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    BCL2 B-cell CLL/lymphoma 2 [ Homo sapiens ]

    Gene ID: 596, updated on 20-May-2012
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    Summary

    Official Symbol
    BCL2provided by HGNC
    Official Full Name
    B-cell CLL/lymphoma 2provided by HGNC
    Primary source
    HGNC:990
    See related
    Ensembl:ENSG00000171791; HPRD:01045; MIM:151430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Bcl-2; PPP1R50
    Summary
    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    18q21.3
    Sequence :
    Chromosome: 18; NC_000018.9 (60790579..60986613, complement)
    See BCL2 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505657 Neighboring gene zinc finger, CCHC domain containing 2 Neighboring gene PH domain and leucine rich repeat protein phosphatase 1 Neighboring gene uncharacterized LOC100652895 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 5 pseudogene Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4 homolog B (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The use of an immunocytochemical double-labeling staining can display the distribution of Bcl-2/Ki-67 cells in endometrial adenocarcinomas as well as in normal endometrium. Mourtzikou A, et al. Clin Lab, 2012. PMID 22372356.
    2. Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. Niture SK, et al. J Biol Chem, 2012 Mar 23. PMID 22275372.
    3. Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease. Tarantino G, et al. World J Gastroenterol, 2011 Dec 28. PMID 22219597.
    4. Expression of the apoptosis-related genes Bcl-2 and p53 in clinical samples from endometrial carcinoma patients. González-Rodilla I, et al. Anticancer Res, 2011 Dec. PMID 22199279.
    5. Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. Naydenov NG, et al. J Biol Chem, 2012 Feb 17. PMID 22194596.

    See all (1063) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. first evidence of Nrf2 in control of Bcl-2 expression and apoptotic cell death with implications in antioxidant protection, survival of cancer cells, and drug resistance.
      Title: Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
    2. MDR1, MRP1 and BCL-2 have potential clinical relevance in adult patients with acute leukemia in the context of induction chemotherapy.
      Title: Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.
    3. the expression of anti-apoptotic factor Bcl-2 and Survivin in transferred HepG2 cells and evaluate the synergistic effect of IFN-gamma gene on LIGHT-induced apoptosis signal transduction pathways
      Title: Synergistic effect of IFN-γ gene on LIGHT-induced apoptosis in HepG2 cells via down regulation of Bcl-2.
    4. Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by accumulation of TP53, reduced levels of Bcl-2 and increased levels of Bax.
      Title: Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins.
    5. B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21) appear to behave as poorly as MYC/BCL2 lymphomas, possibly expanding the disease spectrum.
      Title: B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome.
    6. The miR-143 suppressed the activity of a luciferase reporter carrying the 3'-UTR of Bcl-2, which was abolished by mutation of the predicted miR-143-binding site, indicating that Bcl-2 is a miR-143 target gene.
      Title: miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2.
    7. Human embryonic stem cells express elevated levels of the pro-apoptotic BH3-only BCL-2 family members.
      Title: Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.
    8. results show that aberrant Notch-1 activation, Bcl-2 overexpression and increased cell survival are likely to play a crucial role in neoplastic transformation associated with E-cadherin impairment
      Title: E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2.
    9. Data show that ABT-737, a small molecule inhibitor of Bcl-2, Bcl-X(L), and Bcl-w, significantly induced apoptosis in HTLV-1 infected T-cell lines as well as in fresh adult T-cell leukemia/lymphoma (ATLL) cells
      Title: Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737.
    10. andrographolide induces apoptosis via inhibiting NF-kappaB-induced bcl-2-mediated survival signaling and modulating p53-induced caspase-3-mediated proapoptotic signaling.
      Title: Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression.
    Submit: New GeneRIF Correction See all (842)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Leukemia/lymphoma, B-cell, 2

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Binding of HIV-1 envelope protein gp120 to CD4 downregulates Bcl-2 expression; this effect is inhibited by gp17/GCDFP-15, which blocks the ability of CD4 to interact with gp120, leading to moderate up-regulation of Bcl-2 PubMed
    env Binding of HIV-1 gp120 to CD4 downregulates Bcl-2 protein in CD4+ T lymphocytes and facilitates Fas/Fas-ligand triggered apoptosis; addition of IL-2 rescues CD4+ T cells from CD4/gp120-induced Bcl-2 downmodulation and apoptosis induction PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced apoptosis is affected in part by the release of TNF-alpha and is associated with attenuated Bcl-2 mRNA expression PubMed
    Nef nef HIV-1 Nef enhances apoptosis in CD4+ human lymphoblastoid cell lines through mechanisms that include the downregulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL PubMed
    Tat tat Expression of HIV-1 Tat in hematopoietic cells results in downregulation of Bcl-2 and induction of apoptosis PubMed
    tat HIV-1 Tat upregulates Bcl-2 expression in a variety of cell types (PBMC, MDM, Jurkat, HeLa, etc.), an effect that is linked to the ability of Tat to inhibit apoptosis PubMed
    tat Tat-expressing EBV-positive B cells show downregulation of Bcl-2, and in serum starvation conditions display the Retinoblastoma (Rb) hyper-phosphorylated form, progress throughout the cell cycle, and retain the ability to grow in small clumps PubMed
    tat A fusion protein between HIV-1 Tat and a Bcl-2 construct with the loop domain deleted (TAT-Bcl-2Deltaloop) binds to neural cell and rat brain mitochondria to increase the survival of cortical neurons PubMed
    tat Tumor protein p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes PubMed
    Vpr vpr HIV-1 Vpr-(52-96)-induced apoptosis is mediated through downregulation of Bcl2 and c-IAP1 genes PubMed
    vpr Constitutive expression of HIV-1 Vpr in Jurkat cells or transgenic mice resulted in upregulation of Bcl-2, providing evidence for the role of Vpr in the regulation of apoptosis during HIV-1 replication PubMed
    vpr Bcl-2 inhibits or reduces HIV-1 Vpr mediated cytotoxicity, induction of mitochondrial membrane permeabilization and apoptosis PubMed
    retropepsin gag-pol Purified bcl-2 is cleaved by HIV-1 protease between phenylalanine 112 and alanine 113 PubMed
    gag-pol HIV-1 protease depletes infected cells of bcl-2, leading to oxidative stress-dependent activation of NF kappa B, a cellular factor required for HIV transcription, and ultimately to cell death PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000018.8     BIND  PubMed The RAG complex interacts with the major breakpoint region (Mbr) of the Bcl-2 gene. This interaction was modelled on a demonstrated interaction between RAG complex from mouse and the human Bcl-2 gene. 
    NP_000624.1 NP_004313.1 BAD    BIND  PubMed Bad interacts with Bcl-2. 
    NP_000624.1 NP_004313.1 BAD    BIND  PubMed Bcl-2 interacts with Bad. 
    NP_000624.1 NP_620116.1 BAX    BIND  PubMed Bcl-2 interacts with Bax. 
    NP_000624.1 NP_055232.1 BBC3    BIND  PubMed Puma interacts with Bcl-2. 
    NP_000624.1 NP_006529.1 BCL2L11    BIND  PubMed Bim interacts with Bcl-2. 
    NP_000624.1 NP_001187.1 BID    BIND  PubMed Bid interacts with Bcl-2. 
    NP_000624.1 NP_001188.1 BIK    BIND  PubMed Bik interacts with Bcl-2. 
    NP_000624.1 NP_001188.1 BIK    BIND  PubMed Bcl-2 interacts with Bik. 
    NP_000624.1 NP_001003940.1 BMF    BIND  PubMed Bmf interacts with Bcl-2. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-2. 
    NP_000624.1 AAK54348.1 BNIPL    BIND  PubMed BNIPL-2 interacts with Bcl-2. 
    NP_000624.1 NP_003797.1 HRK    BIND  PubMed Hrk interacts with Bcl-2. 
    NP_000624.1 NP_003797.1 HRK    BIND  PubMed Hrk interacts with Bcl-2. 
    NP_000624.1 NP_005605.1 RHEB    BIND  PubMed Bcl-2 interacts with Rheb. 
    NP_000648.1 NP_071434.2 MOAP1    BIND  PubMed MAP-1 interacts with Bcl-2. 
    P10415 P16615 ATP2A2    HPRD  PubMed  
    P10415 Q92934 BAD    HPRD  PubMed  
    P10415 Q99933 BAG1    HPRD  PubMed  
    P10415 O95817 BAG3    HPRD  PubMed  
    P10415 O95429 BAG4    HPRD  PubMed  
    P10415 Q16611 BAK1    HPRD  PubMed  
    P10415 Q07814 BAX    HPRD  PubMed  
    P10415 Q9BXH1 BBC3    HPRD  PubMed  
    P10415 P51572 BCAP31    HPRD  PubMed  
    P10415 P10415 BCL2    HPRD  PubMed  
    P10415 Q07817 BCL2L1    HPRD  PubMed  
    P10415 Q9HD36 BCL2L10    HPRD  PubMed  
    P10415 O43521 BCL2L11    HPRD  PubMed  
    P10415 Q9BZR8 BCL2L14    HPRD  PubMed  
    P10415 Q9NYF8 BCLAF1    HPRD  PubMed  
    P10415 Q14457 BECN1    HPRD  PubMed  
    P10415 Q9NZS9 BFAR    HPRD  PubMed  
    P10415 P55957 BID    HPRD  PubMed  
    P10415 Q13323 BIK    HPRD  PubMed  
    P10415 P51451 BLK    HPRD  PubMed  
    P10415 Q96LC9 BMF    HPRD  PubMed  
    P10415 Q12981 BNIP1    HPRD  PubMed  
    P10415 Q12982 BNIP2    HPRD  PubMed  
    P10415 Q12983 BNIP3    HPRD  PubMed  
    P10415 O60238 BNIP3L    HPRD  PubMed  
    P10415 Q7Z465 BNIPL    HPRD  PubMed  
    P10415 P42574 CASP3    HPRD  PubMed  
    P10415 Q14790 CASP8    HPRD  PubMed  
    P10415 P24941 CDK2    HPRD  PubMed  
    P10415 P50416 CPT1A    HPRD  PubMed  
    P10415 P99999 CYCS    HPRD  PubMed  
    P10415 Q14318 FKBP8    HPRD  PubMed  
    P10415 P01112 HRAS    HPRD  PubMed  
    P10415 O00198 HRK    HPRD  PubMed  
    P10415 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P10415 Q9Y287 ITM2B    HPRD  PubMed  
    P10415 Q14643 ITPR1    HPRD  PubMed  
    P10415 P01116 KRAS    HPRD  PubMed  
    P10415 P28482 MAPK1    HPRD  PubMed  
    P10415 Q15759 MAPK11    HPRD  PubMed  
    P10415 Q16539 MAPK14    HPRD  PubMed  
    P10415 P27361 MAPK3    HPRD  PubMed  
    P10415 P45983 MAPK8    HPRD  PubMed  
    P10415 Q96BY2 MOAP1    HPRD  PubMed  
    P10415 P01106 MYC    HPRD  PubMed  
    P10415 Q9C000 NLRP1    HPRD  PubMed  
    P10415 O60551 NMT2    HPRD  PubMed  
    P10415 P22736 NR4A1    HPRD  PubMed  
    P10415 P01111 NRAS    HPRD  PubMed  
    P10415 P09874 PARP1    HPRD  PubMed  
    P10415 Q13526 PIN1    HPRD  PubMed  
    P10415 Q99640 PKMYT1    HPRD  PubMed  
    P10415 Q13794 PMAIP1    HPRD  PubMed  
    P10415 P29590 PML    HPRD  PubMed  
    P10415 P62136 PPP1CA    HPRD  PubMed  
    P10415 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    P10415 Q15172 PPP2R5A    HPRD  PubMed  
    P10415 Q08209 PPP3CA    HPRD  PubMed  
    P10415 P17612 PRKACA    HPRD  PubMed  
    P10415 P17252 PRKCA    HPRD  PubMed  
    P10415 P49768 PSEN1    HPRD  PubMed  
    P10415 P49023 PXN    HPRD  PubMed  
    P10415 Q99638 RAD9A    HPRD  PubMed  
    P10415 P04049 RAF1    HPRD  PubMed  
    P10415 P10301 RRAS    HPRD  PubMed  
    P10415 Q9NQC3 RTN4    HPRD  PubMed  
    P10415 Q15637 SF1    HPRD  PubMed  
    P10415 Q16637 SMN2    HPRD  PubMed  
    P10415 P00441 SOD1    HPRD  PubMed  
    P10415 SPINL SPNS1    HPRD  PubMed  
    P10415 P55061 TMBIM6    HPRD  PubMed  
    P10415 Q15388 TOMM20    HPRD  PubMed  
    P10415 P04637 TP53    HPRD  PubMed  
    P10415 p53 regulated apoptosis inducing protein 1 TP53AIP1    HPRD  PubMed  
    P10415 Q13625 TP53BP2    HPRD  PubMed  
    BioGRID:107068 BioGRID:121366 AVEN    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    NP_004313.1 BAD    BIND  PubMed Bad interacts with Bcl-2. 
    BioGRID:107068 BioGRID:107048 BAD    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107068 BioGRID:107049 BAG1    BioGRID  PubMed Reconstituted Complex 
    NP_004272.2 BAG3    BIND  PubMed Bcl-2 interacts with BAG-3. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-3. 
    NP_004865.1 BAG4    BIND  PubMed Bcl-2 interacts with BAG-4. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-4. 
    BioGRID:107068 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    NP_620116.1 BAX    BIND  PubMed Bax interacts with Bcl-2. 
    BioGRID:107068 BioGRID:107057 BAX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    AAK39543.1 BBC3    BIND  PubMed PUMA-beta interacts with Bcl-2. 
    NP_055232.1 BBC3    BIND  PubMed PUMA interacts with Bcl-2. 
    NP_055232.1 BBC3    BIND  PubMed PUMA-alpha interacts with Bcl-2. 
    BioGRID:107068 BioGRID:118009 BBC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:115437 BCAP31    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107068 BioGRID:107070 BCL2L1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107068 BioGRID:115334 BCL2L10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:115335 BCL2L11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:114226 BECN1    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    NP_001187.1 BID    BIND  PubMed Bid interacts with Bcl-2. 
    BioGRID:107068 BioGRID:107106 BID    BioGRID  PubMed Protein-peptide 
    BioGRID:107068 BioGRID:107107 BIK    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107068 BioGRID:136097 BLID    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:107109 BLK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107068 BioGRID:124716 BMF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:107130 BNIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107068 BioGRID:107131 BNIP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:107132 BNIP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107068 BioGRID:107133 BNIP3L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:127211 BNIPL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:198352 Bcl2l11    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:107068 BioGRID:207843 Becn1    BioGRID  PubMed Two-hybrid 
    BioGRID:107068 BioGRID:107274 CAPN2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107068 BioGRID:107285 CASP2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107068 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107068 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:107068 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:114206 DYNLL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:108362 EPHB2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107068 BioGRID:117270 FKBP8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107068 BioGRID:114276 HRK    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:107068 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:114209 IRS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:114835 ITM2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:109913 ITPR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:107068 BioGRID:122069 MOAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107068 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107068 BioGRID:106652 PARP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107068 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:111379 PMAIP1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107068 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107068 BioGRID:111516 PPP2R4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107068 BioGRID:111517 PPP2R5A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:111522 PPP3CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:111642 PSEN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107068 BioGRID:111820 RAD9A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107068 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:112151 RRAS    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    NP_722550.1 RTN4    BIND  PubMed RTN-XS interacts with Bcl-2. 
    BioGRID:107068 BioGRID:121400 RTN4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107068 BioGRID:111289 SERPINB8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:112530 SOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107068 BioGRID:123836 SPNS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:112868 TMBIM6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:115144 TOMM20    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107068 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:122018 TP53AIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107068 BioGRID:113012 TP53BP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107068 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107068 BioGRID:1205538 gag-pol    BioGRID  PubMed Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      ATF-2 transcription factor network, organism-specific biosystem
      ATF-2 transcription factor network
    • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BAD and translocation to mitochondria, organism-specific biosystemThe switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activate...
    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Estrogen signaling pathway, organism-specific biosystem (from WikiPathways)
      Estrogen signaling pathway, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17??-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemIn contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem (from Pathway Interaction Database)
      RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem
      RXR and RAR heterodimerization with other nuclear receptor
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP1 inflammasome, organism-specific biosystemNLRP1 is activated by MDP (Faustin et al. 2007). The NLRP1 inflammasome was the first to be characterized. It was described as a complex containing NALP1, ASC, caspase-1 and caspase-5 (Martinon et al...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    BH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protease binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    CD8-positive, alpha-beta T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    anti-apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptosis in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cochlear nucleus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ear development IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    female pregnancy NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    glial cell apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    glomerulus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
    		  
    humoral immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    immune system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    lymphoid progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    melanin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    mesenchymal cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cellular pH reduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of mitochondrial depolarization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of myeloid cell apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of neuron apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    oocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    pigment granule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of neuron maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of glycoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of mitochondrial membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    release of cytochrome c from mitochondria NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    renal system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to L-ascorbic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to UV-B IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to caffeine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to copper ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to external stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to folic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to inorganic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to iron ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to nicotine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to radiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    response to toxin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spleen development IEA
    Inferred from Electronic Annotation
    more info
    		  
    thymus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    microsome IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    apoptosis regulator Bcl-2
    Names
    apoptosis regulator Bcl-2
    protein phosphatase 1, regulatory subunit 50
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009361.1 RefSeqGene

      Range
      5001..201035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000633.2 → NP_000624.2  apoptosis regulator Bcl-2 alpha isoform

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) represents the longer transcript and encodes the longer isoform (alpha).
      Source sequence(s)
      AC021803, AC022726, BC027258
      Consensus CDS
      CCDS11981.1
      UniProtKB/Swiss-Prot
      P10415
      Related
      ENSP00000329623, ENST00000333681
      Conserved Domains (3) summary
      cd06845
      Location:94 – 201
      Blast Score: 401
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      cl02540
      Location:7 – 30
      Blast Score: 123
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1 – 239
      Blast Score: 749
      bcl-2; apoptosis regulator

    2. NM_000657.2 → NP_000648.2  apoptosis regulator Bcl-2 beta isoform

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) differs in the 3' UTR and coding region compared to variant alpha. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AC021803, AI401297
      Consensus CDS
      CCDS45882.1
      UniProtKB/TrEMBL
      C9JHD5
      Related
      ENSP00000404214, ENST00000444484
      Conserved Domains (2) summary
      cd06845
      Location:94 – 197
      Blast Score: 381
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      cl02540
      Location:7 – 30
      Blast Score: 124
      BH4; Bcl-2 homology region 4

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      60790579..60986613, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      57487199..57684751, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC021803.8 (38144..39142) None
    genomic AC022726.13 (128909..132607) None
    genomic AY220759.1 AAO26045.1
    genomic CH471096.1 EAW63136.1
      EAW63137.1
      EAW63138.1
      EAW63139.1
    genomic FB571387.1 CAR95111.1
    genomic FB571389.1 CAR95112.1
    genomic JA362596.1 CCA94580.1
    genomic S72602.1 AAD14111.1
    mRNA AF401211.1 AAL02169.1
    mRNA AI401297.1 None
    mRNA BC027258.1 AAH27258.1
    mRNA EU287875.1 ABX60202.1
    mRNA M13994.1 AAA51813.1
    mRNA M13995.1 AAA51814.1
    mRNA M14745.1 AAA35591.1
    mRNA X06487.1 CAA29778.1
    other-genetic DQ891470.2 ABM82396.1
    other-genetic DQ894654.2 ABM85580.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10415.2 GenPept UniProtKB/Swiss-Prot:P10415
    Q96PA0 GenPept UniProtKB/TrEMBL:Q96PA0
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    Additional Links

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