CHEK2 checkpoint kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHEK2provided by HGNC
Official Full Name: checkpoint kinase 2provided by HGNC
Primary source: HGNC:HGNC:16627
See related: Ensembl:ENSG00000183765 MIM:604373; AllianceGenome:HGNC:16627
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDS1; CHK2; LFS2; RAD53; TPDS4; hCds1; HuCds1; PP1425
Summary: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression: Ubiquitous expression in bone marrow (RPKM 3.3), lymph node (RPKM 3.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q12.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (28687743..28741834, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (29149178..29203469, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (29083731..29137822, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.
Title: Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.
Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
Title: Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
Title: Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
Title: LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
The heterogeneous cancer phenotype of individuals with biallelic germline pathogenic variants in CHEK2.
Title: The heterogeneous cancer phenotype of individuals with biallelic germline pathogenic variants in CHEK2.
A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.
Title: A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.
Title: Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.
CHEK2 Founder Variants and Thyroid Cancer Risk.
Title: CHEK2 Founder Variants and Thyroid Cancer Risk.
CHEK2 germline variants identified in familial nonmedullary thyroid cancer lead to impaired protein structure and function.
Title: CHEK2 germline variants identified in familial nonmedullary thyroid cancer lead to impaired protein structure and function.
Germline CHEK2 mutations in patients with myeloid neoplasms.
Title: Germline CHEK2 mutations in patients with myeloid neoplasms.

Submit: New GeneRIF Correction See all GeneRIFs (490)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bone osteosarcoma MedGen: C0585442 OMIM: 259500 GeneReviews: Not available	Compare labs
CHEK2-related cancer predisposition MedGen: C5882668 OMIM: 609265 GeneReviews: CHEK2-Related Cancer Predisposition	Compare labs
Familial prostate cancer MedGen: C2931456 OMIM: 176807 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2020-01-08) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-08) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study of optic disc parameters. EBI GWAS Catalog EBI GWAS CatalogPubMed
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants associated with breast size also influence breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. EBI GWAS Catalog EBI GWAS CatalogPubMed
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia	PubMed
Vpr	vpr	Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection	PubMed
	vpr	HIV-1 Vpr induces expression of gamma-H2AX and phosphorylation of Chk2	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S275 (e-PCR)
- UniSTS:87591

PMC111029P1 (e-PCR)
- UniSTS:270202

PMC111029P10 (e-PCR)
- UniSTS:270203

PMC111029P12 (e-PCR)
- UniSTS:270205

PMC111029P13 (e-PCR)
- UniSTS:270206

PMC111029P14 (e-PCR)
- UniSTS:270207

PMC111029P2 (e-PCR)
- UniSTS:270208

PMC111029P3 (e-PCR)
- UniSTS:270209

PMC111029P4 (e-PCR)
- UniSTS:270210

PMC111029P5 (e-PCR)
- UniSTS:270211

PMC111029P6 (e-PCR)
- UniSTS:270212

PMC111029P7 (e-PCR)
- UniSTS:270213

PMC111029P8 (e-PCR)
- UniSTS:270214

PMC111029P9 (e-PCR)
- UniSTS:270215

PMC149355P2 (e-PCR)
- UniSTS:271033

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA damage checkpoint signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bisphenol A	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	TAS Traceable Author Statement more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage checkpoint	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in replicative senescence	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to glycoside	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in signal transduction in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase Chk2

Names: CHK2 checkpoint homolog; cds1 homolog; checkpoint-like protein CHK2

NP_001005735.1

EC 2.7.11.1

NP_001244316.1

EC 2.7.11.1

NP_001336885.1

EC 2.7.11.1

NP_009125.1

EC 2.7.11.1

NP_665861.1

EC 2.7.11.1

XP_006724177.3

EC 2.7.11.1

XP_006724179.2

EC 2.7.11.1

XP_011528141.1

EC 2.7.11.1

XP_011528142.1

EC 2.7.11.1

XP_011528144.1

EC 2.7.11.1

XP_011528146.1

EC 2.7.11.1

XP_011528147.1

EC 2.7.11.1

XP_016884049.1

EC 2.7.11.1

XP_024307916.1

EC 2.7.11.1

XP_024307917.1

EC 2.7.11.1

XP_047297060.1

EC 2.7.11.1

XP_047297061.1

EC 2.7.11.1

XP_047297062.1

EC 2.7.11.1

XP_047297063.1

EC 2.7.11.1

XP_047297064.1

EC 2.7.11.1

XP_054181012.1

EC 2.7.11.1

XP_054181013.1

EC 2.7.11.1

XP_054181014.1

EC 2.7.11.1

XP_054181015.1

EC 2.7.11.1

XP_054181016.1

EC 2.7.11.1

XP_054181017.1

EC 2.7.11.1

XP_054181018.1

EC 2.7.11.1

XP_054181019.1

EC 2.7.11.1

XP_054181020.1

EC 2.7.11.1

XP_054181021.1

EC 2.7.11.1

XP_054181022.1

EC 2.7.11.1

XP_054181023.1

EC 2.7.11.1

XP_054181024.1

EC 2.7.11.1

XP_054181025.1

EC 2.7.11.1

XP_054181026.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008150.2 RefSeqGene

Range

5047..59124

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_302

mRNA and Protein(s)

NM_001005735.3 → NP_001005735.1 serine/threonine-protein kinase Chk2 isoform c

See identical proteins and their annotated locations for NP_001005735.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is longer compared to isoform a.

Source sequence(s)

AL117330, AL121825

Consensus CDS

CCDS33629.1

UniProtKB/TrEMBL

A8JZZ5

Related

ENSP00000372023.2, ENST00000382580.6

Conserved Domains (2) summary

cd00060
Location:156 → 244

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:256 → 529

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_001257387.3 → NP_001244316.1 serine/threonine-protein kinase Chk2 isoform d

See identical proteins and their annotated locations for NP_001244316.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AL117330, AL121825

UniProtKB/TrEMBL

A0A087X102

Conserved Domains (2) summary

smart00220
Location:3 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:1 → 265

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_001349956.3 → NP_001336885.1 serine/threonine-protein kinase Chk2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) [is shorter/has a distinct C-terminus], compared to isoform a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL117330, AL121825

Consensus CDS

CCDS93141.1

UniProtKB/TrEMBL

A0A7P0MUT5, A8JZZ5

Related

ENSP00000384835.2, ENST00000402731.6

Conserved Domains (1) summary

cd14084
Location:162 → 419

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_001437942.1 → NP_001424871.1 serine/threonine-protein kinase Chk2 isoform f

Status: REVIEWED

Source sequence(s)

AL117330, AL121825

UniProtKB/TrEMBL

A0A087X102
NM_001438293.1 → NP_001425222.1 serine/threonine-protein kinase Chk2 isoform d

Status: REVIEWED

Source sequence(s)

AL117330, AL121825

UniProtKB/TrEMBL

A8JZZ5
NM_001438294.1 → NP_001425223.1 serine/threonine-protein kinase Chk2 isoform g

Status: REVIEWED

Source sequence(s)

AL117330, AL121825

UniProtKB/TrEMBL

A8JZZ5
NM_001438295.1 → NP_001425224.1 serine/threonine-protein kinase Chk2 isoform h

Status: REVIEWED

Source sequence(s)

AL117330, AL121825

UniProtKB/TrEMBL

A8JZZ5
NM_007194.4 → NP_009125.1 serine/threonine-protein kinase Chk2 isoform a

See identical proteins and their annotated locations for NP_009125.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.

Source sequence(s)

AF096279, AW778747, BM838597

Consensus CDS

CCDS13843.1

UniProtKB/Swiss-Prot

A8K3Y9, B7ZBF3, B7ZBF4, B7ZBF5, O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HBS5, Q9HCQ8, Q9UGF0, Q9UGF1

UniProtKB/TrEMBL

A8JZZ5

Related

ENSP00000385747.1, ENST00000404276.6

Conserved Domains (2) summary

cd00060
Location:93 → 201

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:213 → 486

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
NM_145862.3 → NP_665861.1 serine/threonine-protein kinase Chk2 isoform b

See identical proteins and their annotated locations for NP_665861.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL117330, AL121825

Consensus CDS

CCDS13844.1

UniProtKB/TrEMBL

A8JZZ5

Related

ENSP00000329012.5, ENST00000348295.7

Conserved Domains (4) summary

smart00220
Location:220 → 457

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:116 → 199

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:93 → 201

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:213 → 457

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

28687743..28741834 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011529845.3 → XP_011528147.1 serine/threonine-protein kinase Chk2 isoform X15

Related

ENSP00000390244.2, ENST00000425190.7

Conserved Domains (2) summary

smart00220
Location:3 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:1 → 265

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_047441106.1 → XP_047297062.1 serine/threonine-protein kinase Chk2 isoform X7
XM_047441104.1 → XP_047297060.1 serine/threonine-protein kinase Chk2 isoform X3
XM_047441105.1 → XP_047297061.1 serine/threonine-protein kinase Chk2 isoform X5
XM_011529839.3 → XP_011528141.1 serine/threonine-protein kinase Chk2 isoform X1

UniProtKB/TrEMBL

A8JZZ5

Conserved Domains (2) summary

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:266 → 539

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_024452149.2 → XP_024307917.1 serine/threonine-protein kinase Chk2 isoform X9

UniProtKB/TrEMBL

A8JZZ5

Conserved Domains (2) summary

cd00060
Location:103 → 211

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:223 → 467

PKc_like; Protein Kinases, catalytic domain
XM_024452148.2 → XP_024307916.1 serine/threonine-protein kinase Chk2 isoform X6

UniProtKB/TrEMBL

A8JZZ5

Conserved Domains (2) summary

cd00060
Location:103 → 211

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:223 → 496

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_047441107.1 → XP_047297063.1 serine/threonine-protein kinase Chk2 isoform X8

UniProtKB/TrEMBL

A8JZZ5
XM_011529840.4 → XP_011528142.1 serine/threonine-protein kinase Chk2 isoform X4

UniProtKB/TrEMBL

A8JZZ5

Conserved Domains (4) summary

smart00220
Location:273 → 510

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:123 → 252

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:266 → 510

PKc_like; Protein Kinases, catalytic domain
XM_011529842.3 → XP_011528144.1 serine/threonine-protein kinase Chk2 isoform X10

UniProtKB/TrEMBL

A8JZZ5

Conserved Domains (2) summary

smart00220
Location:172 → 429

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:172 → 429

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_017028560.2 → XP_016884049.1 serine/threonine-protein kinase Chk2 isoform X2

UniProtKB/TrEMBL

A8JZZ5
XM_047441108.1 → XP_047297064.1 serine/threonine-protein kinase Chk2 isoform X13

UniProtKB/TrEMBL

A0A087X102
XM_006724114.4 → XP_006724177.3 serine/threonine-protein kinase Chk2 isoform X12

UniProtKB/TrEMBL

A0A087X102

Related

ENST00000648295.1
XM_006724116.3 → XP_006724179.2 serine/threonine-protein kinase Chk2 isoform X14

UniProtKB/TrEMBL

A0A087X102

Related

ENSP00000483777.2, ENST00000464581.6

Conserved Domains (2) summary

smart00220
Location:46 → 305

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14084
Location:39 → 305

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
XM_011529844.3 → XP_011528146.1 serine/threonine-protein kinase Chk2 isoform X11

UniProtKB/TrEMBL

A0AA34QVK6

Related

ENSP00000518557.1, ENST00000711048.1

Conserved Domains (4) summary

smart00220
Location:273 → 390

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1716
Location:123 → 252

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:166 → 254

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl21453
Location:266 → 390

PKc_like; Protein Kinases, catalytic domain

RNA

XR_937806.3 RNA Sequence
XR_007067955.1 RNA Sequence
XR_007067954.1 RNA Sequence
XR_937807.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

29149178..29203469 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325051.1 → XP_054181026.1 serine/threonine-protein kinase Chk2 isoform X15
XM_054325043.1 → XP_054181018.1 serine/threonine-protein kinase Chk2 isoform X7
XM_054325039.1 → XP_054181014.1 serine/threonine-protein kinase Chk2 isoform X3
XM_054325041.1 → XP_054181016.1 serine/threonine-protein kinase Chk2 isoform X5
XM_054325037.1 → XP_054181012.1 serine/threonine-protein kinase Chk2 isoform X1

UniProtKB/TrEMBL

A8JZZ5
XM_054325045.1 → XP_054181020.1 serine/threonine-protein kinase Chk2 isoform X9

UniProtKB/TrEMBL

A8JZZ5
XM_054325042.1 → XP_054181017.1 serine/threonine-protein kinase Chk2 isoform X6

UniProtKB/TrEMBL

A8JZZ5
XM_054325044.1 → XP_054181019.1 serine/threonine-protein kinase Chk2 isoform X8

UniProtKB/TrEMBL

A8JZZ5
XM_054325040.1 → XP_054181015.1 serine/threonine-protein kinase Chk2 isoform X4

UniProtKB/TrEMBL

A8JZZ5
XM_054325046.1 → XP_054181021.1 serine/threonine-protein kinase Chk2 isoform X10

UniProtKB/TrEMBL

A8JZZ5
XM_054325038.1 → XP_054181013.1 serine/threonine-protein kinase Chk2 isoform X2

UniProtKB/TrEMBL

A8JZZ5
XM_054325049.1 → XP_054181024.1 serine/threonine-protein kinase Chk2 isoform X17
XM_054325048.1 → XP_054181023.1 serine/threonine-protein kinase Chk2 isoform X16
XM_054325050.1 → XP_054181025.1 serine/threonine-protein kinase Chk2 isoform X14

UniProtKB/TrEMBL

A0A087X102
XM_054325047.1 → XP_054181022.1 serine/threonine-protein kinase Chk2 isoform X11

UniProtKB/TrEMBL

A0AA34QVK6