Nov 30, 2020
Jul 22, 2020see all
Feb 23, 2021Human: HG-2587
Analysis demonstrates that AF065393.1, the sole component of GRCh38 chr Un scaffold KI270752.1 (HSCHRUN_RANDOM_CTG29) is hamster sequence, likely derived from the human-hamster CHO cell line (the source of the clone). RefSeq has removed this scaffold from their component of the assembly. Removal of this sequence from the GenBank assembly can only be done at the time of a new major assembly release.
Dec 2, 2020Zebrafish: ZG-7280
WGS or other sequence currently not available to allow representation of missing sequence
Putting sequences into a chromosome context
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Slides from GRC presentations in 2019 are now on SlideShare
The GRC has released GRCm39, a new, coordinate-changing version of the mouse reference assembly! The next patch release of the human assembly, GRCh38.p14, is planned for Fall 2020.
The GRC remains committed to its mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best representation of the human genome to meet basic and clinical research needs. We will continue to make these updates publicly available at regular intervals in the form of patch releases, but have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content for the human reference assembly currently in development.
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