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ZNF7 zinc finger protein 7 [ Homo sapiens (human) ]

Gene ID: 7553, updated on 1-Jun-2020

Summary

Official Symbol
ZNF7provided by HGNC
Official Full Name
zinc finger protein 7provided by HGNC
Primary source
HGNC:HGNC:13139
See related
Ensembl:ENSG00000147789 MIM:194531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX4; zf30; HF.16
Expression
Ubiquitous expression in testis (RPKM 4.3), endometrium (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See ZNF7 in Genome Data Viewer
Location:
8q24.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144827509..144848070)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146052855..146072893)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 6850 Neighboring gene ribosomal protein L8 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 517 Neighboring gene COMM domain containing 5 Neighboring gene zinc finger protein 250 Neighboring gene zinc finger protein 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38706

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 7
Names
C2-H2 type zinc finger protein
Zinc finger protein-7 (KOX4)
zinc finger protein 7 (KOX 4, clone HF.16)
zinc finger protein HF.16
zinc finger protein KOX4
zinc finger protein zfp30

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282795.2NP_001269724.1  zinc finger protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001269724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF235103, AK300001
    Consensus CDS
    CCDS64996.1
    UniProtKB/Swiss-Prot
    P17097
    Related
    ENSP00000393260.2, ENST00000446747.6
    Conserved Domains (7) summary
    PHA02693
    Location:54127
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:1576
    KRAB; krueppel associated box
    COG5048
    Location:229686
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1552
    KRAB; KRAB box
    pfam13465
    Location:360384
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001282796.2NP_001269725.1  zinc finger protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001269725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The enocded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF235103, AI862153, AK096025
    Consensus CDS
    CCDS64998.1
    UniProtKB/Swiss-Prot
    P17097
    Related
    ENSP00000435252.1, ENST00000525266.5
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    pfam01352
    Location:441
    KRAB; KRAB box
    pfam10212
    Location:30129
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein
  3. NM_001282797.1NP_001269726.1  zinc finger protein 7 isoform 4

    See identical proteins and their annotated locations for NP_001269726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 6 encode the same protein (isoform 4).
    Source sequence(s)
    AF235103, AK301561, BJ989518, M29580
    Consensus CDS
    CCDS64999.1
    UniProtKB/Swiss-Prot
    P17097
    UniProtKB/TrEMBL
    B4DWJ4, F5H290
    Related
    ENSP00000439424.1, ENST00000544249.2
    Conserved Domains (2) summary
    COG5048
    Location:122543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001330623.1NP_001317552.1  zinc finger protein 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF235103, AK300001, DA538365
    Consensus CDS
    CCDS83336.1
    UniProtKB/Swiss-Prot
    P17097
    UniProtKB/TrEMBL
    E9PIH3
    Related
    ENSP00000318848.5, ENST00000325217.9
  5. NM_001349805.2NP_001336734.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, DB554904, DC345768, M29580
    Consensus CDS
    CCDS64999.1
    Conserved Domains (2) summary
    COG5048
    Location:122543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001349806.2NP_001336735.1  zinc finger protein 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, DB554904, DC345768, DC357767, M29580
    Conserved Domains (4) summary
    smart00349
    Location:2182
    KRAB; krueppel associated box
    COG5048
    Location:235692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:60133
    PHA02693; hypothetical protein; Provisional
  7. NM_001349807.2NP_001336736.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, DA926250, DB554904, DC345768, M29580
    Conserved Domains (4) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:217674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:46115
    PHA02693; hypothetical protein; Provisional
  8. NM_001349808.2NP_001336737.1  zinc finger protein 7 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, CD617091, DB554904, DC345768, DC357767, M29580
    Conserved Domains (4) summary
    smart00349
    Location:2181
    KRAB; krueppel associated box
    COG5048
    Location:234691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:63132
    PHA02693; hypothetical protein; Provisional
  9. NM_001349809.2NP_001336738.1  zinc finger protein 7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, CT004931, DB554904, DC345768, DC357767, M29580
    Conserved Domains (4) summary
    smart00349
    Location:2586
    KRAB; krueppel associated box
    COG5048
    Location:239696
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:64137
    PHA02693; hypothetical protein; Provisional
  10. NM_003416.4NP_003407.1  zinc finger protein 7 isoform 2

    See identical proteins and their annotated locations for NP_003407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF235103, BC058923
    Consensus CDS
    CCDS6435.1
    UniProtKB/Swiss-Prot
    P17097
    Related
    ENSP00000432724.1, ENST00000528372.5
    Conserved Domains (7) summary
    PHA02693
    Location:43116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:218675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:441
    KRAB; KRAB box
    pfam13465
    Location:349373
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144827509..144848070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013816.2XP_016869305.1  zinc finger protein 7 isoform X6

  2. XM_017013815.2XP_016869304.1  zinc finger protein 7 isoform X2

  3. XM_006716654.3XP_006716717.1  zinc finger protein 7 isoform X5

    See identical proteins and their annotated locations for XP_006716717.1

    UniProtKB/TrEMBL
    F5H290
    Conserved Domains (2) summary
    COG5048
    Location:122543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011517293.2XP_011515595.1  zinc finger protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011515595.1

    UniProtKB/Swiss-Prot
    P17097
    Conserved Domains (7) summary
    PHA02693
    Location:43116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:218675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:441
    KRAB; KRAB box
    pfam13465
    Location:349373
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011517292.3XP_011515594.1  zinc finger protein 7 isoform X3

    See identical proteins and their annotated locations for XP_011515594.1

    UniProtKB/Swiss-Prot
    P17097
    Conserved Domains (7) summary
    PHA02693
    Location:54127
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:1576
    KRAB; krueppel associated box
    COG5048
    Location:229686
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1552
    KRAB; KRAB box
    pfam13465
    Location:360384
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011517296.3XP_011515598.1  zinc finger protein 7 isoform X4

    See identical proteins and their annotated locations for XP_011515598.1

    Conserved Domains (4) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:217674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:46115
    PHA02693; hypothetical protein; Provisional
  7. XM_011517294.2XP_011515596.1  zinc finger protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011515596.1

    UniProtKB/Swiss-Prot
    P17097
    Conserved Domains (7) summary
    PHA02693
    Location:43116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:218675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:441
    KRAB; KRAB box
    pfam13465
    Location:349373
    zf-H2C2_2; Zinc-finger double domain
  8. XM_006716656.4XP_006716719.1  zinc finger protein 7 isoform X5

    See identical proteins and their annotated locations for XP_006716719.1

    UniProtKB/TrEMBL
    F5H290
    Conserved Domains (2) summary
    COG5048
    Location:122543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
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