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ZNF776 zinc finger protein 776 [ Homo sapiens (human) ]

Gene ID: 284309, updated on 12-Oct-2019

Summary

Official Symbol
ZNF776provided by HGNC
Official Full Name
zinc finger protein 776provided by HGNC
Primary source
HGNC:HGNC:26765
See related
Ensembl:ENSG00000152443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 5.3), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF776 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57746815..57758148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58258164..58269527)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 154 Neighboring gene zinc finger protein 671 Neighboring gene zinc finger protein 586 Neighboring gene zinc finger protein 552

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

Markers

Homology

Clone Names

  • FLJ30886, FLJ38288, DKFZp781G1213, DKFZp686K10134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052796.1 RefSeqGene

    Range
    5020..16353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348007.2NP_001334936.1  zinc finger protein 776 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice structure in its 3' coding region, resulting in a translational frameshift and shorter 3' UTR, compared to variant 1. The encoded isoform (2) is substantially shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK127764, AK299680, BX105932, DA534001
    UniProtKB/Swiss-Prot
    Q68DI1
    UniProtKB/TrEMBL
    B4DSC6
    Conserved Domains (1) summary
    pfam01352
    Location:1354
    KRAB; KRAB box
  2. NM_173632.4NP_775903.3  zinc finger protein 776 isoform 1

    See identical proteins and their annotated locations for NP_775903.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI446541, AK127764, AK299680, BC136753, CR936802
    Consensus CDS
    CCDS12962.2
    UniProtKB/Swiss-Prot
    Q68DI1
    UniProtKB/TrEMBL
    B2RN90, B4DSC6
    Related
    ENSP00000321812.5, ENST00000317178.10
    Conserved Domains (5) summary
    smart00349
    Location:1455
    KRAB; krueppel associated box
    COG5048
    Location:291439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:322342
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:390415
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_145326.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK127764, AK299680, BX105932, DA534001
  2. NR_145327.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK127764, AK299680, BX105932, CR936802, DA534001
  3. NR_145328.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK127764, BX105932, HY045891

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57746815..57758148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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