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CD22 CD22 molecule [ Homo sapiens (human) ]

Gene ID: 933, updated on 7-Jun-2020

Summary

Official Symbol
CD22provided by HGNC
Official Full Name
CD22 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1643
See related
Ensembl:ENSG00000012124 MIM:107266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIGLEC2; SIGLEC-2
Expression
Biased expression in lymph node (RPKM 101.0), ovary (RPKM 64.7) and 2 other tissues See more
Orthologs

Genomic context

See CD22 in Genome Data Viewer
Location:
19q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35329169..35347361)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35820069..35838264)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hepcidin antimicrobial peptide Neighboring gene myelin associated glycoprotein Neighboring gene microRNA 5196 Neighboring gene free fatty acid receptor 1 Neighboring gene free fatty acid receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef B lymphocytes exposed to supernatants from HIV-1 Nef-expressing macrophages have upregulated expression of receptors CD22, CD54, and CD58 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MAG

Homology

Clone Names

  • FLJ22814, MGC130020

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CD4 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CD4 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
IgM binding TAS
Traceable Author Statement
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase binding TAS
Traceable Author Statement
more info
PubMed 
sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
sialic acid binding TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of immunoglobulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
B-cell receptor CD22
Names
B-lymphocyte cell adhesion molecule
BL-CAM
CD22 antigen
T-cell surface antigen Leu-14
sialic acid-binding Ig-like lectin 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185099.2NP_001172028.1  B-cell receptor CD22 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK225625, AK225694, X59350
    Consensus CDS
    CCDS54248.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000442279.1, ENST00000536635.6
    Conserved Domains (5) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:518589
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  2. NM_001185100.2NP_001172029.1  B-cell receptor CD22 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC109306, BC109307, DA989528, DB333800, U62631, X59350
    Consensus CDS
    CCDS54247.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000441237.1, ENST00000544992.6
    Conserved Domains (6) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:606677
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:335400
    Ig_3; Immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  3. NM_001185101.1NP_001172030.1  B-cell receptor CD22 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001172030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC109306, DA989528, DB333800, X52785, X59350
    Consensus CDS
    CCDS54249.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000339349.6, ENST00000341773.10
    Conserved Domains (5) summary
    smart00408
    Location:431489
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:429500
    IG_like; Immunoglobulin like
    pfam07679
    Location:333412
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  4. NM_001278417.2NP_001265346.1  B-cell receptor CD22 isoform 5

    See identical proteins and their annotated locations for NP_001265346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks the exon containing the translation initiation site and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC109306, BQ054599, CF138699, KC877723, U62631
    Consensus CDS
    CCDS62634.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000403822.2, ENST00000419549.6
    Conserved Domains (4) summary
    smart00410
    Location:434505
    IG_like; Immunoglobulin like
    pfam13927
    Location:163228
    Ig_3; Immunoglobulin domain
    cl11960
    Location:456
    Ig; Immunoglobulin domain
    cl28434
    Location:70155
    I-set; Immunoglobulin I-set domain
  5. NM_001771.4NP_001762.2  B-cell receptor CD22 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001762.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK225625, AK225694, BC109306, DB333800, X59350
    Consensus CDS
    CCDS12457.1
    UniProtKB/Swiss-Prot
    P20273
    UniProtKB/TrEMBL
    Q0EAF5
    Related
    ENSP00000085219.4, ENST00000085219.10
    Conserved Domains (6) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:606677
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:335400
    Ig_3; Immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35329169..35347361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024916.1: Suppressed sequence

    Description
    NM_024916.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
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