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CD22 CD22 molecule [ Homo sapiens (human) ]

Gene ID: 933, updated on 1-Mar-2024

Summary

Official Symbol
CD22provided by HGNC
Official Full Name
CD22 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1643
See related
Ensembl:ENSG00000012124 MIM:107266; AllianceGenome:HGNC:1643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIGLEC2; SIGLEC-2
Summary
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 101.0), ovary (RPKM 64.7) and 2 other tissues See more
Orthologs
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Genomic context

See CD22 in Genome Data Viewer
Location:
19q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35329187..35347361)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37873914..37892093)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35820090..35838264)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14470 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35824208-35824417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35831571-35832072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14475 Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene microRNA 5196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene free fatty acid receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef B lymphocytes exposed to supernatants from HIV-1 Nef-expressing macrophages have upregulated expression of receptors CD22, CD54, and CD58 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MAG

Clone Names

  • FLJ22814, MGC130020

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CD4 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CD4 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables IgM binding TAS
Traceable Author Statement
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein phosphatase binding TAS
Traceable Author Statement
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sialic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sialic acid binding TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of B cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
B-cell receptor CD22
Names
B-lymphocyte cell adhesion molecule
BL-CAM
CD22 antigen
T-cell surface antigen Leu-14
sialic acid-binding Ig-like lectin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185099.2NP_001172028.1  B-cell receptor CD22 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK225625, AK225694, X59350
    Consensus CDS
    CCDS54248.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000442279.1, ENST00000536635.6
    Conserved Domains (5) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:518589
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  2. NM_001185100.2NP_001172029.1  B-cell receptor CD22 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC109306, BC109307, DA989528, DB333800, U62631, X59350
    Consensus CDS
    CCDS54247.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000441237.1, ENST00000544992.6
    Conserved Domains (6) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:606677
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:335400
    Ig_3; Immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  3. NM_001185101.2NP_001172030.1  B-cell receptor CD22 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001172030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC109306, DA989528, DB333800, X52785, X59350
    Consensus CDS
    CCDS54249.1
    UniProtKB/Swiss-Prot
    P20273
    Related
    ENSP00000339349.6, ENST00000341773.10
    Conserved Domains (5) summary
    smart00408
    Location:431489
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:429500
    IG_like; Immunoglobulin like
    pfam07679
    Location:333412
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
  4. NM_001278417.2NP_001265346.1  B-cell receptor CD22 isoform 5

    See identical proteins and their annotated locations for NP_001265346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks the exon containing the translation initiation site and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC109306, BQ054599, CF138699, KC877723, U62631
    Consensus CDS
    CCDS62634.1
    UniProtKB/TrEMBL
    B7Z6Y6
    Related
    ENSP00000403822.2, ENST00000419549.6
    Conserved Domains (4) summary
    smart00410
    Location:434505
    IG_like; Immunoglobulin like
    pfam13927
    Location:163228
    Ig_3; Immunoglobulin domain
    cl11960
    Location:456
    Ig; Immunoglobulin domain
    cl28434
    Location:70155
    I-set; Immunoglobulin I-set domain
  5. NM_001771.4NP_001762.2  B-cell receptor CD22 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001762.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK225625, AK225694, BC109306, DB333800, X59350
    Consensus CDS
    CCDS12457.1
    UniProtKB/Swiss-Prot
    F5GYU4, F5H7U3, O95699, O95701, O95702, O95703, P20273, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
    UniProtKB/TrEMBL
    Q0EAF5
    Related
    ENSP00000085219.4, ENST00000085219.10
    Conserved Domains (6) summary
    smart00408
    Location:257316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:606677
    IG_like; Immunoglobulin like
    pfam07679
    Location:242327
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:143228
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:335400
    Ig_3; Immunoglobulin domain
    cl11960
    Location:24122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35329187..35347361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37873914..37892093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024916.1: Suppressed sequence

    Description
    NM_024916.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.