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PRKRIP1 PRKR interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 79706, updated on 4-Dec-2022

Summary

Official Symbol
PRKRIP1provided by HGNC
Official Full Name
PRKR interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:21894
See related
Ensembl:ENSG00000128563 MIM:617458; AllianceGenome:HGNC:21894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C114; KRBOX3
Summary
Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 12.5), lymph node (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

See PRKRIP1 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102396363..102426666)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103714021..103744302)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102036810..102067113)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family member E6 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene uncharacterized LOC100289561 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o Neighboring gene Sharpr-MPRA regulatory region 9959 Neighboring gene ORAI calcium release-activated calcium modulator 2 Neighboring gene alkB homolog 4, lysine demethylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ORAI2

Readthrough LOC100630923

Readthrough gene: LOC100630923, Included gene: LOC100289561

Homology

Clone Names

  • FLJ13902, FLJ40957

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in renal system process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PRKR-interacting protein 1
Names
KRAB box domain containing 3
PRKR interacting protein 1 (IL11 inducible)
likely ortholog of mouse C114 dsRNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024653.4NP_078929.1  PRKR-interacting protein 1

    See identical proteins and their annotated locations for NP_078929.1

    Status: VALIDATED

    Source sequence(s)
    AC073517
    Consensus CDS
    CCDS34714.1
    UniProtKB/Swiss-Prot
    Q96CF8, Q9H875
    UniProtKB/TrEMBL
    A0A024QYV5
    Related
    ENSP00000381010.3, ENST00000397912.3
    Conserved Domains (1) summary
    pfam06658
    Location:42125
    DUF1168; Protein of unknown function (DUF1168)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102396363..102426666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103714021..103744302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)