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    HLA-G major histocompatibility complex, class I, G [ Homo sapiens ]

    Gene ID: 3135, updated on 20-May-2012
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    Summary

    Official Symbol
    HLA-Gprovided by HGNC
    Official Full Name
    major histocompatibility complex, class I, Gprovided by HGNC
    Primary source
    HGNC:4964
    Locus tag
    DADB-15K14.8
    See related
    Ensembl:ENSG00000204632; HPRD:00834; MIM:142871; Vega:OTTHUMG00000031157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MHC-G
    Summary
    HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (29794756..29798899)
    See HLA-G in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 7 Neighboring gene MHC class I polypeptide-related sequence G (pseudogene) Neighboring gene HLA complex group 4 pseudogene 8 Neighboring gene HCGVIII-2 pseudogene Neighboring gene MHC class I polypeptide-related sequence F (pseudogene)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma. Lau DT, et al. Tissue Antigens, 2011 Dec. PMID 22115424.
    2. Human leukocyte antigen-G 3' untranslated region polymorphisms are associated with better kidney allograft acceptance. Cilião Alves DC, et al. Hum Immunol, 2012 Jan. PMID 22044721.
    3. Soluble human leukocyte antigen G level in fluid from single dominant follicle and the association with oocyte competence. Jee BC, et al. Yonsei Med J, 2011 Nov. PMID 22028161.
    4. The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells. Carosella ED, et al. Blood, 2011 Dec 15. PMID 21960588.
    5. Enhancement of the immunosuppressive effect of human adipose tissue-derived mesenchymal stromal cells through HLA-G1 expression. Yang HM, et al. Cytotherapy, 2012 Jan. PMID 21954834.

    See all (451) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. High level of FF sHLA-G could predict the fertilization failure of the corresponding oocyte, but was not related with the formation of good-quality embryo.
      Title: Soluble human leukocyte antigen G level in fluid from single dominant follicle and the association with oocyte competence.
    2. Data show associations among numerous polymorphic sites in the HLA-G 3'UTR in kidney allotransplantation, which may contribute to the understanding of HLA-G post-transcriptional mechanisms.
      Title: Human leukocyte antigen-G 3' untranslated region polymorphisms are associated with better kidney allograft acceptance.
    3. a role for recipient HLA-G 14 bp polymorphism in allo-SCT immunotolerance status and follow-up.
      Title: The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis.
    4. enhances the immunosuppressive effect of human adipose tissue-derived mesenchymal stromal cells
      Title: Enhancement of the immunosuppressive effect of human adipose tissue-derived mesenchymal stromal cells through HLA-G1 expression.
    5. Human HLA-G protein is expressed in male seminal plasma, normal testis and epididymal tissue. These findings suggest an immunoregulatory role of HLA-G in the male, and may have an influence on the risk of developing pre-eclampsia in females.
      Title: Human leukocyte antigen-G in the male reproductive system and in seminal plasma.
    6. Studies indicated how intertwined the HLA-G/myeloid APCs/regulatory cell relationship is.
      Title: The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells.
    7. analyses did not detect an association between common HLA-G polymorphisms and clinical outcome in patients treated for neuroblastoma.
      Title: HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma.
    8. genetic polymorphism is associated with susceptibility to non-segmental vitiligo in the Korean population
      Title: Promoter polymorphisms of the HLA-G gene, but not the HLA-E and HLA-F genes, is associated with non-segmental vitiligo patients in the Korean population.
    9. Data describe aspects of HLA-G expression and function in fetal extravillous trophoblast cells during placentation.
      Title: Ex vivo functional responses to HLA-G differ between blood and decidual NK cells.
    10. upregulated plasma expression in patients with hepatitis B virus infection
      Title: Plasma soluble human leukocyte antigen-G expression is a potential clinical biomarker in patients with hepatitis B virus infection.
    Submit: New GeneRIF Correction See all (312)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Asthma, susceptibility to

    Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    env Conformational changes in HIV-1 gp120, including an enhanced expression of the V3 loop of gp120 and of epitopes that are exposed upon CD4 binding, are consistent with the formation of a multimolecular complex between HLA class I and gp120/160 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules is processed by angiotensin-1 converting enzyme (ACE) prior to T cell stimulation by the peptide p18 PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin PubMed
    nef HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity PubMed
    nef Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes PubMed
    nef Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery PubMed
    nef A methionine residue at amino acid 20 in the alpha-helix domain is required for the ability of HIV-1 Nef to downregulate MHC-I expression but not for the downregulation of CD4 PubMed
    nef Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface PubMed
    nef HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded PubMed
    nef HLA-G, which is mainly expressed in placental tissues and in thymic epithelial cells, resists Nef-induced cell surface downregulation as a result of its short intracytoplasmic domain PubMed
    Tat tat HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses PubMed
    tat HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P17693 P61769 B2M    HPRD  PubMed  
    P17693 P01732 CD8A    HPRD  PubMed  
    P17693 P53618 COPB1    HPRD  PubMed  
    P17693 P17693 HLA-G    HPRD  PubMed  
    P17693 Q99706 KIR2DL4    HPRD  PubMed  
    P17693 Q13241 KLRD1    HPRD  PubMed  
    P17693 Q8NHL6 LILRB1    HPRD  PubMed  
    P17693 Q8N423 LILRB2    HPRD  PubMed  
    P17693 Q03518 TAP1    HPRD  PubMed  
    P17693 Q03519 TAP2    HPRD  PubMed  
    BioGRID:109380 BioGRID:107363 CD8A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109380 BioGRID:107710 COPB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109380 BioGRID:109380 HLA-G    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:109380 BioGRID:110006 KIR2DL4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109380 BioGRID:116070 LILRB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109380 BioGRID:115577 LILRB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109380 BioGRID:112753 TAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109380 BioGRID:112754 TAP2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem (from REACTOME)
      Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystemUnlike other glycoproteins, correct folding of MHC class I molecules is not sufficient to trigger their exit from the ER, they exit only after peptide loading. Described here is the process of antige...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
      ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endosomal/Vacuolar pathway, organism-specific biosystem (from REACTOME)
      Endosomal/Vacuolar pathway, organism-specific biosystemSome antigens are cross-presented through a vacuolar mechanism that involves generation of antigenic peptides and their loading on to MHC-I molecules within the endosomal compartment in a proteasome ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
      Proteasome Degradation, organism-specific biosystem
      Proteasome Degradation
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class I receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response-inhibiting cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of T cell tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    HLA class I histocompatibility antigen, alpha chain G
    Names
    HLA class I histocompatibility antigen, alpha chain G
    HLA G antigen
    b2 microglobulin
    HLA class I molecule
    MHC class I antigen G
    HLA-G histocompatibility antigen, class I, G
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029039.1 RefSeqGene

      Range
      5001..9144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002127.5 → NP_002118.1  HLA class I histocompatibility antigen, alpha chain G precursor

      Status: REVIEWED

      Source sequence(s)
      AL551999, AL645929, DC397107, X17273
      Consensus CDS
      CCDS4668.1
      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
      Related
      ENSP00000412927, ENST00000428701
      Conserved Domains (2) summary
      cd07698
      Location:207 – 298
      Blast Score: 355
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 – 203
      Blast Score: 878
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      29794756..29798899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      1310647..1314804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      1095377..1099520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      1095086..1099228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      1095035..1099178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      1095341..1099498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      1132308..1136465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      29598096..29602239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB088083.1 BAC54916.1
    genomic AB201550.1 BAE78597.1
    genomic AF020714.1 AAC51863.1
    genomic AF055066.1 AAC24826.1
    genomic AF312697.1 AAK38203.1
    genomic AF523298.1 AAM74993.1
    genomic AF523300.1 AAM74994.1
    genomic AF523301.1 AAM74995.1
    genomic AF523302.1 AAM74996.1
    genomic AF523303.1 AAM74997.1
    genomic AF523304.1 AAM74998.1
    genomic AF523305.1 AAM74999.1
    genomic AF523306.1 AAM75000.1
    genomic AF523307.1 AAM75001.1
    genomic AF523308.1 AAM75002.1
    genomic AF523309.1 AAM75003.1
    genomic AF523310.1 AAM75004.1
    genomic AF523311.1 AAM75005.1
    genomic AL022723.4 CAB46612.1
    genomic AL645929.4 (2321..6464) None
    genomic AL671561.7 (41609..45766) None
    genomic AY645760.1 AAT73243.1
    genomic AY645761.1 AAT73244.1
    genomic AY645762.1 AAT73245.1
    genomic AY645763.1 AAT73246.1
    genomic AY645764.1 AAT73247.1
    genomic AY645765.1 AAT73248.1
    genomic AY645766.1 AAT73249.1
    genomic AY645767.1 AAT73250.1
    genomic AY645768.1 AAT73251.1
    genomic AY645769.1 AAT73252.1
    genomic AY645770.1 AAT73253.1
    genomic AY645771.1 AAT73254.1
    genomic AY645772.1 AAT73255.1
    genomic AY645773.1 AAT73256.1
    genomic AY645774.1 AAT73257.1
    genomic AY645775.1 AAT73258.1
    genomic AY645776.1 AAT73259.1
    genomic AY661647.1 AAT76793.1
    genomic AY661648.1 AAT76794.1
    genomic AY661649.1 AAT76795.1
    genomic AY661650.1 AAT76796.1
    genomic AY661651.1 AAT76797.1
    genomic AY661652.1 AAT76798.1
    genomic AY667429.1 AAT74562.1
    genomic AY667430.1 AAT74563.1
    genomic AY667431.1 AAT74564.1
    genomic AY667432.1 AAT74565.1
    genomic AY667433.1 AAT74566.1
    genomic AY672592.1 AAT76964.1
    genomic AY672593.1 AAT76965.1
    genomic AY672594.1 AAT76966.1
    genomic AY672595.1 AAT76967.1
    genomic AY672596.1 AAT76968.1
    genomic AY672597.1 AAT76969.1
    genomic AY672598.1 AAT76970.1
    genomic AY675175.1 AAT81378.1
    genomic AY675176.1 AAT81379.1
    genomic AY675177.1 AAT81380.1
    genomic AY675178.1 AAT81381.1
    genomic AY675179.1 AAT81382.1
    genomic AY675180.1 AAT81383.1
    genomic AY675181.1 AAT81384.1
    genomic AY675182.1 AAT81385.1
    genomic BA000025.2 BAB63336.1
    genomic BX001005.6 CAI18589.1
      CAI18590.1
      CAI18591.1
    genomic BX247949.9 (12889..17032) None
    genomic BX927141.7 CAQ09696.1
      CAQ09697.1
      CAQ09698.1
    genomic CH471081.1 EAX03231.1
      EAX03232.1
      EAX03233.1
      EAX03234.1
      EAX03235.1
      EAX03236.1
    genomic CR759769.4 CAQ09666.1
      CAQ09667.1
      CAQ09668.1
    genomic CR788234.4 CAQ07527.1
      CAQ07528.1
      CAQ07529.1
    genomic CT009517.12 CAQ10051.1
      CAQ10052.1
      CAQ10053.1
      CAQ10054.1
    genomic D67005.2 BAA11031.1
    genomic D67008.2 BAA11032.1
    genomic D67011.2 BAA11033.1
    genomic D78000.2 BAA11185.1
    genomic J03027.1 AAA98745.1
    genomic L07784.1 AAA17890.1
    genomic L20777.1 AAB59351.1
    genomic L78072.1 AAL40074.1
    genomic L78073.1 AAF25961.1
    genomic U65246.1 AAC50997.1
    genomic U97035.1 AAC51855.1
    genomic U97036.1 AAC51856.1
    genomic U97037.1 AAC51857.1
    genomic U97038.1 AAC51858.1
    genomic U97039.1 AAC51859.1
    genomic X60983.1 CAA43298.1
    mRNA AF071017.1 AAC25569.1
    mRNA AF071018.1 AAC25570.1
    mRNA AF071019.1 AAC25571.1
    mRNA AF071020.1 AAC25572.1
    mRNA AF071021.1 AAC25573.1
    mRNA AF071022.1 AAC25574.1
    mRNA AF196177.1 None
    mRNA AF196178.1 None
    mRNA AF226990.2 AAF37570.1
    mRNA AF436089.1 AAL30408.1
    mRNA AK093478.1 None
    mRNA AK302054.1 BAG63444.1
    mRNA AL551999.3 None
    mRNA AY359818.1 AAQ83724.1
    mRNA BC021708.2 AAH21708.1
    mRNA DC397107.1 None
    mRNA M32800.1 AAA59846.1
    mRNA M90683.1 AAA52673.1
    mRNA M90684.1 AAA59836.1
    mRNA M90685.1 AAA58653.1
    mRNA M90686.1 AAA58654.1
    mRNA U58024.1 AAC04369.1
    mRNA U58025.1 AAC04370.1
    mRNA U58026.1 AAC04371.1
    mRNA U58027.1 AAC04372.1
    mRNA U58028.1 AAC04373.1
    mRNA U58029.1 AAC04374.1
    mRNA U58094.1 AAC04375.1
    mRNA U88244.1 AAD45397.1
    mRNA X17273.1 CAA35174.1
    other-genetic DQ896809.2 ABM87808.1
    other-genetic EU176192.1 ABW03643.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02923 GenPept UniProtKB/TrEMBL:O02923
    O02924 GenPept UniProtKB/TrEMBL:O02924
    O02925 GenPept UniProtKB/TrEMBL:O02925
    O02926 GenPept UniProtKB/TrEMBL:O02926
    O02927 GenPept UniProtKB/TrEMBL:O02927
    O02928 GenPept UniProtKB/TrEMBL:O02928
    O02929 GenPept UniProtKB/TrEMBL:O02929
    O19588 GenPept UniProtKB/TrEMBL:O19588
    O19658 GenPept UniProtKB/TrEMBL:O19658
    O19659 GenPept UniProtKB/TrEMBL:O19659
    O19684 GenPept UniProtKB/TrEMBL:O19684
    O19745 GenPept UniProtKB/TrEMBL:O19745
    O19766 GenPept UniProtKB/TrEMBL:O19766
    O19767 GenPept UniProtKB/TrEMBL:O19767
    O19768 GenPept UniProtKB/TrEMBL:O19768
    O19805 GenPept UniProtKB/TrEMBL:O19805
    O19806 GenPept UniProtKB/TrEMBL:O19806
    O19807 GenPept UniProtKB/TrEMBL:O19807
    O19808 GenPept UniProtKB/TrEMBL:O19808
    O19809 GenPept UniProtKB/TrEMBL:O19809
    O78131 GenPept UniProtKB/TrEMBL:O78131
    O78132 GenPept UniProtKB/TrEMBL:O78132
    O78133 GenPept UniProtKB/TrEMBL:O78133
    O78134 GenPept UniProtKB/TrEMBL:O78134
    O78135 GenPept UniProtKB/TrEMBL:O78135
    O78136 GenPept UniProtKB/TrEMBL:O78136
    P17693.1 GenPept UniProtKB/Swiss-Prot:P17693
    Q29897 GenPept UniProtKB/TrEMBL:Q29897
    Q30170 GenPept UniProtKB/TrEMBL:Q30170
    Q30182 GenPept UniProtKB/TrEMBL:Q30182
    Q31611 GenPept UniProtKB/TrEMBL:Q31611
    Q68YR8 GenPept UniProtKB/TrEMBL:Q68YR8
    Q68YR9 GenPept UniProtKB/TrEMBL:Q68YR9
    Q68YS0 GenPept UniProtKB/TrEMBL:Q68YS0
    Q68YS1 GenPept UniProtKB/TrEMBL:Q68YS1
    Q68YS2 GenPept UniProtKB/TrEMBL:Q68YS2
    Q68YS3 GenPept UniProtKB/TrEMBL:Q68YS3
    Q68YS4 GenPept UniProtKB/TrEMBL:Q68YS4
    Q6B844 GenPept UniProtKB/TrEMBL:Q6B844
    Q6B845 GenPept UniProtKB/TrEMBL:Q6B845
    Q6B846 GenPept UniProtKB/TrEMBL:Q6B846
    Q6B847 GenPept UniProtKB/TrEMBL:Q6B847
    Q6B848 GenPept UniProtKB/TrEMBL:Q6B848
    Q6B849 GenPept UniProtKB/TrEMBL:Q6B849
    Q6B850 GenPept UniProtKB/TrEMBL:Q6B850
    Q6B851 GenPept UniProtKB/TrEMBL:Q6B851
    Q6B9Y0 GenPept UniProtKB/TrEMBL:Q6B9Y0
    Q6B9Y1 GenPept UniProtKB/TrEMBL:Q6B9Y1
    Q6B9Y2 GenPept UniProtKB/TrEMBL:Q6B9Y2
    Q6B9Y3 GenPept UniProtKB/TrEMBL:Q6B9Y3
    Q6B9Y4 GenPept UniProtKB/TrEMBL:Q6B9Y4
    Q6B9Y5 GenPept UniProtKB/TrEMBL:Q6B9Y5
    Q6B9Y6 GenPept UniProtKB/TrEMBL:Q6B9Y6
    Q6DL85 GenPept UniProtKB/TrEMBL:Q6DL85
    Q6DL86 GenPept UniProtKB/TrEMBL:Q6DL86
    Q6DL87 GenPept UniProtKB/TrEMBL:Q6DL87
    Q6DL88 GenPept UniProtKB/TrEMBL:Q6DL88
    Q6DL89 GenPept UniProtKB/TrEMBL:Q6DL89
    Q6DU08 GenPept UniProtKB/TrEMBL:Q6DU08
    Q6DU14 GenPept UniProtKB/TrEMBL:Q6DU14
    Q6UV35 GenPept UniProtKB/TrEMBL:Q6UV35
    Q7JFN0 GenPept UniProtKB/TrEMBL:Q7JFN0
    Q8MGQ7 GenPept UniProtKB/TrEMBL:Q8MGQ7
    Q8MH47 GenPept UniProtKB/TrEMBL:Q8MH47
    Q8MH48 GenPept UniProtKB/TrEMBL:Q8MH48
    Q8WLP2 GenPept UniProtKB/TrEMBL:Q8WLP2
    Q8WLS1 GenPept UniProtKB/TrEMBL:Q8WLS1
    Q95347 GenPept UniProtKB/TrEMBL:Q95347
    Q95356 GenPept UniProtKB/TrEMBL:Q95356
    Q95370 GenPept UniProtKB/TrEMBL:Q95370
    Q95391 GenPept UniProtKB/TrEMBL:Q95391
    Q95HM6 GenPept UniProtKB/TrEMBL:Q95HM6
    Q9BCT7 GenPept UniProtKB/TrEMBL:Q9BCT7
    Q9MW45 GenPept UniProtKB/TrEMBL:Q9MW45
    Q9MYA2 GenPept UniProtKB/TrEMBL:Q9MYA2
    Q9TP10 GenPept UniProtKB/TrEMBL:Q9TP10
    Q9TP11 GenPept UniProtKB/TrEMBL:Q9TP11
    Q9TP12 GenPept UniProtKB/TrEMBL:Q9TP12
    Q9TP13 GenPept UniProtKB/TrEMBL:Q9TP13
    Q9TP14 GenPept UniProtKB/TrEMBL:Q9TP14
    Q9UM45 GenPept UniProtKB/TrEMBL:Q9UM45
    Help top of page

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