3MFR,2R7B,1ZYC,3HX4,1A06,2W4O,3O96,2QNJ,3Q5I,3HYH,2BDW,3A60,1QL6,3COM,2R5T,2WNT,2Z7Q,2PK9,2X0G,2J51,3COK,2ESM,2XIK,1UA2,3MTL,1KOA,2V5Q,3GOK,3G33,2CLQ,2HOG,2W5A,3BLH,2VD5,3C4X,3ELJ,3DLS,3KVW,2I6L,3ALN,1O6Y,1TKI,2ZMC,1Z57,2WTK,2IWI,2E2B,3C4F,3RP0


Conserved Protein Domain Family
S_TKc

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smart00220: S_TKc 
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Serine/Threonine protein kinases, catalytic domain
Phosphotransferases. Serine or threonine-specific kinase subfamily.
Statistics
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PSSM-Id: 214567
View PSSM: smart00220
Aligned: 351 rows
Threshold Bit Score: 160.003
Threshold Setting Gi: 19113931
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MFR_A        26 YELCEVIGKGAFSVVRRCINRE-TGQQFAVKIVDVAKFTSSPglstEDLKREASICHML---------KHP------HIV 89   human
XP_002687443 220 YEVLKVIGKGSFGQVVKAYDHK-VHQHVALKMVRNEKR--FH----RQAAEEIRILEHLr-------kQDK------DNT 279  cattle
AAI29889     150 YEIDSLIGKGSFGQVVKAYDRV-EQEWVAIKIIKNKKAF--L----NQAQIEVRLLELMnk-----hdTEM------KYY 211  house mouse
NP_593019     11 LTDIRHLTDGTISEVFVGERKN-SKKLYVIKVQGLVFKR-PP----HDAMRGKLILESI---------GHP------HIE 69   Schizosaccharo...
EDN64231      39 VTNHNSLGDGNFSVVKECMNIH-TKDLYAMKLIKKQTVKNKI----QLIQREFDLLRSIsekirdmekKNE------HSL 107  Saccharomyces ...
NP_741761    147 YEVLEFLGKGTFGQVVKAWKKG-TSEIVAIKILKKHPS--YA----RQGQIEVSILSRLsne----nsEEF------NFV 209  nematode
NP_588261    159 YIVQSNLGKGMFSTVVSALDRN-RNQTFAIKIIRNNEVM--Y----KEGLKEVSILERLqaa---dreGKQ------HII 222  Schizosaccharo...
XP_002720996 674 YNVYGYTGQGVFSNVVRARDNArANQEVAVKIIRNNEL--MQ----KTGLKELEFLKKLnda---dpdDKF------HCL 738  rabbit
NP_012394    369 YLVLDILGQGTFGQVVKCQNLL-TKEILAVKVVKSRTE--YL----TQSITEAKILELLnq------kIDPt-----NKH 430  Saccharomyces ...
3KVW_A        99 YEVLKVIGKGSFGQVVKAYDHK-VHQHVALKMVRNEKR--FH----RQAAEEIRILEHL---------RKQdkdntmNVI 162  human
3MFR_A        90 ELLETYSSD----------GMLYMVFEFMDGa--DLCFEIVKRAdagfV--YSEAVASHYMRQILEALRYCHDN--NIIH 153  human
XP_002687443 280 MNVIHMLENft------frNHICMTFELLSM---NLYELIKKNK----FqgFSLPLVRKFAHSILQCLDALHKN--RIIH 344  cattle
AAI29889     212 IVHLKRHFMf--------rNHLCLVFEMLSy---NLYDLLRNTN----FrgVSLNLTRKFAQQMCTALLFLATPelSIIH 276  house mouse
NP_593019     70 RIVDSFIDNe--------aGSVYLITSFKSF---VLSDVMDE---------ISIDTKCKIVLQISSALEYLEKH--GILH 127  Schizosaccharo...
EDN64231     108 DIFEGHHHIlqlfdyfetaDNIVLITQLCQKg--DLYEKIVENQ----Cl-DLETQVTSYCACLVSVLEFLHSQ--GIVH 178  Saccharomyces ...
NP_741761    210 RAFECFNHK----------SHTCLVFEMLEQ---NLYDFLKQNK----FmpLPLNAIRPILFQVLTALLKLKSL--GLIH 270  nematode
NP_588261    223 HYERHFMHK----------NHLCMVFEMLSLnlrDILKKFGRNV----G--LSIKAVRLYAYQMFMALDLLKQC--NVIH 284  Schizosaccharo...
XP_002720996 739 RLFRHFYHK----------QHLCLVFEPLSMnlrEVLKKYGKDV----G--LHIKAVRSYSQQLFLALKLLKRC--NILH 800  rabbit
NP_012394    431 HFLRMYDSFvh-------kNHLCLVFELLSN---NLYELLKQNK----FhgLSIQLIRTFTTQILDSLCVLKES--KLIH 494  Saccharomyces ...
3KVW_A       163 HMLENFTFR----------NHICMTFELLSM---NLYELIKKNK----FqgFSLPLVRKFAHSILQCLDALHKN--RIIH 223  human
3MFR_A       154 RDVKPENVLLASK----------------------ENsapVKLGDFGVAIQLGESG----LvAGGRVGTPHFMAPEVVK- 206  human
XP_002687443 345 CDLKPENILLKQQgr--------------------sG---IKVIDFGSSCYEHQ------R-VYTYIQSRFYRAPEVIL- 393  cattle
AAI29889     277 CDLKPENILLCNPk--------------------rSA---IKIVDFGSSCQLGQR-------IYQYIQSRFYRSPEVLL- 325  house mouse
NP_593019    128 RDIHPNNILLDSMn---------------------gP---AYLSDFSIAWSKQHPGeevqE-LIPQIGTGHYRAIETLFg 182  Schizosaccharo...
EDN64231     179 RDLKAENVLFRLRvneneknlqgehhgdfkydllaHD---LVLADFGLAAEYNTSKv--nS-LKEFVGTISYIAPEIVKc 252  Saccharomyces ...
NP_741761    271 ADLKPENIMLVDPqq------------------qpYR---VKVIDFGSASHRSKA-----V-TNTYLQSRYYRAPEIIL- 322  nematode
NP_588261    285 SDIKPDNMLVNEKr---------------------NI---LKICDLGSASDASEN-----E-ITPYLVSRFYRAPEIIL- 333  Schizosaccharo...
XP_002720996 801 ADIKPDNILVNESk---------------------TI---LKLCDFGSASHVADND------ITPYLVSRFYRAPEIII- 849  rabbit
NP_012394    495 CDLKPENILLCAPdk--------------------pE---LKIIDFGSSCEEAR------T-VYTYIQSRFYRAPEIIL- 543  Saccharomyces ...
3KVW_A       224 CDLKPENILLKQQ----------------------GRs-gIKVIDFGSSCYEH--Q----R-VYTXIQSRFYRAPEVIL- 272  human
3MFR_A       207 -------------REPYGKPVDVWGCGVILFILLSGCLPFYG-----------TKERLFEGI------------------ 244  human
XP_002687443 394 -------------GARYGMPIDMWSLGCILAELLTGYPLLPGede------gdQLACMIELL------------------ 436  cattle
AAI29889     326 -------------GMPYDLAIDMWSLGCILVEMHTGEPLFSGa----------NEVDQMNKI------------------ 364  house mouse
NP_593019    183 -------------CHSYGHEVDRWTFGILIAELFSNQALFDDgssegwpselrLTSSIIQTL------------------ 231  Schizosaccharo...
EDN64231     253 kgvgemtpdqvgkLDKYGCPVDIWALGVLTYFMAFGYTPFDCtt--------dDETLECISK------------------ 306  Saccharomyces ...
NP_741761    323 -------------GLPFNESIDMWSLGCVIAELFLGWPLYPGsse------ydQIRFIIQTQ------------------ 365  nematode
NP_588261    334 -------------GFPYSCPIDTWSVGCSLYELYTGQILFPGr----------TNNQMLRYM------------------ 372  Schizosaccharo...
XP_002720996 850 -------------GKSYDYGIDMWSVGCTLYELYTGKILFPGk----------TNNHMLKLA------------------ 888  rabbit
NP_012394    544 -------------GIPYSTSIDMWSLGCIVAELFLGIPIFPGase------ynQLTRIIDTL------------------ 586  Saccharomyces ...
3KVW_A       273 -------------GARYGMPIDMWSLGCILAELLTGYPLLPGe---------dEGDQLACMIellgmpsqklldaskrak 330  human
3MFR_A       245 -----------------------------IKGKYKMNPRQWSh------------------------------------- 258  human
XP_002687443 437 -----------------------------GMP-SQKLLDASKraknfvsskgypryctvttlsdgsvvl----------- 475  cattle
AAI29889     365 -----------------------------VEVLGIPPAHILDqapkarkffeklpdgtwslkktkdgkreyk-------- 407  house mouse
NP_593019    232 -----------------------------GTPNPS-MWPELStfpdwnkfifhe-------------------------- 255  Schizosaccharo...
EDN64231     307 -----------------------------CDYYVDEQMMHDP-------------------------------------- 319  Saccharomyces ...
NP_741761    366 -----------------------------GLPPTSMLESASKlhrffkevksespnhtnvggsyyrlktveeyeasss-- 414  nematode
NP_588261    373 -----------------------------MECKGKFSHKMLKrsqflndhfdad-------------------------- 397  Schizosaccharo...
XP_002720996 889 -----------------------------MDLKGKMPNKMIRkgvfkdqhfdqnlnfmyievdkvterekv--------- 930  rabbit
NP_012394    587 -----------------------------GYP-PSWMIDMGKnsgkfmkklapeesssstqkhrmktieefcreynivek 636  Saccharomyces ...
3KVW_A       331 nfvsxkgypryctvttlsdgsvvlnggrsRRGKLRGPPESRE-------------------------------------- 372  human
3MFR_A       259 ------------------------------------I--------SESAKD-LVRRMLMLDPAERITVYEALN-HPWL 290  human
XP_002687443 476 ----------nggrsrrgklrgppesrewgnalkgcD--------DPLFLD-FLKQCLEWDPAVRMTPGQALR-HPWL 533  cattle
AAI29889     408 ------ppgtrklhnilgvetggpggrragesghtvA--------DYLKFKdLILRMLDYDPKTRIQPYYALQ-HSFF 470  house mouse
NP_593019    256 -------------------------yppkpwseilpS--------VDTSIQ-YIVSHLVTYSN-RASPSFVIE-SFPK 297  Schizosaccharomy...
EDN64231     320 ------------------------------------K--------YEQFWN-FVQCCFTIDPAVRRSAKNLKQ-HPFI 351  Saccharomyces ce...
NP_741761    415 taksketrkyifnviddisrvcygfesdpvehlcdrI--------DRQEFVdVLKKMLVLNPDFRITPAEGLE-SKFV 483  nematode
NP_588261    398 ------------------------fnfiqidhdpitN--------QETRKP-VKFSKPTKDIRSRLKEVPTSTdEEFI 442  Schizosaccharomy...
XP_002720996 931 --------tvmstinptkdlladlvgcqrlpedqrkK--------VHQLKD-LLDQILMLDPAKRISINQALQ-HAFI 990  rabbit
NP_012394    637 pskqyfkwrklpdiirnyrypksiqnsqelidqemqN--------RECLIH-FLGGVLNLNPLERWTPQQAML-HPFI 704  Saccharomyces ce...
3KVW_A       373 ------------------------------------WgnalkgcdDPLFLD-FLKQCLEWDPAVRMTPGQALR-HPWL 412  human
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