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UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 56886, updated on 5-May-2024

Summary

Official Symbol
UGGT1provided by HGNC
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:15663
See related
Ensembl:ENSG00000136731 MIM:605897; AllianceGenome:HGNC:15663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGT1; HUGT1; UGCGL1
Summary
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Expression
Ubiquitous expression in thyroid (RPKM 7.1), colon (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

Location:
2q14.3
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (128091200..128195677)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128527394..128631631)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128848774..128953251)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 pseudogene Neighboring gene Sin3A associated protein 130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:128743539-128744039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16509 Neighboring gene SRM pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 10373 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:128944162-128945361 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:128960126-128960359 Neighboring gene dynein light chain Tctex-type 3 pseudogene 2 Neighboring gene RPL14 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21763, FLJ23671, FLJ23796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UDP-glucose:glycoprotein glucosyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 'de novo' post-translational protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in UDP-glucosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 1
Names
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020120.4NP_064505.1  UDP-glucose:glycoprotein glucosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_064505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
    Source sequence(s)
    AC017079, AC108059, AF227905, AK025416, BC041098, DB226703
    Consensus CDS
    CCDS2154.1
    UniProtKB/Swiss-Prot
    Q53QP2, Q53SL3, Q8IW30, Q9H8I4, Q9NYU2
    UniProtKB/TrEMBL
    A8KAK1
    Related
    ENSP00000259253.6, ENST00000259253.11
    Conserved Domains (2) summary
    cd06432
    Location:12561503
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:451202
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RNA

  1. NR_027671.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, would render this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC017079, AC108059, AK025416, AK293066

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    128091200..128195677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712635.5XP_006712698.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A8KAK1
    Conserved Domains (2) summary
    cd06432
    Location:12481495
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:451194
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  2. XM_006712634.4XP_006712697.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A8KAK1
    Conserved Domains (2) summary
    cd06432
    Location:12501497
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:391196
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  3. XM_047445121.1XP_047301077.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X4

  4. XM_006712636.4XP_006712699.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A8KAK1
    Conserved Domains (2) summary
    cd06432
    Location:12451492
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:341191
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
  5. XM_047445122.1XP_047301078.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X5

  6. XM_047445123.1XP_047301079.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X6

  7. XM_047445124.1XP_047301080.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X7

  8. XM_047445125.1XP_047301081.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X8

  9. XM_017004509.2XP_016859998.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X9

  10. XM_017004510.2XP_016859999.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    128527394..128631631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343041.1XP_054199016.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X3

  2. XM_054343039.1XP_054199014.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

  3. XM_054343042.1XP_054199017.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X4

  4. XM_054343043.1XP_054199018.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X5

  5. XM_054343045.1XP_054199020.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X7

  6. XM_054343040.1XP_054199015.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X2

  7. XM_054343044.1XP_054199019.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X6

  8. XM_054343046.1XP_054199021.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X8

  9. XM_054343047.1XP_054199022.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X9

  10. XM_054343048.1XP_054199023.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025777.1: Suppressed sequence

    Description
    NM_001025777.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.