3MFR,2R7B,1ZYC,3HX4,1A06,2W4O,3O96,2QNJ,3Q5I,3HYH,2BDW,3A60,1QL6,3COM,2R5T,2WNT,2Z7Q,2PK9,2X0G,2J51,3COK,2ESM,2XIK,1UA2,3MTL,1KOA,2V5Q,3GOK,3G33,2CLQ,2HOG,2W5A,3BLH,2VD5,3C4X,3ELJ,3DLS,3KVW,2I6L,3ALN,1O6Y,1TKI,2ZMC,1Z57,2WTK,2IWI,2E2B,3C4F,3RP0


Conserved Protein Domain Family
S_TKc

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smart00220: S_TKc 
Click on image for an interactive view with Cn3D
Serine/Threonine protein kinases, catalytic domain
Phosphotransferases. Serine or threonine-specific kinase subfamily.
Statistics
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PSSM-Id: 214567
View PSSM: smart00220
Aligned: 351 rows
Threshold Bit Score: 121.098
Threshold Setting Gi: 2209374
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFR_A        26 YELCEVIGKGAFSVVRRCINRE-TGQQFAVKIVDVAKFTSSPglstEDLKREASICHML---------KHP------HIV 89
gi 297474669 220 YEVLKVIGKGSFGQVVKAYDHK-VHQHVALKMVRNEKR--FH----RQAAEEIRILEHLr-------kQDK------DNT 279
gi 120537328 150 YEIDSLIGKGSFGQVVKAYDRV-EQEWVAIKIIKNKKAF--L----NQAQIEVRLLELMnk-----hdTEM------KYY 211
gi 19113931   11 LTDIRHLTDGTISEVFVGERKN-SKKLYVIKVQGLVFKR-PP----HDAMRGKLILESI---------GHP------HIE 69
gi 151945999  39 VTNHNSLGDGNFSVVKECMNIH-TKDLYAMKLIKKQTVKNKI----QLIQREFDLLRSIsekirdmekKNE------HSL 107
gi 25146830  147 YEVLEFLGKGTFGQVVKAWKKG-TSEIVAIKILKKHPS--YA----RQGQIEVSILSRLsne----nsEEF------NFV 209
gi 19075761  159 YIVQSNLGKGMFSTVVSALDRN-RNQTFAIKIIRNNEVM--Y----KEGLKEVSILERLqaa---dreGKQ------HII 222
gi 291409415 674 YNVYGYTGQGVFSNVVRARDNArANQEVAVKIIRNNEL--MQ----KTGLKELEFLKKLnda---dpdDKF------HCL 738
gi 6322320   369 YLVLDILGQGTFGQVVKCQNLL-TKEILAVKVVKSRTE--YL----TQSITEAKILELLnq------kIDPt-----NKH 430
3KVW_A        99 YEVLKVIGKGSFGQVVKAYDHK-VHQHVALKMVRNEKR--FH----RQAAEEIRILEHL---------RKQdkdntmNVI 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFR_A        90 ELLETYSSD----------GMLYMVFEFMDGa--DLCFEIVKRAdagfV--YSEAVASHYMRQILEALRYCHDN--NIIH 153
gi 297474669 280 MNVIHMLENft------frNHICMTFELLSM---NLYELIKKNK----FqgFSLPLVRKFAHSILQCLDALHKN--RIIH 344
gi 120537328 212 IVHLKRHFMf--------rNHLCLVFEMLSy---NLYDLLRNTN----FrgVSLNLTRKFAQQMCTALLFLATPelSIIH 276
gi 19113931   70 RIVDSFIDNe--------aGSVYLITSFKSF---VLSDVMDE---------ISIDTKCKIVLQISSALEYLEKH--GILH 127
gi 151945999 108 DIFEGHHHIlqlfdyfetaDNIVLITQLCQKg--DLYEKIVENQ----Cl-DLETQVTSYCACLVSVLEFLHSQ--GIVH 178
gi 25146830  210 RAFECFNHK----------SHTCLVFEMLEQ---NLYDFLKQNK----FmpLPLNAIRPILFQVLTALLKLKSL--GLIH 270
gi 19075761  223 HYERHFMHK----------NHLCMVFEMLSLnlrDILKKFGRNV----G--LSIKAVRLYAYQMFMALDLLKQC--NVIH 284
gi 291409415 739 RLFRHFYHK----------QHLCLVFEPLSMnlrEVLKKYGKDV----G--LHIKAVRSYSQQLFLALKLLKRC--NILH 800
gi 6322320   431 HFLRMYDSFvh-------kNHLCLVFELLSN---NLYELLKQNK----FhgLSIQLIRTFTTQILDSLCVLKES--KLIH 494
3KVW_A       163 HMLENFTFR----------NHICMTFELLSM---NLYELIKKNK----FqgFSLPLVRKFAHSILQCLDALHKN--RIIH 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFR_A       154 RDVKPENVLLASK----------------------ENsapVKLGDFGVAIQLGESG----LvAGGRVGTPHFMAPEVVK- 206
gi 297474669 345 CDLKPENILLKQQgr--------------------sG---IKVIDFGSSCYEHQ------R-VYTYIQSRFYRAPEVIL- 393
gi 120537328 277 CDLKPENILLCNPk--------------------rSA---IKIVDFGSSCQLGQR-------IYQYIQSRFYRSPEVLL- 325
gi 19113931  128 RDIHPNNILLDSMn---------------------gP---AYLSDFSIAWSKQHPGeevqE-LIPQIGTGHYRAIETLFg 182
gi 151945999 179 RDLKAENVLFRLRvneneknlqgehhgdfkydllaHD---LVLADFGLAAEYNTSKv--nS-LKEFVGTISYIAPEIVKc 252
gi 25146830  271 ADLKPENIMLVDPqq------------------qpYR---VKVIDFGSASHRSKA-----V-TNTYLQSRYYRAPEIIL- 322
gi 19075761  285 SDIKPDNMLVNEKr---------------------NI---LKICDLGSASDASEN-----E-ITPYLVSRFYRAPEIIL- 333
gi 291409415 801 ADIKPDNILVNESk---------------------TI---LKLCDFGSASHVADND------ITPYLVSRFYRAPEIII- 849
gi 6322320   495 CDLKPENILLCAPdk--------------------pE---LKIIDFGSSCEEAR------T-VYTYIQSRFYRAPEIIL- 543
3KVW_A       224 CDLKPENILLKQQ----------------------GRs-gIKVIDFGSSCYEH--Q----R-VYTXIQSRFYRAPEVIL- 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFR_A       207 -------------REPYGKPVDVWGCGVILFILLSGCLPFYG-----------TKERLFEGI------------------ 244
gi 297474669 394 -------------GARYGMPIDMWSLGCILAELLTGYPLLPGede------gdQLACMIELL------------------ 436
gi 120537328 326 -------------GMPYDLAIDMWSLGCILVEMHTGEPLFSGa----------NEVDQMNKI------------------ 364
gi 19113931  183 -------------CHSYGHEVDRWTFGILIAELFSNQALFDDgssegwpselrLTSSIIQTL------------------ 231
gi 151945999 253 kgvgemtpdqvgkLDKYGCPVDIWALGVLTYFMAFGYTPFDCtt--------dDETLECISK------------------ 306
gi 25146830  323 -------------GLPFNESIDMWSLGCVIAELFLGWPLYPGsse------ydQIRFIIQTQ------------------ 365
gi 19075761  334 -------------GFPYSCPIDTWSVGCSLYELYTGQILFPGr----------TNNQMLRYM------------------ 372
gi 291409415 850 -------------GKSYDYGIDMWSVGCTLYELYTGKILFPGk----------TNNHMLKLA------------------ 888
gi 6322320   544 -------------GIPYSTSIDMWSLGCIVAELFLGIPIFPGase------ynQLTRIIDTL------------------ 586
3KVW_A       273 -------------GARYGMPIDMWSLGCILAELLTGYPLLPGe---------dEGDQLACMIellgmpsqklldaskrak 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFR_A       245 -----------------------------IKGKYKMNPRQWSh------------------------------------- 258
gi 297474669 437 -----------------------------GMP-SQKLLDASKraknfvsskgypryctvttlsdgsvvl----------- 475
gi 120537328 365 -----------------------------VEVLGIPPAHILDqapkarkffeklpdgtwslkktkdgkreyk-------- 407
gi 19113931  232 -----------------------------GTPNPS-MWPELStfpdwnkfifhe-------------------------- 255
gi 151945999 307 -----------------------------CDYYVDEQMMHDP-------------------------------------- 319
gi 25146830  366 -----------------------------GLPPTSMLESASKlhrffkevksespnhtnvggsyyrlktveeyeasss-- 414
gi 19075761  373 -----------------------------MECKGKFSHKMLKrsqflndhfdad-------------------------- 397
gi 291409415 889 -----------------------------MDLKGKMPNKMIRkgvfkdqhfdqnlnfmyievdkvterekv--------- 930
gi 6322320   587 -----------------------------GYP-PSWMIDMGKnsgkfmkklapeesssstqkhrmktieefcreynivek 636
3KVW_A       331 nfvsxkgypryctvttlsdgsvvlnggrsRRGKLRGPPESRE-------------------------------------- 372
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3MFR_A       259 ------------------------------------I--------SESAKD-LVRRMLMLDPAERITVYEALN-HPWL 290
gi 297474669 476 ----------nggrsrrgklrgppesrewgnalkgcD--------DPLFLD-FLKQCLEWDPAVRMTPGQALR-HPWL 533
gi 120537328 408 ------ppgtrklhnilgvetggpggrragesghtvA--------DYLKFKdLILRMLDYDPKTRIQPYYALQ-HSFF 470
gi 19113931  256 -------------------------yppkpwseilpS--------VDTSIQ-YIVSHLVTYSN-RASPSFVIE-SFPK 297
gi 151945999 320 ------------------------------------K--------YEQFWN-FVQCCFTIDPAVRRSAKNLKQ-HPFI 351
gi 25146830  415 taksketrkyifnviddisrvcygfesdpvehlcdrI--------DRQEFVdVLKKMLVLNPDFRITPAEGLE-SKFV 483
gi 19075761  398 ------------------------fnfiqidhdpitN--------QETRKP-VKFSKPTKDIRSRLKEVPTSTdEEFI 442
gi 291409415 931 --------tvmstinptkdlladlvgcqrlpedqrkK--------VHQLKD-LLDQILMLDPAKRISINQALQ-HAFI 990
gi 6322320   637 pskqyfkwrklpdiirnyrypksiqnsqelidqemqN--------RECLIH-FLGGVLNLNPLERWTPQQAML-HPFI 704
3KVW_A       373 ------------------------------------WgnalkgcdDPLFLD-FLKQCLEWDPAVRMTPGQALR-HPWL 412
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