Feb 23, 2018
Feb 09, 2018see all
Putting sequences into a chromosome context
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Attending ASHG 2018? Register now for the free GRC/GIAB workshop "Getting the Most from the Reference Assembly and Reference Materials"
Slides from the GRC workshop at ASHG 2017 are now on SlideShare
Transitioning to GRCh38 or GRCz11? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.
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