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ORAI2 ORAI calcium release-activated calcium modulator 2 [ Homo sapiens (human) ]

Gene ID: 80228, updated on 2-Nov-2024

Summary

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Official Symbol
ORAI2provided by HGNC
Official Full Name
ORAI calcium release-activated calcium modulator 2provided by HGNC
Primary source
HGNC:HGNC:21667
See related
Ensembl:ENSG00000160991 MIM:610929; AllianceGenome:HGNC:21667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBCIP2; C7orf19; MEM142B; TMEM142B
Summary
Enables store-operated calcium channel activity. Involved in store-operated calcium entry. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues See more
Orthologs
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Genomic context

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See ORAI2 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102433575..102456825)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103751220..103774454)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102074022..102097272)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100289561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18502 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18503 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102036787-102037328 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26431 Neighboring gene NANOG hESC enhancer GRCh37_chr7:102061269-102061799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102066011-102066914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26433 Neighboring gene Sharpr-MPRA regulatory region 9959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102086939-102087486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102095159-102095659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102105053-102105702 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102105832-102106358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102106359-102106884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26437 Neighboring gene microRNA 5090 Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly. Wu S, et al. Cancer Res, 2021 Feb 15. PMID 33310726
  2. Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses. Yuan F, et al. Dis Markers, 2019. PMID 31772693, Free PMC Article
  3. Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling. Singh AK, et al. Life Sci, 2020 Nov 15. PMID 32882268
  4. ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells. Scremin E, et al. Int J Mol Sci, 2020 Jul 25. PMID 32722509, Free PMC Article
  5. Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue. Ma Y, et al. Nat Commun, 2021 Dec 2. PMID 34857756, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
    Title: Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
  2. Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
    Title: Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
  3. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly.
    Title: ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly.
  4. ORAI2 Down-Regulation Potentiates SOCE and Decreases Abeta42 Accumulation in Human Neuroglioma Cells.
    Title: ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells.
  5. Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-kappaB signalling.
    Title: Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling.
  6. Higher expression of Orai2 was independently associated with a worse prognosis of patients with the classical and mesenchymal subtypes of glioblastoma.A strong association between Orai2 expression and apoptosis, stemness, and an epithelial-mesenchymal transition in the glioblastoma.
    Title: Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses.
  7. ORAI1-3, are preferentially expressed in proximal tubular epithelial cells and downregulated in patients with diabetic nephropathy.
    Title: ORAI channels are critical for receptor-mediated endocytosis of albumin.
  8. findings provide evidence for a role for Orai1 and Orai2, in SOCE and migration in the human HL60 promyeloblastic cell line
    Title: Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.
  9. results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
    Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
  10. Orai1, Orai2 and STIM1 form functional Ca(2+) release-activated Ca(2+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2+) entry in response to agonist stimulation.
    Title: Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12474, FLJ14733, FLJ44818

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables store-operated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in store-operated calcium entry IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein orai-2
Names
CAP-binding protein complex interacting protein 2
H_NH0514P08.8
putative protein ORAI2-2
transmembrane protein 142B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126340.3 → NP_001119812.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_001119812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
    UniProtKB/TrEMBL
    C9JQR7
    Related
    ENSP00000420178.2, ENST00000495936.7
    Conserved Domains (1) summary
    pfam07856
    Location:47 → 228
    Orai-1; Mediator of CRAC channel activity

  2. NM_001271818.2 → NP_001258747.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_001258747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, CN366874, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
    UniProtKB/TrEMBL
    C9JQR7
    Related
    ENSP00000348752.2, ENST00000356387.6
    Conserved Domains (1) summary
    pfam07856
    Location:47 → 228
    Orai-1; Mediator of CRAC channel activity

  3. NM_001271819.2 → NP_001258748.1  protein orai-2 isoform b

    See identical proteins and their annotated locations for NP_001258748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' UTR compared to variant 3, initiating translation at an alternate downstream in-frame start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC093668, DC384892, HY064081
    UniProtKB/TrEMBL
    B4DUB4
    Conserved Domains (1) summary
    pfam07856
    Location:1 → 151
    Orai-1; Mediator of CRAC channel activity

  4. NM_032831.4 → NP_116220.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_116220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, AK027639, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
    UniProtKB/TrEMBL
    C9JQR7
    Related
    ENSP00000385489.3, ENST00000403646.8
    Conserved Domains (1) summary
    pfam07856
    Location:47 → 228
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102433575..102456825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103751220..103774454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96SN7.1 GenPept UniProtKB/Swiss-Prot:Q96SN7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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