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ZNF586 zinc finger protein 586 [ Homo sapiens (human) ]

Gene ID: 54807, updated on 23-Nov-2021

Summary

Official Symbol
ZNF586provided by HGNC
Official Full Name
zinc finger protein 586provided by HGNC
Primary source
HGNC:HGNC:25949
See related
Ensembl:ENSG00000083828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 8.7), lymph node (RPKM 4.9) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF586 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57769676..57780616)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58281044..58291984)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 671 Neighboring gene zinc finger protein 776 Neighboring gene zinc finger protein 552 Neighboring gene FKBP prolyl isomerase 1A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ20070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077426.3NP_001070894.1  zinc finger protein 586 isoform b

    See identical proteins and their annotated locations for NP_001070894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI962754, BC051325, BC124558, BP352135
    Consensus CDS
    CCDS56107.1
    UniProtKB/Swiss-Prot
    Q9NXT0
    Related
    ENSP00000379454.3, ENST00000396150.4
  2. NM_001204814.2NP_001191743.1  zinc finger protein 586 isoform c

    See identical proteins and their annotated locations for NP_001191743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI962754, AK095993, BC051325, BP352135
    Consensus CDS
    CCDS56108.1
    UniProtKB/Swiss-Prot
    Q9NXT0
    Related
    ENSP00000375583.3, ENST00000391702.3
    Conserved Domains (3) summary
    COG5048
    Location:61323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:165185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233257
    zf-H2C2_2; Zinc-finger double domain
  3. NM_017652.4NP_060122.2  zinc finger protein 586 isoform a

    See identical proteins and their annotated locations for NP_060122.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI962754, BC051325, BP352135
    Consensus CDS
    CCDS42640.1
    UniProtKB/Swiss-Prot
    Q9NXT0
    Related
    ENSP00000379458.1, ENST00000396154.7
    Conserved Domains (5) summary
    smart00349
    Location:1556
    KRAB; krueppel associated box
    COG5048
    Location:104366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1554
    KRAB; KRAB box
    pfam13465
    Location:276300
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57769676..57780616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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