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MECOM MDS1 and EVI1 complex locus [ Homo sapiens (human) ]

Gene ID: 2122, updated on 28-Jun-2020

Summary

Official Symbol
MECOMprovided by HGNC
Official Full Name
MDS1 and EVI1 complex locusprovided by HGNC
Primary source
HGNC:HGNC:3498
See related
Ensembl:ENSG00000085276 MIM:165215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1
Summary
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Expression
Broad expression in stomach (RPKM 15.9), kidney (RPKM 12.6) and 18 other tissues See more
Orthologs

Genomic context

See MECOM in Genome Data Viewer
Location:
3q26.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (169083499..169663781, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (168801287..169381563, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986051 Neighboring gene long intergenic non-protein coding RNA 1997 Neighboring gene Sharpr-MPRA regulatory region 14107 Neighboring gene VISTA enhancer hs1433 Neighboring gene uncharacterized LOC105374206 Neighboring gene MECOM antisense RNA 1 Neighboring gene ribosomal protein L22 pseudogene 1 Neighboring gene RNA, U6 small nuclear 637, pseudogene Neighboring gene succinate dehydrogenase complex subunit D pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Radioulnar synostosis with amegakaryocytic thrombocytopenia 2
MedGen: C4225221 OMIM: 616738 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of aging.
NHGRI GWA Catalog
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
NHGRI GWA Catalog
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Genome-wide association study of blood pressure and hypertension.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.
NHGRI GWA Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MDS1 and EVI1 complex locus (MECOM) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC97004, MGC163392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity (H3-K9 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
heterochromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-K9 methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase MECOM
Names
AML1-EVI-1 fusion protein
MDS1 and EVI1 complex locus protein EVI1
MDS1 and EVI1 complex locus protein MDS1
PR domain 3
ecotropic virus integration site 1 protein homolog
myelodysplasia syndrome-associated protein 1
oncogene EVI1
zinc finger protein Evi1
NP_001098547.3
NP_001098548.2
NP_001157471.1
NP_001157472.1
NP_001192123.1
NP_001353395.1
NP_001353396.1
NP_001353397.1
NP_001353398.1
NP_001353399.1
NP_001353400.1
NP_001353401.1
NP_001353402.1
NP_001353403.1
NP_004982.2
NP_005232.2
XP_005247270.1
XP_005247271.1
XP_005247278.1
XP_005247281.1
XP_005247282.1
XP_011510848.1
XP_016861363.1
XP_016861366.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028279.2 RefSeqGene

    Range
    5064..585269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105077.3NP_001098547.3  histone-lysine N-methyltransferase MECOM isoform a

    See identical proteins and their annotated locations for NP_001098547.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AA043944, AC078985, BC130520, BX647613
    Consensus CDS
    CCDS54670.1
    UniProtKB/Swiss-Prot
    Q03112
    Related
    ENSP00000264674.3, ENST00000264674.7
    Conserved Domains (5) summary
    smart00317
    Location:872
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:800820
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:798820
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:812836
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:228309
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001105078.4NP_001098548.2  histone-lysine N-methyltransferase MECOM isoform b

    See identical proteins and their annotated locations for NP_001098548.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as EVI1_1b) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
    Source sequence(s)
    AC078985, AK292865, BX647613
    Consensus CDS
    CCDS3205.1
    UniProtKB/Swiss-Prot
    Q03112
    Related
    ENSP00000419995.1, ENST00000468789.5
    Conserved Domains (6) summary
    PHA00733
    Location:689785
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:735755
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:733755
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:747771
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  3. NM_001163999.1NP_001157471.1  histone-lysine N-methyltransferase MECOM isoform d

    See identical proteins and their annotated locations for NP_001157471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' UTR and 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AA043944, AC078985, BC143952, BX647613
    UniProtKB/Swiss-Prot
    Q03112
    Conserved Domains (4) summary
    PHA00733
    Location:658777
    PHA00733; hypothetical protein
    sd00017
    Location:727747
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:739763
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164248
    zf-C2H2_8; C2H2-type zinc ribbon
  4. NM_001164000.2NP_001157472.1  histone-lysine N-methyltransferase MECOM isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as EVI1_1a) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC078985, BX640908, BX647613
    Consensus CDS
    CCDS54669.1
    UniProtKB/Swiss-Prot
    Q03112
    Related
    ENSP00000419770.1, ENST00000464456.5
    Conserved Domains (5) summary
    PHA00733
    Location:657776
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:726746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:738762
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  5. NM_001205194.2NP_001192123.1  histone-lysine N-methyltransferase MECOM isoform b

    See identical proteins and their annotated locations for NP_001192123.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
    Source sequence(s)
    BC130520, BX647613, DC347146, GQ352634
    Consensus CDS
    CCDS3205.1
    UniProtKB/Swiss-Prot
    Q03112
    UniProtKB/TrEMBL
    C7FEN9
    Conserved Domains (6) summary
    PHA00733
    Location:689785
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:735755
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:733755
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:747771
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  6. NM_001366466.2NP_001353395.1  histone-lysine N-methyltransferase MECOM isoform f

    Status: REVIEWED

    Source sequence(s)
    AC078985, AK308404, AL700380, DC417787
    Related
    ENSP00000417899.1, ENST00000494292.6
    Conserved Domains (6) summary
    PHA00733
    Location:845964
    PHA00733; hypothetical protein
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5189
    Location:302395
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:914934
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:926950
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:351435
    zf-C2H2_8; C2H2-type zinc ribbon
  7. NM_001366467.2NP_001353396.1  histone-lysine N-methyltransferase MECOM isoform g

    Status: REVIEWED

    Source sequence(s)
    AC078985, AK025934
    Conserved Domains (5) summary
    PHA00733
    Location:690786
    PHA00733; hypothetical protein
    sd00017
    Location:736756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164248
    zf-C2H2_8; C2H2-type zinc ribbon
  8. NM_001366468.2NP_001353397.1  histone-lysine N-methyltransferase MECOM isoform g

    Status: REVIEWED

    Source sequence(s)
    AC078985, CN272058, DA229108, DB222598
    Related
    ENSP00000420048.1, ENST00000472280.5
    Conserved Domains (5) summary
    PHA00733
    Location:690786
    PHA00733; hypothetical protein
    sd00017
    Location:736756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164248
    zf-C2H2_8; C2H2-type zinc ribbon
  9. NM_001366469.2NP_001353398.1  histone-lysine N-methyltransferase MECOM isoform b

    Status: REVIEWED

    Source sequence(s)
    AC078985, AK025934
    Conserved Domains (6) summary
    PHA00733
    Location:689785
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:735755
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:733755
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:747771
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  10. NM_001366470.2NP_001353399.1  histone-lysine N-methyltransferase MECOM isoform d

    Status: REVIEWED

    Source sequence(s)
    AC078985, BC031019
    Conserved Domains (4) summary
    PHA00733
    Location:658777
    PHA00733; hypothetical protein
    sd00017
    Location:727747
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:739763
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164248
    zf-C2H2_8; C2H2-type zinc ribbon
  11. NM_001366471.2NP_001353400.1  histone-lysine N-methyltransferase MECOM isoform e

    Status: REVIEWED

    Source sequence(s)
    AC078985, AF487422, DA450456
    Related
    ENSP00000420466.1, ENST00000460814.5
    Conserved Domains (5) summary
    PHA00733
    Location:657776
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:726746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:738762
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  12. NM_001366472.2NP_001353401.1  histone-lysine N-methyltransferase MECOM isoform e

    Status: REVIEWED

    Source sequence(s)
    AC078985
    Conserved Domains (5) summary
    PHA00733
    Location:657776
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:726746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:738762
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon
  13. NM_001366473.2NP_001353402.1  histone-lysine N-methyltransferase MECOM isoform h

    Status: REVIEWED

    Source sequence(s)
    AC078985, AL700380, BC031019, BG427944, DB225328, DC417787
    Conserved Domains (4) summary
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:289631
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:590610
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:630656
    zf-H2C2_2; Zinc-finger double domain
  14. NM_001366474.2NP_001353403.1  histone-lysine N-methyltransferase MECOM isoform i

    Status: REVIEWED

    Source sequence(s)
    AC078985, BF035536, BG427944, BX482681, DA588194, DA738166, DT219127
    Conserved Domains (4) summary
    PHA00733
    Location:333452
    PHA00733; hypothetical protein
    COG5048
    Location:101443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:414438
    zf-H2C2_2; Zinc-finger double domain
  15. NM_004991.4NP_004982.2  histone-lysine N-methyltransferase MECOM isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as MDS1/EVI1) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. There are no publicly available full-length transcripts representing this variant, but it is supported by cloning evidence in PMID:11050005.
    Source sequence(s)
    AK304098, AL700380, BC130520, BX647613, CR541866, DC348381
    UniProtKB/Swiss-Prot
    Q03112, Q13465
    Related
    ENSP00000498411.1, ENST00000651503.2
    Conserved Domains (5) summary
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:923943
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:921943
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:935959
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:351432
    zf-C2H2_8; C2H2-type zinc ribbon
  16. NM_005241.3NP_005232.2  histone-lysine N-methyltransferase MECOM isoform b

    See identical proteins and their annotated locations for NP_005232.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as EVI1_1c) lacks a portion of the 5' UTR and 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
    Source sequence(s)
    AA043944, AC078985, BC130520, BX647613, X54989
    Consensus CDS
    CCDS3205.1
    UniProtKB/Swiss-Prot
    Q03112
    Related
    ENSP00000486104.1, ENST00000628990.2
    Conserved Domains (6) summary
    PHA00733
    Location:689785
    PHA00733; hypothetical protein
    COG5189
    Location:114207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:735755
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:733755
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:747771
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:163247
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    169083499..169663781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247225.4XP_005247282.1  histone-lysine N-methyltransferase MECOM isoform X11

    Conserved Domains (5) summary
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:289640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:599619
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:597619
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:611635
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005247224.3XP_005247281.1  histone-lysine N-methyltransferase MECOM isoform X10

    Conserved Domains (5) summary
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:289641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:600620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:598620
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:612636
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005247214.3XP_005247271.1  histone-lysine N-methyltransferase MECOM isoform X2

    Conserved Domains (6) summary
    PHA00733
    Location:846965
    PHA00733; hypothetical protein
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:915935
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:913935
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:927951
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:352433
    zf-C2H2_8; C2H2-type zinc ribbon
  4. XM_005247213.3XP_005247270.1  histone-lysine N-methyltransferase MECOM isoform X1

    Conserved Domains (5) summary
    smart00317
    Location:80196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:924944
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:922944
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:936960
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:352433
    zf-C2H2_8; C2H2-type zinc ribbon
  5. XM_017005877.1XP_016861366.1  histone-lysine N-methyltransferase MECOM isoform X12

  6. XM_011512546.2XP_011510848.1  histone-lysine N-methyltransferase MECOM isoform X4

    Conserved Domains (5) summary
    smart00317
    Location:280
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:808828
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:806828
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:820844
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:236317
    zf-C2H2_8; C2H2-type zinc ribbon
  7. XM_005247221.2XP_005247278.1  histone-lysine N-methyltransferase MECOM isoform X6

    See identical proteins and their annotated locations for XP_005247278.1

    UniProtKB/Swiss-Prot
    Q03112
    UniProtKB/TrEMBL
    A0A0C3SFZ7
    Conserved Domains (5) summary
    PHA00733
    Location:690786
    PHA00733; hypothetical protein
    sd00017
    Location:736756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164248
    zf-C2H2_8; C2H2-type zinc ribbon
  8. XM_017005874.1XP_016861363.1  histone-lysine N-methyltransferase MECOM isoform X5

    UniProtKB/Swiss-Prot
    Q03112
    Conserved Domains (5) summary
    smart00317
    Location:872
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:800820
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:798820
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:812836
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:228309
    zf-C2H2_8; C2H2-type zinc ribbon
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