Conserved Protein Domain Family

cd00096: Ig 
Immunoglobulin domain
The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
PSSM-Id: 409353
Aligned: 586 rows
Threshold Bit Score: 28.0639
Created: 1-Nov-2000
Updated: 25-Oct-2021
Aligned Rows:
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand B [structural motif]
  • None

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1      #####                                                                           
1BIH_A     230 TMIYCmygs-npmgYPNYFkngkdvngnpe--------------dritrhnrtsgKRLLFkttlp-edegVYTCEVdngv 293  cecropia moth
1E07_A     221 LNLSChaas-nppaQYSWFvngtfq------------------------qstqelFIPNItvn----nsgSYTCQAhnsd 271  human
2GK2_A      21 VLLLVhnlp-qqlfGYSWYkgervdgnrqivgyaigtqqatpgpansgretiypnASLLIqnvtq-ndtgFYTLQViksd 98   human
4OFD_A     127 YNLTCrafnakpaaTIIWFrdgtqqegavtst-----------ellkdgkrettiSQLLIeptdl-digrVFTCRSmnea 194  house mouse
6ARQ_D     237 ATLTCdarsnpeptGYNWSttmgplp----------------------pfavaqgAQLLIrpvdk-pintTLICNVtnal 293  human
O75326     562 YYLSCpmes--rhaTYSWRhkenveqsc-------------------epghqspnCILFIenlta-qqygHYFCEAqegs 619  human
O60500     563 LNLTCvsvssnppvNLSWDkegerlegvaapp-----------rrapfkgsaaarSVLLQvssr--dhgqRVTCRAhsae 629  human
CAF97406    46 VELRCtvpdhmstwQYRWFkgsee---------------------------lhyhGQIFVlwkarvddtgKYSCQGvrdt 98   Tetraodon nigrov...
A1YIY0     131 VEFLCeahqgslpiFYSFYingeilgk---------------------plapsgrAASLLasvkaewstkNYSCEAknni 189  house mouse
6166019    349 VEFLCmslanplptNYTWYhngkemq----------------------grteekvHIPKIlpw----hagTYSCVAenil 402  human
Feature 1                          
1BIH_A     294 ------------gkpqKHSL 301  cecropia moth
1E07_A     272 t-----------glnrTTVT 280  human
2GK2_A      99 ------------lvneEATG 106  human
4OFD_A     195 i-----------pngkETSI 203  house mouse
6ARQ_D     294 g-----------arqaELTV 302  human
O75326     620 -------------yfrEAQH 626  human
O60500     630 ------------lretVSSF 637  human
CAF97406    99 vvgdirtlqsvpveiiVDGG 118  Tetraodon nigroviridis
A1YIY0     190 s-----------reisELKK 198  house mouse
6166019    403 -------------gtgQRGP 409  human

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