My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    XIAP X-linked inhibitor of apoptosis [ Homo sapiens ]

    Gene ID: 331, updated on 23-May-2012
    Help top of page

    Summary

    Official Symbol
    XIAPprovided by HGNC
    Official Full Name
    X-linked inhibitor of apoptosisprovided by HGNC
    Primary source
    HGNC:592
    Locus tag
    RP1-315G1.5
    See related
    Ensembl:ENSG00000101966; HPRD:02094; MIM:300079; Vega:OTTHUMG00000022336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; FLJ26913
    Summary
    This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
    Help top of page

    Genomic context

    Location :
    Xq25
    Sequence :
    Chromosome: X; NC_000023.10 (122993662..123047829)
    See XIAP in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene mediator of cell motility 1 pseudogene 4 Neighboring gene RNA, U7 small nuclear 69 pseudogene Neighboring gene par-6 partitioning defective 6 homolog beta (C. elegans) pseudogene Neighboring gene stromal antigen 2 Neighboring gene zinc finger protein interacting with K protein 1 homolog (mouse) pseudogene 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies. Kawamoto Y, et al. Neuroreport, 2012 Feb 15. PMID 22273571.
    2. X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Bornstein B, et al. Int J Biochem Cell Biol, 2012 Mar. PMID 22185822.
    3. Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Lewis EM, et al. Biochemistry, 2011 Dec 27. PMID 22103349.
    4. IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis. Nakhaei P, et al. J Virol, 2012 Jan. PMID 22072751.
    5. AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells. Shan H, et al. Invest Ophthalmol Vis Sci, 2011. PMID 22039248.

    See all (290) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Bortezomib can inhibit the proliferation of K562 cells, and induce apoptosis by down-regulating the expression of XIAP.
      Title: [Effect of proteasome inhibitor bortezomib on proliferation, apoptosis and XIAP expression in K562 cells].
    2. Human XIAP may be partially associated with the pathogenesis of Parkinson's disease and dementia with Lewy bodies.
      Title: Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
    3. Translocation of ARTS initiates a first wave of caspase activation leading to the subsequent release of additional mitochondrial factors, including cytochrome C and SMAC/Diablo.
      Title: The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.
    4. embelin results in human leukemia cells apoptosis through caspase-dependent mechanisms involving down-regulation of XIAP.
      Title: Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells.
    5. Seven novel mutations in PRF1, UNC13D, and XIAP were identified in Chinese EBV-HLH patients. Only a fraction of Chinese children with EBV-HLH have genetic defects in PRF1, UNC13D, and XIAP.
      Title: Screening the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK gene mutations in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.
    6. Overexpression of human XIAP protects ARPE-19 cells against H(2)O(2)-induced oxidative cell death by acting downstream on the apoptotic pathway.
      Title: AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells.
    7. IKKepsilon regulated Sendai virus-induced apoptosis via the phosphorylation-dependent turnover of XIAP.
      Title: IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.
    8. Data indicate that XIAP blocks cell death inducing activity of apoptosis inducing factor (AIF) (not NADH oxidation) through nondegradative ubiquitination; specific residue of AIF (K255) in DNA-binding site appears to be involved in this interaction.
      Title: Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation.
    9. our experiments have identified XIAP as a novel substrate of HtrA1 and the degradation of XIAP by HtrA1 contributes to cell response to chemotherapy.
      Title: HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.
    10. There was a significant increase of XIAP mRNA expression in accelerated and blastic phase of CML, compared with the patients in chronic phase.
      Title: [Expression of XIAP gene in chronic myeloid leukemia and its clinical significance].
    Submit: New GeneRIF Correction See all (212)
    Help top of page

    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Lymphoproliferative syndrome, X-linked, 2

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001158.2 ACVR1B    BIND  PubMed An unspecified isoform of ALK4 interacts with XIAP. This interaction was modeled on a demonstrated interaction between ALK4 from an unspecified species and human XIAP. 
    NP_001158.2 NP_000011.1 ACVRL1    BIND  PubMed ALK1 interacts with XIAP. This interaction was modeled on a demonstrated interaction between ALK1 from an unspecified species and human XIAP. 
    NP_001158.2 NP_004337.2 CASP3    BIND  PubMed Caspase-3 interacts with XIAP. 
    NP_001158.2 NP_116786.1 CASP3    BIND  PubMed XIAP interacts with Casp-3. 
    NP_001158.2 CASP6    BIND  PubMed XIAP interacts with Casp-6. 
    NP_001158.2 NP_203125.1 CASP7    BIND  PubMed Caspase-7 interacts with XIAP. 
    NP_001158.2 CASP7    BIND  PubMed XIAP interacts with caspase-7. 
    NP_001158.2 CASP7    BIND  PubMed XIAP interacts with Casp-7. 
    NP_001158.2 NP_001220.2 CASP9    BIND  PubMed XIAP interacts with and ubiquitinates Caspase-9. 
    NP_001158.2 NP_063940.1 DIABLO    BIND  PubMed XIAP interacts with and ubiquitinates SMAC. 
    NP_001158.2 NP_063940.1 DIABLO    BIND  PubMed Smac interacts with XIAP. 
    NP_001158.2 NP_037379.1 HTRA2    BIND  PubMed XIAP interacts with HtrA2. 
    NP_001158.2 NP_006107.1 TAB1    BIND  PubMed XIAP interacts with TAB1. 
    NP_001158.2 NP_004603.1 TGFBR1    BIND  PubMed TGF-beta-RI interacts with XIAP. This interaction was modeled on a demonstrated interaction between TGF-beta-RI from an unspecified species and human XIAP. 
    NP_001158.2     BIND  PubMed Biotinylated compound 3 interacts with XIAP. 
    P98170 P37023 ACVRL1    HPRD  PubMed  
    P98170 P31749 AKT1    HPRD  PubMed  
    P98170 P31751 AKT2    HPRD  PubMed  
    P98170 O15392 BIRC5    HPRD  PubMed  
    P98170 P42574 CASP3    HPRD  PubMed  
    P98170 P55210 CASP7    HPRD  PubMed  
    P98170 P55211 CASP9    HPRD  PubMed  
    P98170 O14757 CHEK1    HPRD  PubMed  
    P98170 Q8N668 COMMD1    HPRD  PubMed  
    P98170 Q9NR28 DIABLO    HPRD  PubMed  
    P98170 Q96FJ2 DYNLL2    HPRD  PubMed  
    P98170 P15170 GSPT1    HPRD  PubMed  
    P98170 O43464 HTRA2    HPRD  PubMed  
    P98170 Q9Y5V3 MAGED1    HPRD  PubMed  
    P98170 O43318 MAP3K7    HPRD  PubMed  
    P98170 P46531 NOTCH1    HPRD  PubMed  
    P98170 Q9C0K7 STRADB    HPRD  PubMed  
    P98170 Q15750 TAB1    HPRD  PubMed  
    P98170 Q9NYJ8 TAB2    HPRD  PubMed  
    P98170 P36897 TGFBR1    HPRD  PubMed  
    P98170 Q9Y4K3 TRAF6    HPRD  PubMed  
    P98170 Ubiquitin B UBB    HPRD  PubMed  
    P98170 Q96HA8 WDYHV1    HPRD  PubMed  
    P98170 XAF1 XAF1    HPRD  PubMed  
    P98170 P98170 XIAP    HPRD  PubMed  
    BioGRID:106828 BioGRID:114579 AIFM1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106828 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106828 BioGRID:106711 AKT2    BioGRID  PubMed Biochemical Activity 
    BioGRID:106828 BioGRID:106889 ARHGDIA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:114429 BCL10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:106826 BIRC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:106829 BIRC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106828 BioGRID:107126 BMPR1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:107127 BMPR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:107285 CASP2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:106828 BioGRID:107286 CASP3    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:106828 BioGRID:107287 CASP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:107290 CASP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:107291 CASP8    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:106828 BioGRID:107292 CASP9    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106828 BioGRID:115298 CCS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:107536 CHEK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:127317 COMMD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:121157 DIABLO    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex 
    BioGRID:106828 BioGRID:126680 DYNLL2    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:116714 ERC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:108438 EXTL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:109190 GSPT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:115719 HAX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106828 BioGRID:118165 HTRA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106828 BioGRID:114879 MAGED1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106828 BioGRID:115969 MAP3K2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106828 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:198339 Ngfrap1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106828 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:114274 RIPK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:114300 RIPK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:116224 RIPK3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:119899 RIPK4    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:106828 BioGRID:111415 SEPT4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106828 BioGRID:118987 SERTAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:112372 SIAH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:120668 STRADB    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106828 BioGRID:115563 STUB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106828 BioGRID:115717 TAB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106828 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:119978 TOLLIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106828 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:116608 TRIM32    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106828 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106828 BioGRID:113169 UBE2D1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106828 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113171 UBE2D3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106828 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:125598 UBE2J2    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113180 UBE2L3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113183 UBE2V1    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113184 UBE2V2    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106828 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106828 BioGRID:120405 WDYHV1    BioGRID  PubMed Two-hybrid 
    BioGRID:106828 BioGRID:120121 XAF1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Two-hybrid 
    BioGRID:106828 BioGRID:106828 XIAP    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic factor-mediated response, organism-specific biosystem (from REACTOME)
      Apoptotic factor-mediated response, organism-specific biosystemIn response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome form...
    • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      BMP receptor signaling, organism-specific biosystem
      BMP receptor signaling
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • SMAC binds to IAPs, organism-specific biosystem (from REACTOME)
      SMAC binds to IAPs, organism-specific biosystemSMAC binds to the XIAP:caspase complexes.
    • SMAC-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      SMAC-mediated apoptotic response, organism-specific biosystemOnce released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.
    • SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystem (from REACTOME)
      SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystemSmac/DIABLO regulates IAP function. Residues 56â??59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    anti-apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    copper ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of canonical Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of BMP signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    		  
    regulation of innate immune response TAS
    Traceable Author Statement
    more info
    		  
    regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    response to DNA damage stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 4
    Names
    baculoviral IAP repeat-containing protein 4
    X-linked IAP
    IAP-like protein
    E3 ubiquitin-protein ligase XIAP
    inhibitor of apoptosis protein 3
    baculoviral IAP repeat-containing 4
    X-linked inhibitor of apoptosis protein
    NP_001158.2
    NP_001191330.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007264.1 RefSeqGene

      Range
      4615..58782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001167.3 → NP_001158.2  baculoviral IAP repeat-containing protein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL121601, DA316362, H09548, U32974
      Consensus CDS
      CCDS14606.1
      UniProtKB/Swiss-Prot
      P98170
      Related
      ENSP00000360242, OTTHUMP00000023975, ENST00000371199, OTTHUMT00000058165
      Conserved Domains (2) summary
      cd00022
      Location:164 – 232
      Blast Score: 279
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cl15348
      Location:448 – 489
      Blast Score: 153
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001204401.1 → NP_001191330.1  baculoviral IAP repeat-containing protein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK313883, AL121601, H09548
      Consensus CDS
      CCDS14606.1
      UniProtKB/TrEMBL
      B2R9R2
      UniProtKB/Swiss-Prot
      P98170
      Related
      ENSP00000395230, ENST00000434753
      Conserved Domains (2) summary
      cd00022
      Location:164 – 232
      Blast Score: 279
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cl15348
      Location:448 – 489
      Blast Score: 153
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. NR_037916.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) lacks an exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK309704, AL121601, DA316362, H09548

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      122993662..123047829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      112377835..112430903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL022156.2 (2000..12609) None
    genomic AL121601.13 CAB95312.1
      CAI42584.1
    genomic AL121601.13 CAB95312.1
      CAI42584.1
    genomic AL591583.14 (69521..70692) None
    genomic AY886519.1 AAW62257.1
    genomic CH471107.2 EAX11858.1
      EAX11859.1
      EAX11860.1
      EAX11861.1
    genomic FB777841.1 CAW32364.1
    genomic FB777857.1 CAW32374.1
    mRNA AK130423.1 None
    mRNA AK309704.1 None
    mRNA AK313883.1 BAG36609.1
    mRNA BC030771.1 None
    mRNA BC032729.1 AAH32729.1
    mRNA BQ423165.1 None
    mRNA DA316362.1 None
    mRNA H09548.1 None
    mRNA U32974.1 AAC50518.1
    other-genetic DQ890857.2 ABM81783.1
    other-genetic DQ894012.2 ABM84938.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98170.2 GenPept UniProtKB/Swiss-Prot:P98170
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...