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Malignant tumor of prostate

MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
Synonyms: Prostate cancer; Prostatic cancer
SNOMED CT: Malignant tumor of prostate (399068003); Malignant prostatic tumor (399068003); CA - Cancer of prostate (399068003); Cancer of prostate (399068003)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
Sources: HPO, OMIM
A mode of inheritance in which a trait or disorder results from a de novo mutation occurring after conception, rather than being inherited from a preceding generation.
Somatic mutation (HPO, OMIM)
 
Genes (locations): AR (Xq12); BRCA2 (13q13.1); CDH1 (16q22.1); CHEK2 (22q12.1); KLF6 (10p15.2); MAD1L1 (7p22.3); MXI1 (10q25.2); PTEN (10q23.31); ZFHX3 (16q22.2-22.3)
 
HPO: HP:0012125
OMIM®: 176807

Definition

A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas. [from NCI]

Clinical features

From HPO
Malignant tumor of prostate
MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas.
Malignant tumor of prostate
MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas.

Term Hierarchy

Conditions with this feature

Malignant tumor of prostate
MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas.
Li-Fraumeni syndrome 1
MedGen UID:
322656
Concept ID:
C1835398
Disease or Syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and adult-onset malignancies. The lifetime risk of cancer in individuals with LFS is =70% for men and =90% for women. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. LFS is associated with an increased risk of several additional cancers including leukemia, lymphoma, gastrointestinal cancers, cancers of head and neck, kidney, larynx, lung, skin (e.g., melanoma), ovary, pancreas, prostate, testis, and thyroid. Individuals with LFS are at increased risk for cancer in childhood and young adulthood; survivors are at increased risk for multiple primary cancers.
Prostate cancer, hereditary, X-linked 1
MedGen UID:
339479
Concept ID:
C1846279
Neoplastic Process
Prostate cancer/brain cancer susceptibility
MedGen UID:
400334
Concept ID:
C1863600
Finding
Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal and multiply without control or order to form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical procedure called a digital rectal exam. As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. Bone metastases of prostate cancer most often cause pain in the lower back, pelvis, or hips.\n\nA small percentage of all prostate cancers cluster in families. These hereditary cancers are associated with inherited gene mutations. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases.
Prostate cancer, hereditary, 1
MedGen UID:
1648436
Concept ID:
C4722327
Neoplastic Process
A small percentage of all prostate cancers cluster in families. These hereditary cancers are associated with inherited gene mutations. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. Bone metastases of prostate cancer most often cause pain in the lower back, pelvis, or hips.\n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical procedure called a digital rectal exam. As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nProstate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal and multiply without control or order to form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.

Professional guidelines

PubMed

Hampel H, Bennett RL, Buchanan A, Pearlman R, Wiesner GL; Guideline Development Group, American College of Medical Genetics and Genomics Professional Practice and Guidelines Committee and National Society of Genetic Counselors Practice Guidelines Committee.
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Suggested Reading

Recent clinical studies

Etiology

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Diagnosis

Xu Y, Li Z, Shi J, Fu Y, Zhu L, Fan X, Foo WC
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Therapy

Kulkarni P, Dasgupta P, Bhat NS, Hashimoto Y, Saini S, Shahryari V, Yamamura S, Shiina M, Tanaka Y, Dahiya R, Majid S
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Prognosis

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BMC Cancer 2020 Jun 15;20(1):555. doi: 10.1186/s12885-020-07049-z. PMID: 32539763Free PMC Article
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Kim H, Kim DY, Seol YM, Ku JY, Choi KU, Choi YJ
Medicine (Baltimore) 2018 Sep;97(39):e12040. doi: 10.1097/MD.0000000000012040. PMID: 30278486Free PMC Article
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Clinical prediction guides

Li Q, Shi Y, Sa R, Hao J, Hu J, Xiao M, Wang C, Yan L, Qiao B, Chen G
BMC Cancer 2020 Jun 15;20(1):555. doi: 10.1186/s12885-020-07049-z. PMID: 32539763Free PMC Article
Janiczek M, Szylberg Ł, Antosik P, Kasperska A, Marszałek A
J Immunol Res 2020;2020:4910595. Epub 2020 May 25 doi: 10.1155/2020/4910595. PMID: 32537467Free PMC Article
Smrkolj T, Gubina B, Bizjak J, Kumer K, Fabjan T, Osredkar J
Adv Clin Exp Med 2017 Oct;26(7):1085-1090. doi: 10.17219/acem/65432. PMID: 29211355
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
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Recent systematic reviews

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J Urol 2017 Feb;197(2):385-390. Epub 2016 Aug 26 doi: 10.1016/j.juro.2016.08.088. PMID: 27569436
Cao H, Mu Y, Li X, Wang Y, Chen S, Liu JP
PLoS One 2016;11(8):e0160253. Epub 2016 Aug 4 doi: 10.1371/journal.pone.0160253. PMID: 27490098Free PMC Article
van den Bergh RC, Ahmed HU, Bangma CH, Cooperberg MR, Villers A, Parker CC
Eur Urol 2014 Jun;65(6):1023-31. Epub 2014 Jan 28 doi: 10.1016/j.eururo.2014.01.027. PMID: 24491309
Botelho F, Pina F, Lunet N
Eur J Cancer Prev 2010 Sep;19(5):385-92. doi: 10.1097/CEJ.0b013e32833b48e1. PMID: 20502342

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