1FHR,1G6G


Conserved Protein Domain Family
FHA

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cd00060: FHA 
Click on image for an interactive view with Cn3D
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
Statistics
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PSSM-Id: 238017
View PSSM: cd00060
Aligned: 141 rows
Threshold Bit Score: 32.7434
Threshold Setting Gi: 1399466
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
phosphopeptide
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site
Evidence:
  • Comment:conserved residues are involved in binding directly to the ligand backbone and phosphate group
  • Comment: non-conserved residues may determine binding specificity
  • Structure:1FHR_A; FHA2 binds a phosphotyrosyl peptide
    View structure with Cn3D
  • Structure:1G6G_A; FHA binds a phosphothreonine peptide
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                     # ##                        
1FHR_A         5 FLTLKPLpds--iiqESLEIQqgvnPFFIGRSEDc--------NCKIE--DNRLSRVHCFIFKKrhavgksmyespaqgl 72
gi 1170654     7 LVTIKRSgv----dgPHFPLSl--sTCLFGRGIEc--------DIRIQ--LPVVSKQHCKIEIHe--------------q 56
gi 2555105   633 QACLVNLtadpilsgTLFYLLpq-gLVRIGRGRLpggssssqpDIVLD--GPLVALQHCSIEHEr--------------g 695
gi 7513614     7 LVTIKRSgd----dgAHFPLSl--sSCLFGRSIEc--------DIRIQ--LPVVSQRHCPIVVQe--------------q 56
gi 4996101     5 GYIVIIKrtg--segHRYPLSq--rECLFGRGTEc--------DIRLQ--LPVVSKQQCKIEFNeq-------------l 57
gi 15618622    2 AVRLIVDegp--lsgVIFVLEdg-iSWSIGRDSSa-------nDIPIE--DPKLGASQAIINKTd--------------g 55
gi 4426593   354 LPVLIVMnndghlstHRITLHe--gVTGVGSDSQmsnf--sqhNIYLD--GPDIRGRHAAIAFMe--------------- 412
gi 17531741    5 GIKIKNSsg-----eEVYVLKekgsVVNFGREKKv-------cHITFDphAARVSRIHASIEWGd--------------- 57
gi 15605397    2 GIRLVIDkgp--lsgTVLILEng-tSWSLGSDGKa-------sDILLQ--DEKLAPSQIRITLKd--------------g 55
gi 15834660    2 GIRLVVDkgp--lsgTVLILEng-tSWSLGSDGKa-------sDILLQ--DEKLAPAQVRVTLKd--------------- 54
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1                 ## #                                        
1FHR_A        73 DDIWYCHTGTN-VSYLNNNRMIqgTKFLLQdgDEIKIIwdknnkfVIGFKVEI 124
gi 1170654    57 EAILHNFSSTN-PTQVNGSVID--EPVRLKhgDVITIId-----rSFRYENES 101
gi 2555105   696 GKLYVIPGSEDfETYVNGELLKd-RRQLFHg-DRLVIGg------SHYFRISN 740
gi 7513614    57 EAILYNFSSTN-PTQVNGVTID--EPVRLRhgDIITIId-----rSFRYEDGN 101
gi 4996101    58 EAILINLNSAN-PTQLNGATFY--HPVKLEhgDLITIFd-----rSFRFEYEN 102
gi 15618622   56 SYYITNLDDTI-PIVVNGVAIQ--ETTQLKneDTILLG-------SNQYSFLS 98
gi 4426593   413 GVVTLTPSTRDaYLEVNGHQLM--QTEILRdgDHIRIGa------DHSFKFST 457
gi 17531741   58 EGLFFTDKSKE-GTEINGTRLKqsSQELHEgvYQLAIG-------GISMTLEV 102
gi 15605397   56 EYYLENLDALR-PVSVDGTVIT--APVLLKdgVSFVMG-------SCQVSFFK 98
gi 15834660   55 GEYYLENLDVSrPVLVNGVAIT--APTLLKegIPFVMG-------SCEWSFFK 98

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