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KALRN kalirin RhoGEF kinase [ Homo sapiens (human) ]

Gene ID: 8997, updated on 2-Oct-2018

Summary

Official Symbol
KALRNprovided by HGNC
Official Full Name
kalirin RhoGEF kinaseprovided by HGNC
Primary source
HGNC:HGNC:4814
See related
Ensembl:ENSG00000160145 MIM:604605; Vega:OTTHUMG00000125545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24
Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
Expression
Broad expression in brain (RPKM 3.5), small intestine (RPKM 1.5) and 20 other tissues See more
Orthologs

Genomic context

See KALRN in Genome Data Viewer
Location:
3q21.1-q21.2
Exon count:
66
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (124033341..124726325)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123813558..124440036)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1 Neighboring gene uncharacterized LOC105374077 Neighboring gene microRNA 5002 Neighboring gene ribosomal protein L7 pseudogene 15 Neighboring gene uncharacterized LOC107986123 Neighboring gene microRNA 6083 Neighboring gene RNA, U6 small nuclear 143, pseudogene Neighboring gene uncharacterized LOC105374076 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene ribosomal protein S26 pseudogene 22 Neighboring gene microRNA 544b Neighboring gene uridine monophosphate synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coronary heart disease 5
MedGen: C1837173 OMIM: 608901 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kalirin, RhoGEF kinase (KALRN) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 downstream pathway, organism-specific biosystem
    Arf6 downstream pathway
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
    EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12332, FLJ16443, FLJ18196, FLJ18623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
 
Rho guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
habituation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of growth hormone secretion IEA
Inferred from Electronic Annotation
more info
 
nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
social behavior IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kalirin
Names
huntingtin-associated protein interacting protein (duo)
serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
NP_001019831.2
NP_001309917.1
NP_001309918.1
NP_001309919.1
NP_001309920.1
NP_001309921.1
NP_001309922.1
NP_001309923.1
NP_001309924.1
NP_001309925.1
NP_001309926.1
NP_001309927.1
NP_001309928.1
NP_001309929.1
NP_001309930.1
NP_003938.1
NP_008995.2
XP_006713873.1
XP_006713874.1
XP_006713875.1
XP_006713876.1
XP_006713877.1
XP_006713878.1
XP_011511581.1
XP_011511582.1
XP_011511583.1
XP_011511585.1
XP_011511587.1
XP_016862918.1
XP_016862919.1
XP_016862920.1
XP_016862921.1
XP_016862922.1
XP_016862923.1
XP_016862924.1
XP_024309579.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012742.2 RefSeqGene

    Range
    4971..636615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024660.4NP_001019831.2  kalirin isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). There are no publicly available transcripts representing the full-length splicing pattern of this variant; it is inferred from data in PMID:11891045 and from the rat homolog, NM_032062.1.
    Source sequence(s)
    AB011422, AC022336, AK125979, AK131379, AK314126, BM930007, BQ345377, DA756158, H11479, R45191, U94190
    UniProtKB/Swiss-Prot
    O60229
    UniProtKB/TrEMBL
    J3QSW6
    Related
    ENSP00000353109.3, ENST00000360013.7
    Conserved Domains (16) summary
    cd00096
    Location:24882562
    Ig; Immunoglobulin domain
    cd11852
    Location:16491708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23252383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26842938
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25692660
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12841454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24712565
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14611583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21072241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26902937
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14941579
    PH; PH domain
    pfam00621
    Location:19332103
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17061932
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:10991238
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_001322988.1NP_001309917.1  kalirin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC069233, AC080008, AC112129, AC117401, AL137629
    UniProtKB/Swiss-Prot
    O60229
  3. NM_001322989.1NP_001309918.1  kalirin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC069233, AC112129, AI024603, AK314126, U94190
    Consensus CDS
    CCDS82829.1
    UniProtKB/Swiss-Prot
    O60229
    UniProtKB/TrEMBL
    C9IZQ6
    Related
    ENSP00000418611.1, OTTHUMP00000215857, ENST00000460856.5, OTTHUMT00000356282
    Conserved Domains (6) summary
    smart00150
    Location:11261226
    SPEC; Spectrin repeats
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12751445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14521574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:14851570
    PH; PH domain
  4. NM_001322990.1NP_001309919.1  kalirin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC069233, AC080008, AC112129, AC117401, AI024603
  5. NM_001322991.1NP_001309920.1  kalirin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC069233, AC080008, AC112129, AC117401, AI024603
  6. NM_001322992.1NP_001309921.1  kalirin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC069233, AC080008, AC112129, AC117401, AI024603
  7. NM_001322993.1NP_001309922.1  kalirin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022336, AC080008, H11479
  8. NM_001322994.1NP_001309923.1  kalirin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  9. NM_001322995.1NP_001309924.1  kalirin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  10. NM_001322996.1NP_001309925.1  kalirin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
    Conserved Domains (5) summary
    cd11853
    Location:627685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:410544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:443529
    PH; PH domain
    pfam00621
    Location:236406
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25235
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  11. NM_001322997.1NP_001309926.1  kalirin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  12. NM_001322998.1NP_001309927.1  kalirin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  13. NM_001322999.1NP_001309928.1  kalirin isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  14. NM_001323000.1NP_001309929.1  kalirin isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  15. NM_001323001.1NP_001309930.1  kalirin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC080008, AL137629
    UniProtKB/Swiss-Prot
    O60229
  16. NM_003947.5NP_003938.1  kalirin isoform 2

    See identical proteins and their annotated locations for NP_003938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks many exons in the 3' coding region, compared to variant 1. The encoded protein (isoform 2), also known as Trad and Duet, is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI024603, AK131379, AK314126, BQ345377, U94190
    Consensus CDS
    CCDS3027.1
    UniProtKB/Swiss-Prot
    O60229
    Related
    ENSP00000240874.3, OTTHUMP00000165775, ENST00000240874.7, OTTHUMT00000258843
    Conserved Domains (6) summary
    smart00150
    Location:11351235
    SPEC; Spectrin repeats
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12841454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537718
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14611583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:14941579
    PH; PH domain
  17. NM_007064.4NP_008995.2  kalirin isoform 3

    See identical proteins and their annotated locations for NP_008995.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks many exons in the 5' coding region, compared to variant 1. The encoded protein (isoform 3), also known as Duo, is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011422, AC022336, AC080008, AK125979, BM930007, DA756158, DB450617, H11479, R45191
    Consensus CDS
    CCDS3028.1
    UniProtKB/Swiss-Prot
    O60229
    Related
    ENSP00000291478.4, OTTHUMP00000155215, ENST00000291478.9, OTTHUMT00000246891
    Conserved Domains (9) summary
    cd00096
    Location:791865
    Ig; Immunoglobulin domain
    cd11853
    Location:628686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:9871241
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:872963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:774868
    I-set; Immunoglobulin I-set domain
    cd13241
    Location:410544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:9931240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236406
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25235
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RNA

  1. NR_028136.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes the same 5' exon but differs in the remaining exons, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK128223, AK311154, AK314126, BC037924

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    124033341..124726325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713815.3XP_006713878.1  kalirin isoform X16

    Conserved Domains (6) summary
    smart00150
    Location:11371237
    SPEC; Spectrin repeats
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539720
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:14961581
    PH; PH domain
  2. XM_017007433.2XP_016862922.1  kalirin isoform X17

  3. XM_017007434.2XP_016862923.1  kalirin isoform X18

  4. XM_017007435.2XP_016862924.1  kalirin isoform X19

  5. XM_011513280.2XP_011511582.1  kalirin isoform X3

    Conserved Domains (16) summary
    cd00096
    Location:24892563
    Ig; Immunoglobulin domain
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23262384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26852939
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25702661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24722566
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21082242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26912938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19342104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081933
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_006713810.3XP_006713873.1  kalirin isoform X1

    Conserved Domains (16) summary
    cd00096
    Location:24902564
    Ig; Immunoglobulin domain
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23272385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26862940
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25712662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24732567
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21092243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26922939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19352105
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081934
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_011513279.2XP_011511581.1  kalirin isoform X2

    Conserved Domains (16) summary
    cd00096
    Location:24892563
    Ig; Immunoglobulin domain
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23262384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26852939
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25702661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24722566
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21092243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26912938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19352105
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081934
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. XM_017007429.1XP_016862918.1  kalirin isoform X7

  9. XM_006713814.3XP_006713877.1  kalirin isoform X9

    Conserved Domains (16) summary
    cd00096
    Location:24582532
    Ig; Immunoglobulin domain
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22952353
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26542908
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25392630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24412535
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20772211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26602907
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19032073
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081865
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. XM_017007430.1XP_016862919.1  kalirin isoform X10

  11. XM_006713811.3XP_006713874.1  kalirin isoform X4

    Related
    OTTHUMP00000165774, OTTHUMT00000258842
    Conserved Domains (16) summary
    cd00096
    Location:24812555
    Ig; Immunoglobulin domain
    cd11852
    Location:16421701
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23182376
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26772931
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25622653
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12771447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24642558
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14541576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21002234
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26832930
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14871572
    PH; PH domain
    pfam00621
    Location:19262096
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16991925
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11241293
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  12. XM_006713812.3XP_006713875.1  kalirin isoform X6

    Conserved Domains (16) summary
    cd00096
    Location:24772551
    Ig; Immunoglobulin domain
    cd11852
    Location:16381697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23142372
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26732927
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25582649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12731443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24602554
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14501572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20962230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26792926
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14831568
    PH; PH domain
    pfam00621
    Location:19222092
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16951921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:10881227
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  13. XM_006713813.3XP_006713876.1  kalirin isoform X8

    Conserved Domains (16) summary
    cd00096
    Location:24682542
    Ig; Immunoglobulin domain
    cd11852
    Location:16291688
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23052363
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26642918
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25492640
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12641434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8801109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24512545
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14411563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20872221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26702917
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14741559
    PH; PH domain
    pfam00621
    Location:19132083
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16861912
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11111280
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  14. XM_011513283.2XP_011511585.1  kalirin isoform X11

    Conserved Domains (11) summary
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23272385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539720
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21092243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19352105
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081934
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  15. XM_011513285.2XP_011511587.1  kalirin isoform X13

    Conserved Domains (11) summary
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22942352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539720
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20772211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:14961581
    PH; PH domain
    pfam00621
    Location:19032073
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17081865
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11011240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  16. XM_017007431.1XP_016862920.1  kalirin isoform X12

  17. XM_017007432.1XP_016862921.1  kalirin isoform X14

  18. XM_024453811.1XP_024309579.1  kalirin isoform X15

    Conserved Domains (10) summary
    smart00150
    Location:11281228
    SPEC; Spectrin repeats
    cd11852
    Location:16421701
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22842342
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12771447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14541576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20672201
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:18932062
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16991855
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  19. XM_011513281.3XP_011511583.1  kalirin isoform X5

    Related
    ENSP00000346122.4, ENST00000354186.8
    Conserved Domains (16) summary
    cd00096
    Location:24792553
    Ig; Immunoglobulin domain
    cd11852
    Location:16401699
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23162374
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26752929
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25602651
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12751445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:24622556
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14521574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20982232
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26812928
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14851570
    PH; PH domain
    pfam00621
    Location:19242094
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16971923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:11221291
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RNA

  1. XR_001740356.1 RNA Sequence

  2. XR_001740357.1 RNA Sequence

  3. XR_001740358.1 RNA Sequence

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