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Chek2 checkpoint kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 50883, updated on 18-Nov-2018

Summary

Official Symbol
Chek2provided by MGI
Official Full Name
checkpoint kinase 2provided by MGI
Primary source
MGI:MGI:1355321
See related
Ensembl:ENSMUSG00000029521 Vega:OTTMUSG00000054224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHK2; Cds1; Rad53; HUCDS1
Expression
Broad expression in liver E14 (RPKM 9.9), liver E14.5 (RPKM 8.7) and 23 other tissues See more
Orthologs

Genomic context

See Chek2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (110839800..110874140)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111269036..111303152)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene unc-51 like kinase 1 Neighboring gene HscB iron-sulfur cluster co-chaperone Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene predicted gene, 35973 Neighboring gene microRNA 701

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
replicative cell aging ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
PML body ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
Cds1 homolog
Rad53 homolog
NP_057890.1
XP_006535130.1
XP_006535131.2
XP_006535132.1
XP_006535133.1
XP_006535134.2
XP_006535135.2
XP_017176462.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363308.1NP_001350237.1  serine/threonine-protein kinase Chk2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121934
    Conserved Domains (1) summary
    cd14084
    Location:1251
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  2. NM_016681.4NP_057890.1  serine/threonine-protein kinase Chk2 isoform 1

    See identical proteins and their annotated locations for NP_057890.1

    Status: VALIDATED

    Source sequence(s)
    AK044913, BX512104, CJ079787
    Consensus CDS
    CCDS19533.1
    UniProtKB/Swiss-Prot
    Q9Z265
    UniProtKB/TrEMBL
    Q543W6
    Related
    ENSMUSP00000066679.1, OTTMUSP00000071369, ENSMUST00000066160.2
    Conserved Domains (3) summary
    smart00220
    Location:224490
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:97205
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:217490
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    110839800..110874140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535067.3XP_006535130.1  serine/threonine-protein kinase Chk2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:284550
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:157265
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:277550
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  2. XM_006535071.3XP_006535134.2  serine/threonine-protein kinase Chk2 isoform X4

  3. XM_006535072.3XP_006535135.2  serine/threonine-protein kinase Chk2 isoform X5

  4. XM_006535068.3XP_006535131.2  serine/threonine-protein kinase Chk2 isoform X2

  5. XM_006535069.2XP_006535132.1  serine/threonine-protein kinase Chk2 isoform X3

    See identical proteins and their annotated locations for XP_006535132.1

    UniProtKB/Swiss-Prot
    Q9Z265
    UniProtKB/TrEMBL
    Q543W6
    Conserved Domains (3) summary
    smart00220
    Location:224490
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:97205
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:217490
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  6. XM_006535070.2XP_006535133.1  serine/threonine-protein kinase Chk2 isoform X3

    See identical proteins and their annotated locations for XP_006535133.1

    UniProtKB/Swiss-Prot
    Q9Z265
    UniProtKB/TrEMBL
    Q543W6
    Conserved Domains (3) summary
    smart00220
    Location:224490
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:97205
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:217490
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  7. XM_017320973.1XP_017176462.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:1251
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RNA

  1. XR_001784718.1 RNA Sequence

    Related
    ENSMUST00000199937.4, OTTMUST00000134618
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