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STXBP4 syntaxin binding protein 4 [ Homo sapiens (human) ]

Gene ID: 252983, updated on 8-May-2016
Official Symbol
STXBP4provided by HGNC
Official Full Name
syntaxin binding protein 4provided by HGNC
Primary source
HGNC:HGNC:19694
See related
Ensembl:ENSG00000166263 HPRD:18127; MIM:610415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Synip
Orthologs
Location:
17q22
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (54968735..55164285)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (53046119..53241646)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 8 Neighboring gene target of myb1 like 1 membrane trafficking protein Neighboring gene COX11 cytochrome c oxidase copper chaperone Neighboring gene HLF, PAR bZIP transcription factor Neighboring gene monocyte to macrophage differentiation associated

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies STXBP4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16496, MGC50337, MGC149829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glucose transport IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
syntaxin-binding protein 4
Names
STX4-interacting protein
syntaxin 4 interacting protein
syntaxin 4-interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178509.5NP_848604.3  syntaxin-binding protein 4

    See identical proteins and their annotated locations for NP_848604.3

    Status: VALIDATED

    Source sequence(s)
    AK122865, AK123793, BC041485, CA848494
    Consensus CDS
    CCDS11584.2
    UniProtKB/Swiss-Prot
    Q6ZWJ1
    Related
    ENSP00000365530, OTTHUMP00000082667, ENST00000376352, OTTHUMT00000157184
    Conserved Domains (3) summary
    cd00201
    Location:499529
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22883
    Location:300378
    Bac_GDH; Bacterial NAD-glutamate dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    54968735..55164285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524581.1XP_011522883.1  

    Conserved Domains (3) summary
    cd00201
    Location:504534
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22883
    Location:305383
    Bac_GDH; Bacterial NAD-glutamate dehydrogenase
  2. XM_005257187.3XP_005257244.1  

    Conserved Domains (3) summary
    cd00201
    Location:501531
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22883
    Location:302380
    Bac_GDH; Bacterial NAD-glutamate dehydrogenase
  3. XM_011524582.1XP_011522884.1  

    Conserved Domains (3) summary
    cd00201
    Location:502532
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22883
    Location:303381
    Bac_GDH; Bacterial NAD-glutamate dehydrogenase
  4. XM_011524583.1XP_011522885.1  

    UniProtKB/TrEMBL
    E7EPP7
    Related
    ENSP00000391087, OTTHUMP00000227400, ENST00000434978, OTTHUMT00000380097
    Conserved Domains (2) summary
    cd00201
    Location:477507
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_011524584.1XP_011522886.1  

    Conserved Domains (1) summary
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006721797.2XP_006721860.1  

    Conserved Domains (1) summary
    cd00992
    Location:22100
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_006721798.2XP_006721861.1  

    UniProtKB/TrEMBL
    B5MCT9
    Related
    ENSP00000385944, OTTHUMP00000198125, ENST00000405898, OTTHUMT00000157190
    Conserved Domains (1) summary
    cd00992
    Location:2298
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_934431.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    53111024..53306373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)