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LDHB lactate dehydrogenase B [ Homo sapiens (human) ]

Gene ID: 3945, updated on 18-Oct-2014
Official Symbol
LDHBprovided by HGNC
Official Full Name
lactate dehydrogenase Bprovided by HGNC
Primary source
HGNC:HGNC:6541
See related
Ensembl:ENSG00000111716; HPRD:01026; MIM:150100; Vega:OTTHUMG00000133760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281
Summary
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]
See LDHB in Epigenomics, MapViewer
Location:
12p12.2-p12.1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (21635341..21657971, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21788275..21810789, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 (liver) Neighboring gene uncharacterized LOC102724261 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify lactate dehydrogenase B (LDHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release PubMed
Envelope transmembrane glycoprotein gp41 env A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify lactate dehydrogenase B (LDHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify lactate dehydrogenase B (LDHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify lactate dehydrogenase B (LDHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of lactate dehydrogenase B (LDHB) in the nucleoli of Jurkat T-cells PubMed
tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
capsid gag HIV-1 CA is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
NAD metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular metabolic process TAS
Traceable Author Statement
more info
 
lactate metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
L-lactate dehydrogenase B chain
Names
L-lactate dehydrogenase B chain
LDH heart subunit
lactate dehydrogenase H chain
renal carcinoma antigen NY-REN-46
epididymis secretory protein Li 281
NP_001167568.1
NP_002291.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017038.1 

    Range
    5001..27515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174097.1NP_001167568.1  L-lactate dehydrogenase B chain

    See proteins identical to NP_001167568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010197, AL516910, CX867875
    Consensus CDS
    CCDS8691.1
    UniProtKB/Swiss-Prot
    P07195
    UniProtKB/TrEMBL
    Q5U077
    Related
    ENSP00000379386, OTTHUMP00000165229, ENST00000396076, OTTHUMT00000258220
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:4332
    PLN02602; lactate dehydrogenase
  2. NM_002300.6NP_002291.1  L-lactate dehydrogenase B chain

    See proteins identical to NP_002291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010197, BC015122
    Consensus CDS
    CCDS8691.1
    UniProtKB/Swiss-Prot
    P07195
    UniProtKB/TrEMBL
    Q5U077
    Related
    ENSP00000229319, OTTHUMP00000165228, ENST00000350669, OTTHUMT00000258219
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:4332
    PLN02602; lactate dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    21635341..21657971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719074.1XP_006719137.1  

    Conserved Domains (2) summary
    cd05293
    Location:20279
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:26279
    L-LDH-NAD; L-lactate dehydrogenase

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    21561869..21584405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    21753523..21776056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)