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Orai2 ORAI calcium release-activated calcium modulator 2 [ Mus musculus (house mouse) ]

Gene ID: 269717, updated on 5-Mar-2024

Summary

Official Symbol
Orai2provided by MGI
Official Full Name
ORAI calcium release-activated calcium modulator 2provided by MGI
Primary source
MGI:MGI:2443195
See related
Ensembl:ENSMUSG00000039747 AllianceGenome:MGI:2443195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem142b; A730041O15Rik
Summary
Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Located in membrane. Is expressed in several structures, including foregut; nervous system; nose; skin; and tooth. Orthologous to human ORAI2 (ORAI calcium release-activated calcium modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 40.1), spleen adult (RPKM 26.5) and 20 other tissues See more
Orthologs
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Genomic context

See Orai2 in Genome Data Viewer
Location:
5 G2; 5 75.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136176310..136201418, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136147456..136170697, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6388 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene STARR-positive B cell enhancer ABC_E3629 Neighboring gene Prkr interacting protein 1 (IL11 inducible) Neighboring gene STARR-positive B cell enhancer ABC_E531 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein orai-2
Names
calcium release-activated calcium channel 2
transmembrane protein 142B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178751.3NP_848866.2  protein orai-2

    See identical proteins and their annotated locations for NP_848866.2

    Status: VALIDATED

    Source sequence(s)
    AC087420, BB640180, BC115648
    Consensus CDS
    CCDS39326.1
    UniProtKB/Swiss-Prot
    Q8BH10, Q8C953
    UniProtKB/TrEMBL
    A3KCG2, Q14BR6
    Related
    ENSMUSP00000037137.2, ENSMUST00000041048.6
    Conserved Domains (1) summary
    pfam07856
    Location:47224
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136176310..136201418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504431.5XP_006504494.1  protein orai-2 isoform X2

    See identical proteins and their annotated locations for XP_006504494.1

    UniProtKB/Swiss-Prot
    Q8BH10, Q8C953
    UniProtKB/TrEMBL
    A3KCG2, Q14BR6
    Conserved Domains (1) summary
    pfam07856
    Location:47224
    Orai-1; Mediator of CRAC channel activity
  2. XM_006504430.5XP_006504493.1  protein orai-2 isoform X2

    See identical proteins and their annotated locations for XP_006504493.1

    UniProtKB/Swiss-Prot
    Q8BH10, Q8C953
    UniProtKB/TrEMBL
    A3KCG2, Q14BR6
    Conserved Domains (1) summary
    pfam07856
    Location:47224
    Orai-1; Mediator of CRAC channel activity
  3. XM_006504429.5XP_006504492.1  protein orai-2 isoform X1

    See identical proteins and their annotated locations for XP_006504492.1

    UniProtKB/TrEMBL
    A3KCG2, A5CVE1
    Related
    ENSMUSP00000142597.2, ENSMUST00000196454.5
    Conserved Domains (1) summary
    pfam07856
    Location:61238
    Orai-1; Mediator of CRAC channel activity