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Zfp7 zinc finger protein 7 [ Mus musculus (house mouse) ]

Gene ID: 223669, updated on 3-Apr-2024

Summary

Official Symbol
Zfp7provided by MGI
Official Full Name
zinc finger protein 7provided by MGI
Primary source
MGI:MGI:99208
See related
Ensembl:ENSMUSG00000033669 AllianceGenome:MGI:99208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB7; Zfp-7; Zfp65; Zfp80; KRAB20; Krox-2; mszf73-2; Zfp86-rs1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; ganglia; metanephros; nasal cavity epithelium; and ureter. Orthologous to human ZNF7 (zinc finger protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.7), bladder adult (RPKM 4.6) and 27 other tissues See more
Orthologs
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Genomic context

See Zfp7 in Genome Data Viewer
Location:
15 D3; 15 36.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76763440..76786089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76879253..76892395)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene zinc finger protein 251 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 647

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC6397

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 7
Names
zinc finger protein 86, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358816.2NP_001345745.1  zinc finger protein 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS37124.1
    UniProtKB/TrEMBL
    Q3TFZ4, Q921K6
    Related
    ENSMUSP00000155599.2, ENSMUST00000230106.2
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:246668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001358817.3NP_001345746.1  zinc finger protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC157554
    UniProtKB/TrEMBL
    Q921K6
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:245667
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441461
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001358818.3NP_001345747.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC157554
    Conserved Domains (2) summary
    COG5048
    Location:103525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299319
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001416163.1NP_001403092.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157554
  5. NM_001416164.1NP_001403093.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157554
  6. NM_001416166.1NP_001403095.1  zinc finger protein 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157554
  7. NM_001416167.1NP_001403096.1  zinc finger protein 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157554
  8. NM_001416168.1NP_001403097.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157554
  9. NM_001416169.1NP_001403098.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157554
  10. NM_001416170.1NP_001403099.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  11. NM_001416171.1NP_001403100.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  12. NM_001416172.1NP_001403101.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  13. NM_001416173.1NP_001403102.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  14. NM_001416174.1NP_001403103.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  15. NM_001416175.1NP_001403104.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  16. NM_001416176.1NP_001403105.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  17. NM_001416177.1NP_001403106.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  18. NM_001416178.1NP_001403107.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  19. NM_001416179.1NP_001403108.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  20. NM_001416180.1NP_001403109.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  21. NM_001416181.1NP_001403110.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  22. NM_001416182.1NP_001403111.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  23. NM_001416183.1NP_001403112.1  zinc finger protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157554
  24. NM_001416184.1NP_001403113.1  zinc finger protein 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157554
  25. NM_145916.5NP_666021.2  zinc finger protein 7 isoform 1

    See identical proteins and their annotated locations for NP_666021.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS37124.1
    UniProtKB/TrEMBL
    Q3TFZ4, Q921K6
    Related
    ENSMUSP00000023179.6, ENSMUST00000023179.7
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:246668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_183485.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157554
  2. NR_183486.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157554

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76763440..76786089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)