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Mapk10 mitogen-activated protein kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 26414, updated on 9-Mar-2023

Summary

Official Symbol
Mapk10provided by MGI
Official Full Name
mitogen-activated protein kinase 10provided by MGI
Primary source
MGI:MGI:1346863
See related
Ensembl:ENSMUSG00000046709 AllianceGenome:MGI:1346863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); C230008H04Rik
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in cortex adult (RPKM 28.0), frontal lobe adult (RPKM 20.7) and 7 other tissues See more
Orthologs
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Genomic context

See Mapk10 in Genome Data Viewer
Location:
5; 5 E5
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (103056413..103360470, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (102908547..103212604, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene ferredoxin 1-like pseudogene Neighboring gene predicted gene, 30396 Neighboring gene RIKEN cDNA 4930429D17 gene Neighboring gene RIKEN cDNA 1700021F02 gene Neighboring gene discs, large homolog 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in JUN phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor transport to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 10
Names
JNK3 beta1 protein kinase
JNK3 beta2 protein kinase
MAP kinase 10
MAP kinase p49 3F12
SAPK/Erk/kinase 2
c-Jun N-terminal kinase 3
stress-activated protein kinase JNK3
NP_001075036.1
NP_001297612.1
NP_001297614.1
NP_001297615.1
NP_001305031.1
NP_001305060.1
NP_033184.2
XP_006535013.1
XP_011247752.1
XP_017176375.1
XP_017176377.1
XP_017176378.1
XP_017176379.1
XP_017176380.1
XP_030110376.1
XP_030110378.1
XP_030110379.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081567.3NP_001075036.1  mitogen-activated protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_001075036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also know as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    Consensus CDS
    CCDS39185.1
    UniProtKB/TrEMBL
    A0A6P5PJ24, Q78GB8, Q8C9D4
    Related
    ENSMUSP00000108468.3, ENSMUST00000112847.9
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001310683.2NP_001297612.1  mitogen-activated protein kinase 10 isoform 3

    See identical proteins and their annotated locations for NP_001297612.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PNN8, Q78GB8
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. NM_001310685.2NP_001297614.1  mitogen-activated protein kinase 10 isoform 4

    See identical proteins and their annotated locations for NP_001297614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame coding exon compared to variant 1. The resulting isoform (4, also known as JNK3 beta2) is the same length; however, contains a different 24 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    Consensus CDS
    CCDS80350.1
    UniProtKB/TrEMBL
    A0A8C6G6C8, Q80W80
    Related
    ENSMUSP00000084065.4, ENSMUST00000086854.10
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. NM_001310686.3NP_001297615.1  mitogen-activated protein kinase 10 isoform 5

    See identical proteins and their annotated locations for NP_001297615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site in the 5' region and at the 3' terminal exon compared to variant 1. These differences result in translation initiation from an in-frame, downstream start codon, and an isoform (5) with a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/Swiss-Prot
    Q61831
    UniProtKB/TrEMBL
    Q78GB8
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  5. NM_001318102.1NP_001305031.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also know as JNK3 alpha1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AC125252, AC137121, AK082242, BC046625
    Consensus CDS
    CCDS89959.1
    UniProtKB/TrEMBL
    A0A5F8MP75, Q78GB8
    Related
    ENSMUSP00000158744.3, ENSMUST00000238446.3
    Conserved Domains (2) summary
    smart00220
    Location:64359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  6. NM_001318131.2NP_001305060.1  mitogen-activated protein kinase 10 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate in-frame coding exon and uses an alternate acceptor splice site at the 3' terminal exon (which causes a frameshift) compared to variant 1. The resulting isoform (6, also known as JNK3 beta1) has a different, internal 24 aa protein segment and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    Q3TQZ7, Q78GB8, Q80W81
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  7. NM_001407572.1NP_001394501.1  mitogen-activated protein kinase 10 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121
    UniProtKB/TrEMBL
    E9QN59
  8. NM_001407573.1NP_001394502.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PJ24, Q8C9D4
  9. NM_001407574.1NP_001394503.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PJ24, Q8C9D4
  10. NM_001407575.1NP_001394504.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PJ24, Q8C9D4
  11. NM_001407576.1NP_001394505.1  mitogen-activated protein kinase 10 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  12. NM_001407577.1NP_001394506.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PNN8, Q78GB8
  13. NM_001407578.1NP_001394507.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PNN8, Q78GB8
  14. NM_001407579.1NP_001394508.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PNN8, Q78GB8
  15. NM_001407580.1NP_001394509.1  mitogen-activated protein kinase 10 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  16. NM_001407584.1NP_001394513.1  mitogen-activated protein kinase 10 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PRD5, A0A8C6G6M8, Q80W82
  17. NM_001407586.1NP_001394515.1  mitogen-activated protein kinase 10 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  18. NM_001407588.1NP_001394517.1  mitogen-activated protein kinase 10 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121
  19. NM_001407589.1NP_001394518.1  mitogen-activated protein kinase 10 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121
  20. NM_001407592.1NP_001394521.1  mitogen-activated protein kinase 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  21. NM_001407595.1NP_001394524.1  mitogen-activated protein kinase 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  22. NM_001407599.1NP_001394528.1  mitogen-activated protein kinase 10 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  23. NM_001407600.1NP_001394529.1  mitogen-activated protein kinase 10 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC137121
    UniProtKB/TrEMBL
    A0A0G2JG69
  24. NM_001407601.1NP_001394530.1  mitogen-activated protein kinase 10 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
  25. NM_009158.4NP_033184.2  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_033184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2, also know as JNK3 alpha1) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC123664, AC125252, AC137121, AC160244
    UniProtKB/TrEMBL
    A0A6P5PRD5, A0A8C6G6M8, Q80W82
    Related
    ENSMUSP00000108467.2, ENSMUST00000112846.8
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. NR_176398.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC123664, AC160244

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    103056413..103360470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320886.3XP_017176375.1  mitogen-activated protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    Q80W80
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. XM_006534950.5XP_006535013.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    Q80W81
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. XM_017320889.3XP_017176378.1  mitogen-activated protein kinase 10 isoform X4

    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. XM_030254519.2XP_030110379.1  mitogen-activated protein kinase 10 isoform X9

    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  5. XM_030254518.2XP_030110378.1  mitogen-activated protein kinase 10 isoform X7

    Conserved Domains (1) summary
    cd07850
    Location:6324
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  6. XM_030254516.1XP_030110376.1  mitogen-activated protein kinase 10 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  7. XM_017320888.2XP_017176377.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    Q78GB8
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  8. XM_017320891.2XP_017176380.1  mitogen-activated protein kinase 10 isoform X8

    UniProtKB/Swiss-Prot
    Q61831
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  9. XM_017320890.3XP_017176379.1  mitogen-activated protein kinase 10 isoform X8

    UniProtKB/Swiss-Prot
    Q61831
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  10. XM_011249450.4XP_011247752.1  mitogen-activated protein kinase 10 isoform X6

    Conserved Domains (1) summary
    cd07850
    Location:6324
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase