Format

Send to:

Choose Destination

ORAI2 ORAI calcium release-activated calcium modulator 2 [ Homo sapiens (human) ]

Gene ID: 80228, updated on 9-Aug-2021

Summary

Official Symbol
ORAI2provided by HGNC
Official Full Name
ORAI calcium release-activated calcium modulator 2provided by HGNC
Primary source
HGNC:HGNC:21667
See related
Ensembl:ENSG00000160991 MIM:610929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBCIP2; C7orf19; MEM142B; TMEM142B
Expression
Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ORAI2 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102433575..102456825)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102074022..102097272)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene microRNA 5090 Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12474, FLJ14733, FLJ44818

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein orai-2
Names
CAP-binding protein complex interacting protein 2
H_NH0514P08.8
putative protein ORAI2-2
transmembrane protein 142B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126340.3NP_001119812.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_001119812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q96SN7
    Related
    ENSP00000420178.2, ENST00000495936.7
    Conserved Domains (1) summary
    pfam07856
    Location:47228
    Orai-1; Mediator of CRAC channel activity
  2. NM_001271818.2NP_001258747.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_001258747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, CN366874, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q96SN7
    Related
    ENSP00000348752.2, ENST00000356387.6
    Conserved Domains (1) summary
    pfam07856
    Location:47228
    Orai-1; Mediator of CRAC channel activity
  3. NM_001271819.2NP_001258748.1  protein orai-2 isoform b

    See identical proteins and their annotated locations for NP_001258748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' UTR compared to variant 3, initiating translation at an alternate downstream in-frame start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC093668, DC384892, HY064081
    UniProtKB/TrEMBL
    B4DUB4
    Conserved Domains (1) summary
    pfam07856
    Location:1151
    Orai-1; Mediator of CRAC channel activity
  4. NM_032831.4NP_116220.1  protein orai-2 isoform a

    See identical proteins and their annotated locations for NP_116220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC093668, AK027639, HY064081
    Consensus CDS
    CCDS5722.1
    UniProtKB/Swiss-Prot
    Q96SN7
    Related
    ENSP00000385489.3, ENST00000403646.8
    Conserved Domains (1) summary
    pfam07856
    Location:47228
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102433575..102456825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center