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    BECN1 beclin 1, autophagy related [ Homo sapiens ]

    Gene ID: 8678, updated on 13-May-2012
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    Summary

    Official Symbol
    BECN1provided by HGNC
    Official Full Name
    beclin 1, autophagy relatedprovided by HGNC
    Primary source
    HGNC:1034
    See related
    Ensembl:ENSG00000126581; HPRD:05087; MIM:604378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG6; VPS30; beclin1
    Summary
    Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
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    Genomic context

    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (40962150..40976310, complement)
    See BECN1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene coiled-coil domain containing 56 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Neighboring gene amine oxidase, copper containing 2 (retina-specific)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells. Piya S, et al. PLoS One, 2011. PMID 22242123.
    2. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. Zou Z, et al. J Biol Chem, 2012 Feb 3. PMID 22157765.
    3. Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer. Guo GF, et al. World J Gastroenterol, 2011 Nov 21. PMID 22147978.
    4. Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers. Idikio HA. PLoS One, 2011. PMID 22039439.
    5. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Liu J, et al. Cell, 2011 Sep 30. PMID 21962518.

    See all (138) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This work offers new information on the mechanisms of action of the adenoviral E1B19K protein as partner of Beclin 1 and positive regulator of autophagy.
      Title: The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells.
    2. Our results indicate that BECN 1 and autophagy play an important role in controlling the development and progression of cutaneous SCC.
      Title: Overexpression of autophagy-related beclin-1 in cutaneous squamous cell carcinoma with lymph-node metastasis.
    3. Beclin-1 is depleted in Alzheimer's disease brain following caspase-3 cleavage.
      Title: Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain.
    4. Beclin 1-independent autophagy is an important contributor to both the caspase-dependent and -independent components of neuronal apoptosis and may be considered as an important therapeutic target in neural conditions involving apoptosis
      Title: Beclin 1-independent autophagy contributes to apoptosis in cortical neurons.
    5. Beclin 1 cleaving has a role in suppressing autophagy in chemotherapy-induced apoptosis
      Title: Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis.
    6. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
      Title: cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1.
    7. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy.
      Title: MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy.
    8. Beclin 1 has a role in intrahepatic cholangiocellular carcinoma
      Title: Prognostic significance of Beclin 1 in intrahepatic cholangiocellular carcinoma.
    9. Both mRNA and protein levels of Beclin-1 and LC3-II were significantly decreased in lung cancer tissues which suggested that autophagy may be involved in the pathogenesis of lung cancer.
      Title: Decreased expression of Beclin-1 and LC3 in human lung cancer.
    10. High levels of Beclin1 mRNA levels were in liver and prostate cancers when compared to normal tissues
      Title: Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers.
    Submit: New GeneRIF Correction See all (112)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q14457 Hypothetical protein FLJ20294 AMBRA1    HPRD  PubMed  
    Q14457 P10415 BCL2    HPRD  PubMed  
    Q14457 Q07817 BCL2L1    HPRD  PubMed  
    Q14457 Growth factor independent 1B GFI1B    HPRD  PubMed  
    Q14457 Q9HD26 GOPC    HPRD  PubMed  
    Q14457 O14980 XPO1    HPRD  PubMed  
    BioGRID:114226 BioGRID:116139 AFG3L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:120765 AMBRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:116531 ATG14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    BioGRID:114226 BioGRID:107070 BCL2L1    BioGRID  PubMed Two-hybrid 
    BioGRID:114226 BioGRID:114226 BECN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114226 BioGRID:115021 DZIP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:121384 GOPC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114226 BioGRID:109190 GSPT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114226 BioGRID:115062 KIAA0226    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:123162 KIAA0226L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:119009 NRBF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:111307 PIK3C3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:119059 PIK3R4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:119792 PTOV1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:123629 SEH1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:116192 SLC27A4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:114574 SMC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:119412 TBC1D7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114226 BioGRID:113012 TP53BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:123218 TRABD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114226 BioGRID:113099 TSC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114226 BioGRID:113248 UVRAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114226 BioGRID:116303 ZWINT    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the BECN1 gene: The BECN1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    autophagic vacuole assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    beclin-1
    Names
    beclin-1
    ATG6 autophagy related 6 homolog
    coiled-coil myosin-like BCL2-interacting protein
    beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
    beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003766.3 → NP_003757.1  beclin-1

      Status: VALIDATED

      Source sequence(s)
      BC010276, BI496049, DC296896
      Consensus CDS
      CCDS11441.1
      UniProtKB/Swiss-Prot
      Q14457
      Related
      ENSP00000355231, ENST00000361523
      Conserved Domains (2) summary
      pfam04111
      Location:115 – 450
      Blast Score: 1263
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196 – 269
      Blast Score: 86
      MT; Microtubule-binding stalk of dynein motor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      40962150..40976310, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      36726539..36740774, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016889.28 (75745..89874) None
    genomic CH471152.1 EAW60888.1
      EAW60889.1
      EAW60890.1
    mRNA AF077301.1 AAC68653.1
    mRNA AF139131.1 AAD27650.1
    mRNA AK223411.1 BAD97131.1
    mRNA AK298619.1 BAG60798.1
    mRNA AK299616.1 BAG61544.1
    mRNA AK312651.1 BAG35534.1
    mRNA BC010276.1 AAH10276.1
    mRNA BI496049.1 None
    mRNA BX647788.1 None
    mRNA DC296896.1 None
    mRNA L38932.1 AAB59573.1
    other-genetic DQ891633.2 ABM82559.1
    other-genetic DQ894823.2 ABM85749.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14457.2 GenPept UniProtKB/Swiss-Prot:Q14457
    Q53F78 GenPept UniProtKB/TrEMBL:Q53F78
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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