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    MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens (human) ]

    Gene ID: 5602, updated on 15-Jan-2022

    Summary

    Official Symbol
    MAPK10provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:6872
    See related
    Ensembl:ENSG00000109339 MIM:602897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in brain (RPKM 15.3), fat (RPKM 4.4) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK10 in Genome Data Viewer
    Location:
    4q21.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (86010405..86594625, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86931558..87374348, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC105377319 Neighboring gene microRNA 4451 Neighboring gene MAPK10 antisense RNA 1 Neighboring gene RN7SK pseudogene 96 Neighboring gene microRNA 4452 Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene uncharacterized LOC107986189 Neighboring gene solute carrier family 10 member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog
    Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
    env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
    Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
    env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12099, FLJ33785, MGC50974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables JUN kinase activity TAS
    Traceable Author Statement
    more info
     
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to light stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 10
    Names
    JNK3 alpha protein kinase
    MAP kinase 10
    MAP kinase p49 3F12
    c-Jun N-terminal kinase 3
    stress activated protein kinase beta
    stress-activated protein kinase 1b
    stress-activated protein kinase JNK3
    NP_001304996.1
    NP_001304997.1
    NP_001304998.1
    NP_001338553.1
    NP_001338554.1
    NP_001350586.1
    NP_002744.1
    NP_620446.1
    NP_620448.1
    XP_005263186.1
    XP_005263187.1
    XP_005263188.1
    XP_005263192.1
    XP_006714331.1
    XP_006714332.1
    XP_011530419.1
    XP_011530420.1
    XP_011530422.1
    XP_011530423.1
    XP_016863909.1
    XP_016863911.1
    XP_016863912.1
    XP_016863916.1
    XP_016863917.1
    XP_016863918.1
    XP_016863919.1
    XP_016863921.1
    XP_016863922.1
    XP_016863923.1
    XP_016863924.1
    XP_016863925.1
    XP_016863926.1
    XP_016863930.1
    XP_016863934.1
    XP_016863936.1
    XP_016863937.1
    XP_016863938.1
    XP_016863939.1
    XP_016863940.1
    XP_016863941.1
    XP_016863942.1
    XP_016863943.1
    XP_024309907.1
    XP_024309908.1
    XP_024309909.1
    XP_024309910.1
    XP_024309911.1
    XP_024309912.1
    XP_024309913.1
    XP_024309914.1
    XP_024309915.1
    XP_024309916.1
    XP_024309917.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013325.2 RefSeqGene

      Range
      4936..447697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318067.1NP_001304996.1  mitogen-activated protein kinase 10 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate in-frame coding exon compared to variant 1. The resulting isoform (5) is the same length; however, contains a different 23 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK225974, BC035057
      Consensus CDS
      CCDS87243.1
      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A0A286YF97
      Related
      ENSP00000493344.1, ENST00000641718.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001318068.1NP_001304997.1  mitogen-activated protein kinase 10 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon, lacks an internal exon and contains an alternate in-frame coding exon compared to variant 1. These differences result in translation initiation from an in-frame, downstream start codon, and an isoform (6) with a shorter N-terminus and containing a different 23 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC035057, BC051731
      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      Q499Y8
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001318069.2NP_001304998.1  mitogen-activated protein kinase 10 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057
      UniProtKB/Swiss-Prot
      P53779
      Conserved Domains (2) summary
      smart00220
      Location:64359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. NM_001351624.2NP_001338553.1  mitogen-activated protein kinase 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC104059, AF052141, AK307129, BC022492, BC035057
      Consensus CDS
      CCDS3612.1
      Related
      ENSP00000493040.1, ENST00000642015.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. NM_001351625.3NP_001338554.1  mitogen-activated protein kinase 10 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC104059, AF052141, AK307129, BC022492, BC035057, CB069160
      Consensus CDS
      CCDS87242.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. NM_001363657.3NP_001350586.1  mitogen-activated protein kinase 10 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC096953, AC104059, AC104827, AC108054
      Consensus CDS
      CCDS87241.1
      Related
      ENSP00000492922.1, ENST00000641208.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    7. NM_002753.6NP_002744.1  mitogen-activated protein kinase 10 isoform 2

      See identical proteins and their annotated locations for NP_002744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2, also know as JNK3 alpha1) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC096953, AC104059, AF052141, AK057723, U07620
      Consensus CDS
      CCDS43247.1
      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A8MWW6
      Related
      ENSP00000493237.1, ENST00000641170.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    8. NM_138980.4NP_620446.1  mitogen-activated protein kinase 10 isoform 3

      See identical proteins and their annotated locations for NP_620446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057, DA192997
      Consensus CDS
      CCDS3612.1
      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000491866.1, ENST00000638225.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    9. NM_138982.4NP_620448.1  mitogen-activated protein kinase 10 isoform 1

      See identical proteins and their annotated locations for NP_620448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      AC104059, AF052141, AK057723, BC022492, BC035057
      Consensus CDS
      CCDS34026.1
      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000493435.1, ENST00000641462.2
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      86010405..86594625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454141.1XP_024309909.1  mitogen-activated protein kinase 10 isoform X1

      Related
      ENSP00000493275.1, ENST00000641051.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. XM_017008428.2XP_016863917.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      A0A286YFD7
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. XM_011532120.3XP_011530422.1  mitogen-activated protein kinase 10 isoform X4

      See identical proteins and their annotated locations for XP_011530422.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000493177.1, ENST00000641737.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. XM_024454142.1XP_024309910.1  mitogen-activated protein kinase 10 isoform X1

      Related
      ENSP00000493363.1, ENST00000641157.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. XM_024454145.1XP_024309913.1  mitogen-activated protein kinase 10 isoform X6

      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. XM_011532117.3XP_011530419.1  mitogen-activated protein kinase 10 isoform X1

      See identical proteins and their annotated locations for XP_011530419.1

      UniProtKB/Swiss-Prot
      P53779
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    7. XM_024454144.1XP_024309912.1  mitogen-activated protein kinase 10 isoform X6

      Related
      ENSP00000493270.1, ENST00000641050.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    8. XM_024454140.1XP_024309908.1  mitogen-activated protein kinase 10 isoform X1

      Related
      ENSP00000493013.1, ENST00000641952.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    9. XM_024454148.1XP_024309916.1  mitogen-activated protein kinase 10 isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    10. XM_024454139.1XP_024309907.1  mitogen-activated protein kinase 10 isoform X1

      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    11. XM_017008448.2XP_016863937.1  mitogen-activated protein kinase 10 isoform X13

      UniProtKB/TrEMBL
      I6L9F3
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    12. XM_005263131.3XP_005263188.1  mitogen-activated protein kinase 10 isoform X2

      See identical proteins and their annotated locations for XP_005263188.1

      UniProtKB/TrEMBL
      A0A286YF97
      Related
      ENSP00000492913.1, ENST00000641553.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    13. XM_006714269.3XP_006714332.1  mitogen-activated protein kinase 10 isoform X7

      See identical proteins and their annotated locations for XP_006714332.1

      UniProtKB/TrEMBL
      A0A1P0B7D2
      Related
      ENSP00000378598.5, ENST00000395169.9
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    14. XM_005263135.4XP_005263192.1  mitogen-activated protein kinase 10 isoform X6

      See identical proteins and their annotated locations for XP_005263192.1

      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A8MWW6
      Related
      ENSP00000378586.4, ENST00000395157.9
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    15. XM_017008434.2XP_016863923.1  mitogen-activated protein kinase 10 isoform X9

      UniProtKB/TrEMBL
      D6RJF9
      Related
      ENSP00000352157.4, ENST00000359221.8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    16. XM_017008450.2XP_016863939.1  mitogen-activated protein kinase 10 isoform X14

      UniProtKB/TrEMBL
      Q499Y8
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    17. XM_017008433.2XP_016863922.1  mitogen-activated protein kinase 10 isoform X8

      UniProtKB/TrEMBL
      A0A286YEQ7
      Related
      ENSP00000492898.1, ENST00000641384.1
      Conserved Domains (1) summary
      cd07850
      Location:25336
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    18. XM_017008441.2XP_016863930.1  mitogen-activated protein kinase 10 isoform X11

      UniProtKB/TrEMBL
      A0A286YFN2
      Related
      ENSP00000493447.1, ENST00000642023.1
      Conserved Domains (1) summary
      cd07850
      Location:25336
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    19. XM_017008427.2XP_016863916.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      A0A286YFD7
      Related
      ENSP00000493350.1, ENST00000641166.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    20. XM_017008445.2XP_016863934.1  mitogen-activated protein kinase 10 isoform X12

      UniProtKB/TrEMBL
      A0A286YES0
      Related
      ENSP00000492920.1, ENST00000641607.1
      Conserved Domains (1) summary
      cd07850
      Location:1284
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    21. XM_017008451.2XP_016863940.1  mitogen-activated protein kinase 10 isoform X15

      UniProtKB/TrEMBL
      A0A286YF02
      Related
      ENSP00000493455.1, ENST00000641047.1
      Conserved Domains (1) summary
      cd07850
      Location:1284
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    22. XM_017008449.2XP_016863938.1  mitogen-activated protein kinase 10 isoform X14

      UniProtKB/TrEMBL
      Q499Y8
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    23. XM_017008447.2XP_016863936.1  mitogen-activated protein kinase 10 isoform X13

      UniProtKB/TrEMBL
      I6L9F3
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    24. XM_017008452.2XP_016863941.1  mitogen-activated protein kinase 10 isoform X16

      Related
      ENSP00000492912.1, ENST00000641881.1
      Conserved Domains (1) summary
      cl21453
      Location:1253
      PKc_like; Protein Kinases, catalytic domain
    25. XM_017008420.2XP_016863909.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000493045.1, ENST00000641983.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    26. XM_006714268.3XP_006714331.1  mitogen-activated protein kinase 10 isoform X4

      See identical proteins and their annotated locations for XP_006714331.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000493049.1, ENST00000641803.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    27. XM_017008435.2XP_016863924.1  mitogen-activated protein kinase 10 isoform X9

      UniProtKB/TrEMBL
      D6RJF9
      Related
      ENSP00000425654.2, ENST00000512689.6
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    28. XM_017008429.2XP_016863918.1  mitogen-activated protein kinase 10 isoform X6

      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A8MWW6
      Related
      ENSP00000491122.1, ENST00000640858.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    29. XM_005263129.3XP_005263186.1  mitogen-activated protein kinase 10 isoform X1

      See identical proteins and their annotated locations for XP_005263186.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000493072.1, ENST00000641066.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    30. XM_017008430.2XP_016863919.1  mitogen-activated protein kinase 10 isoform X6

      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A8MWW6
      Related
      ENSP00000492231.1, ENST00000640970.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    31. XM_017008423.2XP_016863912.1  mitogen-activated protein kinase 10 isoform X4

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000378595.1, ENST00000395166.6
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    32. XM_017008436.2XP_016863925.1  mitogen-activated protein kinase 10 isoform X9

      UniProtKB/TrEMBL
      D6RJF9
      Related
      ENSP00000493206.1, ENST00000641989.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    33. XM_011532118.3XP_011530420.1  mitogen-activated protein kinase 10 isoform X1

      See identical proteins and their annotated locations for XP_011530420.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000492292.1, ENST00000638313.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    34. XM_024454146.1XP_024309914.1  mitogen-activated protein kinase 10 isoform X6

      Related
      ENSP00000492942.1, ENST00000642038.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    35. XM_011532121.3XP_011530423.1  mitogen-activated protein kinase 10 isoform X4

      See identical proteins and their annotated locations for XP_011530423.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000491089.1, ENST00000639242.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    36. XM_017008437.2XP_016863926.1  mitogen-activated protein kinase 10 isoform X9

      UniProtKB/TrEMBL
      D6RJF9
      Related
      ENSP00000493309.1, ENST00000641767.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    37. XM_005263130.3XP_005263187.1  mitogen-activated protein kinase 10 isoform X1

      See identical proteins and their annotated locations for XP_005263187.1

      UniProtKB/Swiss-Prot
      P53779
      Related
      ENSP00000414469.4, ENST00000449047.8
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    38. XM_017008432.2XP_016863921.1  mitogen-activated protein kinase 10 isoform X6

      UniProtKB/Swiss-Prot
      P53779
      UniProtKB/TrEMBL
      A8MWW6
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    39. XM_024454143.1XP_024309911.1  mitogen-activated protein kinase 10 isoform X1

      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    40. XM_024454147.1XP_024309915.1  mitogen-activated protein kinase 10 isoform X6

      Related
      ENSP00000493396.1, ENST00000641862.1
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    41. XM_017008422.2XP_016863911.1  mitogen-activated protein kinase 10 isoform X3

      Conserved Domains (1) summary
      cd07850
      Location:63374
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    42. XM_017008454.2XP_016863943.1  mitogen-activated protein kinase 10 isoform X18

      UniProtKB/TrEMBL
      D6RCB1
      Related
      ENSP00000422277.2, ENST00000511167.6
      Conserved Domains (1) summary
      cl21453
      Location:63243
      PKc_like; Protein Kinases, catalytic domain
    43. XM_024454149.1XP_024309917.1  mitogen-activated protein kinase 10 isoform X18

      Conserved Domains (1) summary
      cl21453
      Location:63243
      PKc_like; Protein Kinases, catalytic domain
    44. XM_017008453.2XP_016863942.1  mitogen-activated protein kinase 10 isoform X17

      Conserved Domains (2) summary
      smart00220
      Location:64240
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:63243
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001741289.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138981.2: Suppressed sequence

      Description
      NM_138981.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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