May 23, 2019
Mar 26, 2019see all
Sep 13, 2019Mouse: MG-131
LXEJ02004842.1 corrects misassembly in reference component AC102524.11 and improves alignments of Muc6 (GeneID: 353328) transcripts, NM_001330001.2 and NM_001368953.1.
Aug 14, 2019Mouse: MG-3179
Optical mapping analysis and independent C57BL/6J sequences identified that there is no gap between AC131776.5 and AC191865.3. AC131776.5 is redundant to AC191865.3,.
Putting sequences into a chromosome context
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Attending ASHG 2019? Register now for the free GRC/GIAB workshop The Reference Assembly & Reference Materials: Updates from the GRC & GIAB"
Attending IMGC 2019? Join the GRC workshop "Previewing GRCm39: assembly updates from the GRC"
Transitioning to GRCh38 or GRCz11? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.
The GRC remains committed to its mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best representation of the human genome to meet basic and clinical research needs. We will continue to make these updates publicly available at regular intervals in the form of patch releases, but have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content for the human reference assembly currently in development.
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