRNA	AK313585.1	BAG36354.1
mRNA	AY042221.1	AAK91846.1
mRNA	AY042222.1	AAK91847.1
mRNA	AY042223.1	AAK91848.1
mRNA	AY042224.1	AAK91849.1
mRNA	AY042225.1	AAK91850.1
mRNA	AY042226.1	AAK91851.1
mRNA	AY042227.1	AAK91852.1
mRNA	AY042228.1	AAK91853.1
mRNA	AY042229.1	AAK91854.1
mRNA	AY042230.1	AAK91855.1
mRNA	AY042231.1	AAK91856.1
mRNA	AY042232.1	AAK91857.1
mRNA	AY042233.1	AAK91858.1
mRNA	BC110615.2	AAI10616.1
mRNA	M98457.1	AAF77072.1