CHEK2 checkpoint kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHEK2provided by HGNC
Official Full Name: checkpoint kinase 2provided by HGNC
Primary source: HGNC:HGNC:16627
See related: Ensembl:ENSG00000183765 MIM:604373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
Summary: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression: Ubiquitous expression in bone marrow (RPKM 3.3), lymph node (RPKM 3.1) and 24 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 22q12.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	22	NC_000022.11 (28687743..28741866, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (29083731..29137822, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT1, a metabolic sensor, protects cells from oxidative stress-dependent DNA damage response by the deacetylation of CHK2.
Title: Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
CHEK2 pathogenic variants in the BRCA-negative Hispanic women with breast cancer.
Title: Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Study suggests that structure and function of CHK2 can be distributed by various nsSNPs. In native protein of CHK2 gene, out of 79 SNPs, seven major variants found were: p.Arg160Gly, p.Arg188Trp, p.Ile203Thr, p.Gly210Arg, p.Arg223Cys, p.Pro225His and p.Ser415Phe. Among seven most significant SNPs, 3 were highly conserved and 4 SNPs were averaged conserved residues.
Title: Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact.
The authors report a BRCA negative family with multiple affected women having breast cancer, with a novel, missense, likely pathogenic variant in the CHEK2 gene (c.1376T>G; p.Ile459Ser) that segregated with subjects with breast cancer.
Title: A novel CHEK2 variant identified by next generation sequencing in an Indian family with hereditary breast cancer syndrome.
Hereditary CHEK2 mutations contribute to the development of hereditary Breast Cancer.
Title: Germline CHEK2 Gene Mutations in Hereditary Breast Cancer Predisposition - Mutation Types and their Biological and Clinical Relevance.
A single nucleotide polymorphism in the CHEK2 gene, rs1033667, was significantly associated with OSCC.
Title: Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population.
This multicenter case-control analysis of men with or without in Checkpoint Kinase 2 (CHEK2) With Susceptibility to Testicular Germ Cell Tumors (TGCTs) provides evidence for CHEK2 as a novel moderate-penetrance TGCT susceptibility gene.
Title: Association of Inherited Pathogenic Variants in Checkpoint Kinase 2 (CHEK2) With Susceptibility to Testicular Germ Cell Tumors.
Mutations c.1100delC and I157T can distinguish which patients with breast cancer are susceptible to metastasis (Review).
Title: Prognostic Significance of CHEK2 Mutation in Progression of Breast Cancer.
Results demonstrate that CHK2 is deubiquitinated by USP39 enhancing its stability. CHK2 regulates cell cycle checkpoint, cell apoptosis and chemo-radiation response. Furthermore, USP39 and CHK2 expression are correlatively downregulated in lung cancer samples.
Title: USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2.
Study identified germline CHEK2 variants in high-risk breast and ovarian cancer patients in addition to two types of large intragenic rearrangements of unknown significance.
Title: Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer.

Submit: New GeneRIF Correction See all GeneRIFs (409)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Familial cancer of breast MedGen: C0006142 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs
Li-Fraumeni syndrome 2 MedGen: C1836482 OMIM: 609265 GeneReviews: Not available	Compare labs
Malignant tumor of prostate MedGen: C0376358 OMIM: 176807 GeneReviews: Not available	Compare labs
Osteosarcoma MedGen: C0029463 OMIM: 259500 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated (2020-01-08) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated (2020-01-08) ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study of optic disc parameters. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic variants associated with breast size also influence breast cancer risk. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia	PubMed
Vpr	vpr	Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection	PubMed
	vpr	HIV-1 Vpr induces expression of gamma-H2AX and phosphorylation of Chk2	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S275 (e-PCR)
- UniSTS:87591

PMC111029P1 (e-PCR)
- UniSTS:270202

PMC111029P10 (e-PCR)
- UniSTS:270203

PMC111029P12 (e-PCR)
- UniSTS:270205

PMC111029P13 (e-PCR)
- UniSTS:270206

PMC111029P14 (e-PCR)
- UniSTS:270207

PMC111029P2 (e-PCR)
- UniSTS:270208

PMC111029P3 (e-PCR)
- UniSTS:270209

PMC111029P4 (e-PCR)
- UniSTS:270210

PMC111029P5 (e-PCR)
- UniSTS:270211

PMC111029P6 (e-PCR)
- UniSTS:270212

PMC111029P7 (e-PCR)
- UniSTS:270213

PMC111029P8 (e-PCR)
- UniSTS:270214

PMC111029P9 (e-PCR)
- UniSTS:270215

PMC149355P2 (e-PCR)
- UniSTS:271033

Homology

Homologs of the CHEK2 gene: The CHEK2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, and frog.
Orthologs from Annotation Pipeline: 320 organisms have orthologs with human gene CHEK2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase activity	TAS Traceable Author Statement more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA damage checkpoint	TAS Traceable Author Statement more info	PubMed
DNA damage induced protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS Traceable Author Statement more info
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IEA Inferred from Electronic Annotation more info
G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
cellular protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to DNA damage stimulus	TAS Traceable Author Statement more info	PubMed
cellular response to bisphenol A	IEA Inferred from Electronic Annotation more info
cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info
double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
mitotic DNA damage checkpoint	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of DNA damage checkpoint	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle arrest	IEA Inferred from Electronic Annotation more info
peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of anoikis	IEA Inferred from Electronic Annotation more info
positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein stabilization	IDA Inferred from Direct Assay more info	PubMed
regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
replicative cell aging	IMP Inferred from Mutant Phenotype more info	PubMed
replicative senescence	NAS Non-traceable Author Statement more info	PubMed
response to glycoside	IEA Inferred from Electronic Annotation more info
signal transduction in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info	PubMed
signal transduction in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
signal transduction involved in intra-S DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
PML body	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase Chk2

Names: CHK2 checkpoint homolog; cds1 homolog; checkpoint-like protein CHK2

NP_001005735.1

EC 2.7.11.1

NP_001244316.1

EC 2.7.11.1

NP_001336885.1

EC 2.7.11.1

NP_009125.1

EC 2.7.11.1

NP_665861.1

EC 2.7.11.1

XP_006724177.2

EC 2.7.11.1

XP_006724179.2

EC 2.7.11.1

XP_011528141.1

EC 2.7.11.1

XP_011528142.1

EC 2.7.11.1

XP_011528143.1

EC 2.7.11.1

XP_011528144.1

EC 2.7.11.1

XP_011528146.1

EC 2.7.11.1

XP_011528147.1

EC 2.7.11.1

XP_016884049.1

EC 2.7.11.1

XP_016884050.1

EC 2.7.11.1

XP_024307916.1

EC 2.7.11.1

XP_024307917.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008150.2 RefSeqGene

Range

5047..59124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001005735.2 → NP_001005735.1 serine/threonine-protein kinase Chk2 isoform c

See identical proteins and their annotated locations for NP_001005735.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is longer compared to isoform a.

Source sequence(s)

AW778747, AY551297, BM838597

Consensus CDS

CCDS33629.1

UniProtKB/Swiss-Prot

O96017

Related

ENSP00000372023.2, ENST00000382580.6

Conserved Domains (3) summary

smart00220
Location:263 → 529

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00060
Location:156 → 244

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:256 → 529

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_001257387.2 → NP_001244316.1 serine/threonine-protein kinase Chk2 isoform d

See identical proteins and their annotated locations for NP_001244316.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AF217975

UniProtKB/Swiss-Prot

O96017

Conserved Domains (2) summary

smart00220
Location:3 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:1 → 265

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_001349956.2 → NP_001336885.1 serine/threonine-protein kinase Chk2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) [is shorter/has a distinct C-terminus], compared to isoform a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AF096279, AK290754, AW778747, BX393617

Conserved Domains (1) summary

cd14084
Location:162 → 419

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_007194.4 → NP_009125.1 serine/threonine-protein kinase Chk2 isoform a

See identical proteins and their annotated locations for NP_009125.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.

Source sequence(s)

AF096279, AW778747, BM838597

Consensus CDS

CCDS13843.1

UniProtKB/Swiss-Prot

O96017

Related

ENSP00000385747.1, ENST00000404276.6

Conserved Domains (3) summary

smart00220
Location:220 → 486

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00060
Location:93 → 201

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:213 → 486

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_145862.2 → NP_665861.1 serine/threonine-protein kinase Chk2 isoform b

See identical proteins and their annotated locations for NP_665861.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AW778747, AY551299, BM838597

Consensus CDS

CCDS13844.1

UniProtKB/Swiss-Prot

O96017

Related

ENSP00000329012.5, ENST00000348295.7

Conserved Domains (4) summary

smart00220
Location:220 → 457

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:116 → 199

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:93 → 201

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:213 → 457

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p13 Primary Assembly

Range

28687743..28741866 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011529845.2 → XP_011528147.1 serine/threonine-protein kinase Chk2 isoform X11

See identical proteins and their annotated locations for XP_011528147.1

UniProtKB/Swiss-Prot

O96017

Conserved Domains (2) summary

smart00220
Location:3 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:1 → 265

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_011529841.1 → XP_011528143.1 serine/threonine-protein kinase Chk2 isoform X6

Conserved Domains (2) summary

smart00220
Location:205 → 462

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:205 → 462

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_011529840.3 → XP_011528142.1 serine/threonine-protein kinase Chk2 isoform X3

Conserved Domains (4) summary

smart00220
Location:273 → 510

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:123 → 252

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:266 → 510

PKc_like; Protein Kinases, catalytic domain
XM_017028560.1 → XP_016884049.1 serine/threonine-protein kinase Chk2 isoform X2
XM_011529839.2 → XP_011528141.1 serine/threonine-protein kinase Chk2 isoform X1

Conserved Domains (3) summary

smart00220
Location:273 → 539

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:266 → 539

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_011529842.2 → XP_011528144.1 serine/threonine-protein kinase Chk2 isoform X7

Conserved Domains (2) summary

smart00220
Location:172 → 429

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:172 → 429

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_024452149.1 → XP_024307917.1 serine/threonine-protein kinase Chk2 isoform X5

Conserved Domains (2) summary

cd00060
Location:103 → 211

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:223 → 467

PKc_like; Protein Kinases, catalytic domain
XM_024452148.1 → XP_024307916.1 serine/threonine-protein kinase Chk2 isoform X4

Conserved Domains (2) summary

cd00060
Location:103 → 211

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:223 → 496

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_017028561.2 → XP_016884050.1 serine/threonine-protein kinase Chk2 isoform X11

UniProtKB/Swiss-Prot

O96017

Related

ENSP00000496928.1, ENST00000649563.1

Conserved Domains (2) summary

smart00220
Location:3 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:1 → 265

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_006724114.3 → XP_006724177.2 serine/threonine-protein kinase Chk2 isoform X9

Related

ENST00000648295.1
XM_006724116.2 → XP_006724179.2 serine/threonine-protein kinase Chk2 isoform X10

Conserved Domains (2) summary

smart00220
Location:46 → 305

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:39 → 305

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_011529844.2 → XP_011528146.1 serine/threonine-protein kinase Chk2 isoform X8

Conserved Domains (4) summary

smart00220
Location:273 → 390

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:123 → 252

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:266 → 390

PKc_like; Protein Kinases, catalytic domain