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Mag myelin-associated glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 17136, updated on 11-Jan-2022

Summary

Official Symbol
Magprovided by MGI
Official Full Name
myelin-associated glycoproteinprovided by MGI
Primary source
MGI:MGI:96912
See related
Ensembl:ENSMUSG00000036634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gma; siglec-4a
Summary
This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Biased expression in cerebellum adult (RPKM 107.5), cortex adult (RPKM 67.5) and 2 other tissues See more
Orthologs
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Genomic context

See Mag in Genome Data Viewer
Location:
7 B1; 7 19.26 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30598600..30614347, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30899175..30914922, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31684202..31699851, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CD22 antigen Neighboring gene DNA segment, Chr 7, ERATO Doi 128, expressed Neighboring gene hepcidin antimicrobial peptide 2 Neighboring gene upstream transcription factor 2, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC123387

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables ganglioside GT1b binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ganglioside GT1b binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system myelin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
located_in compact myelin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mesaxon ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath adaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in paranode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myelin-associated glycoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346084.1NP_001333013.1  myelin-associated glycoprotein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC165340, AW457356, BC103523, BY253394, CD776457, CJ054351
    Consensus CDS
    CCDS90207.1
    UniProtKB/TrEMBL
    A0A087WPR1, Q3ZB60
    Related
    ENSMUSP00000139881.2, ENSMUST00000191081.7
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  2. NM_001346085.1NP_001333014.1  myelin-associated glycoprotein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC165340, AW457356, BC103523, BY253394, CD776457, CJ054351
    Consensus CDS
    CCDS90207.1
    UniProtKB/TrEMBL
    A0A087WPR1, Q3ZB60
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  3. NM_001346086.1NP_001333015.1  myelin-associated glycoprotein isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate exon in the 3' coding region resulting in novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Variants 4, 5, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AC165340, AI893951, AW457356, BC103523, BY253394, CD776457, CJ054351
    Consensus CDS
    CCDS21115.1
    UniProtKB/Swiss-Prot
    P20917
    UniProtKB/TrEMBL
    Q3ZB60
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  4. NM_001346087.1NP_001333016.1  myelin-associated glycoprotein isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate exon in the 3' coding region resulting in novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Variants 4, 5, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AC165340, AI893951, AW457356, BC103523, BY253394, BY294008, CD776457, CJ054351
    Consensus CDS
    CCDS21115.1
    UniProtKB/Swiss-Prot
    P20917
    UniProtKB/TrEMBL
    Q3ZB60
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  5. NM_001346088.1NP_001333017.1  myelin-associated glycoprotein isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate exon in the 3' coding region resulting in novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Variants 4, 5, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AC165340, AI893951, AW457356, BC103523, BY253394, CD776457, CJ054351
    Consensus CDS
    CCDS21115.1
    UniProtKB/Swiss-Prot
    P20917
    UniProtKB/TrEMBL
    Q3ZB60
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  6. NM_001346089.1NP_001333018.1  myelin-associated glycoprotein isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    BC103523, CD776457, CJ054351
    UniProtKB/TrEMBL
    Q3ZB60
    Related
    ENSMUSP00000140526.2, ENSMUST00000188569.7
  7. NM_001369262.1NP_001356191.1  myelin-associated glycoprotein isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 8 encode the same isoform (1).
    Source sequence(s)
    AC165340
    Consensus CDS
    CCDS90207.1
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  8. NM_010758.3NP_034888.1  myelin-associated glycoprotein isoform 3 precursor

    See identical proteins and their annotated locations for NP_034888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate exon in the 3' coding region resulting in novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Variants 4, 5, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AC165340, AI893951, AW457356, BC103523, BY253394, CD776457, CJ054351
    Consensus CDS
    CCDS21115.1
    UniProtKB/Swiss-Prot
    P20917
    UniProtKB/TrEMBL
    Q3ZB60
    Related
    ENSMUSP00000139564.2, ENSMUST00000187137.7
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30598600..30614347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250440.3XP_011248742.1  myelin-associated glycoprotein isoform X1

    See identical proteins and their annotated locations for XP_011248742.1

    UniProtKB/TrEMBL
    A0A087WPR1
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  2. XM_030242189.2XP_030098049.1  myelin-associated glycoprotein isoform X2

    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  3. XM_036152726.1XP_036008619.1  myelin-associated glycoprotein isoform X1

    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  4. XM_011250439.3XP_011248741.1  myelin-associated glycoprotein isoform X1

    See identical proteins and their annotated locations for XP_011248741.1

    UniProtKB/TrEMBL
    A0A087WPR1
    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
  5. XM_036152725.1XP_036008618.1  myelin-associated glycoprotein isoform X1

    Conserved Domains (5) summary
    smart00409
    Location:333409
    IG; Immunoglobulin
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cd00096
    Location:239242
    Ig; Ig strand A [structural motif]
    cd05712
    Location:22137
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:141235
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
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