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    MAG myelin associated glycoprotein [ Homo sapiens (human) ]

    Gene ID: 4099, updated on 17-Jun-2024

    Summary

    Official Symbol
    MAGprovided by HGNC
    Official Full Name
    myelin associated glycoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:6783
    See related
    Ensembl:ENSG00000105695 MIM:159460; AllianceGenome:HGNC:6783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GMA; S-MAG; SPG75; SIGLEC4; SIGLEC4A; SIGLEC-4A
    Summary
    The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in brain (RPKM 53.6) and ovary (RPKM 16.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAG in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35292161..35313807)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37836825..37858521)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35783064..35804710)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14470 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35824208-35824417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14472 Neighboring gene CD22 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35831571-35832072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14475 Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene microRNA 5196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene free fatty acid receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CD22

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ganglioside GT1b binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sialic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system myelin formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Schmidt-Lanterman incisure IEA
    Inferred from Electronic Annotation
    more info
     
    located_in compact myelin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mesaxon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath adaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in paranode region of axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    myelin-associated glycoprotein
    Names
    sialic acid binding Ig-like lectin 4A
    sialic acid-binding immunoglobulin-like lectin 4A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034078.1 RefSeqGene

      Range
      5076..26722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199216.2NP_001186145.1  myelin-associated glycoprotein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK308976, BC093045
      Consensus CDS
      CCDS56090.1
      UniProtKB/TrEMBL
      Q53ES7, Q53HA1
      Related
      ENSP00000440695.1, ENST00000537831.2
      Conserved Domains (5) summary
      cd05712
      Location:1114
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00408
      Location:314374
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:308384
      IG_like; Immunoglobulin like
      pfam07679
      Location:215297
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:116198
      Ig; Immunoglobulin domain
    2. NM_002361.4NP_002352.1  myelin-associated glycoprotein isoform a precursor

      See identical proteins and their annotated locations for NP_002352.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks exon 11 and has the stop codon in exon 12, as compared to variant 2. Isoform a is 44 aa longer and contains a different carboxy terminus when compared to isoform b.
      Source sequence(s)
      AK223562, BC093045
      Consensus CDS
      CCDS12455.1
      UniProtKB/Swiss-Prot
      B7Z2E5, F5GYC0, P20916, Q15489, Q567S4
      UniProtKB/TrEMBL
      Q53ES7, Q53HA1
      Related
      ENSP00000376048.2, ENST00000392213.8
      Conserved Domains (4) summary
      cd05712
      Location:22139
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:333409
      IG_like; Immunoglobulin like
      pfam13927
      Location:239309
      Ig_3; Immunoglobulin domain
      cl11960
      Location:141223
      Ig; Immunoglobulin domain
    3. NM_080600.3NP_542167.1  myelin-associated glycoprotein isoform b precursor

      See identical proteins and their annotated locations for NP_542167.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is a full-length transcript with the stop codon contained in exon 11. It encodes an isoform (b) that is 44 aa shorter and contains a different carboxy terminus when compared to isoform a.
      Source sequence(s)
      BC093045
      Consensus CDS
      CCDS12456.1
      UniProtKB/TrEMBL
      Q53ES7
      Related
      ENSP00000355234.4, ENST00000361922.8
      Conserved Domains (5) summary
      cd05712
      Location:22139
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00408
      Location:339399
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:333409
      IG_like; Immunoglobulin like
      pfam07679
      Location:240322
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:141223
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35292161..35313807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37836825..37858521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)