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RPS10 ribosomal protein S10 [ Homo sapiens (human) ]

Gene ID: 6204, updated on 13-Sep-2014
Official Symbol
RPS10provided by HGNC
Official Full Name
ribosomal protein S10provided by HGNC
Primary source
HGNC:HGNC:10383
Locus tag
RP11-375E1__A.4
See related
Ensembl:ENSG00000124614; HPRD:04697; MIM:603632; Vega:OTTHUMG00000014546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S10; DBA9
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]
See RPS10 in Epigenomics, MapViewer
Location:
6p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (34417454..34426125, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34385231..34393902, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723521 Neighboring gene RPS10-NUDT3 readthrough Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 3 Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene SAM pointed domain containing ETS transcription factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef inhibits translation in vitro by interacting with two components of the 40S small ribosomal subunits, the RPS10 protein and the 18S rRNA PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC88819

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mRNA metabolic process TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational elongation TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
translational termination TAS
Traceable Author Statement
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
40S ribosomal protein S10
Names
40S ribosomal protein S10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023200.1 

    Range
    4975..13646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014.4NP_001005.1  40S ribosomal protein S10

    See proteins identical to NP_001005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157372, BC001032, BG940847
    Consensus CDS
    CCDS4792.1
    UniProtKB/Swiss-Prot
    P46783
    Related
    ENSP00000347271, OTTHUMP00000016229, ENST00000326199, OTTHUMT00000040230
    Conserved Domains (1) summary
    pfam03501
    Location:3101
    S10_plectin; Plectin/S10 domain
  2. NM_001203245.2NP_001190174.1  40S ribosomal protein S10

    See proteins identical to NP_001190174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157372, BC071946, BG532491
    Consensus CDS
    CCDS4792.1
    UniProtKB/Swiss-Prot
    P46783
    Related
    ENSP00000481646, ENST00000621356
    Conserved Domains (1) summary
    pfam03501
    Location:3101
    S10_plectin; Plectin/S10 domain
  3. NM_001204091.1NP_001191020.1  40S ribosomal protein S10

    See proteins identical to NP_001191020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157372, BU956627
    Consensus CDS
    CCDS4792.1
    UniProtKB/Swiss-Prot
    P46783
    Conserved Domains (1) summary
    pfam03501
    Location:3101
    S10_plectin; Plectin/S10 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    34417454..34426125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    34107972..34116617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    34388245..34396900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)