LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ]

Gene ID: 4067, updated on 19-May-2012

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Summary

Official Symbol: LYNprovided by HGNC
Official Full Name: v-yes-1 Yamaguchi sarcoma viral related oncogene homologprovided by HGNC
Primary source: HGNC:6735
See related: Ensembl:ENSG00000254087; HPRD:01301; MIM:165120; Vega:OTTHUMG00000044345
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JTK8; p53Lyn; p56Lyn; FLJ26625
Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

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Genomic context

Location :: 8q13

Sequence :: Chromosome: 8; NC_000008.10 (56792386..56923940)

See LYN in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In chorea acanthocytosis red blood cells, band 3 Tyr phosphorylation by Lyn was independent of the canonical Syk-mediated pathway.
Title: Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity.
describe a Lyn-dependent mechanism for promoting localized integrin activation and establishing adhesion sites at the leading edge to allow neutrophils to move forward in the chemoattractant gradient.
Title: The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge.
Lyn kinase blockage down-regulates TLR9-induced cytokines, but up-regulates non-canonical TLR3-induced cytokines in THP1 cells exposed to cytomegalovirus.
Title: Blockade of Lyn kinase upregulates both canonical and non-canonical TLR-3 pathways in THP-1 monocytes exposed to human cytomegalovirus.
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Title: PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Lyn is a likely candidate to be the kinase required for myeloid differentiation factor-2 tyrosine phosphorylation following exposure to lipopolysaccharide
Title: Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.
an oncogenic signaling mediated by Lyn and Syk can bypass the need of Bcr-Abl in CML cells
Title: Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells.
Lyn coimmunoprecipitates with the interleukin-2 beta receptor and JAK3 proteins in human T-cell leukemia virus type 1-infected T-cells.
Title: Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.
Lyn contributes to the upregulation of the Ras-ERK-MAP kinase 1/2 and phosphatidylinositol 3-kinase-Akt cascades, as well as the increased leukotriene C4 release observed in response to formylated tripeptide F-Met-Leu-Phe (fMLP) in primed eosinophils.
Title: Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.
Results suggest that initiation of Golgi export of Lyn involves association of ACSL3 with the Lyn C-lobe, which is exposed to the molecular surface in an open conformation.
Title: The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.
Lyn-dependent regulation of miR181 is a novel mechanism of regulating Mcl-1 expression and cell survival.
Title: Lyn kinase-dependent regulation of miR181 and myeloid cell leukemia-1 expression: implications for drug resistance in myelogenous leukemia.

Submit: New GeneRIF Correction See all (69)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Many sequence variants affecting diversity of adult human height.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha	PubMed
Nef	nef	Interaction of HIV-1 Nef with the SH3 domain of Lyn regulates its effects on Lyn tyrosine kinase activation	PubMed
	nef	The interaction of HIV-1 Nef with Lyn does not induce Lyn kinase activation	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
AAB50019.1	NP_000213.1	KIT	BIND	PubMed	c-Kit interacts with p53Lyn.
NP_002341.1	NP_751927.1	HCVgp1	BIND	PubMed	NS5A interacts with Lyn.
NP_002341.1	NP_000213.1	KIT	BIND	PubMed	c-Kit interacts with p56Lyn.
NP_002341.1	NP_002341.1	LYN	BIND	PubMed	LYN autophosphorylates. This interaction was modeled on a demonstrated interaction using LYN from an unspecified species.
NP_002341.1	AAC00042.1	PDE4D	BIND	PubMed	PDE4D4 interacts with Lyn SH3 domain.
NP_002341.1	NP_002919.2	RGS16	BIND	PubMed	LYN phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between LYN from an unspecified species and human RSG16.
NP_002341.1	NP_061828.1	UBB	BIND	PubMed	Lyn interacts with ubiquitin.
P07948	P60709	ACTB	HPRD	PubMed
P07948	Q13444	ADAM15	HPRD	PubMed
P07948	Q8NDB2	BANK1	HPRD	PubMed
P07948	P56945	BCAR1	HPRD	PubMed
P07948	Q06187	BTK	HPRD	PubMed
P07948	P42574	CASP3	HPRD	PubMed
P07948	P55210	CASP7	HPRD	PubMed
P07948	P55211	CASP9	HPRD	PubMed
P07948	P22681	CBL	HPRD	PubMed
P07948	Q9ULV8	CBLC	HPRD	PubMed
P07948	P15391	CD19	HPRD	PubMed
P07948	P20273	CD22	HPRD	PubMed
P07948	P25063	CD24	HPRD	PubMed
P07948	P16671	CD36	HPRD	PubMed
P07948	P11912	CD79A	HPRD	PubMed
P07948	P40259	CD79B	HPRD	PubMed
P07948	P06493	CDK1	HPRD	PubMed
P07948	P24941	CDK2	HPRD	PubMed
P07948	P46527	CDKN1B	HPRD	PubMed
P07948	B cell RAG associated protein	CHST15	HPRD	PubMed
P07948	P46109	CRKL	HPRD	PubMed
P07948	P07333	CSF1R	HPRD	PubMed
P07948	P15509	CSF2RA	HPRD	PubMed
P07948	P32927	CSF2RB	HPRD	PubMed
P07948	Q99062	CSF3R	HPRD	PubMed
P07948	P41240	CSK	HPRD	PubMed
P07948	P67870	CSNK2B	HPRD	PubMed
P07948	P16410	CTLA4	HPRD	PubMed
P07948	Q9UN19	DAPP1	HPRD	PubMed
P07948	P78352	DLG4	HPRD	PubMed
P07948	Q99704	DOK1	HPRD	PubMed
P07948	O60496	DOK2	HPRD	PubMed
P07948	Q7L591	DOK3	HPRD	PubMed
P07948	P00533	EGFR	HPRD	PubMed
P07948	P19235	EPOR	HPRD	PubMed
P07948	Q9UI08	EVL	HPRD	PubMed
P07948	P24071	FCAR	HPRD	PubMed
P07948	P30273	FCER1G	HPRD	PubMed
P07948	P12318	FCGR2A	HPRD	PubMed
P07948	P31994	FCGR2B	HPRD	PubMed
P07948	P15328	FOLR1	HPRD	PubMed
P07948	Q9UQC2	GAB2	HPRD	PubMed
P07948	GRB2 associated binding protein 3	GAB3	HPRD	PubMed
P07948	Q9HCN6	GP6	HPRD	PubMed
P07948	P42263	GRIA3	HPRD	PubMed
P07948	P14317	HCLS1	HPRD	PubMed
P07948	P61978	HNRNPK	HPRD	PubMed
P07948	P14784	IL2RB	HPRD	PubMed
P07948	P16871	IL7R	HPRD	PubMed
P07948	O00145	INPP5D	HPRD	PubMed
P07948	Q14643	ITPR1	HPRD	PubMed
P07948	O60674	JAK2	HPRD	PubMed
P07948	Q07666	KHDRBS1	HPRD	PubMed
P07948	P10721	KIT	HPRD	PubMed
P07948	Q13094	LCP2	HPRD	PubMed
P07948	Q9H400	LIME1	HPRD	PubMed
P07948	P07948	LYN	HPRD	PubMed
P07948	Q92918	MAP4K1	HPRD	PubMed
P07948	P27361	MAPK3	HPRD	PubMed
P07948	P42679	MATK	HPRD	PubMed
P07948	P08473	MME	HPRD	PubMed
P07948	P11836	MS4A1	HPRD	PubMed
P07948	Q01362	MS4A2	HPRD	PubMed
P07948	P15941	MUC1	HPRD	PubMed
P07948	Q14511	NEDD9	HPRD	PubMed
P07948	P30419	NMT1	HPRD	PubMed
P07948	O60500	NPHS1	HPRD	PubMed
P07948	Q9NWQ8	PAG1	HPRD	PubMed
P07948	Q13177	PAK2	HPRD	PubMed
P07948	P27815	PDE4A	HPRD	PubMed
P07948	P16284	PECAM1	HPRD	PubMed
P07948	P48736	PIK3CG	HPRD	PubMed
P07948	Paired immunoglobulin like type 2 receptor beta	PILRB	HPRD	PubMed
P07948	P19174	PLCG1	HPRD	PubMed
P07948	P16885	PLCG2	HPRD	PubMed
P07948	Protein phosphatase 1, regulatory subunit 15A	PPP1R15A	HPRD	PubMed
P07948	Q12972	PPP1R8	HPRD	PubMed
P07948	Q96QH2	PRAM1	HPRD	PubMed
P07948	Q05655	PRKCD	HPRD	PubMed
P07948	Q04759	PRKCQ	HPRD	PubMed
P07948	P78527	PRKDC	HPRD	PubMed
P07948	Q05397	PTK2	HPRD	PubMed
P07948	Q14289	PTK2B	HPRD	PubMed
P07948	P29350	PTPN6	HPRD	PubMed
P07948	P08575	PTPRC	HPRD	PubMed
P07948	P20936	RASA1	HPRD	PubMed
P07948	O15492	RGS16	HPRD	PubMed
P07948	O14492	SH2B2	HPRD	PubMed
P07948	P29353	SHC1	HPRD	PubMed
P07948	Q86WV1	SKAP1	HPRD	PubMed
P07948	O75563	SKAP2	HPRD	PubMed
P07948	P02730	SLC4A1	HPRD	PubMed
P07948	P37840	SNCA	HPRD	PubMed
P07948	Q9NYA1	SPHK1	HPRD	PubMed
P07948	Q9NRA0	SPHK2	HPRD	PubMed
P07948	P43405	SYK	HPRD	PubMed
P07948	P42680	TEC	HPRD	PubMed
P07948	Q6PIZ9	TRAT1	HPRD	PubMed
P07948	Q15642	TRIP10	HPRD	PubMed
P07948	Q9HBA0	TRPV4	HPRD	PubMed
P07948	P29597	TYK2	HPRD	PubMed
P07948	Ubiquitin B	UBB	HPRD	PubMed
P07948	Q13432	UNC119	HPRD	PubMed
BioGRID:110245	BioGRID:120354	BANK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107160	BTK	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:117156	CBLC	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:107371	CD22	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110245	BioGRID:107372	CD24	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107386	CD36	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107409	CD72	BioGRID	PubMed	Biochemical Activity
BioGRID:110245	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110245	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107454	CDK4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110245	BioGRID:128365	CENPV	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:107823	CSF1R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107826	CSF2RB	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:110245	BioGRID:107828	CSF3R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:107843	CSNK2B	BioGRID	PubMed	Two-hybrid
BioGRID:110245	BioGRID:107875	CTLA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:108131	DOK1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:110245	BioGRID:108371	EPOR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:119556	EVL	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:106852	FASLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:108498	FCAR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:108506	FCGR2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:115181	GAB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:126581	GAB3	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:119379	GP6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:109309	HCLS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:109847	INPP5D	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:109920	JAK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:110015	KIT	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:110129	LCP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:111581	MAPK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:110455	MME	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:110669	MUC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:120074	NDFIP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:110816	NEDD9	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:110899	NMT1	BioGRID	PubMed	Biochemical Activity
BioGRID:110245	BioGRID:120931	PAG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:111167	PDE4A	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:111201	PECAM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:111312	PIK3CG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:111352	PLCG2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:117172	PPP1R15A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110245	BioGRID:111503	PPP1R8	BioGRID	PubMed	Biochemical Activity
BioGRID:110245	BioGRID:123894	PRAM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:111577	PRKDC	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:108480	PTK2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:111742	PTPN6	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:111752	PTPRC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:112054	RPL10	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:112112	RPS6KB1	BioGRID	PubMed	Biochemical Activity
BioGRID:110245	BioGRID:112113	RPS6KB2	BioGRID	PubMed	Biochemical Activity
BioGRID:110245	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:114184	SKAP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:114448	SKAP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:112592	SRC	BioGRID	PubMed	Protein-peptide
BioGRID:110245	BioGRID:112717	SYK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110245	BioGRID:112865	TEC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110245	BioGRID:119154	TRAT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:121883	TRPV4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110245	BioGRID:113148	TYK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110245	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110245	BioGRID:125434	UHRF2	BioGRID	PubMed	Far Western
BioGRID:110245	BioGRID:114548	UNC119	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
SH3 domain binding	IEA Inferred from Electronic Annotation more info
enzyme binding	IEA Inferred from Electronic Annotation more info
glycosphingolipid binding	IEA Inferred from Electronic Annotation more info
integrin binding	IEA Inferred from Electronic Annotation more info
ion channel binding	IPI Inferred from Physical Interaction more info	PubMed
non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphoprotein binding	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
receptor signaling protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
Fc receptor mediated inhibitory signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
Fc receptor mediated stimulatory signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
JAK-STAT cascade involved in growth hormone signaling pathway	TAS Traceable Author Statement more info
T cell costimulation	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cellular response to extracellular stimulus	IEA Inferred from Electronic Annotation more info
cellular response to heat	IEA Inferred from Electronic Annotation more info
cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
cytokine secretion	IEA Inferred from Electronic Annotation more info
dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
histamine secretion by mast cell	IEA Inferred from Electronic Annotation more info
immune response-regulating cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
immune response-regulating cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
leukocyte migration	TAS Traceable Author Statement more info
lipopolysaccharide-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of immune response	TAS Traceable Author Statement more info	PubMed
negative regulation of intracellular protein kinase cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of mast cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of toll-like receptor 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
oligodendrocyte development	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Fc receptor mediated stimulatory signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cellular component movement	IDA Inferred from Direct Assay more info	PubMed
positive regulation of dendritic cell apoptosis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of mast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of oligodendrocyte progenitor proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of stress-activated protein kinase signaling cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of mast cell activation	ISS Inferred from Sequence or Structural Similarity more info
regulation of mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
response to axon injury	IEA Inferred from Electronic Annotation more info
response to carbohydrate stimulus	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
response to insulin stimulus	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to sterol depletion	IEA Inferred from Electronic Annotation more info
response to toxin	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
signal transduction by phosphorylation	TAS Traceable Author Statement more info	PubMed
tolerance induction to self antigen	ISS Inferred from Sequence or Structural Similarity more info
tolerance induction to self antigen	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
alpha2-beta1 integrin complex	IEA Inferred from Electronic Annotation more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
membrane fraction	IEA Inferred from Electronic Annotation more info
membrane raft	IDA Inferred from Direct Assay more info	PubMed
mitochondrial crista	IEA Inferred from Electronic Annotation more info
mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
mitochondrial membrane	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tyrosine-protein kinase Lyn

Names: tyrosine-protein kinase Lyn; lck/Yes-related novel protein tyrosine kinase

NP_001104567.1

EC 2.7.10.2

NP_002341.1

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029593.1 RefSeqGene

Range

5001..137621

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001111097.2 → NP_001104567.1 tyrosine-protein kinase Lyn isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the 5' coding region compared to variant 1. This results in a shorter isoform (B) missing an internal protein segment compared to isoform A.

Source sequence(s)

BC068551, BG059526, BU954348, CB990993, DA948647

Consensus CDS

CCDS47859.1

UniProtKB/Swiss-Prot

P07948

UniProtKB/TrEMBL

Q6NUK7

Related

ENSP00000428424, OTTHUMP00000226394, ENST00000520220, OTTHUMT00000378158

Conserved Domains (4) summary

cd00174
Location:46 – 99
Blast Score: 162

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd05072
Location:219 – 479
Blast Score: 1413

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

cd10364
Location:104 – 204
Blast Score: 540

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

pfam07714
Location:226 – 476
Blast Score: 1044

Pkinase_Tyr; Protein tyrosine kinase
NM_002350.3 → NP_002341.1 tyrosine-protein kinase Lyn isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (A).

Source sequence(s)

AK290494, BC068551, BG059526, BU954348, CB990993, DA948647

Consensus CDS

CCDS6162.1

UniProtKB/TrEMBL

A8K379

UniProtKB/Swiss-Prot

P07948

UniProtKB/TrEMBL

Q6NUK7

Related

ENSP00000428924, OTTHUMP00000226393, ENST00000519728, OTTHUMT00000378155

Conserved Domains (4) summary

cd00174
Location:67 – 120
Blast Score: 163

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd05072
Location:240 – 500
Blast Score: 1414

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

cd10364
Location:125 – 225
Blast Score: 539

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

pfam07714
Location:247 – 497
Blast Score: 1047

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

56792386..56923940

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

52260576..52392001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC018607.12	None
genomic	AC046176.13 (44074..117055)	None
genomic	CH471068.1	EAW86764.1
		EAW86765.1
		EAW86766.1
		EAW86767.1
		EAW86768.1
mRNA	AK130135.1	None
mRNA	AK290494.1	BAF83183.1
mRNA	AK298677.1	BAG60841.1
mRNA	BC059394.1	AAH59394.1
mRNA	BC068551.1	AAH68551.1
mRNA	BC075001.2	AAH75001.1
mRNA	BC075002.2	AAH75002.1
mRNA	BC126456.1	AAI26457.1
mRNA	BC126458.1	AAI26459.1
mRNA	BG059526.1	None
mRNA	BU954348.1	None
mRNA	CB990993.1	None
mRNA	CN480554.1	None
mRNA	DA948647.1	None
mRNA	M16038.1	AAA59540.1
mRNA	M79321.1	AAB50019.1