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Bone osteosarcoma

MedGen UID:
108437
Concept ID:
C0585442
Neoplastic Process
Synonyms: Osteogenic sarcoma; Osteosarcoma, somatic
SNOMED CT: Osteosarcoma of bone (307576001)
 
Genes (locations): CHEK2 (22q12.1); RB1 (13q14.2); TP53 (17p13.1)
 
OMIM®: 259500

Definition

A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs. [from NCI]

Recent clinical studies

Etiology

Kasperkiewicz K, Major R, Sypien A, Kot M, Dyner M, Major Ł, Byrski A, Kopernik M, Lackner JM
Molecules 2021 May 24;26(11) doi: 10.3390/molecules26113145. PMID: 34074062Free PMC Article
Wang Y, Wu J, Li W, Li J, Liu R, Yang B, Li C, Jiang T
Childs Nerv Syst 2021 Feb;37(2):411-417. Epub 2020 Sep 15 doi: 10.1007/s00381-020-04885-z. PMID: 32930885
Kushlinskii NE, Alferov AA, Boulytcheva IV, Timofeev YS, Korotkova EA, Khvan OT, Kuzmin YB, Kuznetsov IN, Bondarev AV, Shchupak MY, Sokolov NY, Efimova MM, Gershtein ES, Sushentsov EA, Aliev MD, Musaev ER
Klin Lab Diagn 2020 Dec 4;65(11):669-675. doi: 10.18821/0869-2084-2020-65-11-669-675. PMID: 33301655
Saadaat R, Abdul-Ghafar J, Ud Din N, Haidary AM
J Med Case Rep 2020 Apr 20;14(1):51. doi: 10.1186/s13256-020-02365-1. PMID: 32312303Free PMC Article
Iwata S, Nakamura T, Gaston CL, Carter SR, Tillman RM, Abudu A, Jeys L, Grimer RJ
Eur J Surg Oncol 2014 Sep;40(9):1095-100. Epub 2014 Jun 26 doi: 10.1016/j.ejso.2014.06.003. PMID: 25037733

Diagnosis

Kushlinskii NE, Alferov AA, Boulytcheva IV, Timofeev YS, Korotkova EA, Khvan OT, Kuzmin YB, Kuznetsov IN, Bondarev AV, Shchupak MY, Sokolov NY, Efimova MM, Gershtein ES, Sushentsov EA, Aliev MD, Musaev ER
Klin Lab Diagn 2020 Dec 4;65(11):669-675. doi: 10.18821/0869-2084-2020-65-11-669-675. PMID: 33301655
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G
Cancer Treat Rev 2006 Oct;32(6):423-36. Epub 2006 Jul 24 doi: 10.1016/j.ctrv.2006.05.005. PMID: 16860938
Marcove RC, Heelan R, Lindeque B, Healey J, Rosen G
Acta Orthop Scand 1994 Aug;65(4):480-2. doi: 10.3109/17453679408995497. PMID: 7976302
Coffre C, Vanel D, Contesso G, Kalifa C, Dubousset J, Genin J, Masselot J
Skeletal Radiol 1985;13(2):147-53. doi: 10.1007/BF00352085. PMID: 3856325
Bonfiglio M
Proc Natl Cancer Conf 1970;6:721-30. PMID: 5272232

Therapy

Lellupitiyage Don SS, Robertson KL, Lin HH, Labriola C, Harrington ME, Taylor SR, Farkas ME
PLoS One 2020;15(7):e0236315. Epub 2020 Jul 24 doi: 10.1371/journal.pone.0236315. PMID: 32706791Free PMC Article
Lakshmi Manasa K, Thatikonda S, Sigalapalli DK, Sagar A, Kiranmai G, Kalle AM, Alvala M, Godugu C, Nagesh N, Nagendra Babu B
Bioorg Chem 2020 Aug;101:103983. Epub 2020 Jun 1 doi: 10.1016/j.bioorg.2020.103983. PMID: 32683136
Palmerini E, Torricelli E, Cascinu S, Pierini M, De Paolis M, Donati D, Cesari M, Longhi A, Abate M, Paioli A, Setola E, Ferrari S
Pediatr Blood Cancer 2019 Aug;66(8):e27792. Epub 2019 May 6 doi: 10.1002/pbc.27792. PMID: 31058424
Chen C, Dong J, Chen H, Wang X, Mei J, Wang L, Xian CJ
J Cell Physiol 2019 Jul;234(7):10771-10781. Epub 2018 Nov 27 doi: 10.1002/jcp.27753. PMID: 30480804
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G
Cancer Treat Rev 2006 Oct;32(6):423-36. Epub 2006 Jul 24 doi: 10.1016/j.ctrv.2006.05.005. PMID: 16860938

Prognosis

Weglarz-Tomczak E, Rijlaarsdam DJ, Tomczak JM, Brul S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031470. PMID: 33540580Free PMC Article
Righi L, Righi A, Vatrano S, Rapa I, Listì A, Metovic J, Rocca M, Salone M, Giovenali P, Sidoni A, Tabbò F, Dei Tos AP, Volante M, Papotti M
Virchows Arch 2021 Jun;478(6):1125-1134. Epub 2021 Jan 9 doi: 10.1007/s00428-020-02990-7. PMID: 33420836
Iwata S, Nakamura T, Gaston CL, Carter SR, Tillman RM, Abudu A, Jeys L, Grimer RJ
Eur J Surg Oncol 2014 Sep;40(9):1095-100. Epub 2014 Jun 26 doi: 10.1016/j.ejso.2014.06.003. PMID: 25037733
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G
Cancer Treat Rev 2006 Oct;32(6):423-36. Epub 2006 Jul 24 doi: 10.1016/j.ctrv.2006.05.005. PMID: 16860938
Marcove RC, Heelan R, Lindeque B, Healey J, Rosen G
Acta Orthop Scand 1994 Aug;65(4):480-2. doi: 10.3109/17453679408995497. PMID: 7976302

Clinical prediction guides

Weglarz-Tomczak E, Rijlaarsdam DJ, Tomczak JM, Brul S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031470. PMID: 33540580Free PMC Article
Zakhireh S, Adibkia K, Beygi-Khosrowshahi Y, Barzegar-Jalali M
Biol Trace Elem Res 2021 May;199(5):1802-1811. Epub 2020 Aug 20 doi: 10.1007/s12011-020-02309-2. PMID: 32816138
Pierce TT, Shailam R, Lozano-Calderon S, Sagar P
Surg Oncol 2019 Mar;28:135-139. Epub 2018 Nov 26 doi: 10.1016/j.suronc.2018.11.018. PMID: 30851887
Bertin H, Guilho R, Brion R, Amiaud J, Battaglia S, Moreau A, Brouchet-Gomez A, Longis J, Piot B, Heymann D, Corre P, Rédini F
J Transl Med 2019 Feb 27;17(1):56. doi: 10.1186/s12967-019-1807-5. PMID: 30813941Free PMC Article
Coffre C, Vanel D, Contesso G, Kalifa C, Dubousset J, Genin J, Masselot J
Skeletal Radiol 1985;13(2):147-53. doi: 10.1007/BF00352085. PMID: 3856325

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