Feb 23, 2018
Feb 09, 2018see all
The GRC has built tools to facilitate the curation of genome assemblies based on the sequence overlaps of long, high quality sequences (clones and PCR products, not short sequence reads). The GRC currently supports production of assemblies for human, mouse or zebrafish. If your assembly data fits this model and you are interested in using these tools, please contact us. Subscribe to the grc-announce email list to receive email notification for all GRC assembly updates.
The human genome assembly was produced as part of the Human Genome Project (HGP). The previous assembly (NCBI36) was the last one produced by the HGP and was described in 2004 (PMID: 15496913); this was the starting point for the GRC. The assembly is based largely on assembling overlapping clone sequences.
|Current major assembly||GRCh38|
|Regions with alternate loci||178|
|Assembly N50||67,794,873 bp|
|Patch release version||p12|
|Patches released||FIX: 70, NOVEL: 70|
The GRC has produced an updated assembly (GRCm38). This is an update of the last MGSC assembly (MGSCv37) which was described in 2009 (PMID: 19468303). The primary assembly is based on assembling overlapping BAC clones derived from the C57BL/6J strain and several loci have sequence available from other strains.
|Current major assembly||GRCm38|
|Regions with alternate loci||70|
|Assembly N50||54,517,951 bp|
|Patch release version||p6|
|Patches released||FIX: 65, NOVEL: 9|
The zebrafish genome assembly was produced at the Wellcome Sanger Institute. The last assembly produced from the original project was Zv9 and was described in 2013 (PMID: 23594743). This assembly is the starting point for the GRC. The assembly is based on assembling overlapping BAC clones and integrating these sequences with the whole genome shotgun assembly.
|Current major assembly||GRCz11|
|Regions with alternate loci||607|
|Assembly N50||7,379,053 bp|
The chicken genome assembly was produced by the International Chicken Genome Consortium. Gallus_gallus-5.0 is the latest assembly produced from this project. This assembly is the starting point for the GRC. It is comprised primarily of WGS contigs, into which overlapping genomic clones from the same DNA source have been integrated.
|Current major assembly||GRCg6a|
|Regions with alternate loci||0|
|Assembly N50||20,785,086 bp|