May 23, 2019
Mar 26, 2019see all
Jun 25, 2019Mouse: MG-48
There is currently no evidence available that proves absence of GeneID: 547349 in the reference is due to missing sequence. In the case of any contradictory C57BL/6J data becoming available please contact the GRC.
Jun 25, 2019Mouse: MG-42
Investigation of C57BL/6J sequences find no evidence that supports missing of predicted gene Gm4736 (Gene ID: 114600) in the reference. In the case of any contradictory C57BL/6J data becoming available please contact the GRC.
Putting sequences into a chromosome context
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Slides from the GRC workshop at ASHG 2018 are now on SlideShare
Transitioning to GRCh38 or GRCz11? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.
The GRC remains committed to its mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best representation of the human genome to meet basic and clinical research needs. We will continue to make these updates publicly available at regular intervals in the form of patch releases, but have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content for the human reference assembly currently in development.
Subscribe to the grc-announce email list to receive email notification for all GRC assembly updates.