2WBU,1TF6,1TF3,1UBD,2LT7,1A1F,1P47,1ZAA,1UN6


Conserved Protein Domain Family
ZF_C2H2

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sd00017: ZF_C2H2 
Click on image for an interactive view with Cn3D
Zinc finger, C2H2 type
The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
Statistics
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PSSM-Id: 275368
View PSSM: sd00017
Aligned: 288 rows
Threshold Bit Score: 47.586
Threshold Setting Gi: 327270582
Created: 21-Dec-2011
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1TF6: Xenopus TFIIIA zinc finger contacts to Zn ion.
    View structure with Cn3D
  • Comment:The small C2H2 zinc finger domain is conformationally stabilized by coordinating a zinc ion on the two invariant cysteine and histidine residues.
  • Citation:PMID 2028256

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #    #            #    #                                                       
2WBU_A          8 TCDyaGCGKTYTKSSHLKAHLr-THTgek--------------------------------------------------- 35   house mouse
1TF6_A         14 ICSfaDCGAAYNKNWKLQAHLc-KHTgek--------------------------------------------------- 41   African clawe...
AFZ45977      268 ECK--ECDQVFPDMQSLEKHLl-SHTeer--------------------------------------------------- 293  African clawe...
XP_794235     680 RCE--YCGSLYAIPLILARHLkwKHGhygivpqavdnmpyvcgky----------------------------------- 722  purple urchin
XP_002065594  344 RCE--VCDKVYTDLERLDDHLvgAHHfkr--------------------------------------------------- 370  Drosophila wi...
XP_004931842  211 RCS--FCDAPCANIELLDQHLiqRHGqpa--------------------------------------------------- 237  domestic silk...
XP_002610785  156 ECT--DCDRIFPNMPSLERHVmtGHGset--------------------------------------------------- 182  Florida lancelet
NP_001004998  132 SCE--ICAKGFRLQRMLNRHLk-CHNqvk--------------------------------------------------- 157 
XP_001862948  343 RCV--VCDQQCHDIDQLDVHLvtSHHypk--------------------------------------------------- 369  southern hous...
XP_003702506  236 KCE--LCSSKFNSQLKFFEHLk-VHYepvkqetrtaqatntnitisvaetaqnlentvieefsepedlmegirgvveetg 312  alfalfa leafc...
Feature 1                                                                                         
2WBU_A         36 -----------------------------------------------------------------------pyHCDWdgC 44   house mouse
1TF6_A         42 -----------------------------------------------------------------------pfPCKEegC 50   African clawe...
AFZ45977      294 -----------------------------------------------------------------------eyKCDQ--C 300  African clawe...
XP_794235     723 ------------------------------------------------------gnafnnnlvkdkenyvakkSCVCdqC 748  purple urchin
XP_002065594  371 ----------------------------------------------------------------------gefACEL--C 378  Drosophila wi...
XP_004931842  238 ----------------------------------------------------------------------gafHCEL--C 245  domestic silk...
XP_002610785  183 ----------------------------------------------------------------------refKCDQ--C 190  Florida lancelet
NP_001004998  158 -----------------------------------------------------------------------rhLCTF--C 164 
XP_001862948  370 ----------------------------------------------------------------------dayRCES--C 377  southern hous...
XP_003702506  313 aqidedttesplstvnatpplwtitdvtehvhrdhvkpptvteptlhnkektdipqtmkkkkilktrkssdelMCSQ--C 390  alfalfa leafc...
Feature 1                                                                                        
2WBU_A         45 GWKFARSDELTRHY-RKHtgh------------------------------rpfQCQK--CDRAFSRSDHLALHM-KRH 89   house mouse
1TF6_A         51 EKGFTSLHHLTRHS-LTHtge------------------------------knfTCDSdgCDLRFTTKANMKKHFnRFH 98   African clawed...
AFZ45977      301 PKAFNWKSNLIRHQ-MSHdtgkhyecencskqvftdpsnlqrhirsqhvgarahACSD--CGKTFATSSGLKQHK-HIH 375  African clawed...
XP_794235     749 GKAFSNAHCLTTHK-RIHtge------------------------------kpyVCDQ--CGKAFNQVNALTRHE-RIH 793  purple urchin
XP_002065594  379 SLRFCHRPLLIKHGaIAHnni------------------------------rkySCEN--CTKVFCDPSNLQRHIrTYH 425  Drosophila wil...
XP_004931842  246 NRSYSSRALLLRHRaLAHtdi------------------------------rkyPCEN--CPKAFTDPSNLQRHIrVQH 292  domestic silkworm
XP_002610785  191 PKSFNWKSNLIRHQ-MSHdeq------------------------------krfPCEN--CDKVFTDPSNLQRHIrSQH 236  Florida lancelet
NP_001004998  165 GKGFNDTFDLKRHV-RTHtgi------------------------------rpyKCEI--CNKAFTQRCSLESHLkKIH 210 
XP_001862948  378 PKAYSYRPSLLRHRaLAHnen------------------------------rryPCEN--CPKVFSDPSNLQRHI-RTH 423  southern house...
XP_003702506  391 DRTFHHKNSLVYHM-RSHsge------------------------------rphQCEV--CGKSFFAPSALKVHK-RLH 435  alfalfa leafcu...

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