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ZNF587 zinc finger protein 587 [ Homo sapiens (human) ]

Gene ID: 84914, updated on 13-Mar-2020

Summary

Official Symbol
ZNF587provided by HGNC
Official Full Name
zinc finger protein 587provided by HGNC
Primary source
HGNC:HGNC:30955
See related
Ensembl:ENSG00000198466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF6
Expression
Ubiquitous expression in prostate (RPKM 5.4), duodenum (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF587 in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57849859..57865117)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58331011..58379953)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene zinc finger protein 587B Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 5 Neighboring gene zinc finger protein 814

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 587 (ZNF587) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14710, FLJ20813, FLJ52732

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 587
Names
zinc finger protein zfp6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204817.2NP_001191746.1  zinc finger protein 587 isoform 2

    See identical proteins and their annotated locations for NP_001191746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AA524202, AC010326, BC144112, DA334859
    Consensus CDS
    CCDS56110.1
    UniProtKB/Swiss-Prot
    Q96SQ5
    Related
    ENSP00000393865.1, ENST00000423137.1
    Conserved Domains (5) summary
    smart00349
    Location:1469
    KRAB; krueppel associated box
    COG5048
    Location:272567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:533556
    zf-H2C2_2; Zinc-finger double domain
  2. NM_032828.4NP_116217.1  zinc finger protein 587 isoform 1

    See identical proteins and their annotated locations for NP_116217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA524202, AC010326, BC126239, DA334859
    Consensus CDS
    CCDS12964.1
    UniProtKB/Swiss-Prot
    Q96SQ5
    Related
    ENSP00000345479.4, ENST00000339656.8
    Conserved Domains (5) summary
    smart00349
    Location:1570
    KRAB; krueppel associated box
    COG5048
    Location:273568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1554
    KRAB; KRAB box
    pfam13465
    Location:534557
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57849859..57865117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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