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    MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens (human) ]

    Gene ID: 5602, updated on 3-Apr-2024

    Summary

    Official Symbol
    MAPK10provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:6872
    See related
    Ensembl:ENSG00000109339 MIM:602897; AllianceGenome:HGNC:6872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in brain (RPKM 15.3), fat (RPKM 4.4) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK10 in Genome Data Viewer
    Location:
    4q21.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (86010405..86594074, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (89339877..89923587, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86931558..87374348, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC105377319 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:86587778-86588977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21694 Neighboring gene uncharacterized LOC124900728 Neighboring gene Sharpr-MPRA regulatory region 4363 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:86694939-86695479 Neighboring gene NANOG hESC enhancer GRCh37_chr4:86709821-86710322 Neighboring gene microRNA 4451 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:86747140-86747682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:86996696-86997266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:86997267-86997836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87056245-87056789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87055698-87056244 Neighboring gene MAPK10 antisense RNA 1 Neighboring gene RN7SK pseudogene 96 Neighboring gene NANOG hESC enhancer GRCh37_chr4:87353806-87354348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87374354-87374902 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:87393729-87394298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:87398123-87398623 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87403957-87404713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:87468519-87469019 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:87515119-87515705 Neighboring gene microRNA 4452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15548 Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:87651683-87652182 Neighboring gene solute carrier family 10 member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog
    Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
    env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
    Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
    env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12099, FLJ33785, MGC50974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables JUN kinase activity TAS
    Traceable Author Statement
    more info
     
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to light stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 10
    Names
    JNK3 alpha protein kinase
    MAP kinase 10
    MAP kinase p49 3F12
    c-Jun N-terminal kinase 3
    stress activated protein kinase beta
    stress-activated protein kinase 1b
    stress-activated protein kinase JNK3
    NP_001304996.1
    NP_001304997.1
    NP_001304998.1
    NP_001338553.1
    NP_001338554.1
    NP_001350586.1
    NP_002744.1
    NP_620446.1
    NP_620448.1
    XP_047271920.1
    XP_047271921.1
    XP_047271922.1
    XP_047271923.1
    XP_047271924.1
    XP_054206482.1
    XP_054206483.1
    XP_054206484.1
    XP_054206485.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013325.3 RefSeqGene

      Range
      239021..588669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318067.1NP_001304996.1  mitogen-activated protein kinase 10 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate in-frame coding exon compared to variant 1. The resulting isoform (5) is the same length; however, contains a different 23 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK225974, BC035057
      Consensus CDS
      CCDS87243.1
      UniProtKB/TrEMBL
      A0A286YF97, A0A286YFA6
      Related
      ENSP00000493344.1, ENST00000641718.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001318068.1NP_001304997.1  mitogen-activated protein kinase 10 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon, lacks an internal exon and contains an alternate in-frame coding exon compared to variant 1. These differences result in translation initiation from an in-frame, downstream start codon, and an isoform (6) with a shorter N-terminus and containing a different 23 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC035057, BC051731
      UniProtKB/TrEMBL
      B7Z1Z1, Q499Y8
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001318069.2NP_001304998.1  mitogen-activated protein kinase 10 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057
      Consensus CDS
      CCDS93556.1
      UniProtKB/TrEMBL
      A0A286YFA6, F8W9R5
      Related
      ENSP00000414469.4, ENST00000449047.8
      Conserved Domains (2) summary
      smart00220
      Location:64359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. NM_001351624.2NP_001338553.1  mitogen-activated protein kinase 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC104059, AF052141, AK307129, BC022492, BC035057
      Consensus CDS
      CCDS3612.1
      UniProtKB/TrEMBL
      A0A286YEN5
      Related
      ENSP00000493040.1, ENST00000642015.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. NM_001351625.3NP_001338554.1  mitogen-activated protein kinase 10 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC104059, AF052141, AK307129, BC022492, BC035057, CB069160
      Consensus CDS
      CCDS87242.1
      UniProtKB/TrEMBL
      A0A286YFI3, D6RJF9
      Related
      ENSP00000352157.4, ENST00000359221.8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. NM_001363657.3NP_001350586.1  mitogen-activated protein kinase 10 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC096953, AC104059, AC104827, AC108054
      Consensus CDS
      CCDS87241.1
      UniProtKB/TrEMBL
      A0A286YEQ0, A0A286YFI3
      Related
      ENSP00000492922.1, ENST00000641208.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    7. NM_002753.6NP_002744.1  mitogen-activated protein kinase 10 isoform 2

      See identical proteins and their annotated locations for NP_002744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2, also know as JNK3 alpha1) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC096953, AC104059, AF052141, AK057723, U07620
      Consensus CDS
      CCDS43247.1
      UniProtKB/TrEMBL
      A0A286YFJ4
      Related
      ENSP00000493237.1, ENST00000641170.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    8. NM_138980.4NP_620446.1  mitogen-activated protein kinase 10 isoform 3

      See identical proteins and their annotated locations for NP_620446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057, DA192997
      Consensus CDS
      CCDS3612.1
      UniProtKB/TrEMBL
      A0A286YEN5
      Related
      ENSP00000491866.1, ENST00000638225.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    9. NM_138982.4NP_620448.1  mitogen-activated protein kinase 10 isoform 1

      See identical proteins and their annotated locations for NP_620448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057
      Consensus CDS
      CCDS34026.1
      UniProtKB/Swiss-Prot
      A6NFS3, A6NG28, B3KQ94, P53779, Q15707, Q49AP1
      UniProtKB/TrEMBL
      A0A286YFA6
      Related
      ENSP00000493435.1, ENST00000641462.2
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      86010405..86594074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415964.1XP_047271920.1  mitogen-activated protein kinase 10 isoform X1

    2. XM_047415966.1XP_047271922.1  mitogen-activated protein kinase 10 isoform X3

    3. XM_047415967.1XP_047271923.1  mitogen-activated protein kinase 10 isoform X4

      Related
      ENSP00000422277.2, ENST00000511167.6
    4. XM_047415968.1XP_047271924.1  mitogen-activated protein kinase 10 isoform X4

    5. XM_047415965.1XP_047271921.1  mitogen-activated protein kinase 10 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      89339877..89923587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350507.1XP_054206482.1  mitogen-activated protein kinase 10 isoform X1

    2. XM_054350509.1XP_054206484.1  mitogen-activated protein kinase 10 isoform X3

    3. XM_054350510.1XP_054206485.1  mitogen-activated protein kinase 10 isoform X4

    4. XM_054350508.1XP_054206483.1  mitogen-activated protein kinase 10 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138981.2: Suppressed sequence

      Description
      NM_138981.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.