LDHB lactate dehydrogenase B [Homo sapiens (human)] - Gene

Summary

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Official Symbol: LDHBprovided by HGNC
Official Full Name: lactate dehydrogenase Bprovided by HGNC
Primary source: HGNC:6541
See related: Ensembl:ENSG00000111716; HPRD:01026; MIM:150100; Vega:OTTHUMG00000133760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LDH-B; LDH-H; LDHBD; TRG-5
Summary: This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]

Genomic context

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Location :: 12p12.2-p12.1

Sequence :: Chromosome: 12; NC_000012.11 (21788275..21810789, complement)

See LDHB in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patients with severe vaso-occlusive crisis were more frequently males, who also had higher white blood cell (WBC) count, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels.
Title: High lactate dehydrogenase levels at admission for painful vaso-occlusive crisis is associated with severe outcome in adult SCD patients.
Data reveal that LDHB is upregulated and required only in certain cancer genotypes.
Title: An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.
results indicate that histone deacetylase inhibitors upregulate miRNAs, at least some of which act as tumor suppressors. lactate dehydrogenase B, which is regulated by the tumor suppressive miR-375, may therefore act as an oncogene in esophageal squamous cell carcinoma.
Title: Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.
Serum lactate dehydrogenase is a prognostic and predictive biomarker for survival benefit conferred by TORC1 inhibition in poor-risk renal cell carcinoma.
Title: Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin.
Data indicate that serum lactate dehydrogenase (LDH) seemed able to predict clinical outcome for hepatocellular carcinoma (HCC) patients undergoing hepatocellular carcinoma (HCC).
Title: The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management.
The significant elevation in serum CK [creatine kinase ]and LDH [L-Lactate Dehydrogenase ] activities indicates that these can be used as parameters for screening hypothyroid patients but not hyperthyroid patients.
Title: Serum creatine kinase and lactate dehydrogenase activities in patients with thyroid disorders.
results confirmed the prognostic roles of LDH-B in urinary bladder urothelial carcinoma.
Title: Loss of lactate dehydrogenase B subunit expression is correlated with tumour progression and independently predicts inferior disease-specific survival in urinary bladder urothelial carcinoma.
Results show that S-100B, MIA and LDH levels were significantly higher in patients with advanced melanoma than in disease-free patients or healthy controls.
Title: Evaluation of multiple serum markers in advanced melanoma.
Results suggest that lactate dehydrogenase B suppression plays an important role in triggering or maintaining the mitochondrial defects and then contributes to cancer cell invasiveness by inducing claudin-1 protein.
Title: Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects.
Elevated serum LDH isoenzymes and AST indicate a disturbance (of uncertain clinical significance) within multiple extraosseous tissues when there is CLCN7 deficiency.
Title: Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders.

Submit: New GeneRIF Correction See all (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Lactate dehydrogenase b deficiency

MIM: 614128

Genetic Testing Registry

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release	PubMed
Envelope transmembrane glycoprotein gp41	env	A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines	PubMed
Tat, p14	tat	Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat	PubMed
capsid	gag	HIV-1 CA is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P07195	P07195	LDHB	HPRD	PubMed
P07195	Q6EEV6	SUMO4	HPRD	PubMed
BioGRID:110137	BioGRID:106990	ALDH7A1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:115042	BZW1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107572	CKB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107582	CKS1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107583	CKS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:120866	CNDP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:114028	CUL4B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:971788	EBNA-LP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:108223	ECT2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:117654	FBXO6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:122520	FTO	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:108814	G6PD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:124023	GINS4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109035	GNAI3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109391	HMGB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109422	HNRNPA2B1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109423	HNRNPAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:109883	ITGA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:110131	LDHA	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Two-hybrid
BioGRID:110137	BioGRID:110137	LDHB	BioGRID	PubMed	Co-crystal Structure
BioGRID:110137	BioGRID:110169	LIG4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:117403	METTL21B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:204968	Mapk13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:114897	NPEPPS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:111086	PAFAH1B2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:111087	PAFAH1B3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:111098	PAK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:116625	PAXIP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:111221	PFAS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:111247	PGD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:117417	POT1	BioGRID	PubMed	Two-hybrid
BioGRID:110137	BioGRID:112109	RPS6KA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:114769	SLC9A3R1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:112872	TERF1	BioGRID	PubMed	Two-hybrid
BioGRID:110137	BioGRID:112910	TGM2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:123529	TXNDC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113183	UBE2V1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:121034	UBFD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113885	UBL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110137	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Abnormal metabolism in phenylketonuria, organism-specific biosystem (from REACTOME)
Abnormal metabolism in phenylketonuria, organism-specific biosystemPhenylalanine hydroxylase (PAH) catalyzes the conversion of phenylalanine to tyrosine. In the absence of functional PAH, phenylalanine accumulates to high levels in the blood (Mitchell and Scriver 20...
Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
Cysteine and methionine metabolism, conserved biosystem (from KEGG)
Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Propanoate metabolism, organism-specific biosystem (from KEGG)
Propanoate metabolism, organism-specific biosystem
Propanoate metabolism
Propanoate metabolism, conserved biosystem (from KEGG)
Propanoate metabolism, conserved biosystem
Propanoate metabolism
Pyruvate metabolism, organism-specific biosystem (from REACTOME)
Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
Pyruvate metabolism, organism-specific biosystem (from KEGG)
Pyruvate metabolism, organism-specific biosystem
Pyruvate metabolism
Pyruvate metabolism, conserved biosystem (from KEGG)
Pyruvate metabolism, conserved biosystem
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
pyruvate fermentation to lactate, organism-specific biosystem (from BIOCYC)
pyruvate fermentation to lactate, organism-specific biosystem
pyruvate fermentation to lactate

General gene information

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Markers

SHGC-12682 (e-PCR)
- UniSTS:70432

G07018 (e-PCR)
- UniSTS:11042

RH15605 (e-PCR)
- UniSTS:91210

SHGC-173311 (e-PCR)
- UniSTS:182648

SHGC-132102 (e-PCR)
- UniSTS:170648

GDB:384749 (e-PCR)
- UniSTS:157094

LDHB (e-PCR)
- UniSTS:503974

D13S838E (e-PCR)
- UniSTS:151513

STS-X13800 (e-PCR)
- UniSTS:16120

Genotypes

See LDHB SNP Geneview Report
See LDHB SNP Genotype Report
See LDHB SNP Variation Viewer Report

Homology

Homologs of the LDHB gene: The LDHB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
L-lactate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
NAD binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IEA Inferred from Electronic Annotation more info
kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NAD metabolic process	IEA Inferred from Electronic Annotation more info
cellular carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
glycolysis	IEA Inferred from Electronic Annotation more info
lactate metabolic process	IEA Inferred from Electronic Annotation more info
pyruvate metabolic process	TAS Traceable Author Statement more info
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-lactate dehydrogenase B chain

Names: L-lactate dehydrogenase B chain; LDH heart subunit; lactate dehydrogenase H chain; renal carcinoma antigen NY-REN-46

NP_001167568.1

EC 1.1.1.27

NP_002291.1

EC 1.1.1.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017038.1 RefSeqGene

Range

5001..27515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001174097.1 → NP_001167568.1 L-lactate dehydrogenase B chain

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC010197, AL516910, CX867875

Consensus CDS

CCDS8691.1

UniProtKB/Swiss-Prot

P07195

UniProtKB/TrEMBL

Q5U077

Related

ENSP00000379386, OTTHUMP00000165229, ENST00000396076, OTTHUMT00000258220

Conserved Domains (2) summary

cd05293
Location:20 – 330
Blast Score: 1529

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:26 – 326
Blast Score: 1135

L-LDH-NAD; L-lactate dehydrogenase
NM_002300.6 → NP_002291.1 L-lactate dehydrogenase B chain

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC010197, BC015122

Consensus CDS

CCDS8691.1

UniProtKB/Swiss-Prot

P07195

UniProtKB/TrEMBL

Q5U077

Related

ENSP00000229319, OTTHUMP00000165228, ENST00000350669, OTTHUMT00000258219

Conserved Domains (2) summary

cd05293
Location:20 – 330
Blast Score: 1529

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:26 – 326
Blast Score: 1135

L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p10 Primary Assembly

Range

21788275..21810789, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

21561869..21584405, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018923.1 Alternate CHM1_1.0

Range

21656740..21679250, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01067971.1 (124638..147174)	None
genomic	AC010197.7 (45796..68310)	None
genomic	AMYH01004319.1 (385689..408199)	None
genomic	CH471094.1	EAW96448.1
		EAW96449.1
genomic	EU919185.1	ACF98331.1
genomic	X13794.1	CAA32033.1
genomic	X13800.1	None
mRNA	AB209231.1	BAD92468.1
mRNA	AK129881.1	None
mRNA	AK312328.1	BAG35250.1
mRNA	AL516910.3	None
mRNA	AY189689.1	AAO85222.1
mRNA	BC002362.1	AAH02362.1
mRNA	BC015122.1	AAH15122.1
mRNA	BC022835.1	None
mRNA	BC071860.1	AAH71860.1
mRNA	BT019764.1	AAV38569.1
mRNA	BT019765.1	AAV38570.1
mRNA	CX867875.1	None
mRNA	D28368.1	BAA05734.1
mRNA	Y00711.1	CAA68701.1
other-genetic	DQ891854.2	ABM82780.1