Conserved Protein Domain Family
UDP-g_GGTase
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pfam06427: UDP-g_GGTase (this model, PSSM-Id:283964 is obsolete and has been replaced by 461910)
UDP-glucose:Glycoprotein Glucosyltransferase
UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
Links
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Statistics
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PSSM-Id: 283964
Aligned: 148 rows
Threshold Bit Score: 590.73
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4E3K0         60 KGVHVTLLAPWTETPLLQEGCEMVAarGAHFVGFYQCMQD-VWKRvQAM--------NSSGGAAKLT---QKSQYDILLD 127  Trypanosoma c...
Q8T191         35 KSIQLSLVSNWGETPSYLEAAEFLH--NQDKSLFWKFIEEf----------------NKIDFSTNYS---DKIYYESTIS 93   Dictyostelium...
XP_002108102   30 KSVNVALVSKWPSTPLLLEVSEFMS--KQGGQTFWSFVNS-INKL-P----------------DNSS---DLDTYNFVMK 86   Trichoplax ad...
XP_004990905   34 tSVAVEMDATWDSTPLYMEAAELLG--DVSEQHFWSFVDA-FAQA-GAV--------KH-----------DQDGYERALS 90   Salpingoeca r...
KGB33649       22 nrVSVTLVPKWKNTPLLSEASEYVA--RESNYAFWRFLDL-ISKD-LDFiktnlmppADDYLLISKNrllEKRVKELAIQ 97   Schistosoma h...
XP_004351754   27 KSTYVALDSNWNSTPLYLEARE-----KVDESLYWKFIQS-FNDA-CVK--------ANKD-STQMT---DKEVYDIIID 87   Dictyostelium...
XP_003291934   35 KLIQLSLVSNWGDTPNYIEASEFFS--KQDKLLFWKFIEE-FNK-------------KSIENKSNIT---DKINYDLTIN 95   Dictyostelium...
XP_002507647   26 veVSFTLTTRWQATSFLLETAEFFA--DYGPDSYWAFTES-WLEP-G-----------------------DHDCRARILN 78   Micromonas sp...
GAA36922       23 nRLSVALQAQWSDTSIISEASEYVA--EESTESFWKFVDIlEPVVtSHH--------WQTA-----F---TKTGVSDFLV 84   Clonorchis si...
CDJ03089       23 YQVSVQLGSSWKETPIIAEAAEFLA--QLSPNHFWDFVDSlEY-----------------------L---SKTNGSSDFF 74   Echinococcus ...

Q4E3K0        128 MMEQANW----------------------P--PTQ--VK----LAKMKLAARLYSPVIEAHWQLA--------------- 162  Trypanosoma c...
Q8T191         94 LMKSVlssn----------------------tqfL--SE----FLSIDLAMRTYSPRVETYRQLA--------------- 130  Dictyostelium...
XP_002108102   87 KGQDLLQ-------------------------PLT--LD----VLKLSLSLRSYSPRVEMFLQI---------------- 119  Trichoplax ad...
XP_004990905   91 -ITEDLL----------------------S--ASS--VD----AVKLSLSARTKSPKVAMFFQIG--------------- 124  Salpingoeca r...
KGB33649       98 AISATSL----------------------K--NSS--LEihnrLFTLSVSSRMFSPTVEMSHQLA--------------- 136  Schistosoma h...
XP_004351754   88 TSKEILG----------------------D--DSAylLE----FLIADLSIRTYSPRVQTYRQLY--------------- 124  Dictyostelium...
XP_003291934   96 TAKEILLp--------------------sT--KYL--IE----FLNVELSMRTYSPIVETFRQLS--------------- 132  Dictyostelium...
XP_002507647   79 AARGASD----------------------S--EDI--FK----ALQLALRVRQYSPRLEMFRSIAqesfk-----nnfnr 123  Micromonas sp...
GAA36922       85 DVdtyvqlenlvldal-----ggggktsdqvrtkQ--RQ----LFRLFLSSRTYSPSVEMMQQLAvtsasqifncsqqsa 153  Clonorchis si...
CDJ03089       75 SSsekisldamreleetilnvqgvpvdmdgnrdlQ--RR----LFSLTLASRALSPAVQTANHMArvahfqw-------l 141  Echinococcus ...

Q4E3K0        163 RKAKQL---IDGCsteg-------------gpfvLTA--GKVICSEDL---L---EETL--SA---PapvnetqdshedE 213  Trypanosoma c...
Q8T191        131 -ISNMK---LNNIehsittadnktitlfnsggwvQIK--NKIITDVNE---In--------ES---LfkdvavvddeenE 190  Dictyostelium...
XP_002108102  120 SRYFKD---KPKCaa-----------------faQLN--GKFICTTKE---L---EAEL--KS---Sg----------lH 156  Trichoplax ad...
XP_004990905  125 QDDSALlsaNDNCea-----------------vaVVG--QSATCSAAD---L---SAII--STa--S------------D 163  Salpingoeca r...
KGB33649      137 LTDASY---LLNCsretvlaela--srtsgvawvLAG--SEAVFSIDK---L---KESI--EKvvgP------------N 189  Schistosoma h...
XP_004351754  125 ETNSKY---NNKQne-----------------fiQLN--D-ITLNIKDkesI---TTIE--YD---K------------S 161  Dictyostelium...
XP_003291934  133 LSQKNF---NEKgw-------------------vQVK--GKSISDASE---IndqFLLS--LS---Q------------N 168  Dictyostelium...
XP_002507647  124 NFEEKQ---MLKCcw------------------aELGtsGFVATTEEE---L---RNLI--FS---S------------S 159  Micromonas sp...
GAA36922      154 vnRLVS---CMSGss-----------------waQVG--AEVVCDIAE---L---SRALdkAnegpv-------esgtiS 198  Clonorchis si...
CDJ03089      142 fdkseV---CKDSkt-----------------wgRIG--STFICNLEI---L---EDSVrkAS---LacsngcpesladS 190  Echinococcus ...

Q4E3K0        214 AFSL--------------F-----AELDQMH--P-----------N---------------------AKGS----RVVIL 236  Trypanosoma c...
Q8T191        191 FIRL--------------Y------DFDHIF--PtlantvsssssS---------------------PSSI----PIVIL 223  Dictyostelium...
XP_002108102  157 SEPE--------------L-----YTFDHIY--P-----------Tsa------------------qASDL----PVAIL 182  Trichoplax ad...
XP_004990905  164 PPST--------------V-----YDVDHIR--P-----------Ss-------------------sRNDV----PVVVL 188  Salpingoeca r...
KGB33649      190 SQPT--------------L-----FSLEKVYssP-----------Kd-------------------tSNNI----PTVIL 216  Schistosoma h...
XP_004351754  162 KENE--------------V-----YSYDTIY--P-----------Stlthsfdh------itmmqeeEKDK----RVVIY 199  Dictyostelium...
XP_003291934  169 SKSQdgadlneekdeelkI-----FDFDHIY--P-----------Is-------------------sGISAidntPIVIM 211  Dictyostelium...
XP_002507647  160 KINV--------------SgirrsSVFDHVY--G-----------GlavymnmsktgtgqlesqnmtPLGS----PTIIL 208  Micromonas sp...
GAA36922      199 --VT--------------L------SREKTF--Rssg------akP---------------------IRPT----PTVVL 223  Clonorchis si...
CDJ03089      191 --AL--------------L------S-DNVY--Ptt--------nE---------------------SNAV----PRLVI 212  Echinococcus ...

Q4E3K0        237 YGVVGEEQTMQLLQVVERHL--HAVRLAFRHLPI-----------SGRmwEHPLHVQGYAVTVDLKNVEYKVIDEKDKND 303  Trypanosoma c...
Q8T191        224 YVDIKSEFFKLVHPKLKQFSqmGKIKYCLRYVV--------------QesNQKLNLQGYGYELSIKNLEYKVMDDSAikk 289  Dictyostelium...
XP_002108102  183 YGQLGENHCRELHSFLYKRAkdGQIKYVFRHFVV-----------NED--QERLSLSGYGVELDIKSTEYKAEDDTKVDE 249  Trichoplax ad...
XP_004990905  189 YADIGSPSFKDWHEALSQLCqeGKVQYVLRHLQR-----------TPA--SR-MRLVGWGAELAIKKTEYTVMDDAAVQD 254  Salpingoeca r...
KGB33649      217 YGDLSHHEFYSWHRSLKALSddGLCNYAFRHYFQ-----------NRN--LSGTSLNGYGVELALKSTEYKAMDDTKSEE 283  Schistosoma h...
XP_004351754  200 YADITSKDFSAVHKYLIKLYqeKKIIYVVRFYVP------------AS--TDHVRLQGYGYSLSIKSLEYKVMNDAVIQN 265  Dictyostelium...
XP_003291934  212 YADIKSEFFQLVHPKLKQFSkmGKIIYCYRYIIK-----------E-S--SQKFNLQGYGYELSIKNLEYKVMDDSAIKK 277  Dictyostelium...
XP_002507647  209 YAALGTSCFNSFHNIMAAASlrGQIQYVHRPILLagcevsgcvglGAT--DDELRLGGFGVEMVIKNTEYNSVDITRIRS 286  Micromonas sp...
GAA36922      224 YGDLGQPDFYTWHRHLKSLTekGLCSYVFRHFKkfps-------------knkAVLSGYGVELALKSTEYKAMDDTK-VE 289  Clonorchis si...
CDJ03089      213 HGDLRRKEFYAWHKKAKQLAkeNRIVYIFRHFFktas-------------sskTWLNGYGVALSLKSTEYKAMDDK--NS 277  Echinococcus ...

Q4E3K0        304 A------G----TDandantveeiesIDSV---GGFNLTLLTQRYpQ-LK-PQLNAFASHLvdmidrdevK-----V--- 360  Trypanosoma c...
Q8T191        290 diiidgv----------ksktiinipNEDV---QGFNFHKLQKRKpE-LT-SKLSTFRSYLmak---sqeA-----K--- 343  Dictyostelium...
XP_002108102  250 AnvdnlgS----TQes---------sDDEV---DGFLFHTLRKKY-P-QKlKELGQFKKHL---------L-----Ddrn 297  Trichoplax ad...
XP_004990905  255 D------D----ATtaav-----ddsEDEV---AGFSFTTLRRLYpD-KT-DDLDAFRSVL---------L-----N--- 297  Salpingoeca r...
KGB33649      284 P------DnvslKEtd---------kIVDVpivAGFNFTQLLNIHpE-LT-KELNEFHSHL---------L-----Ttdd 332  Schistosoma h...
XP_004351754  266 E------G----GDsnta----asipNEDV---GGFNFHVLQKRHpD-LT-KKLTTFRSYL---------L-----Ahqq 312  Dictyostelium...
XP_003291934  278 D------I----ITdsgksktvisipNEDV---SGFNFHKLQKRKpD-LT-SKLSTFRSYL---------L-----Aksq 328  Dictyostelium...
XP_002507647  287 K------D----DGdmskmr-hvlsrHVEV---GGCNLTALVVRF-PgLA-SKLTTIPNHP---------QhenirE--- 338  Micromonas sp...
GAA36922      290 E------K----SSskeal---eapeDAIV---QGFNFTQLRLNHpD-LD-SQLKEYQKYLlst---deeL-----R--- 340  Clonorchis si...
CDJ03089      278 E------G----SQdmsddtpdlnetGSTL---QGFNFAQLRANYpH-LT-TELNAFQSHLitg---iteV-----K--- 331  Echinococcus ...

Q4E3K0        361 ---D------FQMWETQYMGIAAAQYVMDa---------------EneKRLNVLMNLLTKFPLHASKLSKmgatvraKMN 416  Trypanosoma c...
Q8T191        344 ---E------LKVWELKDLGIQSAQKIIQs---------------G--DPLRSLEYISQKFPTLSNSLSKi------TLN 391  Dictyostelium...
XP_002108102  298 evaP------LKVWQLQNLGFQAAQRVLSa--------------gN--DALTTLRDISQNLPTFARPTIKf------QVR 349  Trichoplax ad...
XP_004990905  298 ---NtavikdLKAWELQDISFQAAQRVMTa---------------K--EPVGMLQRVSQNFPSIAHTLVGv------KVG 351  Salpingoeca r...
KGB33649      333 elrP------LKAWQFRDLSLQACQVVMDgflsnmkhegfigsyiD--LGLWSLRDISQNLPARASRLVNv------NVN 398  Schistosoma h...
XP_004351754  313 -qaE------LKMWEIQNLGLQTAQKIVTs---------------S--NPMQSLVYISQAFPSYASSLSRi------SVN 362  Dictyostelium...
XP_003291934  329 eakE------LKVWELKDLGIQSAQKIISs---------------N--DPFRTLKTISQKLPTISSYISKt------AVN 379  Dictyostelium...
XP_002507647  339 ---N------LDIWHFKNIGLQATHRILSa---------------A--DPFQMLEDISQNFPSLAASLSRv------EPG 386  Micromonas sp...
GAA36922      341 ---P------LKVWQFRELNLQATQAIVDasrqsg-----pdtgsVlhPGLAALRDITQNLPSRAGRLVSm------TVD 400  Clonorchis si...
CDJ03089      332 ---P------LRAWQMQDLGLQAVQTIMDvan----------esrNdiAGLLMLQDISQNFPSRAYQLSQh------KVS 386  Echinococcus ...

Q4E3K0        417 KKMHEELMEFASVV-----R------SGTSPVFLNGRNL----AvEKLNLFSLLQKLDEEEQLLEGVQrvftsyrlps-- 479  Trypanosoma c...
Q8T191        392 ESLKSVIESNQKII-----Ps-----TTDQTLLLNGRLId---T-NELSPIELSRIILEEYEHSTTIQqqgplssktvqd 457  Dictyostelium...
XP_002108102  350 NEVRKEIKANQKIFsaelgLd-----AGQSAMYFNGVPFa---L-GEMTIYDLLEIIEEDSNVVSNLQklgiake----- 415  Trichoplax ad...
XP_004990905  352 DAFRKEVETNQRSM-----Qqfg-isPGTSALIVDGVYTd---VtSNTNLFSLLKVIQSESDTLGSLQqlgtdad----- 417  Salpingoeca r...
KGB33649      399 SNLRTESSKNQHVLtgtygIq-----PGQSLLLLN-GILl---S-SSVDIFALLDVIRQESKMMTQLHdlgipgsnisql 468  Schistosoma h...
XP_004351754  363 STLKQSIANYQKIF-----T------EGENQLYLNDRVIditeE-FDLNPLGLSETILNELKSMMNVKkigies------ 424  Dictyostelium...
XP_003291934  380 ETLKKQIEANQKSIp-----------VTETILLLNGRSVn---V-DDLNPFDLTNIIQQEYESASTIQsvgpisl----- 439  Dictyostelium...
XP_002507647  387 NILMTEIIENQKVI-----R------PGAHVMHMNRRPLn---L-DTIDLFSLVEHIWTDIREGHSLKdfgldse----- 446  Micromonas sp...
GAA36922      401 SGLRSEIANNQLLLgaa------eiqPGQTTWFINGLLLs-----PTVDIFALLDLLRQELKAMSRLYnlgvpagrisel 469  Clonorchis si...
CDJ03089      387 TKLRDEIKYNHEAL-----EhlygirPGSSLLLLNGLALs-----PDIDIYALLDLLRSESRLLNQLHglglstg----- 451  Echinococcus ...

Q4E3K0        480 --------vnddgflsaK--TDALHQAMESFRRSVHRYiasngleDGesvprIwlpQrSVLW-LNNIQRDVNYIYMPAAL 548  Trypanosoma c...
Q8T191        458 ii--saqlpiriqllptK--EELELNGG----------------------------NePFVS-LNNLELDYIYRQWEPKL 504  Dictyostelium...
XP_002108102  416 -----------dqqhfiK--L-----AAKSTFSSRVIDmr---------------dN-SVIY-INNIETDQDYFRWPSSV 460  Trichoplax ad...
XP_004990905  418 -----------tahainS--LLASHQAPATPKRVDVR---------------S---S-AVKY-MNNLEKDSMYSRWASSL 464  Salpingoeca r...
KGB33649      469 iieygsssgsatnkndpN--LPGSRHSISNQFVLDLSNa-------------------PITY-INNLETDPAYAYWPASL 526  Schistosoma h...
XP_004351754  425 ---------------------nliskiASTFMAPNLVRfnm--lpEN-----K---D-VLIT-LNNLETDPAFSKWEKSL 471  Dictyostelium...
XP_003291934  440 -------------------etvnqiiAQSSDVTPIRIKfyp--nnEEeaqavG---K-HIIFpLNSLEMDYTYNSWENSL 494  Dictyostelium...
XP_002507647  447 -----------qirallQpqLPMQIAFGEGQPRINLEDsd-----------------rlVSW-TNNIELDKNFEDWSRSI 497  Micromonas sp...
GAA36922      470 lamtgsfsqpisdtngaA--VPGLRYSLSGRFVldl------------------snS-PIVY-LNNLESDSAYATWPESL 527  Clonorchis si...
CDJ03089      452 ----------------qatqllQASPRGEDSYRlstfmesykht-vtgehlldmrnA-PILF-LNDLERNFGYNSWTASI 512  Echinococcus ...

Q4E3K0        549 EA--ILHLNINGVPVipRKNLIHAVCVVDPTTFAGLQNIFTil-klEESK--QPVRLGIVFADN---------------- 607  Trypanosoma c...
Q8T191        505 QSsvLDKPVTSPQDIfiRKNLLTTVIVLDWNNINTFEIIPEiq-emVQGNslIPTRIQLLFNTK---------------- 567  Dictyostelium...
XP_002108102  461 QE--LLRPAFPGMLRyvRKNLYHVVFCIDPVESQSVEVIQMld-lfHRNY--VPMRLGILFVSA---------------- 519  Trichoplax ad...
XP_004990905  465 VT--LLRPGPPPHQRhvARNMYTLTAVINPARAEDRALLSAlhhevFENK--LPVRVGVVFATSqgqaaitarvpafepy 540  Salpingoeca r...
KGB33649      527 HT--LFNFDFSGGLRriRKNLYNVILIIDPVSFESREMLKLte-sfLLHM--TPVRFGIIWAVN---------------- 585  Schistosoma h...
XP_004351754  472 SD--LKNEAISYSSIfkKKNLFTLVFVVDLDNADAFQTIAyaq-nlANNN--IPCQIAIVFKTS---------------- 530  Dictyostelium...
XP_003291934  495 NS--LSKESTEPTDIffRKNLLTTVIVLDWNELNTLSILPElq-smIQSN--IPTRFAIVFNTN---------------- 553  Dictyostelium...
XP_002507647  498 EL--LISAQQDGSIPrlRRNIFNIVAVIDLSQREGLNLVSTvqryiNKFD--VPLRLGLVFVDR---------------- 557  Micromonas sp...
GAA36922      528 QM--LFIPDFSGGIRriRRNLYNIILVLDPGSTECQGIIRLae-sfLLHK--IAIRVGLLWSVD---------------- 586  Clonorchis si...
CDJ03089      513 HA--LFTMGPPGALRhiRKNLFNVVFVVDPSQPTSIEMLKLae-iiIMKK--VPIRIGLLWSVN---------------- 571  Echinococcus ...

Q4E3K0        608 ----------KWspelsvftrG--------N--DFItdms--------------------lsgVTVIIAATVWELLKge- 646  Trypanosoma c...
Q8T191        568 ----------SNnnnnnnnnnN--------D--QNSqtsn---------------------fiqGKDLAKVFLTIKNsn- 605  Dictyostelium...
XP_002108102  520 ----------NKnk-----nvD--------G--TVD---------------------------ASVGIVRAFSYIQEsk- 546  Trichoplax ad...
XP_004990905  541 sstekvngdlDE---------D--------S--VPT---------------------------AGVLVARAFEYVKRkg- 573  Salpingoeca r...
KGB33649      586 ----------PK---------L--------N--ST-----------------------------SLILTRIFSYISStil 607  Schistosoma h...
XP_004351754  531 ----------NS---------D--------RlrDNL---------------------------TSEKIAKIFLTFRSkm- 555  Dictyostelium...
XP_003291934  554 ----------KN---------SvrarylreN--GYV---------------------------SGEEIAKVFLGFKNsn- 584  Dictyostelium...
XP_002507647  558 ----------EA---------E--------S--ESEwkrdandngvfqnkkqngdfelpfgisIGTALARAGTLLSRry- 607  Micromonas sp...
GAA36922      587 ----------SSvk------------------------------------------------siSLILVRMFTYISStvs 608  Clonorchis si...
CDJ03089      572 ----------PEva------------------------------------------------svSRSMVRTFNYLASnvk 593  Echinococcus ...

Q4E3K0        647 ----------------ehPQDVLEFLSE---------------V-------------------VQAR------STRGNL- 669  Trypanosoma c...
Q8T191        606 ----------------lgNRGAFFFITAlnyfkkmyipnelgiT-------------------RSVL------SSSFQA- 643  Dictyostelium...
XP_002108102  547 -----------------gAQAALRWLTQ---------------Ly------------------GNSI------PSAKQV- 569  Trichoplax ad...
XP_004990905  574 -----------------sNIKAFAFLTA---------------Lfka--------------maDSVAgdggdgELVDVL- 606  Salpingoeca r...
KGB33649      608 nshespfpvqinglgspgPMAALSFLTE---------------Iyan--------------aeKSNS------ELSIDL- 651  Schistosoma h...
XP_004351754  556 -----------------gIKAATFFVNA---------------Lnyykrsy------gmdqvtMQLV------SSAFNT- 590  Dictyostelium...
XP_003291934  585 ----------------igNRGAIFFINA---------------Lnyfkkayt----psedgvtRSVL------QSAFNA- 622  Dictyostelium...
XP_002507647  608 -----------------gGKYAGEFARG---------------IgethklisrvnvlndpfynNATW------AAAKEIf 649  Micromonas sp...
GAA36922      609 hfgesplpvgvsglgspgPMTALSFLTElya---------eaeR-------------------TKKE------LTIAFI- 653  Clonorchis si...
CDJ03089      594 typnrrg--vtpglgnpgAITALNFLTDlyan--------snnG-------------------DKDL------LTNDFV- 637  Echinococcus ...

Q4E3K0        670 --------------------EEdeikmissniltlagkttldnILTDASFVEY-YQDTQ--------------------- 707  Trypanosoma c...
Q8T191        644 --------------------V-------------------------LQQMGGS-VRSLQhaltntdfd------nlless 671  Dictyostelium...
XP_002108102  570 --------------------VE---------------------KFKSWFGGTL-VNKVLknggtydn--------lrles 599  Trichoplax ad...
XP_004990905  607 --------------------RE---------------------AFVAQYDMST-WEKLLpasttydk--------trkkm 636  Salpingoeca r...
KGB33649      652 --------------------IK---------------------RKFEKLFPTAdTDDIFtpepgnsdyd-----nevtsh 685  Schistosoma h...
XP_004351754  591 --------------------VV---------------------SQMGN-NVGR-LQTIVeattyndl---------lkea 618  Dictyostelium...
XP_003291934  623 --------------------VI---------------------NQM-HSNFRS-LNQGLqsdeynnl---------lkas 650  Dictyostelium...
XP_002507647  650 nqifkrafvareystkgvrpDE---------------------DTIDMQLQFA-LADILsfdlderddltpssalyvsqa 707  Micromonas sp...
GAA36922      654 --------------------QQrf------------------eKLFPNAD----IEEIIspeagaseyd-----sqlhrh 686  Clonorchis si...
CDJ03089      638 --------------------KTef------------------eSSFPEAY----HEDVFveqgfqcpyd-----aeiknh 670  Echinococcus ...

Q4E3K0        708 ---MKlrem-------------kldaSPFTLLNGKMFR------Gn-------mLHALRQNFMEELHYVRGLVQSDALTE 758  Trypanosoma c...
Q8T191        672 nqlIErlelldtttsqstttttttkiLPKVFVNGVQVK------Ysni---dqlSFDLLVSLYDEFDNLKPLFKESILST 742  Dictyostelium...
XP_002108102  600 ssfFDsig---------------irkLPQVIVNGVQLT------Dlh-----diEGGIVGEYHNQMPKLQEYVQAGKISD 653  Trichoplax ad...
XP_004990905  637 dvfVHklgl-------------gdnaEPVVLFNGEPLT------Pgqp---devLSQVHTAMTSTLPAIQRAVYYGWLSD 694  Salpingoeca r...
KGB33649      686 hefLIrsglq------------sikkIPLILFNGIILD------SdgirkiggfEDTVVTLSMEELMHVQSAVFQGQMSN 747  Schistosoma h...
XP_004351754  619 ndfIQqka---------------isvFPQIFMNGLLLD------Akk-----siAESINHICFEELRQVRKLYLEGIITD 672  Dictyostelium...
XP_003291934  651 nlfIErms---------------lnsFPQVFLNGIPIE------Ftsp---eqfSSQLLVSLYDEFERLKPLYKQGIIVD 706  Dictyostelium...
XP_002507647  708 kdlIAakg----------------itvPSVLVNGLYCSlanarkLes-----elEQVAMHLVQLEIQTFATAISEGNLTD 766  Micromonas sp...
GAA36922      687 nefLRrsgls-----------tidnaPPLLLFNGIILD------RmglrkmggfEDAVVTLCMEEMVNIQHAVYHGHMST 749  Clonorchis si...
CDJ03089      671 ydyLDisgir------------qsvgSSSLISNGMVFS------MdgiskmgglQETVMTAALEQTTYFQQAALEGRLHD 732  Echinococcus ...

Q4E3K0        759 RDDddf--yeSI------------LR----LS-G--ARERYNEAFY------------------------S------EKF 787  Trypanosoma c...
Q8T191        743 TTAqyyeti---------ltssywKD----NNlP--FLKKLNSMIS---------------------------------- 773  Dictyostelium...
XP_002108102  654 STNiy----dYL------------MS----QP-H--VIPRYSYQVFrdnlh---------------yikgLsryteeSKA 695  Trichoplax ad...
XP_004990905  695 HSDvl----dFF------------MK----Q--G--VSSR----VLpsllt---------------spshL------HVA 725  Salpingoeca r...
KGB33649      748 SQTif---dlY-------------QK----TA-T--IVPRFNVRLLnkkkdnsnq-------rsleslkyI------NFN 791  Schistosoma h...
XP_004351754  673 LDQdy---ysIM------------MDyhatHE-S--LLESLNPLVVpsdin---------------pvefR------SLS 713  Dictyostelium...
XP_003291934  707 TPNsy---asSFqlyktitldtdyWS----EN-NipTLEKYSPILFssnysyfit-------nsknqlkeV------EAQ 765  Dictyostelium...
XP_002507647  767 KILdtypggaYG------------WV----LR-D--ATPRYVPFIQdavif-----------------------pstyLV 804  Micromonas sp...
GAA36922      750 TDTifs----------------lyQK----RN-S--VVPRFNPRILatsat--------------ataryL------EF- 785  Clonorchis si...
CDJ03089      733 SLSvvd----------------lfTA----DD-L--FVSRVNRRLLpispplvnkfslgdgsdgtsvtpfL------HFG 783  Echinococcus ...

Q4E3K0        788 --YADWTSKPVLDFLLHR------------P---FL-L-P--TI----------------------RSKKTP-LV-SSVL 822  Trypanosoma c...
Q8T191        774 ----NEKYSHLITNSKNR------------N---QE-V-D--AQnvlknllyf----rnnenkdeqNLLNLI-VI-GDFD 824  Dictyostelium...
XP_002108102  696 --DEVEGTSAAASVIKSV------------N---YViS-S--KDsl------------------kvRPLTFW-VV-VDLF 735  Trichoplax ad...
XP_004990905  726 --QPADPEHPADKLLAHV------------A---YT-TkP--EThp------------------svKPMTYW-LV-VDLD 765  Salpingoeca r...
KGB33649      792 --GYSMPVGLSDENVLPTsqllksftdqmrY---FQ-K-G--DLea------------------siRPVTMWiVI-GDLD 843  Schistosoma h...
XP_004351754  714 ppNSNKKIEKLGQDLLAE------------QlhwIS-A-T--GAed------------------evKLISHM-IV-GDFD 757  Dictyostelium...
XP_003291934  766 --NVLKKQLFFIQDKE------------------ID-T-E--EDpe------------------keKTVTIE-VV-GDFD 801  Dictyostelium...
XP_002507647  805 --MRPPSNRVESHTYPIE------------N---FV-N-YicKDsl------------------kvKDTTVW-FV-SDAS 845  Micromonas sp...
GAA36922      786 --------GIEAPRWSTS------------D---GP-P-T--SSelltyfvdhmrylqkgdlesavRPVTVW-IVvGDLD 837  Clonorchis si...
CDJ03089      784 --RFNVPNG------GLD------------M---KN-A-S--AGeitnylademrylqkgelesetRANTVW-VVlGDVE 835  Echinococcus ...

Q4E3K0        823 -------TiqspmgEAAL-------D--------ALVKTIRNLLQcedeTQKCVN-----------------------VR 857  Trypanosoma c...
Q8T191        825 -------H------YNTR-------D--------ISLELLRQLEK----GE-LKN-----------------------CK 848  Dictyostelium...
XP_002108102  736 -------T------SSGK-------Q--------LLL---QALQY----LSSSEK-----------------------AR 757  Trichoplax ad...
XP_004990905  766 -------T------RDGQ------------------LSAFELLRR----QLSTSK-----------------------LR 787  Salpingoeca r...
KGB33649      844 qifdsnlS------EEHRlqlqmdcN--------LALNALTFLRS----GHSTKGlrigfvynplkltkeetstnhwlTR 905  Schistosoma h...
XP_004351754  758 -------H------DTTV-------Q--------LAKNAMD--RL----QKGSPKd----------------------VR 781  Dictyostelium...
XP_003291934  802 -------Q------YNTR-------E--------VSLYLLKEISS----SESYKN-----------------------AR 826  Dictyostelium...
XP_002507647  846 -------R------PAAK-------A--------VIDAAIDFNKRtwkgAHCQAN-----------------------VR 874  Micromonas sp...
GAA36922      838 -------AifdnpqDSAR-------RsqlehdlgLVRTAVTHLRS----AHASKD-----------------------LR 876  Clonorchis si...
CDJ03089      836 -------PsagvisSHSL-------Q--------LLAQAAKFMR-----RHAAVG-----------------------TR 865  Echinococcus ...

Q4E3K0        858 FTYVV---------------------CDVakeskr----------------------rtmagdLE--------------- 879  Trypanosoma c...
Q8T191        849 LTFIS---------------------NPIdinsvvntagnenqi----lgklitilkhygkilTP--------------- 888  Dictyostelium...
XP_002108102  758 VGVIH---------------------NTKsssvldgkrhslielyealvqvdnfaeissvkslLS--------------- 801  Trichoplax ad...
XP_004990905  788 VAILHggardtpgqqletylqavaryVPAskalg-------------------------vagkVL--------------- 827  Salpingoeca r...
KGB33649      906 VLYLVg--------------------NPInitsp-------------------------lsnqLNneiiakrkyaeqmsg 940  Schistosoma h...
XP_004351754  782 VAFVNa--------------------NTKsklgrqltf----------------antveeatsIL--------------- 810  Dictyostelium...
XP_003291934  827 AAFIS---------------------NPSnqetltsssqntlg-------klvsilkhykkevTN--------------- 863  Dictyostelium...
XP_002507647  875 FAVLH---------------------PPGvapsq-------------------------eareAA--------------- 893  Micromonas sp...
GAA36922      877 VGIVY---------------------NPPidswkspssssrwl------trvlhlighpvripAG--------------- 914  Clonorchis si...
CDJ03089      866 LGLVL---------------------NPSrpptgqaigiwggw------gwltralliighpaER--------------- 903  Echinococcus ...

Q4E3K0        880 -------------------------RLI----VR------------------------------R------KggDDGKqh 894  Trypanosoma c...
Q8T191        889 -------------------------QLV----IG------------------------------L------FekVQSD-- 901  Dictyostelium...
XP_002108102  802 -------------------------HFV----EK------------------------------Q------I--DSIS-- 812  Trichoplax ad...
XP_004990905  828 -------------------------ERV----LAgdavsnalgqtvvgvkawadvmakvkededS------F--SSLL-- 868  Salpingoeca r...
KGB33649      941 rnfairlikemlesiktskpiksleELL----VS------------------------------G------M--DSKQ-- 976  Schistosoma h...
XP_004351754  811 -------------------------SGVtgdsKS------------------------------L------D--ETKI-- 825  Dictyostelium...
XP_003291934  864 -------------------------DIM----IK------------------------------L------F--EDIQ-- 874  Dictyostelium...
XP_002507647  894 -------------------------QKF----RS------------------------------HhlgdydL--DSLL-- 910  Micromonas sp...
GAA36922      915 -------------------------ADS----PR------------------------------L------LepRMKL-- 927  Clonorchis si...
CDJ03089      904 -------------------------MLH----PS------------------------------T------VkqSQKY-- 916  Echinococcus ...

Q4E3K0        895 vqwvydflqkiaaqnntrqlmdpdlyeelvaeVN--Fssevkklldasde------------------------------ 942  Trypanosoma c...
Q8T191        902 --------------------------------PT--Iidsfktmkqiielsgfdi----------------------aan 925  Dictyostelium...
XP_002108102  813 --------------------------------SL--D------------------------------------------- 815  Trichoplax ad...
XP_004990905  869 --------------------------------AS--K------------------------------------------- 871  Salpingoeca r...
KGB33649      977 --------------------------------IHdaI------------------------------------------- 981  Schistosoma h...
XP_004351754  826 --------------------------------EN--I------------------------------------------- 828  Dictyostelium...
XP_003291934  875 --------------------------------SD--V------------------------------------------- 877  Dictyostelium...
XP_002507647  911 --------------------------------VQ--Q------------------------------------------- 913  Micromonas sp...
GAA36922      928 --------------------------------ME--Qmaarnfanklikealealnsssvlkpls-elvvsgvniqtlet 972  Clonorchis si...
CDJ03089      917 --------------------------------MN--Imaaknfvikiteealkvvrgemkgvrpfselavtglevdkflq 962  Echinococcus ...

Q4E3K0        943 -gldaqlqvqrgivNG------------------------------F--------------------------------- 958  Trypanosoma c...
Q8T191        926 diwvaqsvnlfkqsSK------------------------------V--------------------------------- 942  Dictyostelium...
XP_002108102  816 --------------EIrnvnvndlksalseeafqksvyrkvqkgleF--------------------------------- 848  Trichoplax ad...
XP_004990905  872 --------------RS------------------------------M--------------------------------- 874  Salpingoeca r...
KGB33649      982 --------------QL------------------------------Fdrnsflq------------------------mh 993  Schistosoma h...
XP_004351754  829 --------------SV------------------------------F--------------------------------- 831  Dictyostelium...
XP_003291934  878 --------------AK------------------------------Ydsiktlkeliesyklpiplsdiwvsqadnlfkq 913  Dictyostelium...
XP_002507647  914 --------------GN------------------------------F--------------------------------- 916  Micromonas sp...
GAA36922      973 aiqaldraeflhghSI------------------------------F--------------------------------- 989  Clonorchis si...
CDJ03089      963 afteldldqklslhMT------------------------------F--------------------------------- 979  Echinococcus ...

Q4E3K0        959 ----CAQ-LEadslstsslsangaaagrekgnkEGA--V----Y-YYVNGRRFVYD--Ds------FLEEDFRtAEEme- 1017 Trypanosoma c...
Q8T191        943 ----CKQ-Ylgi-------------------qsTNK--Sp--lS-ILVNGRIITPP--LsyddaasFIQSDFKlLLEiem 991  Dictyostelium...
XP_002108102  849 ----CQSfINl---------------------eAGQ--N----A-IIANGKVYGPV--Sdd---dpFVASDFRlVETldw 891  Trichoplax ad...
XP_004990905  875 ----IEA-FGl---------------------pPAA--T----T-VILNGHVFGPM--Tdr----aLRAADYHqLDKrhg 915  Salpingoeca r...
KGB33649      994 stiaCQI-IGl---------------------kPGE--R----A-VVVNGKIVGPF--Epf---eeFLSDDFRlAERlal 1039 Schistosoma h...
XP_004351754  832 ----SKS-VLg---------------------lACQfnS----Y-ILTNGRLITVS--Hne---edI-FNDFFmLEKfei 874  Dictyostelium...
XP_003291934  914 aaktSRE-YLn---------------------lQST--NklpvS-ILVNGKIITPPqyEnv---esF-FKDFNlALFme- 963  Dictyostelium...
XP_002507647  917 ----VAR-LLgqehm--------------atfrPPE--V----GlLIVNGRILD-I--Prd---yqMDAEDFClLLSqeh 965  Micromonas sp...
GAA36922      990 ----CQQ-Ilg--------------------fkPGE--R----A-VVINGRIIGPL--Npt---eeFTVDDFRlIERmtl 1032 Clonorchis si...
CDJ03089      980 ----CQK-Alr--------------------iqPGD--S----A-VIINGRVYGPL--Gdn---eiFTSEDFRlAEQlsi 1022 Echinococcus ...

Q4E3K0       1018 ---mlLAGAVSEAL--SK---VEF------------TTMSSelepsdleSHF-YASKVAALSEVLr-----------rD- 1064 Trypanosoma c...
Q8T191        992 ----ikAKKTFELL--NS---DPI------------Lkd--------ksNLK-ISDLLNKVQSLVgyyyngnnqldsnI- 1040 Dictyostelium...
XP_002108102  892 ---rhHLKKISKLL--TK---YQP------------GDTLD--------SIRmVSDMNMAISGLI-------------S- 929  Trichoplax ad...
XP_004990905  916 dsintRA--IVRHI--DQ---TQLatppayaagsgdDDARA--------LQY-RNDVVVGVCAVL-------------Sr 966  Salpingoeca r...
KGB33649     1040 ---dnGAKELGDKL--EK---ILG------------TAAGV--------PDV-ISELTWQLSSVLqs----------gI- 1079 Schistosoma h...
XP_004351754  875 ----gkARSVKDIL--PEnpkVRG------------VELTK--------PRD-KSNLIMTLVSVF-------------G- 913  Dictyostelium...
XP_003291934  964 ---skKANDILNLL--KE---DSL------------LT-GK--------SIN-YSDLINKISSLI-------------G- 999  Dictyostelium...
XP_002507647  966 ---raHIDLVRQIVgrSV---PRS------------LTATD--------TTR-ISDMYMLSTSLL-------------A- 1004 Micromonas sp...
GAA36922     1033 ---dtGVKELGNTL--LD---FAG------------Egl--------ggPEA-ISELTWQVSAMLp------------I- 1070 Clonorchis si...
CDJ03089     1023 --rsaGMDEMAKRL--TK---MVPdt---------------------tsSNY-VSELVWRAASVLesa-------kwrL- 1065 Echinococcus ...

Q4E3K0       1065 -----AARGSPMQEENHLPSTSGltsf---------------vvkpAnGDTVP-----R-HTLTVVIDPVAQQSQFLISL 1118 Trypanosoma c...
Q8T191       1041 -----KRKRIPNSLSISFSHKPPtl-------------------ssSsSSSSSnsndvP-LKFLMIINPFNKVSQKLVPM 1095 Dictyostelium...
XP_002108102  930 ------------------DNSNYvrtqmpslk------hahsavtfS-NSGSE-----LgHEIVAIINPLSKDAQVMTPI 979  Trichoplax ad...
XP_004990905  967 srmraAESAEQGQQVRRVDLSlfkgldtths------aleltsalvG-QSGRT-----P-HQVYAIVDPASDGGQRMGPA 1033 Salpingoeca r...
KGB33649     1080 -----EATSSVISETSSVDGISDkgqnghrilldgvsynhsgfiihG-NKDEP-----N-FELVAIIDPASRDAQRLSHI 1147 Schistosoma h...
XP_004351754  914 -----M--QSSNTDVVRKQVPTTvtpsfry-------------epkanaNITP-----L-LRFTMVVDPLCKTAQKMVSI 967  Dictyostelium...
XP_003291934 1000 -----YHYKGSSIIRKRIPSSIStsftys--------------psnnnaAASS-----P-LKFFLVINPFNKVSQKLIPM 1054 Dictyostelium...
XP_002507647 1005 -----WRRSEYGV---RREEAEIlkvleft----------ksavsiS-GHGTV-----A-FE--AVLDPLSKDAQRVISL 1057 Micromonas sp...
GAA36922     1071 -----YKETSSTGITDIDNVEGIlsknrvrlkg---lsinhsgffiPsNSGEL-----A-FDVLAILNPGSRDAQRLSHV 1136 Clonorchis si...
CDJ03089     1066 -----NAFAKSLSSEGIFTSSGIsrmtfrgtk------stysaftlPaKNAGL-----N-YDIVALVDPISRDAQRLSQI 1128 Echinococcus ...

Q4E3K0       1119 CDYVTRsPL--GVSCTVHMgATEhask--lmrN--------FYQFVSEMELRFDAVGGVV----------PPaAVFHRLP 1176 Trypanosoma c...
Q8T191       1096 VREFSN-KL--NIPVDVIL-NPPvslselplkT--------YYTYVIKLSSEFNNEN-VLy--------nQPlGIATDIP 1154 Dictyostelium...
XP_002108102  980 IMNLLK-AT--KVDITVLM-NPAsmlsemplnS--------FFRYVLEPELKFSKEGRLIs--------kPV-AQFTKIP 1038 Trichoplax ad...
XP_004990905 1034 LSLLMQ-HT--AVHITLLL-NPTprvsempvkR--------FYRAVM-PAITFSDDGTLDp--------gPR-AVFANLP 1091 Salpingoeca r...
KGB33649     1148 LIVLQH-SL--PCTVKVLF-NPSpslselpvkS--------FYRFVWEPSL-FPENESILnps----iivPR-AYFTHLP 1209 Schistosoma h...
XP_004351754  968 VNSVAS-HY--GIAVDVFL-NPLqqlgelplkS--------FYTYVSQLHLNFDDAGKLSkh-------yAS-GVSSNLP 1027 Dictyostelium...
XP_003291934 1055 IQEFSN-KL--NIAVDVVL-NPPvsvsemplkT--------FYTYVIKLDNEFSEETGQLin-------qPL-GVTSNIP 1114 Dictyostelium...
XP_002507647 1058 INVIKE-TLtsSVTVRIVL-NPIntlhylplsS--------YYRYAVPLAP-------ISi--------hPR-AYFTGLP 1111 Micromonas sp...
GAA36922     1137 LAVVQQ-AL--PCNMRVVF-NPVepiselpvkNgdqdvpilFYRFVWEPS-IFLFESSIStnvvnkdpivPR-ALFTHLP 1210 Clonorchis si...
CDJ03089     1129 LLVLQR-SL--PCSITVIL-NPVnglsdlplkN--------YYRFVWHPS-LYAPGGGLAd--------pPS-AFFDQLP 1186 Echinococcus ...

Q4E3K0       1177 SKHLLTLGIEEPESWTVFSLDAKYDLDNILLDKL-P-SSSqY--LHAVYRINSILLTGSARDAEQP-NPSRGLPLLIRS- 1250 Trypanosoma c...
Q8T191       1155 EDRVVTLALDIPSSWLVQPIIAKYDLDNIRLKDL-G-DEQv---LTAVYELENIVIEGSANDMTTD-NAPAGLELLLNP- 1227 Dictyostelium...
XP_002108102 1039 ESLLLTLNMKTPESWMVESMISVYDLDNIRLDQL----NQ-G--VKALYALEYILLEGHCFDSVTS-EPPRGLQFVMGT- 1109 Trichoplax ad...
XP_004990905 1092 RASLLTLGLETPASWMVKSVESKHDLDNIHLQS----SQR-G--VHAVFELEHMAVEGSCVEATTR-RPTAGLQLELGT- 1162 Salpingoeca r...
KGB33649     1210 GQSLLTLGMDEPHGWMVAAIKAVQDLDNLRLVDYrS-TKH-L--VEAVFELEYLLLEGHCVEEGSM-KPPRGLQFTLGP- 1283 Schistosoma h...
XP_004351754 1028 DNRVLALAMDTPSTWIVKPLVAKHDLDNIRLKDL-GvKEP-T--LNALFQLEYLLLQGFAYESRIGvSPPAGLELVIDS- 1102 Dictyostelium...
XP_003291934 1115 EDRVLTLALDAPSSWLVQPIIAKYDLDNIRLKDL-G-EEQ-V--LYAVFELENIVIEGSCNDVSTD-AAPAGLEILLNPv 1188 Dictyostelium...
XP_002507647 1112 LKEKYTAHLDIPEAWLVTTTATQYDLDHLSLEEL-P-DGF-Nl-VEAEFQVEALLVTGHCVDINSN-EHPRGLQLTLKN- 1185 Micromonas sp...
GAA36922     1211 GQPVLTLGMDTPHGWMVAAVEAVHDLDNLRLADV-H-NV-----VEAVFELEHLLLEGHCFEQNSM-KPPRGLQLTLGP- 1281 Clonorchis si...
CDJ03089     1187 GQSLLTLGVDAPHNWMVAPIRAEEDLDNLRLADI-A-AHTgNhrVEAEFELEYLLLEGHCLDESTR-QPPRGLQFTLGT- 1262 Echinococcus ...

Q4E3K0       1251 -TKTnpEAgvTRDTLVMAIMGYFQLQSSPGVWYLTVQPGDIAKIFYI---SQvddI-P-----------VNDGanknhhg 1314 Trypanosoma c...
Q8T191       1228 -ISTqtNK--TQDTIVMNNFGYYQLKSNPGIWKLTIAPGRSSDIMDM---VDhpnQ-K-----------EKe-------- 1281 Dictyostelium...
XP_002108102 1110 -DTD--PA--MVDTIVMANLGYFQMKANPGLWKLQLRPGRSENLYKI---DSh--D-G-----------EIGK------- 1160 Trichoplax ad...
XP_004990905 1163 -RTH--GS--MYDTLVMANLGYFQLKATPGAWQLSLREGRSSDIFAL---SR---VkG-----------ADSH------- 1213 Salpingoeca r...
KGB33649     1284 -TPT--TI--EYDTIVMANLGYFQLKANPGAWHLNIRAGKSQKLYEI---SG---Q-E-----------HTDT------- 1333 Schistosoma h...
XP_004351754 1103 -LGT--LQ--HQDTLVMGN-GYFQLKANPGYWKLALL-GRGKNIMNLlnsDS---K-A-----------SDTD------- 1153 Dictyostelium...
XP_003291934 1189 aTQN--KV--TQDTIVMNNYGYYQLKSNPGIWKLTLAKGRSSDIMNI---VE---A-N-----------GEMV------- 1239 Dictyostelium...
XP_002507647 1186 -PSE------RAGTIVMSTLGYFQLPAAPGVWSLELRPDQSASNYYMvpnDE---F-GkyaqkyvyqqpTQDR------- 1247 Micromonas sp...
GAA36922     1282 -ASD--LE--RHDTIVMANLGYFQLKAGPGLWHLNIRAGRSREFYTM---ADd---eD-----------VG--------- 1330 Clonorchis si...
CDJ03089     1263 -AEK--LD--RYDTIVMANLGYFQLKANPGAWHLNLREGPSRDIYNI---VGh---eY-----------AD--------- 1311 Echinococcus ...

Q4E3K0       1315 RFNy-TAGqnIPVVVSSFTGKFLMLGVSKTPG 1345 Trypanosoma cruzi
Q8T191       1282 TFVi-VPH--RLVVIDSLYQSLSSLSVVRKAG 1310 Dictyostelium discoideum
XP_002108102 1161 STD----S--IAISIENFKGKIIQVKVGKKPG 1186 Trichoplax adhaerens
XP_004990905 1214 SPH--DA---PVILVHDLSGTFVSVSVERRPG 1240 Salpingoeca rosetta
KGB33649     1334 SVN--SKE--IITLISNFRSKIIEVSVNKRae 1361 Schistosoma haematobium
XP_004351754 1154 QVHp-VSY--LTVATDSYRGNSIYLKLSRKAG 1182 Dictyostelium fasciculatum
XP_003291934 1240 P------Y--HTVVIDSLFQPQSSLYVQRKQG 1263 Dictyostelium purpureum
XP_002507647 1248 GVEfmSNH--AELYVASWKGISLNLYVKRRPe 1277 Micromonas sp. RCC299
GAA36922     1331 TSLg-SFG--LLTTIDSFRSKIISVRVTKRPE 1359 Clonorchis sinensis
CDJ03089     1312 SPPd-APS--LIAVIDSFRPKIIRTDVQKKLG 1340 Echinococcus multilocularis
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