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    PTPRF protein tyrosine phosphatase receptor type F [ Homo sapiens (human) ]

    Gene ID: 5792, updated on 11-Apr-2024

    Summary

    Official Symbol
    PTPRFprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Fprovided by HGNC
    Primary source
    HGNC:HGNC:9670
    See related
    Ensembl:ENSG00000142949 MIM:179590; AllianceGenome:HGNC:9670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAR; BNAH2
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 56.2), skin (RPKM 52.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1p34.2
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43522051..43623666)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43392482..43494171)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43991708..44089337)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43916604-43917491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43917492-43918378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 784 Neighboring gene SZT2 antisense RNA 1 Neighboring gene microRNA 6735 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:43937485-43938684 Neighboring gene HYI antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4928 Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43986941-43987441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43997400-43997972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43998601-43999102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43999103-43999602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44000549-44001411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44014162-44014968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44014969-44015773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44022869-44023446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44023447-44024024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44026337-44026914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44030770-44031565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44038483-44038984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44040406-44041268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44041269-44042129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44046933-44047754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44061284-44061784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44061785-44062285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44063935-44064436 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44086190-44086364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 788 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:44125453-44126129 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44126130-44126805 Neighboring gene uncharacterized LOC124904165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 921 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:44131983-44133182 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44142744-44142920 Neighboring gene lysine demethylase 4A Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44172642-44173159 Neighboring gene KDM4A antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Breasts and/or nipples, aplasia or hypoplasia of, 2
    MedGen: C4014918 OMIM: 616001 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRF PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43335, FLJ45062, FLJ45567

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chondroitin sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase F
    Names
    LCA-homolog
    leukocyte antigen-related (LAR) PTP receptor
    leukocyte antigen-related tyrosine phosphatase
    leukocyte common antigen related
    protein tyrosine phosphatase, receptor type, F polypeptide
    receptor-linked protein-tyrosine phosphatase LAR
    NP_001316066.1
    NP_001316067.1
    NP_001316068.1
    NP_001316069.1
    NP_002831.2
    NP_569707.2
    XP_005271136.1
    XP_005271137.1
    XP_005271138.1
    XP_005271139.1
    XP_006710858.1
    XP_006710859.1
    XP_006710860.1
    XP_006710861.1
    XP_006710862.1
    XP_006710863.1
    XP_006710864.1
    XP_011540173.1
    XP_011540174.1
    XP_011540175.1
    XP_016857431.1
    XP_016857433.1
    XP_016857434.1
    XP_016857435.1
    XP_047282431.1
    XP_047282439.1
    XP_047282442.1
    XP_047282448.1
    XP_047282449.1
    XP_047282457.1
    XP_047282460.1
    XP_047282463.1
    XP_047282468.1
    XP_047282470.1
    XP_047282475.1
    XP_054193929.1
    XP_054193930.1
    XP_054193931.1
    XP_054193932.1
    XP_054193933.1
    XP_054193934.1
    XP_054193935.1
    XP_054193936.1
    XP_054193937.1
    XP_054193938.1
    XP_054193939.1
    XP_054193940.1
    XP_054193941.1
    XP_054193942.1
    XP_054193943.1
    XP_054193944.1
    XP_054193945.1
    XP_054193946.1
    XP_054193947.1
    XP_054193948.1
    XP_054193949.1
    XP_054193950.1
    XP_054193951.1
    XP_054193952.1
    XP_054193953.1
    XP_054193954.1
    XP_054193955.1
    XP_054193956.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047072.1 RefSeqGene

      Range
      13646..106429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329137.2NP_001316066.1  receptor-type tyrosine-protein phosphatase F isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266, DA339772
      UniProtKB/TrEMBL
      Q5W9G3
    2. NM_001329138.2NP_001316067.1  receptor-type tyrosine-protein phosphatase F isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266, DA339772
      UniProtKB/TrEMBL
      Q5W9G3
    3. NM_001329139.2NP_001316068.1  receptor-type tyrosine-protein phosphatase F isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266
      UniProtKB/TrEMBL
      Q5W9G3
    4. NM_001329140.2NP_001316069.1  receptor-type tyrosine-protein phosphatase F isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AB621807, AC092815, AL583862, BU624266
      UniProtKB/TrEMBL
      Q5W9G3
    5. NM_002840.5NP_002831.2  receptor-type tyrosine-protein phosphatase F isoform 1 precursor

      See identical proteins and their annotated locations for NP_002831.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC092815, BC048768, BU624266, Y00815
      Consensus CDS
      CCDS489.2
      UniProtKB/Swiss-Prot
      D3DPX6, D3DPX7, P10586, Q5T021, Q5T022, Q5W9G2, Q86WS0
      UniProtKB/TrEMBL
      H0Y6Z7
      Related
      ENSP00000353030.4, ENST00000359947.9
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13511606
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13771606
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    6. NM_130440.4NP_569707.2  receptor-type tyrosine-protein phosphatase F isoform 2 precursor

      See identical proteins and their annotated locations for NP_569707.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC092815, BC048768, BU624266, Y00815
      Consensus CDS
      CCDS490.2
      UniProtKB/TrEMBL
      H0Y6Z7
      Related
      ENSP00000398822.1, ENST00000438120.5
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13421597
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13681597
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      43522051..43623666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541873.3XP_011540175.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540175.1

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14626
      Location:13501625
      R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
      cd14629
      Location:16271917
      R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3336
      Ig; Ig strand A [structural motif]
      cd05738
      Location:136226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
    2. XM_011541871.4XP_011540173.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540173.1

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14626
      Location:13501625
      R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
      cd14629
      Location:16271917
      R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3336
      Ig; Ig strand A [structural motif]
      cd05738
      Location:136226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
    3. XM_011541872.4XP_011540174.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540174.1

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14626
      Location:13501625
      R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
      cd14629
      Location:16271917
      R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3336
      Ig; Ig strand A [structural motif]
      cd05738
      Location:136226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
    4. XM_006710795.4XP_006710858.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_006710858.1

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14626
      Location:13501625
      R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
      cd14629
      Location:16271917
      R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3336
      Ig; Ig strand A [structural motif]
      cd05738
      Location:136226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
    5. XM_005271079.4XP_005271136.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_005271136.1

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14626
      Location:13501625
      R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
      cd14629
      Location:16271917
      R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3336
      Ig; Ig strand A [structural motif]
      cd05738
      Location:136226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
    6. XM_006710797.4XP_006710860.1  receptor-type tyrosine-protein phosphatase F isoform X5

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13551610
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13811610
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    7. XM_006710801.4XP_006710864.1  receptor-type tyrosine-protein phosphatase F isoform X18

      UniProtKB/TrEMBL
      Q5W9G3
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:11731428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:11991428
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    8. XM_047426504.1XP_047282460.1  receptor-type tyrosine-protein phosphatase F isoform X20

    9. XM_006710796.4XP_006710859.1  receptor-type tyrosine-protein phosphatase F isoform X3

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13571612
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13831612
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    10. XM_006710798.4XP_006710861.1  receptor-type tyrosine-protein phosphatase F isoform X8

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13461601
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13721601
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    11. XM_047426501.1XP_047282457.1  receptor-type tyrosine-protein phosphatase F isoform X19

    12. XM_047426512.1XP_047282468.1  receptor-type tyrosine-protein phosphatase F isoform X22

    13. XM_006710799.4XP_006710862.1  receptor-type tyrosine-protein phosphatase F isoform X11

      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12641519
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:12901519
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    14. XM_047426492.1XP_047282448.1  receptor-type tyrosine-protein phosphatase F isoform X13

    15. XM_017001946.2XP_016857435.1  receptor-type tyrosine-protein phosphatase F isoform X25

      UniProtKB/TrEMBL
      Q5W9G3
    16. XM_006710800.4XP_006710863.1  receptor-type tyrosine-protein phosphatase F isoform X12

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12551510
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:12811510
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    17. XM_017001944.2XP_016857433.1  receptor-type tyrosine-protein phosphatase F isoform X16

      UniProtKB/TrEMBL
      H0Y6Z7
    18. XM_005271080.4XP_005271137.1  receptor-type tyrosine-protein phosphatase F isoform X2

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13621617
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13881617
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    19. XM_047426507.1XP_047282463.1  receptor-type tyrosine-protein phosphatase F isoform X21

    20. XM_005271081.4XP_005271138.1  receptor-type tyrosine-protein phosphatase F isoform X6

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13531608
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13791608
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    21. XM_047426514.1XP_047282470.1  receptor-type tyrosine-protein phosphatase F isoform X23

    22. XM_017001945.2XP_016857434.1  receptor-type tyrosine-protein phosphatase F isoform X14

      UniProtKB/TrEMBL
      H0Y6Z7
    23. XM_005271082.4XP_005271139.1  receptor-type tyrosine-protein phosphatase F isoform X17

      UniProtKB/TrEMBL
      H0Y6Z7
      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12401495
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:12661495
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    24. XM_047426493.1XP_047282449.1  receptor-type tyrosine-protein phosphatase F isoform X15

    25. XM_047426486.1XP_047282442.1  receptor-type tyrosine-protein phosphatase F isoform X10

      Related
      ENSP00000408952.1, ENST00000429895.5
    26. XM_047426475.1XP_047282431.1  receptor-type tyrosine-protein phosphatase F isoform X7

    27. XM_047426483.1XP_047282439.1  receptor-type tyrosine-protein phosphatase F isoform X9

    28. XM_047426519.1XP_047282475.1  receptor-type tyrosine-protein phosphatase F isoform X24

    29. XM_017001942.3XP_016857431.1  receptor-type tyrosine-protein phosphatase F isoform X4

      UniProtKB/TrEMBL
      H0Y6Z7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      43392482..43494171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337957.1XP_054193932.1  receptor-type tyrosine-protein phosphatase F isoform X1

    2. XM_054337955.1XP_054193930.1  receptor-type tyrosine-protein phosphatase F isoform X1

    3. XM_054337956.1XP_054193931.1  receptor-type tyrosine-protein phosphatase F isoform X1

    4. XM_054337954.1XP_054193929.1  receptor-type tyrosine-protein phosphatase F isoform X1

    5. XM_054337961.1XP_054193936.1  receptor-type tyrosine-protein phosphatase F isoform X5

    6. XM_054337974.1XP_054193949.1  receptor-type tyrosine-protein phosphatase F isoform X18

    7. XM_054337976.1XP_054193951.1  receptor-type tyrosine-protein phosphatase F isoform X20

    8. XM_054337959.1XP_054193934.1  receptor-type tyrosine-protein phosphatase F isoform X3

    9. XM_054337964.1XP_054193939.1  receptor-type tyrosine-protein phosphatase F isoform X8

    10. XM_054337975.1XP_054193950.1  receptor-type tyrosine-protein phosphatase F isoform X19

    11. XM_054337978.1XP_054193953.1  receptor-type tyrosine-protein phosphatase F isoform X22

    12. XM_054337967.1XP_054193942.1  receptor-type tyrosine-protein phosphatase F isoform X11

    13. XM_054337969.1XP_054193944.1  receptor-type tyrosine-protein phosphatase F isoform X13

    14. XM_054337981.1XP_054193956.1  receptor-type tyrosine-protein phosphatase F isoform X25

    15. XM_054337968.1XP_054193943.1  receptor-type tyrosine-protein phosphatase F isoform X12

    16. XM_054337972.1XP_054193947.1  receptor-type tyrosine-protein phosphatase F isoform X16

    17. XM_054337958.1XP_054193933.1  receptor-type tyrosine-protein phosphatase F isoform X2

    18. XM_054337977.1XP_054193952.1  receptor-type tyrosine-protein phosphatase F isoform X21

    19. XM_054337962.1XP_054193937.1  receptor-type tyrosine-protein phosphatase F isoform X6

    20. XM_054337979.1XP_054193954.1  receptor-type tyrosine-protein phosphatase F isoform X23

    21. XM_054337970.1XP_054193945.1  receptor-type tyrosine-protein phosphatase F isoform X14

    22. XM_054337973.1XP_054193948.1  receptor-type tyrosine-protein phosphatase F isoform X17

    23. XM_054337971.1XP_054193946.1  receptor-type tyrosine-protein phosphatase F isoform X15

    24. XM_054337966.1XP_054193941.1  receptor-type tyrosine-protein phosphatase F isoform X10

    25. XM_054337963.1XP_054193938.1  receptor-type tyrosine-protein phosphatase F isoform X7

    26. XM_054337965.1XP_054193940.1  receptor-type tyrosine-protein phosphatase F isoform X9

    27. XM_054337980.1XP_054193955.1  receptor-type tyrosine-protein phosphatase F isoform X24

    28. XM_054337960.1XP_054193935.1  receptor-type tyrosine-protein phosphatase F isoform X4