2WBU,1TF6,1TF3,1UBD,2LT7,1A1F,1P47,1ZAA,1UN6


Conserved Protein Domain Family
ZF_C2H2

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sd00017: ZF_C2H2 
Click on image for an interactive view with Cn3D
Zinc finger, C2H2 type
The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
Statistics
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PSSM-Id: 275368
View PSSM: sd00017
Aligned: 288 rows
Threshold Bit Score: 36.8005
Threshold Setting Gi: 312371684
Created: 21-Dec-2011
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1TF6: Xenopus TFIIIA zinc finger contacts to Zn ion.
    View structure with Cn3D
  • Comment:The small C2H2 zinc finger domain is conformationally stabilized by coordinating a zinc ion on the two invariant cysteine and histidine residues.
  • Citation:PMID 2028256

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #    #            #    #                                                       
2WBU_A          8 TCDyaGCGKTYTKSSHLKAHLr-THTgek--------------------------------------------------- 35
1TF6_A         14 ICSfaDCGAAYNKNWKLQAHLc-KHTgek--------------------------------------------------- 41
gi 428676594  268 ECK--ECDQVFPDMQSLEKHLl-SHTeer--------------------------------------------------- 293
gi 390338500  680 RCE--YCGSLYAIPLILARHLkwKHGhygivpqavdnmpyvcgky----------------------------------- 722
gi 195435209  344 RCE--VCDKVYTDLERLDDHLvgAHHfkr--------------------------------------------------- 370
gi 512929523  211 RCS--FCDAPCANIELLDQHLiqRHGqpa--------------------------------------------------- 237
gi 260831678  156 ECT--DCDRIFPNMPSLERHVmtGHGset--------------------------------------------------- 182
gi 52345900   132 SCE--ICAKGFRLQRMLNRHLk-CHNqvk--------------------------------------------------- 157
gi 170054042  343 RCV--VCDQQCHDIDQLDVHLvtSHHypk--------------------------------------------------- 369
gi 383853992  236 KCE--LCSSKFNSQLKFFEHLk-VHYepvkqetrtaqatntnitisvaetaqnlentvieefsepedlmegirgvveetg 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2WBU_A         36 -----------------------------------------------------------------------pyHCDWdgC 44
1TF6_A         42 -----------------------------------------------------------------------pfPCKEegC 50
gi 428676594  294 -----------------------------------------------------------------------eyKCDQ--C 300
gi 390338500  723 ------------------------------------------------------gnafnnnlvkdkenyvakkSCVCdqC 748
gi 195435209  371 ----------------------------------------------------------------------gefACEL--C 378
gi 512929523  238 ----------------------------------------------------------------------gafHCEL--C 245
gi 260831678  183 ----------------------------------------------------------------------refKCDQ--C 190
gi 52345900   158 -----------------------------------------------------------------------rhLCTF--C 164
gi 170054042  370 ----------------------------------------------------------------------dayRCES--C 377
gi 383853992  313 aqidedttesplstvnatpplwtitdvtehvhrdhvkpptvteptlhnkektdipqtmkkkkilktrkssdelMCSQ--C 390
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                                        
2WBU_A         45 GWKFARSDELTRHY-RKHtgh------------------------------rpfQCQK--CDRAFSRSDHLALHM-KRH 89
1TF6_A         51 EKGFTSLHHLTRHS-LTHtge------------------------------knfTCDSdgCDLRFTTKANMKKHFnRFH 98
gi 428676594  301 PKAFNWKSNLIRHQ-MSHdtgkhyecencskqvftdpsnlqrhirsqhvgarahACSD--CGKTFATSSGLKQHK-HIH 375
gi 390338500  749 GKAFSNAHCLTTHK-RIHtge------------------------------kpyVCDQ--CGKAFNQVNALTRHE-RIH 793
gi 195435209  379 SLRFCHRPLLIKHGaIAHnni------------------------------rkySCEN--CTKVFCDPSNLQRHIrTYH 425
gi 512929523  246 NRSYSSRALLLRHRaLAHtdi------------------------------rkyPCEN--CPKAFTDPSNLQRHIrVQH 292
gi 260831678  191 PKSFNWKSNLIRHQ-MSHdeq------------------------------krfPCEN--CDKVFTDPSNLQRHIrSQH 236
gi 52345900   165 GKGFNDTFDLKRHV-RTHtgi------------------------------rpyKCEI--CNKAFTQRCSLESHLkKIH 210
gi 170054042  378 PKAYSYRPSLLRHRaLAHnen------------------------------rryPCEN--CPKVFSDPSNLQRHI-RTH 423
gi 383853992  391 DRTFHHKNSLVYHM-RSHsge------------------------------rphQCEV--CGKSFFAPSALKVHK-RLH 435

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