May 23, 2019
Mar 26, 2019see all
Dec 11, 2019Human: HG-2487
A TPF contig including AC270778.1 has been added to the Chromosome 1 ALT_REF_LOCI_1 TPF.
Nov 7, 2019Mouse: MG-4376
The validity of the missing CA at NC_000071.6: 124,624,335-124,624,336 could not be confirmed, we find no evidence for intra-strain variation and thus made the decision to update the base with sequences from CAAA01086732.1. This update provides full representation of NM_026486.3, transcript for Tctn2 (GeneID: 67978), to the reference.
Putting sequences into a chromosome context
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Slides from GRC presentations in 2019 are now on SlideShare
Transitioning to GRCh38 or GRCz11? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.
The GRC remains committed to its mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best representation of the human genome to meet basic and clinical research needs. We will continue to make these updates publicly available at regular intervals in the form of patch releases, but have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content for the human reference assembly currently in development.
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