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TRIM28 tripartite motif containing 28 [ Homo sapiens (human) ]

Gene ID: 10155, updated on 26-Aug-2014
Official Symbol
TRIM28provided by HGNC
Official Full Name
tripartite motif containing 28provided by HGNC
Primary source
HGNC:16384
See related
Ensembl:ENSG00000130726; HPRD:03445; MIM:601742; Vega:OTTHUMG00000183546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP1; TF1B; RNF96; TIF1B; PPP1R157
Summary
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
See TRIM28 in Epigenomics, MapViewer
Location:
19q13.4
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (58544469..58550715)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59055824..59062087)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene microRNA 6807 Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin-conjugating enzyme E2M

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
integrase gag-pol KAP1 inhibits HIV-1 integration via HIV-1 IN acetylation-dependent mechanism through HDAC1 PubMed
gag-pol The interaction between HIV-1 IN and KAP1 is highly favored by HAT/p300-mediated IN acetylation PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ29029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Krueppel-associated box domain binding IDA
Inferred from Direct Assay
more info
 
chromo shadow domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
convergent extension involved in axis elongation IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
gene expression TAS
Traceable Author Statement
more info
 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription factor import into nucleus IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear heterochromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
transcription intermediary factor 1-beta
Names
transcription intermediary factor 1-beta
KAP-1
KRIP-1
TIF1-beta
RING finger protein 96
KRAB-associated protein 1
nuclear corepressor KAP-1
KRAB-interacting protein 1
E3 SUMO-protein ligase TRIM28
tripartite motif-containing 28
tripartite motif-containing protein 28
transcriptional intermediary factor 1-beta
protein phosphatase 1, regulatory subunit 157

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005762.2NP_005753.1  transcription intermediary factor 1-beta

    See proteins identical to NP_005753.1

    Status: REVIEWED

    Source sequence(s)
    BC004978
    Consensus CDS
    CCDS12985.1
    UniProtKB/Swiss-Prot
    Q13263
    Related
    ENSP00000253024, OTTHUMP00000271939, ENST00000253024, OTTHUMT00000467074
    Conserved Domains (6) summary
    cd05502
    Location:696802
    Blast Score: 398
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:252378
    Blast Score: 341
    BBC; B-Box C-terminal domain
    smart00336
    Location:148184
    Blast Score: 102
    BBOX; B-Box-type zinc finger
    cd00021
    Location:207245
    Blast Score: 146
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00628
    Location:627671
    Blast Score: 123
    PHD; PHD-finger
    pfam14634
    Location:64122
    Blast Score: 85
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    58544469..58550715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    55366200..55372319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    59049665..59055911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)