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Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 320011, updated on 26-Sep-2022

Summary

Official Symbol
Uggt1provided by MGI
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 1provided by MGI
Primary source
MGI:MGI:2443162
See related
Ensembl:ENSMUSG00000037470 AllianceGenome:MGI:2443162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GT; UGT1; Ugcgl1; 0910001L17Rik; A930007H10Rik; C820010P03Rik
Summary
Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum lumen and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 12.4), placenta adult (RPKM 11.7) and 28 other tissues See more
Orthologs
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Genomic context

See Uggt1 in Genome Data Viewer
Location:
1; 1 B
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36179109..36283407, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36140028..36244320, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 6-O-sulfotransferase 1 Neighboring gene predicted gene, 53548 Neighboring gene predicted gene, 33280 Neighboring gene microRNA 6897 Neighboring gene elongation factor RNA polymerase II 2 pseudogene Neighboring gene predicted gene, 39625 Neighboring gene neuralized E3 ubiquitin protein ligase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP-glucose:glycoprotein glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 1
Names
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1
UDP-glucose:glycoprotein glucosyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198899.2NP_942602.2  UDP-glucose:glycoprotein glucosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_942602.2

    Status: VALIDATED

    Source sequence(s)
    AI877337, AK044321, AK134231, AK162491, BC062936, CD808359, CK639915
    Consensus CDS
    CCDS48238.1
    UniProtKB/Swiss-Prot
    Q6NV70, Q6P5E4
    Related
    ENSMUSP00000037930.8, ENSMUST00000046875.14
    Conserved Domains (2) summary
    cd06432
    Location:12561503
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:451202
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36179109..36283407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496062.5XP_006496125.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

    Conserved Domains (6) summary
    pfam06427
    Location:11081214
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    pfam18400
    Location:57237
    Thioredoxin_12; Thioredoxin-like domain
    pfam18401
    Location:310440
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:451699
    Thioredoxin_14; Thioredoxin-like domain
    pfam18403
    Location:722947
    Thioredoxin_15; Thioredoxin-like domain
    pfam18404
    Location:12481515
    Glyco_transf_24; Glucosyltransferase 24