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Mecom MDS1 and EVI1 complex locus [ Mus musculus (house mouse) ]

Gene ID: 14013, updated on 12-May-2019

Summary

Official Symbol
Mecomprovided by MGI
Official Full Name
MDS1 and EVI1 complex locusprovided by MGI
Primary source
MGI:MGI:95457
See related
Ensembl:ENSMUSG00000027684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jbo; Mds; Evi1; Mds1; Evi-1; Prdm3; Znfpr1b1; Mds1-Evi1; D630039M04Rik
Expression
Broad expression in bladder adult (RPKM 7.5), limb E14.5 (RPKM 5.2) and 15 other tissues See more
Orthologs

Genomic context

See Mecom in Genome Data Viewer
Location:
3 A3; 3 12.66 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (29951296..30509783, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (29850218..30408409, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene predicted gene, 42197 Neighboring gene predicted gene, 33206 Neighboring gene Mecom adjacent non-protein coding RNA Neighboring gene predicted gene 10258 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene actin related protein T3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC183337, MGC184568

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone methyltransferase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of cell number IGI
Inferred from Genetic Interaction
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pericardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureter morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase MECOM; MDS1 and EVI1 complex locus protein EVI1
Names
MDS1 and EVI1 complex locus protein MDS1
ecotropic viral integration site 1
ecotropic virus integration site 1 protein
myelodysplasia syndrome 1 protein homolog
NP_031989.2
NP_067417.1
XP_006535450.1
XP_006535456.1
XP_006535457.1
XP_011247958.1
XP_011247959.1
XP_011247960.1
XP_011247961.1
XP_011247962.1
XP_011247963.1
XP_011247964.1
XP_011247965.1
XP_011247966.1
XP_017174943.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361034.1NP_001347963.1  histone-lysine N-methyltransferase MECOM isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform 3).
    Source sequence(s)
    AC119995, AL691419, AL772145, AL929377
    Conserved Domains (6) summary
    PHA00733
    Location:880976
    PHA00733; hypothetical protein
    smart00317
    Location:90194
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:926946
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:924946
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:938962
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:354438
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_007963.2NP_031989.2  histone-lysine N-methyltransferase MECOM isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI551247, AK085548, BC076620
    Consensus CDS
    CCDS17281.2
    UniProtKB/TrEMBL
    G3UZ13
    Related
    ENSMUSP00000134303.1, ENSMUST00000172694.7
    Conserved Domains (4) summary
    PHA00733
    Location:333452
    PHA00733; hypothetical protein
    sd00017
    Location:402422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400422
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:414438
    zf-H2C2_2; Zinc-finger double domain
  3. NM_021442.3NP_067417.1  histone-lysine N-methyltransferase MECOM isoform 2

    See identical proteins and their annotated locations for NP_067417.1

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419
    UniProtKB/Swiss-Prot
    Q9Z1L8
    Conserved Domains (1) summary
    cl02566
    Location:90118
    SET; SET domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    29951296..30509783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535387.2XP_006535450.1  MDS1 and EVI1 complex locus protein EVI1 isoform X3

    Conserved Domains (6) summary
    PHA00733
    Location:880976
    PHA00733; hypothetical protein
    smart00317
    Location:90194
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:926946
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:924946
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:938962
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:354438
    zf-C2H2_8; C2H2-type zinc ribbon
  2. XM_011249663.1XP_011247965.1  MDS1 and EVI1 complex locus protein EVI1 isoform X10

    Related
    ENSMUSP00000133310.1, ENSMUST00000173059.7
    Conserved Domains (5) summary
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:263720
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:564584
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:562584
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:576600
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011249658.1XP_011247960.1  MDS1 and EVI1 complex locus protein EVI1 isoform X4

    Conserved Domains (6) summary
    PHA00733
    Location:819938
    PHA00733; hypothetical protein
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:888908
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:886908
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:900924
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:325406
    zf-C2H2_8; C2H2-type zinc ribbon
  4. XM_011249656.1XP_011247958.1  MDS1 and EVI1 complex locus protein EVI1 isoform X1

    Conserved Domains (5) summary
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:897917
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:895917
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:909933
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:325406
    zf-C2H2_8; C2H2-type zinc ribbon
  5. XM_011249662.1XP_011247964.1  MDS1 and EVI1 complex locus protein EVI1 isoform X9

    Conserved Domains (5) summary
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:263615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:574594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:572594
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:586610
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011249657.1XP_011247959.1  MDS1 and EVI1 complex locus protein EVI1 isoform X2

    Conserved Domains (6) summary
    PHA00733
    Location:820939
    PHA00733; hypothetical protein
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:889909
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:887909
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:901925
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:326407
    zf-C2H2_8; C2H2-type zinc ribbon
  7. XM_011249661.2XP_011247963.1  MDS1 and EVI1 complex locus protein EVI1 isoform X8

    See identical proteins and their annotated locations for XP_011247963.1

    Conserved Domains (4) summary
    sd00017
    Location:736756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164245
    zf-C2H2_8; C2H2-type zinc ribbon
  8. XM_006535394.2XP_006535457.1  MDS1 and EVI1 complex locus protein EVI1 isoform X8

    See identical proteins and their annotated locations for XP_006535457.1

    Related
    ENSMUSP00000103905.3, ENSMUST00000108270.9
    Conserved Domains (4) summary
    sd00017
    Location:736756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164245
    zf-C2H2_8; C2H2-type zinc ribbon
  9. XM_006535393.3XP_006535456.1  MDS1 and EVI1 complex locus protein EVI1 isoform X7

    Conserved Domains (5) summary
    smart00317
    Location:768
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:800820
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:798820
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:812836
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:228309
    zf-C2H2_8; C2H2-type zinc ribbon
  10. XM_011249664.2XP_011247966.1  MDS1 and EVI1 complex locus protein EVI1 isoform X12

    Conserved Domains (5) summary
    smart00317
    Location:99203
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:300757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:601621
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:599621
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:613637
    zf-H2C2_2; Zinc-finger double domain
  11. XM_011249660.2XP_011247962.1  MDS1 and EVI1 complex locus protein EVI1 isoform X6

    Related
    ENSMUSP00000128563.1, ENSMUST00000166001.7
    Conserved Domains (5) summary
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:897917
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:895917
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:909933
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:325406
    zf-C2H2_8; C2H2-type zinc ribbon
  12. XM_011249659.2XP_011247961.1  MDS1 and EVI1 complex locus protein EVI1 isoform X5

    Conserved Domains (5) summary
    smart00317
    Location:62166
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:898918
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:896918
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:910934
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:326407
    zf-C2H2_8; C2H2-type zinc ribbon
  13. XM_017319454.1XP_017174943.1  MDS1 and EVI1 complex locus protein EVI1 isoform X11

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