Conserved Protein Domain Family
GT8_HUGT1_C_like

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cd06432: GT8_HUGT1_C_like 
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family.
C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Statistics
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PSSM-Id: 133054
View PSSM: cd06432
Aligned: 15 rows
Threshold Bit Score: 449.147
Threshold Setting Gi: 67478161
Created: 11-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandmetal binding
Feature 1:putative ligand binding site
Evidence:
  • Comment:annotation is based on homology to other subgroups of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###  ##                                                                    
XP_422579 1230 LNIFSVASGHLYERFLRIMMLSVLKHTk-------tPLKFWFLKNYLSPTFKEFIPYmakkYNFQYELVQYKWPRWLHQQ 1302 chicken
AAW41515  1228 INIFTVASGLLYERFASIMILSVMKHTn-------sSVKFWFIENFLSPTFIAFIPKlaeeYGFQYEFVTYKWPHWLRAQ 1300 Cryptococcus neo...
AAM08766  1369 IHIFSVASGHLYERFLKIMMLSVVKNTe-------sPIKFWFLKNYLSPAFKEFIPEmakeYGFQYELVTYKWPWWLRKQ 1441 Dictyostelium di...
NP_177278 1301 INIFSIASGHLYERFLKIMILSVLKNTn-------rPVKFWFIKNYLSPQFKDVIPHmaqeYNFEYELITYKWPSWLHKQ 1373 thale cress
Q09332    1240 INIFSVASGHLYERLLRIMMVSLLKHTk-------sPVKFWFLKNYLSPQFTDFLPHmaseYNFQYELVQYKWPRWLHQQ 1312 fruit fly
XP_788044 1168 LNIFSLASGHLYERLLRIMMLSVLKHTk-------sPVKFWFLKNYLSPSFKEIIPEmakeYDFEYELIQYKWPRWLHQQ 1240 purple urchin
EAA30235  1192 INIFSVASGHLYERMLSIMILSVMEHTd-------hSVKFWFIEQFLSPSFKSFLPHlaaeYGFKYEMVAYKWPHWLRHQ 1264 Neurospora crassa
CAD67998  1164 INIFTVASGHLYERFLSIMTASVMAHTd-------hTVKFWLIENFLSASFKAFLPHlaahYGFEYELVTYQWPHWLRGQ 1236 Yarrowia lipolytica
AAX80632  1364 LNIFTVASGHLYERFLRIMMHTVMRTSsdvhganttRIKFWLIENFLSPQFKELVPLlaehYGFDVGFVTYRWPWWLNKQ 1443 Trypanosoma brucei
Q09140    1157 INIFSVASGHLYERFLYIMTKSVIEHTd-------kKVKFWFIENFLSPSFKSSIPAiakkYNFEYEYITYNWPHWLRKQ 1229 fission yeast
Feature 1                 #               # ###                        #                       
XP_422579 1303 TEKQRIIWGYKILFLDVLFPlavDKILFVDADQIVRTDLKELRdfnldgaPYGYTPFCDSRREMD--GYRFWKSGYWASH 1380 chicken
AAW41515  1301 TEKQRIIWAYKILFLDVLFPmslDKVIFVDADQIVRTDMKELMdvdlhgrVYGYAPMGNSRKEME--GFRFWKSGYWKEA 1378 Cryptococcus neo...
AAM08766  1442 TEKQRIIWSYKILFLDVLFPldvPKIIFVDADQVVRTDLKELWdmdlhgaSLGYTPFCDSNKDTE--GFRFWKSGYWRQH 1519 Dictyostelium di...
NP_177278 1374 KEKQRIIWAYKILFLDVIFPlslEKVIFVDADQIIRTDMGELYdmdikgrPLAYTPFCDNNREMD--GYKFWKQGFWKEH 1451 thale cress
Q09332    1313 TEKQRTIWGYKILFLDVLFPlnvRKIIFVDADAIVRTDIKELYdmdlggaPYAYTPFCDSRKEME--GFRFWKQGYWRSH 1390 fruit fly
XP_788044 1241 TEKQRMIWGYKILFLDVLFPlniKKIIFVDADQIVRADMQELAdfdlkgaPYGYVPFCDSRKEMD--GFRFWKSGYWASH 1318 purple urchin
EAA30235  1265 SEKQREIWGYKILFLDVLFPlslDKVIFVDADQVVRTDMYDLVsldlegaPYGFTPMCDSRTEME--GFRFWKTGYWANY 1342 Neurospora crassa
CAD67998  1237 TEKQRQIWGYKILFLDVLFPqdlERVIFIDSDQIVRTDLYELVemdlegaPYGFTPMCDSRKEMD--GFRFWKQGYWDTF 1314 Yarrowia lipolytica
AAX80632  1444 TEKQRTIWAYKILFLDVLFPlnvDRVIFVDADQIVQADLHELYnmnigaaAMAYTPFCREYPNDAttNFRFWDQGFWLSH 1523 Trypanosoma brucei
Q09140    1230 EEKQREIWGYKILFLDVLFPlelHKVIYVDADQIVRADLQELMdmdlhgaPYGYTPMCDSREEME--GFRFWKKGYWKKF 1307 fission yeast
Feature 1              ###                                   ##                      ##        
XP_422579 1381 LA-GRKYHISALYVVDLKkFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQvpIKSLPQEWLWCETWCDDSSKK 1459 chicken
AAW41515  1379 LR-GRPYHISALYVVDLKkFRQLATGDRLRGQYHALSADPNSLANLDQDLPNSMQDQipIWTLDQDWLWCQTWCSDESLA 1457 Cryptococcus neo...
AAM08766  1520 LA-GRSYHISALYVVDLVrFRRLAAGDQLRATYDQLSRDPNSLANLDQDLPNYLQHYvrIHSLPQEWLWCETWCDQESKS 1598 Dictyostelium di...
NP_177278 1452 LR-GRPYHISALYVVDLVkFRETAAGDNLRVFYETLSKDPNSLSNLDQDLPNYAQHTvpIFSLPQEWLWCESWCGNATKA 1530 thale cress
Q09332    1391 LM-GRRYHISALYVVDLKrFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQvaIKSLPDDWLWCQTWCSDSNFK 1469 fruit fly
XP_788044 1319 LA-GRKYHISALYVVDLVkFRRIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQvaIRSLPQEWLYCETWCHESEKS 1397 purple urchin
EAA30235  1343 LR-GQPYHISALYVVDLRrFRELAAGDRLRQQYHTLSADPNSLANLDQDLPNHMQFQipIKSLPQEWLWCETWCSDETLT 1421 Neurospora crassa
CAD67998  1315 LGdDLVYHISALFVVDLKvFRAQQIGDRLRVHYHQLSADPASLSNLDQDLPNNLQRQvpIFSLPQDWLWCETWCSDESLK 1394 Yarrowia lipolytica
AAX80632  1524 LR-GKPYHISALYLVNVQrLRAALGGDKYRATYARLSEDPGSLANLDQDLPNFMQDEmpIFSLPEEWLWCETWCAGESKA 1602 Trypanosoma brucei
Q09140    1308 LR-GLKYHISALYVVDLDrFRKMGAGDLLRRQYQLLSADPNSLSNLDQDLPNHLQHLipIYSLPQDWLWCETWCSDESLK 1386 fission yeast
Feature 1           # ##    #    
XP_422579 1460 RAKTIDLCNNPMTKEPKL 1477 chicken
AAW41515  1458 TAKTIDLCQNPLTKEPKL 1475 Cryptococcus neoformans var. neoformans JEC21
AAM08766  1599 KAKTIDLCNNPLTKTPKL 1616 Dictyostelium discoideum
NP_177278 1531 KARTIDLCNNPMTKEPKL 1548 thale cress
Q09332    1470 TAKVIDLCNNPQTKEAKL 1487 fruit fly
XP_788044 1398 RAKTIDLCNNPLTKEPKL 1415 purple urchin
EAA30235  1422 KARTIDLCNNPMTKEPKL 1439 Neurospora crassa
CAD67998  1395 TAKTIDMCNNPLTKEPKL 1412 Yarrowia lipolytica
AAX80632  1603 RAKTIDLCNNPLTKIPKL 1620 Trypanosoma brucei
Q09140    1387 TAKTIDLCQNPLTKEKKL 1404 fission yeast

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