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Zfp7 zinc finger protein 7 [ Mus musculus (house mouse) ]

Gene ID: 223669, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp7provided by MGI
Official Full Name
zinc finger protein 7provided by MGI
Primary source
MGI:MGI:99208
See related
Ensembl:ENSMUSG00000033669 AllianceGenome:MGI:99208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB7; Zfp-7; Zfp65; Zfp80; KRAB20; Krox-2; mszf73-2; Zfp86-rs1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; metanephros; nasal cavity epithelium; nervous system; and ureter. Orthologous to human ZNF7 (zinc finger protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.7), bladder adult (RPKM 4.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp7 in Genome Data Viewer
Location:
15 D3; 15 36.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76763440..76786089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76879253..76892395)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene zinc finger protein 251 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 647

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
  2. Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve. Taïb S, et al. Elife, 2022 Jan 12. PMID 35019839, Free PMC Article
  3. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  4. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  5. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC6397

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 7
Names
zinc finger protein 86, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358816.2 → NP_001345745.1  zinc finger protein 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS37124.1
    UniProtKB/TrEMBL
    Q3TFZ4, Q921K6
    Related
    ENSMUSP00000155599.2, ENSMUST00000230106.2
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:246 → 668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001358817.3 → NP_001345746.1  zinc finger protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC157554
    UniProtKB/TrEMBL
    Q921K6
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:245 → 667
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001358818.3 → NP_001345747.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC157554
    Conserved Domains (2) summary
    COG5048
    Location:103 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001416163.1 → NP_001403092.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157554

  5. NM_001416164.1 → NP_001403093.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157554

  6. NM_001416166.1 → NP_001403095.1  zinc finger protein 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157554

  7. NM_001416167.1 → NP_001403096.1  zinc finger protein 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157554

  8. NM_001416168.1 → NP_001403097.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157554

  9. NM_001416169.1 → NP_001403098.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157554

  10. NM_001416170.1 → NP_001403099.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  11. NM_001416171.1 → NP_001403100.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  12. NM_001416172.1 → NP_001403101.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  13. NM_001416173.1 → NP_001403102.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  14. NM_001416174.1 → NP_001403103.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  15. NM_001416175.1 → NP_001403104.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  16. NM_001416176.1 → NP_001403105.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  17. NM_001416177.1 → NP_001403106.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  18. NM_001416178.1 → NP_001403107.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  19. NM_001416179.1 → NP_001403108.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  20. NM_001416180.1 → NP_001403109.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  21. NM_001416181.1 → NP_001403110.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  22. NM_001416182.1 → NP_001403111.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  23. NM_001416183.1 → NP_001403112.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554

  24. NM_001416184.1 → NP_001403113.1  zinc finger protein 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157554

  25. NM_145916.5 → NP_666021.2  zinc finger protein 7 isoform 1

    See identical proteins and their annotated locations for NP_666021.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS37124.1
    UniProtKB/TrEMBL
    Q3TFZ4, Q921K6
    Related
    ENSMUSP00000023179.6, ENSMUST00000023179.7
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:246 → 668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76763440..76786089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_183485.1: Suppressed sequence

    Description
    NR_183485.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

  2. NR_183486.1: Suppressed sequence

    Description
    NR_183486.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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